ACE-I & ARBs | Mechanism of Action, Indications, Adverse Reactions, Contraindications

[@aserehtavlis2866]

I really appreciate your time and effort making all these videos. You're truly amazing and genius. You help me with my exams and really understand how things work. Stay safe and healthy.

[@deepakkumarsingh4994]

Really good

[@TheOldMayfieldPlace]

You are so clear in your teaching. I wish you had taught pharmacology when I was in pharmacy school. I am really enjoying your videos. After 30 years I've forgotten some of the specifics of MOAs of the drugs I dispense daily. It doesn't really come up when speaking to my patients, but is the stuff I geek out on.

[@kimswartz9107]

You are definitely out here teaching me better than the school I pay tuition to... thank you!!

[@loriakelly7969]

Haven't been to college in 35 years and I can follow you easily. Thank you for sharing your knowledge and style of teaching.

[@omdah070]

You're welcome

[@mohamedfathi4599]

At first, I want to thank you and all of your team for the great work and dedication to make these type of videos that is comprehensive and informative. However, I want to comment on some of the information presented: 1) The Receptor that is responsible for mediating most of the angiotensin II activity is called AT-1 receptor not AT-2 receptor and ARB act by specifically inhibiting AT-1 2) ARB class of drugs ends with the suffix SARTAN like valSARTAN , candeSARTAN etc 3) Continous and chronic elevation of Angiotension has a mitotic activity on vascular SMC and cardiac myocyte and that is why ACEI or ARB are beneficial for cardiac hypertrophy as it lower the progression of this process. 4) Renal effect of these drugs is by mainly antagonize the effect of ANG-II on efferent arteriole which will eventually leads to dilation and decrease intraglomerular pressure. By relieving the stress on glomeruli that is beneficial is case of nephrotic syndrome or kidney disease.Also that is why renal artery stenosis is contraindication as it will cause sever drop in glomerular pressure by decreasing blood flow from afferent arteriole and by vasodilatory effect of ACEI on efferent arteriole. Thank you again for all your efforts. I hope you all the best.

[@jihaneziati3535]

You're right

[@aditiadvilkar2000]

thank you so much sir

[@daniellesoileau5234]

I swear I don’t even need to go to class because of you!!!! You truly have a gift!!

[@paulroberts2511]

Boom! Drop the Mic! Wow, your videos are excellent! I am a DNP and studying for my AANP (FNP) exam. Your content is right on, and your manner of teaching is an extremely effective teaching style for so many types of learners! Thank you, what a great refresher and preparation for my exam!

[@libertyblueskyes2564]

You have so clearly and specifically answered my questions about the heart failure I experienced and the drugs I am taking. My cardiologists spends about ten minutes with me, not enough time to thoroughly understand. So thank you from the depths of my heart for taking the time and effort to educate all of us.

[@christineb7757]

You need to be more aggressive with your heart doctor and demand more time and better explanations as it is your life, and you are paying for his time. I'm sure he charges for way more time than he is giving you. Be pro-active. He is employed by you. Ask his office manager if he bills by the hour or the visit. Then explain that if the hour, he owes you money. If it is by the visit, the visit isn't over until you say so or you'll find a physician that will take the time to treat you properly. It's your money and your health. You have a right to get your money's worth.

[@hwasunfiower1769]

It feel like i experience heaven when i found your channel. This really helps me a lot ❤🔥

[@tuilikaandreas4776]

the sound of your laughter as you repeat the process is so comforting and reassuring :)

[@christineb7757]

I am so happy I found your channel. I am confident your knowledge and way of explaining the medications along with mechanisms of action, contraindications, etc. will help me greatly in my adv pharm for adv practice nursing. Thank you for your brain.

[@annabelle9904]

You're the best teacher ever! Thank you

[@Transcend11111]

My friend you are the absolute king of teaching this stuff! Even though you are not my teacher in school, you're actually my teacher in school! Lol

[@brianedwards5113]

I have been following you for years and I almost passed up on this video for a shorter one because it's really late and I have to be up early in the morning but you woke me up with this video. Absolutely crushed it, man! I LOVE the content that you make because you really know how to perfectly scratch the itch of not just wanting to know that " 'x' does 'y' " but HOW it does it. Thank you so much for your content!

