M. Chua, MD, you're one of the best in your field. Thank you, for this podcast. I've lost central vision in my right eye in the last two months. When the time comes, I will consider a dog guide. T.Y.
@agordon478 ай бұрын
Thanks for the video.I’m an ophthalmologist who does intravitreals and I’ve not yet used Synfovre out of the same concerns you have. I think it has a very small place to play and should only be used in a very few patients. I will refer some of my patient’s questions to your video.
@davidlo1688885 ай бұрын
If drusen can't be excreted to surface of cornea, it's impossible to effectively treat and reverse geographic atrophy. Please note accumulated drusen is the culprit. Applying God's mercy nano-grade eye drops, within one hour, drusen will be excreted to surface of cornea. If drusen can be cleared away thoroughly, of course, geogaphic atrophy should be reversed.
@JustanOd Жыл бұрын
Wow, that point you made at about 19:00 about changing the Izervay study protocol from acuity to GA size was really astute.
@andrewzanas93879 ай бұрын
Michael, sorry, Dr. Chu. Thanks for this AMD episode. I'm 79 and was suffering from AMD. Two days ago after listening to you I added raw organic leafy greens spinach and kale twice a day. I could not believe how fast my vision cleared up.
@RavenWolfDrum699 ай бұрын
No way
@truenokill2 ай бұрын
How much?
@AliceR278 күн бұрын
I've just heard about spinach. Love spinach so need to try. I just started taurine to see if it helps at all.
@dianedixon294710 ай бұрын
Thank you for this timely information. I am being offered this latest greatest treatment for AMD and needed this information. My hesitancy is validated.
@VyvienneEaux10 ай бұрын
I just want to say that your videos like this about specific conditions are amazing. They're entertaining and as informative as medical school lectures,. Astoundingly good work. Please keep it up!
@IndianaNana18 ай бұрын
I'm almost 65 and was diagnosed with geographic atrophy. My retina specialist does not do the Syfovre treatment due to the issues you stated. People went blind. I don't see that anyone has gone blind from Izervay. I plan to get that treatment in a few months once my medicare kicks in. My eye doctor told me to look up everything I could and determine the risks for myself. I'm a psychologist, so research is important to me. That said, I realize my visual acuity will not get better, but slowing this awful stuff down is important to me. Everyone has to weigh the benefits to risks. If I'm going to lose my sight anyways then isn't it worth it to have a little more time to see my children and grandchildren with my own eyes? Anywho, that's how I feel. 💓💜 My vision is changing fast and I feel like I'm running out of time to get the things done that I want to do around my home. That said, I signed up for your newsletter and look forward to learning more from you.
@davidlo1688885 ай бұрын
If drusen can't be excreted to surface of cornea, it's impossible to effectively treat and reverse geographic atrophy. Please note accumulated drusen is the culprit. Applying God's mercy nano-grade eye drops, within one hour, drusen will be excreted to surface of cornea. If drusen can be cleared away thoroughly, of course, geogaphic atrophy should be reversed.
@mballer5 ай бұрын
In your research find studies on lifestyle and nutrition. Look for light therapy and air quality, allergens, dust, mold, fungus, irritants. Exercise blood circulation. These things don't just randomly happen, something is causing it.
@truenokill2 ай бұрын
Also acupuncture
@briancowan5288 ай бұрын
Thank you. A nice, clear, honest appraisal of the situation. What about the stem cell research going on in the UK?
@MẮTKÍNHTlTAN9 ай бұрын
Great info! The explanation is very easy to understand! Thank you for sharing about New treatments for macular degeneration!
@janicemcvay81588 ай бұрын
Your information on both treatments is extremely helpful. I was just diagnosed with GA and told by the RS that he plans on injecting Izervay in 3 weeks. I asked him if there are any side effects to this medication and he quickly said some eye irritation may occur but it's very rare. He walked out of the room and left his tech with me to say that I'm not to go and google etc about this treatment as there are so many false information out there to scare the patient. Well, that's the wrong thing to say to any patient because we all tend to do the opposite. Fortunately, I'm on a MD fb group that kind of brought me to your video. I was listening to another video and yours was the next in line.....which I'm thankful for. Right now after listening three xs to your video, I'm leaning more to cancelling my next appt so I can research further. The side effects of these drugs worry me more than anything. As I'm extremely sensitive to a lot medications. I always lean more towards natural treatments...as much as possible. The price tag on these drugs is astronomical, to say the least especially since it does very little to help the disease. When I noticed the difference between the patients that received the drug vs the placebo....It's depressing. Very little difference in the percentages. It makes me feel that if I did the injections, it would make me become another guinea pig at a high cost. But this is just my opinion. thanks once again for your video.
