Musculoskeletal System | Neuromuscular Junction | Sliding Filament Theory: Part 3

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the neuromuscular junction and go into detail on the sliding filament theory. During part 3 of this series we talk about calcium's effect on the myofilaments, the cross bridge formation, and how that will affect the A bands, I bands, and Z discs. We also talk about the repolarization of the cell, and the movement of calcium back into the sarcoplasmic reticulum. We hope you enjoy this lecture and be sure to support us below!
Join this channel to get access to perks:
/ @ninjanerdofficial
APPAREL |
www.amazon.com...
DONATE
PATREON | / ninjanerdscience
PAYPAL | www.paypal.com...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #NMJ #Musculoskeletal

[@nofearnizarnizar9330]

The man carrying my medical degree👏i really appreciate you man!!!

[@Pro0osh]

I think I will release some Ach into the synaptic cleft to open my ligand gated ion channels to allow Na+ to enter my fiber cells and cause my Ryanodine receptor to open my sarcoplasmic reticulum allowing Ca+ to release and bind to my Troponin- C which changes the shape of Troponin- T causing my tropomyosin to move away from the active site of my actin allowing my myosin to bind to my actin which pulls my thin filaments using power stroke to finally get over one another Which allows my palm and forearm muscles to contract in a way that moves my finger towards the like button and clicks it...

[@UsamaKhan-hf8id]

Hhahahha😃😃🤣🤣😂

[@-Noushin]

👍👍🤣

[@meriems9920]

Legend 😂🤙

[@emekaemeka4910]

O.m.g😂

[@trapmoodmworld4663]

This power comment

[@copgreen8781]

This is how all subjects should be taught. Most teachers teach in " pieces" that just leave the students confused .Thank you sir for making this concept very understandable may God bless you .

[@SunShine-vq9sz]

So true

[@kitfisto435]

Underrated. Such a great teacher.

[@patrickdubugrasbaronepbaro8486]

indeed

[@faisalmahmud5307]

Not anymore

[@anjanaraju7201]

Q 🙏🙏q 🙏😂qq 🙏🙏🙏

[@hemantkumar4272]

No guys ...sir is here because of us ....And we love also very well....

[@beatricelungu6586]

Awesome

[@felixxian736]

The best and most in depth lecture I know.

[@repentlessss]

This guy deserves a lot more appreciation. These videos helped me understand a lot more than I could from my teacher or any other KZbin video.

[@aasthadave4842]

Oh my God! Best teaching ever of the t and l sarcoplasmic tubules.May God bless this wonderful person for keeping it free

[@camjenturnbow]

I've been struggling in physiology trying helplessly to understand the material by reading and reading over PowerPoint then I come across your youtube channels and holy crap.... It's the greatest thing since sliced bread. Seriously you are a life savor and I've never found such videos that are so in-depth yet so easy to understand by your illustrations and constant restating what you said. I can't say enough and I hope that thank you will suffice!

[@patrickdubugrasbaronepbaro8486]

I've just contributed to your channel. Hats off for you guys. Amazing lectures. Please keep the excellent work. I hope you have plans for future videos, specially complex subjects like genetics and cancer.

[@ummulkholifah9002]

mnhmmnmmnmnmnhmmmnnmnmmnmnmnmmmmnmnmnnmmnmwa.lp ip9h0le7plgmnNnm.nnmnnmmnn.c. v..

[@waleedhassan1459]

THIS PLAYLIST IS A MOVIE, WHAT A WAY TO EXPLAIN TOPICS, PEAKK

[@justsearchforthearmyofsata4155]

Nothing to say about your capabilty to explain. Far better than any teacher I saw. Thank you from Bangladesh.

[@nhlanhlaluckykhumalo1662]

I am still trying to understand how good this guy is.Indeed you an amazing illustrator,and teacher.Thank you so much for making complex stuff easy like Sunday morning.

[@coexistence5990]

so sooo helpful! you have no idea how much your videos have helped me in Anatomy and Physiology. THANK YOU!!! your work is greatly appreciated :)

[@rebekahsprlyan6982]

I am so grateful for this channel, my first time round at university KZbin wasn't a thing, and learning this stuff hurt my brain and I could barely grasp it. Now, thanks to you guys, I can visualize a lot more so my foundations are improved, allowing me to understand concepts with better application. Thank you so, so much!

[@yoongi4lifeu219]

You're an amazing teacher and I can tell that you're passionate about what you teach. I hope your channel continues to grow and reach broader audiences

[@viniciusaquim141]

You’re the best. Always making hard subjects look easy. Thank you

[@neelo14]

You deserve a billion thumbs up for each video. Your hardwork is really appreciated.

[@margaretcooney2700]

If you were around when I was doing my pharmacology degree 20 years ago I would have gotten a 1st. You really have a gift. Thank you!

[@shi117]

Your lectures are undoubtedly the most interesting one's on KZbin.

