Non-Hodgkin's Lymphoma

Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/non...
** Correction at 1:09:30 - 1:10:51: **
The Ann Arbor Staging looks at the position of involved Lymph nodes on the SUPERIOR and INFERIOR positions regarding the diaphragm, not the left or right hemidiaphragm. In other words, Stage II would have 2+ LN’s above OR below the diaphragm, but can only be on one of those sides. Stage III would have 2+ LN’s both above AND below the diaphragm.
Of note, the Ann Arbor staging has fallen out of favor for NHL and was recently replaced with the Lugano classification.
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Non-Hodgkin's Lymphoma. Non-Hodgkin Lymphoma (also known as NHL, or sometimes just lymphoma) is a cancer that starts in white blood cells called lymphocytes, which are part of the body’s immune system.
NHL is a term that's used for many different types of lymphoma that all share some of the same characteristics. There is another main type of lymphoma, called Hodgkin lymphoma, which has been discussed in our Hodgkin's Lymphoma lecture: • Hodgkin's Lymphoma
NHL usually starts in lymph nodes or other lymph tissue, but it can sometimes affect the skin. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Non-Hodgkin’s Lymphoma Introduction
0:50 Lymphocyte Pathway
16:22 Causes of Increased Neoplastic Lymphocytes (B-Cells)
32:36 Effects of Increased Neoplastic Lymphocytes (B-Cells + T-Cells)
53:22 Diagnostic Approach to Non-Hodgkin’s Lymphoma
1:06:14 Staging of Non-Hodgkin’s Lymphoma
1:13:05 Treatment
1:19:31 Comment, Like, SUBSCRIBE!
Join this channel to get access to perks:
/ @ninjanerdofficial
APPAREL |
shop.ninjanerd.org
www.amazon.com/s?k=ninja+nerd...
PODCAST |
Apple Podcast: podcasts.apple.com/us/podcast...
Spotify: open.spotify.com/show/2ZDXoak...
Google Podcast: podcasts.google.com/feed/aHR0...
DONATE
PAYPAL | www.paypal.com/paypalme/ninja...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #nonhodgkinslymphoma #lymphoma

[@Delatta1961]

Great presentation. I was diagnosed with MZS Lymphoma, Stage IV (low grade) in 2005, only 5 years after retiring from the Army as a Aviator. I was 43. The one thing I think is very important for diagnosis is how my symptoms presented themselves. Dry cotton mouth, severe itching (mainly where my clothes touched my skin tightly), night sweats, periodic fevers with no infection, and very severe fatigue. I never contributed any one of them to be part of the collective issue. I like to think I’m educated and informed, but there was no way I could have connected them all to NHL. Even the doctors were baffled. I was admitted to the hospital, and for a week I was the Guinea pig for about a dozen residents. There’s nothing more concerning when it comes to my health then watching doctors scratch their heads and not have answers. It took a bone biopsy to find the truth. After my enlarged spleen was removed, I went through CHOP (I wouldn’t wish it on anyone), and maintenance treatment for 4 years. I’m still in the fight, and the key for patients is to stay aggressive and informed in your treatment. Including the PET scans and labs as often as possible. What you presented here really helped me understand the process of how it progressed. Thanks

[@Katie-vy5rd]

Thanks for sharing your story. The cotton mouth is perhaps the first I've seen where listed on any stories of lymphoma symptoms but makes so much sense. I have a enlarged lymph node but haven't taken the order in to have the ultrasound yet. Waiting g for insurance to kick in. In the mean time I've been going batty with the dry mouth for about 3 weeks, lozenges don't even help and have been wondering whats going on.ive got the severe fatigue too so hanging onto my job by a thread. I hope I don't have lymphoma but answers would help ease my worries. The treatment for yours sounded harsh. Hope you're doing well now. 😊

[@canbarosomali4757]

Are you still fighting or you win I hope you are doing okey

[@vetnet100]

Best medical and physiology videos anywhere on the internet! Thank you for your dedication!

[@carriesmotherman2273]

I live vicariously through you. Before I was struck by lightning, I tutored physics, chemistry and calculus. I discovered you exploring Hodgkins lymphoma as I have many symptoms and am trying to get referred to an oncologist. Your videos are amazing! I miss teaching so very much.

[@atiqrahman6427]

I have non-hodgkin mantle cell lymphoma. Going through RBAC chemo after 7 cycle of Retoximab and acalabrutinib. Not sure why RCHOP shows everywhere to tackle the cancer. Presentation was mind blowing, the best so far in YT. Thank you!!

[@elinaparkkonen517]

Once again a huge THANK YOU Ninja Team💕 for all your hard work. Team work makes the dream work. All my love to you all. Happy midsummer from Finland 🇫🇮👋!

[@mopthefloor9131]

I’m so glad you are making haematology videos because I have an exam in a week and these are the only thing that makes sense to me. Thank you !!!!