@Helen-o5h7 ай бұрын
I m in the same boat.. so good to hear this Dr…
@ronhuppert750511 ай бұрын
I was on a path to get one of these two treatments. Both my current and previous retina docs advised it would be best to exercise caution and wait for some post-trial evaluations. We all concluded, in my case, the risk outweighed any benefit. I do want to commend both companies in their efforts to find treatments for this insidious disease where none have been available as yet. I have grown to appreciate the investments made without any guarantee of success.
@coloradomark21599 ай бұрын
Two retina docs says a lot. Post trial evaluations is what I think if a prudent approach. I will wait.
@starrkelsey23046 ай бұрын
They did not tell us any of this and they killed my husband after one injection. Murders drug. Thank God you opted out
@coloradomark21596 ай бұрын
@@starrkelsey2304 Say Starr, wonder if you wouldn't mind elaborating a bit. Did the Doc us Iservay or Sifovre? I had concerns after watching this video and you have confirmed my suspicions. These drugs should not be administered. I'm sorry for your loss. For myself I have decided to go the nutrition route. One can view Dr. Knobbe on KZbin and as I have done read both of his books. I am convinced I can make a big difference going the nutrition approach. Thanks for posting Starr.
@maryanndemereckis96733 ай бұрын
You need to slow down in talking please. You are talking mostly to older people whose brains do not register information as fast as it use to. Just ask your grandparents. 😢
@taurianferguson10 ай бұрын
This is terrifying to listen to and shows how little mastery we have over medicine.
@dolores27164 ай бұрын
Disappointing to me, but not terrifying. At least they keep learning more and more. That will eventually get them to the breakthrough we need.
@12thDecember Жыл бұрын
@11:38, really seems like it's damned if you do and damned if you don't. The thought of getting wet AMD scares me; the thought of getting dry AMD _terrifies_ me. Thank you for explaining things so thoroughly. What a disappointment to those who are struggling with this debilitating disease. Hopefully these meds will lead to an effective treatment to reverse this disease and improve quality of life.
@JK-zz4ip11 ай бұрын
ALL macular degeneration starts out dry. 10-15% of dry AMD turns wet. Dry macular degeneration is a much slower progressing disease while wet AMD is much faster but is more treatable.
@laobrien49824 ай бұрын
Appreciate this content! Very informative.
@KooKokKee-e3f10 ай бұрын
For AMD patients, surely the ability to stop the illness getting worse is a HUGE benefit. Surely that is what the anti-VEGF drugs do, they do not improve, but stop or slow down the worsening of the illness
@davidlo1688885 ай бұрын
If drusen can't be excreted to surface of cornea, it's impossible to effectively treat and reverse geographic atrophy. Please note accumulated drusen is the culprit. Applying God's mercy nano-grade eye drops, within one hour, drusen will be excreted to surface of cornea. If drusen can be cleared away thoroughly, of course, geogaphic atrophy should be reversed.
@brynperkins1654 ай бұрын
Your concise presentation, Dr. Chua, is AWESOME. Thank you! Invaluable. No meaningful difference in functional visual endpoints after 24 months?! The rather large Syfovre booklet doesn't mention that!
@SteveSmith-wv8ug10 ай бұрын
Why were they ok to use in the first place by the fda. As my ophthalmologist stated when I was diagnosed with dry AMD, there is nothing available today or in the future to prevent blindness from occurring. AREDS 2 is the only safe and affordable option to delay the eventual blindness..
@coloradomark21599 ай бұрын
I am going to change some diet matters i.e. green veggies in particular kale which is very rich in lutein.
@Lkhrobertson3 ай бұрын
Very helpful presentation.
@AliceR278 күн бұрын
Appreciate your honesty!
