Musculoskeletal System | Neuromuscular Junction | Excitation Contraction Coupling: Part 2

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Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about the neuromuscular junction and go into detail on the process of excitation contraction coupling. During part 2 of this series we talk about resting membrane potential, endplate potential, action potentials, and the release of calcium from the sarcoplasmic reticulum. We hope you enjoy this lecture and be sure to support us below!
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[@MrsGislaine1990]

Great video! Since we all are ninja nerds, another thing: it takes 2 molecules of ACh for each nicotinic receptor. And ACh always binds in the alfa protein of the channel.

[@anyonymous2897]

thank you for this information you wanna say that 2 molecules of ach are required to open each nicotine receptor

[@Sk1pperCS]

Thanks for sharing!

[@hungryhungryrhino1]

" Cause that's what you get in Ninja Nerd Science" LOVE IT!!!!!

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YOU GET E X T R A

[@joycejung5514]

I cant thank you enough for these videos!! I learned more from you in the last 3 videos than having spent 3 weeks of sitting through my physiology class. Hugs! 😊

[@thelaurakyna]

Saving my degree, one video at a time ;D Thank you!

[@praveentsb]

Literally no one Ninja nerd : see this cute little thing out there , that's a very very imp protein and that's the 2546th protein in this video

[@tripti1339]

People like him should be supported as much as possible

[@rinc2006]

By the time Zach finishes telling the interesting story, some of the very complicated concepts in medical science is crystal clear and his quick recap, help us keep the concept alive in our hard disk

[@ericajavaherian2216]

The best videos on NMJ that I've found (and I've been through a dozen). Thank you for this comprehensive lecture. You taught me more than my Professor.

[@jorge.04]

Great work man! Yours are one of the best videos on YT on these topics. I would add that in order for the nicotine receptors to open, TWO molecules of ACh need to bind to it.

[@namtke]

one day i would wanna teach the way you teach!!! . amazing teacher you are :)

[@RAKESHKUMAR-ip1is]

thanks a lot bruhh , as a medical student we have lots of things to study but your videos really helps a lot to save our time and clear all concepts and cove each and every perfectly. its better than reading any books ..... keep it up man

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You are the BEST! You are truly GIFTED! Please keep doing more videos especially about neuroscience and neurology. MANY THANKS.

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I can't Thankyou enough for how well you teach, I literally come here after all my physiology classes because this is your language 👊👏👏👏👏Be blessed.

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These video lectures are the most impressive videos that I have attended. I am doing a course on Neuroscience, but I always watch these in addition as they are so clear and also detailed. I cannot get enough of this!

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Please never stop making these videos, they are insanely helpful! Amazing content and so grateful to have come accross Ninja Nerd!

[@joanbanan2016]

You are so good at this. Like, someone can see how deeply you know this and how you like the subject. Thank you a ton!

[@roberte.6892]

I FINALLY UNDERSTAND THE SARCOPLASMIC RETICULUM! PRAISE ZEUS! AND THE GUY IN THIS VIDEO!

[@mgoyo89]

I love your videos!!! I'm a visual learner and these videos are perfect for me, thanks for your explanations and all the details I really appreciate it!!!

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Who had the nerve to give this a thumbs down?

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Dr. Najeeb

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@@RepaerTool YES😂😂😂

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Lol nerve.

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Dr Najeeb is a legend , the only thing i don’t like is his accent , while this guy speaks much clearly

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Legend has it his son did

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Prof. Zach you are amazing !!!

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Yes, my brain hurts, but I will have a much better recall and understanding this semester and can hope for another high distinction this semester! This is way more useful to me than textbooks and droll lectures. I'm so grateful for KZbin because this stuff wasn't around when I was first studying this stuff! Thanks!!!!

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You are my LIFESAVER!!!!! Would never have understood Physiology without you

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You are amazing! Thank you so much for taking the time to make the two videos on the NMJ. I understand it so much better now!

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I'm from Brazil and currently a pharmacy student. I just want to thank you for helping me understand all these things, you're an awesome professor🙌💕

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Chiropractic student. Youre saving our butts out here too, thanks!!

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The best professor I never had

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Ninja Nerd Science is so fantastic! Your videos are awesome.

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very nice video and you are the real exam savior for the medical students. I am in my 3rd year of medicine and loves watching your videos. thanks bro.

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Have a test in 2 hours ans this was so helpful in summarizing most of what I needed to know!

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Excellent and accurate presentation of this knowledge. Really liked it.

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Magnificent explaining as always. So lucky to found this channel.

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You are studying for which exam?

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Thank u!!!! I kept wondering sooo much in class abt how this and that occurs and this video explains soooo much! 🙏 thank u Professor Ninja!!!

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Phenomenal explanation of the NMJ.💚

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you are incredibly amazing at this. thank you for making med school a lil bit easier for me. God bless! :)

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YOU DA MAN!!! This was perfect!!

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Long Live Ninja Nerds!

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Thank you so much, you are brilliant, so passionate about the subject and you put so much into the lessons, really helped me out!

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We are watching this great video from Med School in Paraguay! Some classmates don't speak english but I personally find this video very useful, I offer my help translating this to spanish for them if you want me to! Just throw me a message.

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You helped revising my lost concepts

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❤ thank you Dr. Awesome Information.

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Hoping it makes sense? You are blowing my mind!

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Thanks, REALLY GREAT video!!!

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[@DocShields84]

Excellent job. That type 1 nicotinic receptor you mentioned actually has an epsilon subunit rather than a gamma subunit. The gamma subunit is located within the first type of extrajunctional nicotinic receptor.

[@brendan0083]

+1 on this, although as always another excellent production! The receptor described in the lecture with a gamma subunit is a fetal nicotinic receptor, which functions slightly differently from the mature receptor. The fetal receptor can proliferate outside of the neuromuscular junction and pop up anywhere on the cell membrane as a result of certain conditions. In addition, they are more sensitive to depolarization and the channel stays open longer. This can be a life-threatening issue in response to certain drugs like for example succinylcholine as massive amounts of potassium can leak into the plasma due to the abnormal kinetics of the channel.

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Beautifully explained!!! İt all makes more sense now. thank you ;)

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REALLY GOOD EXPLANATION

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Easy to understand, great video.

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It made sense Prof! :')

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Simply I addicted to this lectuers I stopped listening classes in our college

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Thanks for such easy explanation, from India.

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You are a gym💎 No words.. very beautifully explained

[@vedatekin97]

thanks zach, it was very nice lecture