[@ajithmampitiya7166]

Sir, I have never across this type of teaching experience. Very interesting. Vast knowledge in short period. Highly appreciated. Never forgotten. Thank you very much. Triple gem bless you.

[@apdullahiboss3492]

Thank you my second teacher ❤️❤️

[@Deadlokd]

My primary teacher :D

[@emilyyoung7201]

I love how it’s so easy to follow your videos for my nursing pharmacology class because of my strong A&P 1 and 2 background…that I also acquired through watching Ninja Nerd videos. 😂 Getting me through every part of my degree. 👏 🙌🏻

[@filippetrovic9823]

I am so grateful for this video, thank you truly. It is so disappointing that there channels on youtube that explain things better than professors in universities.

[@ariespitzfaden6027]

Most thought out and straight forward video on ACE inhibitors and ARBs. Zach, we salute you. I love it when you piece together the mechanisms of these drugs!

[@MrAkooanaih]

he is a genius in explaining thinig, im supporting your channel and website thnk you

[@elisa211]

Love your videos. You break things down so clearly in a way that is easy to understand. The visuals are super helpful for a better understanding as well. Youve made my APN education that much more do-able! Thank you!

[@NinjaNerdOfficial]

Glad you like them! - TG

[@CiaoColeG]

About to start clinical for my MSN in a month and I've been so scared because I'm in pediatrics and don't give BP meds and so many others... Your videos are AMAZING!!? I love your teaching style. It's so engaging I missed my turn while listening and driving yesterday 😄

[@TheEbuitrago]

This dude is way better than my pharmacology professors. Greetings from Panama

[@yachiapatel]

Loved when he said "you guys will never forget this mechanism " I literally felt blessed enough by knowing atleast I'm gonna be good at questions with ACE-I & ARBs 😂😂❤🙈

[@shannonhuntsman7664]

You’re absolutely fantastic at explaining how it all works! Thank you 😊

[@sunshinejoy1391]

Thank u zach for making me understand this so quickly with ur beautiful illustrations and clear explanation...more love to u❤️❤️

[@dougr2237]

Amazing, made everything so clear and one of the only resources to explain bradykinin-ACEI relationship

[@dr.kennethj.sacchetti2765]

Thank you for this indepth explanation of the actions of ACE inhibitors and ARBs. I suffer from Peripheral Vascular (artery) Disease (PVD/PAD) with cyanosis caused by angioedema; and Stage 4 Chronic Kidney Disease. The accepted treatment for PVD indicates administration of statins or ACE inhibitors. From this video I learned to support my original conviction, against that of my cardiologist, to NOT prescribe an ACE inhibitor for myself which could lead to an M. I. (I have already had 5 M. I.'s with accompanying open heart surgeries), and or a CVA (stroke, of which I have already had 3 of rhe ischemic variety).

[@progressisimminentjasbir8564]

Amazing. RAAS mechanism is crystal clear now.

[@ShiflaBanu-f4x]

I REALLY LOVE THESE LECTURES...I THANK YOU FROM THE BOTTOM OF MY HEART..

[@arunabhadebnath1894]

The very best of lectures!!

[@jonathanrogers1346]

Just found you a few mins ago off the Neurology | Autonomic Nervous System video. your pretty cool and smart going to start watching your videos bro keep up the good work.

[@qazal1116]

I appreciate your help today and always !

[@doctorspencer2846]

It's a 10/10 from me💯👍.....U just simplified what seemed to be hard. Can't thank u enough

[@draqsashaikh2595]

My God. I hated this topic, but now after your lecture it makes sense, and im loving it❤️ ❤️ ❤️ ❤️. Thankyou so so sooo much😭

[@dranthonyasturi9790]

You ALWAYS make sense. Each and every lesson Zach gives is a performance akin to "I SOLISTI VENETI", an Italian chamber orchestra founded in Padua in 1959 by Claudio Scimone. I was at the time at the U. of Padua learning electrophysiology. My congratulations to Zach

[@kasunrodrigo6592]

One of the best lectures about ACE and ARB's Thank you sir....