@Geroscientist5 ай бұрын
Great critical analysis. My money (literally) is on OpRegen: the only investigational therapy that can reverse GA AMD in humans. 5 patients had improvements - not slower deterioration, but disease reversal - in outer retina structure with associated vision improvements, albeit in an open-label trial. Roche is currently testing it in Ph2a trials, enrolling in Philadelphia, San Francisco, Sacramento, Beverly Hills and Cincinnati.
@JoeR2036 ай бұрын
That dark spot at 2:08 looks almost exactly like the blurriness I have in my left eye. This showed up after my eye doctor zapped about 7 leaking vessels. (after 6 months of injections to get swelling down) and he says it's due to my diabetes. But I think the laser did something because I had diabetes before the treatment and didn't have any spots in my vision. And if it is due to diabetes, why does it only affect the one eye that was zapped?
@mrscch10577 ай бұрын
I am doing the injections for my geographic atrophy. If it helps slow it down that would be a benefit until other more advanced treatments are available. This made sense to me when my doctor told me this information.
@williameimers Жыл бұрын
But if the new meds only slow down the progression of MD, it seems that there wouldn’t be any improvement in vision, just a slowing of the disease…what am I not understanding? And thanks for the great info!
@JustanOd Жыл бұрын
Some of the patients in the study received the medication and others received a "sham" placebo injection. We would hope those patients receiving the medication would have better visual acuity than the placebo group at some future date, but they did not. Perhaps Dr. Chua could say "improved visual outcome" instead of "improved vision."
@rodpettet28199 ай бұрын
I'm almost 80 and have both wet and dry. I found the injections painfull and expensive sobI gave up and try to clean up my diet and avoid inflammation. Like probably 95% of people in the world I have no health insurance and the costs of conventional treatment unaffordable.
@coloradomark21599 ай бұрын
Rod, look up Dr. Knobbe on KZbin. Your diet can be the key to success. No sure about the wet though.
@lindajakub6242 ай бұрын
How are your eyes doing.
@pavman42 Жыл бұрын
Thank you. When I go to get a second opinion (from a diagnosis received 2018 from an America's Best optometrist), it will be interesting if the Ophthalmologist recommends either of these medications. My doctor referred me to the optometrist, I didn't bother going to the optometrist recommended by America's Best and instead just started ramping up leafy greens.
@ANIMESHMISHRAProfile9 ай бұрын
Your a genius! Thanks 🙏
@nancythomas-wardm.b.a299311 ай бұрын
WOOOO NEW SUB...GOING OVER YOUR PRESENTATION AGAIN..MANY MANY THANKS HNYEAR
@AliceR278 күн бұрын
I see a retinal specialist at a university hospital doing research on macular degeneration. I've been told too many problems with new drugs to use for my dry macular degeneration. Not a chance with 12% of study group going blind. I have one good eye and one pretty shot.
@melodymerritt84199 ай бұрын
I think you may be over thinking one part of results. I am a retired RN and have GA. The onset is so slow that you get used to living with the vision loss.You stop driving, you get used to taking the bus, you use a magnifier on your phone, etc. The benefit of these new meds lie in the need to LESS FREQUENTLY change your retime of the gradual loss of vision. Or maybe you can stop changing your retime altogether. Not noticing a change for the better in vision, because, let's face it as I have, there is no cure to fix the damage that has been done. 24 months may not be long enough to evaluate the benefits. One of the questions of the questionnaire might be to ask how long in-between adjustments of vision loss....ie: how long did it take for you to notice vision problems to the time you stopped driving. Or how long did it take from noticing a problem with reading to the time you had to use a magnifier to read. Hope this helps.
@mommaoinnh26749 ай бұрын
I have stage 3 at age 67. No vision problems, no loss of vision. Now eating salmon, tuna and green leafy veggies.
@justathought58978 ай бұрын
Thank you,, I'm not getting shots. I already have glaucoma, floaters and cataracts. Don't want to damage them with side effects for meds that basically do nothing
@nate74048 ай бұрын
Hi dr chua, could you explain why there seems to be so much buzz around Syfovre and Izervay if there is not benefit to VA outcomes? I guess I just don’t understand how these drugs are marketed if they are just slowing the development of atrophy vs any functional benefit to patients.