[@888167]

Hey dude, thanks once again. I want to add one thing, that I thought was a bit misleading: The hydrolization of ATP moves Myosin to an "unconfortable position", since it's the position of high potential energy. Therefore you need energy to reach it. The powerstroke occurs because this Myosin is moving from the "uncomfortable position" to it's "comfortable position". After the stroke it's NOT in an unconfortable position, it's simply bound to Actin. The position after the stroke is the preferred position of the Myosin head. Then the detachment occurs just as you said and the cycle continues, as long as there is enough Calcium present to "unblock" the Actin-Binding-site

[@docrosa2921]

Such a talented person he was born to be a teacher

[@royg123]

Dude...your videos are amazing. The other day I was sitting around wondering how the food I eat is converted into kinetic energy, and now after about 18 hours of your channel, I see how it all works from the macro level all the way down to the base chemical reactions. You are doing great work.

[@fortunatuswilliams3055]

You are the best, sir. Anybody on earth who watches your videos , will always understand. I want to specially say thank you . You have opened my brain. Again, thanks a lot. God will surely reward your efforts.

[@menkaverma4858]

this man is awesome....like literally awesome and his explanation makes the things crystal clear. If I still forgot than must be there is some problem with me. He makes the complex things understandable very easily. I want to meet this guy in real someday and want to thank him personally for saving me. I have no enough words to praise his way of teaching. thanku thanku thanku soooo much. Lots of love and keep going.

[@vladmasdrag6933]

Greetings from Romania!! Thanks for suck an awesome explination series. I'm passing my finals thanks to this guy...

[@fredoneazx3106]

Im here because of Zagrean

[@haroon.azeem1]

You've taught that lecture in a very unique way 💜 it's helping me alot.

[@SimranKhan-wj2wg]

You have got the best teaching skills .

[@bilalhijjawi8860]

Amazing depth and analysis... thanks. Your mighty clear tutoring has eased my copywriting for a course on fitness, so thanks again.

[@Navneet1980]

I like your videos at the start of it Because ik they are legit the best one 🤷🏻‍♀️♥️

[@arkanshsharma850]

Ninja nerd has certain red marks all over the body in his previous one i saw 2 in back of his neck and now one on the forearm in this video god bless him with long and healthy life

[@MayaxAlshabk]

Never stop doing what you do ❤

[@emmajacobsson7861]

This is saving my grade in anatomy and physiology! thank you so much!

[@wolfie5470]

These myosin heads are like: Ooooh man! :DDDDD Zach, you are the best !!!! Studying with you is BIG fun and I manage to concentrate the whole time. Wish you were my teacher :'( :(

[@markfalina9160]

Must you be a Med student to find this EXTREMELY interesting? I build computers and find these videos overwhelmingly interesting. One thing I would greatly appreciate, though is someone giving me the link to the stuff that is being recapped in the beginning of this video. I feel left out in the cold and shivering (via muscular tissue) will not warm me up this way. :0

[@aspired2be]

Dude if only my professor explained it like this.... thank you

[@jaccycrystal]

You are the best person that happened to me❤️. Your lectures are bomb and very detailed and one process leads to another. Wish me luck, my test is coming up🙏🏽

[@MarkBurghouwt]

How can the titin stretch and the I band decrease at the same time? Aren't they linked?

[@rendlapavan6153]

Really excellent teaching I was literally stopped listening physiology classes in our after listening this classes 👏👏⚕

[@choozomano977]

Understood this cocking and powerstroke mechanism 1st time in my life. Love ur demonstration! Will contribute to ur channel soon. Can't do now cause i'm jobless at this point. But trying to get into training and watching ur videos to pass that exam. May u have a peaceful life. Thanks.

[@youssefalami8585]

This course is legen..wait for it DARY Legendary bro keep it up !!

[@haminami6226]

:D

[@josetrujillo738]

Thank You Ninja Nerds Lectures!

[@Reree-gz5bg]

I love how detailed you are in your videos, thank you :D

[@vinodraut5147]

Superb and awesome techers who explains the things in most easy way. Thanks Ninja Nerd

[@peterm92]

I just became a member on your website! Can't wait to dig in !

[@jigarthakker1880]

Amazing video, in 2 days I covered the structure of muscle to NMJ part 3 and I felt like, It’s worth it nearly 5 videos back to back This is so better then watching Netflix I feel.. Thank you soo much for being there.

[@janvichakra607]

how come you are so damn good at explaining! its so damn clear and its just prints in my brain!

[@riyanbabar8416]

Phenomenal lecture 👌 👏 🙌 Thank you so much ❤

[@jacobjamescabrera431]

God Bless you Doc! I find this topic to be particularly taxing since I don't have that much strong background in undergrad but now I totally got it!

[@traceyodonnell1988]

Currently getting me through Integrated Anatomy and Physiology. THANK YOU!!

[@albarraaabdulla3753]

Yo deserve more and more than thanks

[@victorowusu6051]

You've done marvellous job. Everything look so simple. Thnx a lot.

[@bethanybutler1377]

You are an amazing teacher. I so appreciate you!

[@josetrujillo738]

Sweet Deal! Thank You Zach! Shout Out Rob and Kristen!

[@kumquats2842]

this man is a teaching god

[@Bryyo121]

Amazing Presentation

[@neurosurgerypassion2139]

next time please start a series on microbiology for medical students...:)...please ...so that we r gonna get benefitted ...:)...please my dear ninja nerd...thnx ..:)

[@BlessUpDiHerbs]

best A&P video on the web!!!