[@georgebashour4333]

Thank you .. This video is on time for my last semester in medical school ...having Hematology in a month! ... This surely made everything way easier

[@manojkahar7242]

One of the best lecture ever attended on Non Hodgkin Lymphoma ever attended or learnt in my life...too too good...no words to describe the marvellous way in which the concepts are given by the presenter...hats off to you sir

[@sedatesmeray2437]

Thank you very much, great explanation from start to finish. You first talk about physiopathology and until you finish to treatment. We are grateful.

[@samruddhimahadik4054]

Absolutely the best explanation I have ever received on this topic,even paid platforms fail to give such detailed and understandable explanation ❤

[@ClassicB3bituh]

Thank God for Dr. Zach!! 🙏🏼❤

[@anvisaini789]

This should be paid. THANK YOU SO MUCH

[@maristhelatgalian9366]

I am overflowing with knowledge 🧐 Love this stuff, please do some more!!

[@destaebisa6216]

I have been waiting for this lecture. Thank you sir!

[@elcancerynosotros.7036]

Thanks a lot! Excellent presentation! Zack, you have a natural uncanny set of skills to teach!!!

[@yeikalarrinaga3656]

Amazing lecture! Thank you very much for your dedication

[@venusdarkside4350]

I was diagnosed with hodgkins lymphoma a year ago my chemo is complete and excited to study the hodgkin and non hodgkin as a med student

[@eternitystudent]

Excellent. As an oncologist I can say that this lecture is so true and important for common understanding

[@cathyzeller4987]

Brilliantly explained & presented! Thank you!

[@kennethmanzanares4073]

I am 1yr in remission from diffuse large B cell lymphoma. Thank you for helping me understand my disease.

[@kennethmanzanares4073]

@1Alchemist420I was stage 2E. Did 3 cycles of R-CHOP chemotherapy followed by 21 treatments of radiation.

[@whelmersantos4564]

Thank you for your dedication!

[@nadiakhan1612]

Can’t thank you enough Dr.Zach😊

[@deannaclark1359]

You really are a great teacher! ❤️

[@user-cf5cz4yj3y]

Huge respect for u guys❤

[@humanicgenes8825]

Thanks a lot Professor Zac from 🇿🇲🇿🇲🙏

[@okorobepascalmathew420]

Genius . saved my time instead of cluelessly staring at the text books

[@moongakampoli3533]

And we had this same lecture in class a day ago. Coincidence!!

[@shahiramohammadi7284]

Thanks for this content I don't realize this much in class❤

[@MegaGrownFolks]

Perfect presentation…very inspiring….Great instructor

[@abrightonreign758]

A BIG THANK YOU FROM UGANDA.

[@tadelleyohannes9400]

Thank you Dr Zach

[@jannatulferdaus6777]

Excellent presentation

[@UsRanger]

Wow, you're an amazing teacher.. Thank you so much for doing this... Now, I can talk to my doctor and know more what he's talking about. 🙏

[@Sugi_Ruyeew]

I love your video so much, thank you for giving us such useful information

[@mrsamandabernier]

Great video, as always. Thanks!

[@jeanpaulrukabyarwema1972]

I have been looking for this after watching Hodgkin lymphoma

[@kingsleychinedu252]

Thanks for all you DO🙌🙌. Zach! A video on Renal tumours won’t be a bad idea🙂

[@0111vramj]

I had NO symptoms other than a almond sized lump in my neck. Thought it was an infection. 1 month turned into several lumps that started pressing on my windpipe. I was lucky I had a DR that LISTENED to me and took me seriously.

[@marywakefield3472]

Awesome presentation- thank you

[@marinaschiavi5442]

thank you Zach!

[@user-co4jd7sb8v]

Thanks Mr Zac ❤❤

[@alejacarrasquillo1291]

amazing as always

[@michaeldonaldsherida]

Rockstar! Very informative and I didn’t die of boredom!

[@ahmedmohamedhussein7993]

HUGE THANK YOU , AMAZING

[@Shahrzad3360]

Perfect as always ❤

[@anushaaamir3522]

very well explained

[@ShiraKadosh]

You are awesome!!! Thank you so much! 😊❤

[@mehranhashemian5170]

Great as always Thank you سپاس فراوان

[@ariosmondaca]

excellente, thanks

[@AbuSadatMdSalehAries]

Thank you

[@tadelleyohannes9400]

great lecture ..thank you

[@kamaldinmiya8062]

Thank you❤

[@rawanalmansouri]

Thank you!

[@saraasif2372]

Your lectures are too good

[@SamuelMwene-hu4sw]

Okay but ninja nerd uli chi pondo..👌 From a mad scientist to a Ninja nerd. I salute

[@chombachama4841]

Zambia ku caalo😂... I just had to like your comment

[@lifesciencedecoded]

Thank you sir 😊😊

[@mishkalmujjalla8286]

thanks for this class❤❤❤❤❤

[@user-zv1dm2gy7p]

Thank you so much.