@sweetcello33588 ай бұрын
Big pharma$$$
@georgeewang41922 ай бұрын
Anyone with geographic atrophy should look into the OpRegen clinical trials going on right now. Past safety trials showed the stem cell treatment was not only safe, but demonstrated improved visual function and retinal structure. Roche/Genentech is now taking this therapy through phase II trials and recently received RMAT designation from the FDA. Help is on the way!
@mrscch10573 ай бұрын
I get the injections every 2 months. These injections do not improve vision but rather help to stop the progression. This is what I have been told. This might be better than nothing since helping with the progression would be beneficial.
@charliegee91717 ай бұрын
Wonder if autophagy would clean out the dead cells?
@SmilingDahliaFlower-wz6ld2 ай бұрын
İf these two injections do not cure the distortion and diminishing vision but have these side effects why did FDA approved Syfovre and İzervay?
@taurianferguson10 ай бұрын
Could gene therapy or some kinda CRISPR solution address the root cause?
@AliceR278 күн бұрын
Let me tell you. I've never had any testing except the eye chart and dilated exam. I've never even heard of these other tests. In fact, they tell me I can drive even though I know I can't safely. OMG!
@lpass110 ай бұрын
Well this is depressing
@johnjb32057 ай бұрын
Why is this not available in the UK ?
@coolguy79jeffrey10 ай бұрын
how about CRVO? will CRVO patient benefit from this?
@usprotec4 ай бұрын
Does AMD cause blindness or just getting worse and worse vision like a old TV set?
@DihelsonMendonca8 ай бұрын
💥 I have Chronic CSR - Central Serous Retinopathy in both eyes. I'm almost blind. I can't see anything with the center of my Left eye. I depend now on my right eye, but it's going the same way. I'm almost desperate. Are these injections also good for CSR ? 😮😮
@MsBizzyGurl Жыл бұрын
Will this help Lupus patients?
@lindajakub6242 ай бұрын
I get injections. I am exhausred. I thought it was my thyroid. Bite I think it is the injections. One eye is wet mac. And left eye is dry. Injections in one right eye only. I get the injections s every 3 months
@magnus33john6 ай бұрын
Sadly its only a treatment for AMD and not MMD so i am basically up the creak without a paddle
@mohamedgoldstein55652 ай бұрын
If I am going to go blind in 5 years and am 70 years old, I will take these medications to extend my vision to 80. If I am 30, maybe not.
@Bazerkly11 ай бұрын
The injections are $1,000 each...
@lindajakub6242 ай бұрын
Eye with injections, gaff of face on people gone. Worse since injections. Before injections no disoriented like that.
@ediecooksey93352 ай бұрын
Y
@angeliqueburke12324 ай бұрын
I would rather get a shot once a month then slowly go blind.
@RavenWolfDrum699 ай бұрын
😢😢😢😢😢😢😢😢
@starrkelsey23046 ай бұрын
Avastin
@rosebronikowski20226 ай бұрын
Seed o
@mballer5 ай бұрын
Now tell me about nutrition and lifestyle. Don't be a worthless doctor.
@sheilahdang115 ай бұрын
now let me block this Michael Chua
@monahuntley396111 ай бұрын
How can a Dr. claim to understand Macular Degeneration and put out a video using slides that no one with the diseased could possibly read? This video is beyond irritating, it is insulting.
@maureenmccrackin693310 ай бұрын
I'm sure that no insult was intended. I think that the verbal discussion of the study results presented important information. I know that I learned a lot.
@sweetcello33588 ай бұрын
Oh! Early dry diagnosis- I paused video & he does verbalize key points
@frederikaguggolz33373 ай бұрын
So grateful for Dr.Chua's honest presentation ! Good to know, there IS no safe treatment yet, including injections in- to the eye! Question : Are there positive results from Red Light or Rife treatments ? Desperate for answers 🤔!
@Lkhrobertson3 ай бұрын
If you pause the video, you can spread the screen to enlarge what you want to try to better see.
@davidlo1688885 ай бұрын
If drusen can't be excreted to surface of cornea, it's impossible to effectively treat and reverse geographic atrophy. Please note accumulated drusen is the culprit.