[@sewndebisdream6953]

Glad to have this info when I go to my doctor.

[@ropz_karambit1494]

No amount of Thanks will do justice to how much i appreciate your work! i'll donate when i can in the future)

[@debislomp1207]

You are an inspiration and have taught me SOOOO much. You make the material interesting and present it in a simple way, making it easier to retain

[@injustice5991]

These pharm videos are so helpful!

[@buhlemdluli9605]

You are the best, I like how you explain things a bit by bit. God bless

[@aidakhan8142]

thank u so much, i know to say thanks its not enough. u r real hero for us. may God bless u always. Ameen

[@kendragreen9830]

Your lectures help me solidify everything I learn in class. As soon as I graduate I am going to contribute to your Patreon and to your GoFundMe - it would be awesome if you all could get your own recording studio!

[@kirstielreid]

Same! ❤️

[@psalmina]

You are awesome. I didn't find anywhere this more clearly explained.

[@akps61]

You are an excellent teacher. I really appreciate your work. Your videos make so much sense. Thanks a million.

[@EELLmama]

Please come teach in my nursing school. You are an amazing teacher!

[@ohemaadeyemi5233]

This is the best video honestly. I am dyslexic and the repetition of the RAAS system helps a lot. Thank you! I will be supporting your go fund me, if its still open.

[@robinbentley4982]

Excellent explanation of something that has been so hard for me to wrap my mind around (the RAAS). Thank you for the wonderful videos!

[@0nevergiveup0]

Explained it so well. Love the recapping, i dont think i can forget this now. Thank you for the time, effort and sharing of knowledge.

[@futurendeavours1596]

I've never enjoyed a lecture as much as I enjoy this👍

[@raphaellaballa6884]

Honestly May God continue blessing you coz you are a Life Savior 😘🙏🏽❤️lesson well understood

[@meghakadam5404]

Like the way you have explained in details and step by step , it's helpful in understanding complex topics , thank you for the efforts you have put up , look forward to your videos , also like how you show happiness and interest when narrating , it's like you are having fun teaching and comes through to the viewer .thank you once again.

[@lilianechick904]

Always a very productive class. I appreciate very much your work.

[@shasha6064]

I made through first year with your help ..nd u r supporting me in second year tooo 😭❤️ thanks for making pharma easy

[@westfield90]

So beautifully explained

[@shahabalam3348]

Dr zach is doing a very Good job ❤

[@i_reyaa]

Such amazing lectures..!! Finally I can understand medicine

[@faizanraza8820]

But it is pharmacology 😬😂

[@smileyc2011]

I wish I would’ve seen this while in Hygiene school :/ you make it simple to understand! Glad I found it before my board exam though! God bless you!

[@shelbyvanwagoner584]

Thank you for all your videos! I am preparing to take my boards, I just graduated as an FNP.

[@sherryjenningsjohnson5414]

I appreciate your 3 videos: Hypertension, AutoRegulation, and ACE's, ARB,s. You are the best teacher! Looking for more on bilateral renal FMD and direct renin inhibitor, Aliskiren. Thank you.

[@sadiank3909]

I wish i came across this videos while in pharmacy school, i could have been the best in my set, you make learning so easy and interesting

[@suchethagirish8303]

Beautifully explained

[@bhuvaneshwari236]

You re just amazinggg🤩❤️!!! No words to appreciate ur efforts ✨🔥👏

[@abeikukimani8565]

You are a blessing. keep up the good work. You make pharmacology interesting to learn and understand. Thank You.

[@lilfefeop5856]

The best explanation overrrr!!!,

[@vall9588]

You are amazing!!!! You are getting me through acute care NP school! Thank you!

[@mesfinabebe9572]

This is really an excellent lecture . I am a physician and also hypertensive taking ACE-I inhibitors and helps me for more follow up

[@architasaha8917]

Thank you for your easy way of explaining such a important chapter. Please keep making us rich with your knowledge.