[@zaidsallam2365]

best medical videos at all

[@idrisahmed588]

i was watch this awesome lecture from ninjanerd web page, had to come to youtube just to give BIG THUMBS UP.. what awesome way of teaching.. one little suggestion if ninja nerd team could rearrange the web page lecture's in order. thank you again

[@suzanazlateva7423]

Great videos! Absolute the best. Could you please add normal histology prep of the different NHL next to histopathology. It is difficult for me to know what to look at If I don’t have anything to relate to... Thank you for your interesting videos!

[@cozettalandry3429]

Had severe EB mono in my 20’s. At 62 had DLBC lymphoma from taking Humira for 10yr. Crohns Disease. Remission 5 years. RCHOP and Methotrexate intrathecal

[@user-wg5xl9vo8u]

Biologics can kill. I was on Remicade for nine years, it gave me NHL. It wasn’t worth it.

[@saaaaaa1129]

I love your videos, you help me so much!

[@catherinew.asiimwe]

Thanks Prof👏

[@lubababukhari6794]

Amazing!!!!!!!!! Loveee it!!!! Thankyou so much, you're extremely good mentor

[@nexus3736]

Thank you!😊

[@hopeworld9515]

Im literally only passing my exam because of your videos. Forever grateful ❤

[@qayoommemon3436]

Great work,,,, Very easy to retain now,,,

[@tadelleyohannes9400]

u r great abd dedicated teacher. thank you

[@swilliamzd3154]

Great video. Just a little addition; P53 will suppress proliferation so the mutation in cancers inhibits p53 (like in diffuse B-cell lymphoma)

[@Imusama90]

thanks

[@joadmagezi4778]

Amazing presentation❤

[@hasane982]

Excelent video you really helped to me as a med student

[@mazatv3438]

Please upload two lectures in a week.

[@sajiruddinsk8129]

You are great.donot compare.

[@atifraza421]

Thank you so much sir❤❤

[@bonniehuang8696]

Thank you so much for your lectures on Hodgkin’s and non-Hodgkin’s lymphoma! Learned so much. Can you talk about HLH next?

[@jaspersilver1055]

Good information

[@tenmanina2468]

Thank youuuu ❤

[@donnamacey1446]

Thank you for explaining!!! I'm doing Gazyva infusions and Venclexta tablets Monoclonal Antibodies are a real game changer!!!!!

[@khaoula7389]

thank you so much

[@MalakAhmedd___]

thank you!!

[@akshatgautam964]

Thanks from India 👍

[@troll1801]

Uploaded right after my hematology exam😭 passed though thanks to the other hematology videos🙏

[@chisulochisanga7809]

Excellent

[@Sadhana661]

Ur work is amazing!! I love everything u do... i hv a very humble request... i went thru ur entire channel but couldnt find a section on obstetrics and gynaecology... pls pls can u upload those or make a basic video of it?? I hv exams coming up and would like to hv ur vudeos before it.. thanks in advance @ninja nerds

[@rachidksyar6810]

Excellent presentation. The only thing that I am not ok with is the classification of Ann Arbor: sides of the diaphragm means sub and supra diaphragm and not left to right of the body. Please correct that

[@jawadabo-tabik4035]

As always, you are the best! I appreciate your work and dedication. I'm a MD and I really enjoy and learn a lot from your video. I'd love to know you in person, that would be a huge PLUS! :D

[@khaoula7389]

thank you so much

[@alfredlincoln2407]

Please kindly make a video on BIOSYNTHESIS OF ELCOSANOIDS🙏🙏🙏

[@chamchamz98]

Thanks for the lecture ❤ Haematology is hard for me to understand and memorise😅 this lecture is so helpful ❤

[@WhyNot-si4pj]

1:00:46 Correction = " Follicular cell lymphoma " is associated with chromosomal segment translocation between chromosomes 18 & 14 ; t(14,18) NOT chromosomes 11 & 14 ; t(11,14) .

[@elcancerynosotros.7036]

Correction: It is t(14;18) not t(18;14)

[@MesutTgloglu-lq1bx]

You are really awesome , great lecture ..Multipl Myeloma please 🙏only you can do it properly and perfectly

[@sivajinidarmendra2250]

Thanks dear Prof, Please explain GIST

[@kittensgalore.5444]

Need a lecture on Dendritic cell neoplasm

[@sophieo0]

Thank u so much

[@liamleffler1515]

love you big dawg

[@user-kd9th7dj6x]

Zach , i really like your videos and you always make a very thorough analyse of the topic. Just a small correction about ann arbor stages II and III in hl and nhl . Stage 2 means 2 or more groups of lymph nodes affected either above or below the diaphragm and stage 3 means lymph nodes above and below (its not about left or right part of diaphragm)

[@polyrhythmia]

Had a swelling on the right side of neck appear almost overnight, and go away after two weeks or so. Also was noticing weight loss without trying. Months later, found a cancerous tonsil on the right side. Was found to be B-cell non Hodgkins. Determined I was at stage IIIA. Could chronic lung infection from maybe histoplasmosis have led to this? Had the upper right lobe removed. Now in the process of treatment.

[@tenzrinz8222]

Thank u