[@adithyapatil4346]

Underrated video. Thank you very much!

[@hendheikal7101]

Thank you so much that helped me a lot to understand such complicated topic

[@hitakshimehta9901]

as always you end up hitting the nail right on point. concise and brilliant. thank you thank you soo much!!!!!!

[@tuilikaandreas4776]

Best teacher ever. Thank you!

[@waliullahnaderi7141]

Thanks for the video but Ihave got a question, hope you answer Q:The z disk is common between two actin filaments I mean that the actins are bound to the z disc from both side , now at the moment of the contraction both actins are trying to slide one another in both sides of z disc, then z disk is going to which actin filaments side

[@sarfrazahmed5333]

Can anyone plz explain

[@safiyahussain8671]

Bruh.. I really love your explanations.. ❤Tysm

[@roaasab3499]

before i see the video , i am sure that it will be great , thank you

[@sayedkhan8162]

Legendary bro. NO words to say how much beautiful is it!. Its very much helpful in veterinary medicine.

[@saraalkhoori3174]

you saved my life ughh I can't thank you enough

[@niyadeo7970]

Amazing!

[@a30s]

zach murphy sir....best explanation!!

[@AQkhan5272]

Such an amazing way of teaching 👍👍👍👍

[@jmc9597]

The nicotinic acetylcholine receptor is structurally alpha2, beta, *epsilon*, delta. Gamma is only present in infantile membranes and in denervation states

[@user-dl4cd4vd4g]

I have a doubt If I'm worng Correct me ATP Binds to myosin so the myosin head get dettached from thin Filament (Actin). ATP hydrolysised to ADP+ iP When ADP leave the myosin cross bridge gets Power Stroke. When inorganic Phosphate leave the myosin the head attaches to another Myosin active Site on F-actin

[@madhumitashinde1186]

Amazing mechanism and explanation

[@ntofigh5001]

You are the best 👌 👍

[@sharonnolen2154]

Very in depth, great teaching! Would love to hear why troponin is elevated in a cardiac event, or pulmonary embolism.

[@biologytech4830]

Really fantastic sir 😊

[@Athena_Behafarin]

what is the final voltage of synaptic bulb when at the +30 Ca2+ also is rushing in? does it go beyond +30mV?

[@yusramohammed5362]

Not all heroes wear capes...❤️

[@michaelsiyeba2142]

You are the best

[@sarfrazahmed5333]

Why doesn't the length of I-band increases? I mean the thin filaments in all the adjacent sarcomere have moved forward (inward, towards the M-line) so the distance between them must have increased? Can anyone explain it plz really quick

[@blackyrocky7438]

That’s great video but you didn’t mention voltage gated sodium channel in the first lecture. You mentioned voltage gated calcium channel blast open when inside the cell becomes more positions due to influx of normal sodium channel

[@yanjnus]

Thank you so much for the fantastic lecture! I have a few questions, if you don't mind. First, how many sarcomere units are present in a single myofibril? I'm wondering because each sarcomere contains a thick filament, and if I were to cut a myofibril, how many thick filaments would I find in the cross section? Additionally, each myofiber contains many myofibrils. How are these myofibrils connected to each other within the myofiber? Finally, is each myofibril connected to the sarcolemma through dystrophin? If so, can the myofibrils in the center of the myofiber also reach the sarcolemma?

[@Snowdep]

really mindblowing explaination.

[@macchiathos]

What drives the hydrolysis of the ATP in the first place?

[@mcrycm]

I like your videos, keep up the great work 🩵

[@uv_m234]

Can u please explain it how can actin actually move ,,if either side of myosin forcing it to move in opposite direction to one another 😢😢😢😢😢😢 net force is zero in context at z disc

[@hihih29]

The mature nicotinic acetylcholine receptor at the postsynaptic (muscular) membrane is composed of 5 subunits (two α, and one each of β, δ, and ε subunits).

[@linhan2428]

this is amazing

[@FrontierThesis]

19:30 - Muscle Contraction 34:57 - Sarcomere

[@coffee4coffee]

Doesn't the inorganic phosphate leave the myosin head as the myosin attaches to the actin and *then* the ADP leaves the myosin head as the myosin head goes through the power stroke? This is how it's presented in the other videos. In this video it says that the Pi leaving the myosin initializes the power stroke.

[@chidiebubechidiebube5849]

I love u Zach ❤

[@Alison-kj7ow]

Thank you. Love your video!!!!!

[@mrshmlo0_893]

Thank you teacher

[@shre797]

Loved the video ,great concept🤗🤗thank u very much sir

[@HamCommy]

This man is singlehandedly carrying all our degrees on his back

[@chiamakamaduakonam3749]

Thank you so much😊

[@kishanparmar9701]

doing nice work sir very very great channel for trainers

[@peterm92]

The biggest heart emoji to you ❤

[@Fahadm7md]

Very enough!

[@mahrukhmalik5189]

Great. Marvellous.superb

[@pensadoraapocaliptica4184]

Best explanation ever! Gracias