[@Cozzie018]

This was brilliant! Thank you!

[@agyekumemmanuel3678]

I love your teachings. Your PATHOPHYSIOLOGY is always superb ❤😊

[@saidasaid9565]

your explanation is the BEST as always! Thank you

[@ritihembrom2551]

I'm very grateful to you and this video😭😭✌🏽

[@kaze123ckr]

Really appreciate "the anti-hypertensive agents" series The control of "ADH secretion" 1. Osmolarity (Osomoreceptor in hypothalamus ) 2. Blood pressure (Arteriral baroreceptor) The textbook usually didnt mention the effect of Ang II directly on Hypothalamus it's probably due to the situation Ang II is elevating ,it's usually the situation of Low blood pressure ( through the baroreceptor pathway)

[@ElijahMartin77]

AWESOME, AWESOME explanation!!!!!

[@ShenoudaRouby]

You are a superstar, mate - I am so fortunate to hit your channel.

[@josiepearce5389]

Excellent tuition .You explain the subject so Well step by step .I look forward to more of your videos and zi will save them all Thank you From U K

[@dhirubhansali]

Outstanding outstanding outstanding...

[@anshumandhingan6277]

Very helpful video. Thank you.

[@cccalifornia7206]

Excellent teaching.... I learned so much!!! Thank you 😃👍

[@iamlegend1624]

You and dr najeeb are best in The world

[@a30s]

Best explanation of every topics.Thanks alot.

[@alinassib6483]

I grasped everything...this is really awesome

[@kamalchandrangari6793]

your lecture are very interesting ,I am many many grateful to you

[@abuadams7947]

Very helpful lecture. Thank you zack

[@Di_Moriarti]

The great job that makes sense. Thank you!

[@Di_Moriarti]

Could you explain hypertesion as a leading comorbidity factor among the covid19 serious and critical cases? Knowledge makes our life brighter.

[@ivodepivo21]

Hypertension is a symptom of reduced Blood flow by loss of negative ions on the Surface of the Extracellulair matrix. And Where nitric oxide is Closley regulated by sulfate molecules like heperan sulfates. I've this mechanism is not in Balance the body Will promote vasocontriction and down regulate the vasodilator, nitric oxide because Nitric oxide, I've not controlled, is a very potential toxic radical. Thats why ACE inhibitors Will eventually promote inflammation due to High Nitric oxide and bradykinin levels by promoting vasodilation and Inhibiting the ACE enzym. People with hypertension symptoms and covid19 will develop acute hypotension, Cappilary leakage, and organ failure, because of High on controlled levels of Nitric oxide and bradykinin levels. ACE 2 viral entry is probably Nothing more then RNA own exosomes induced by over shedding of ACE 2 cells by ACE inhibitors. Is the Toxicity induced by these drugs that can explain the whole Cascade that occurs in severe acute Covid-19 patients. ACE inhibitors contains sequences of peptides from snake Venom like Bothrop Jararaca Species. Like bradykinin potential factor, and serine and metallo Proteases.

[@Mina-Rofaeil]

God bless you with long, happy and health life.

[@philipojr5423]

thanks for your time teacher

[@codyprince7378]

These videos are gold!

[@shun3953]

Awesome way of explanation. I just enjoy your classes.

[@evaristokunka3144]

great presentation. Much appreciated!

[@niazwali8169]

thank u so much for uploading such vedio especially cardiovascular pharmacology plus cardiology

[@debbiegoodwin5221]

Great video makes everything so much clearer! Starting my nursing soon and have a feeling i will be on you page alot :))

[@anastesia8455]

You are amazing, thank you, from a patient. ❤

[@ahmedelhadidy7996]

I really appreciate the effort you did in simplifying this information thank you , keep going

[@naelyncarruth6079]

Thank you so much for making such clear and concise videos!

[@luphelelemavuso8594]

Hi, thank you so much for the lecture, really helpful. I have one question though, how do ACEI and ARBS worsen renal stenosis?

[@jibbieoostra]

The best video ever, thank you!!

[@QAWAZAKI]

Amazing as always..