Neurology | Upper Motor Neuron vs Lower Motor Neuron Lesion | UMN vs LMN Lesion

[@MaLu514]

my teacher in college spent 3 days worth of 2h classes to try to teach this and failed miserably. you did everything right in under 1h. my teacher is a neurologist. you are THE ninja nerd

[@imperfectmammal2566]

Best teacher to ever exist in this planet!!!!!

[@rjkmdb]

So true

[@hillsongirl1]

His kids will be blessed, hope he does pass on his DNA

[@MsElina28]

Amen!

[@Foodies28Joy]

True❤️😍

[@prashant23ify]

Sir I have a dbout please help me solve it . If UMN lesion is present, obviously no signals are passed to lower motor neurons, so there should be less release of acetylcholine ….. so basically umn=lmn … why there’s a difference???

[@ismaelbarzani6064]

You deserve to be named as the father of explaining and teaching

[@NenehAgan]

where do we vote🥹

[@selwynhenriques2614]

Very useful to understand difference between upper and lower motor neuron lesions ,really appreciate the ton of research you put in to give us such a detailed and simple to understand explanation .

[@ArundhotiRay]

Throughout the medical life I felt pain whenever I saw the word UMN & LMN because I didn’t understand these complexity. Thank God, I can die in peace now bcz I understand upper & lower motor neuron lesion. Thank you ninja nerd, you are the best teacher of this planet.

[@amalomer3113]

سهلتو حياتنا ربنا يسهلها عليكم دنيا وآخرة يارب

[@DrMimansa]

Seriously - 4 hours of uni lectures - distilled into pure gold.

[@dennishaji2830]

Facts my G

[@riturajmajumder2055]

Zach , you are like one of the best med teacher in the planet currently.

[@flypnay704]

Zach & Ninja Nerds, you constantly blow my mind...in that good neuro way! This subject was so terribly taught at my medical school, thank you for making this clear!

[@pavankumardurgad]

❤

[@Dilinaare]

How this man keeps going all from his memory without a single hiccup is beyond me 🤯

[@evilreborn4088]

Practice. He prepares every lecture. Then practice and then shows us the final product. He Is seriously good. All concepts getting cleared

[@drdeb_ocherry]

He is the Master of the Universe, as in Queen Song!

[@ghadderd.3444]

صلي على محمد لا تحسدينه

[@BrianHurd]

Pretty sure some of the minutia is on a monitor off screen (but I could be wrong!), but 90% he knows. He is a badass.

[@seemo5681]

@@ghadderd.3444 منجد فجعتني ليتها تقول ماشاءالله

[@amirulazam5034]

3 years of doubt and confusion cleared in 1 hour lecture... THANK YOU VERY MUCH..

[@jillybasu8300]

You guys are awesome, insanely good, the best teachers! Thanks for a great lecture Zach, it has really helped me understand about assessing for UMN v LMN lesions 🧠🤩🤙🏼

[@elizabethwetzstein-cm1jp]

You have no idea how helpful those content is. I appreciate you.

[@TheHaretahi]

I am a Japanese doctor first year. I am not good at English, but your writing boad is wonderful, I can understand neurology deeply. Thank you.

[@thehunchbackgirl]

I would travel across the world just to thank you in person, Zach!

[@tanziasharmin7364]

I was waiting for so many years for this video...passed MBBS some years back.. I used to memorize UMN &LMN Lesions.. But this time i wl never forget....Great teacher..! Wonderful way of teaching...

[@grdainylung5216]

Please share this video to freshers in medical school,it's fucking awesome,I have wasted years studying books trying to understand this but you clearly described in simple way.Millions thanks to you.

[@neethu4661]

Being a medical student your videos are such a blessing to me... Thank you sir.. Finally understood it❤

[@josetrujillo738]

The way you teach is honestly amazing! Thank You Zach! Shout out Kristen! Shout out Rob! Thank You Ninja Nerd Lectures!

[@amalomer3113]

I can't imagine my life without ninja nerd💗 I love u guys we owe u alotttt❤️ يارب كلكم تسلمووو

[@TheChartreusePenguin]

I don't know how I'd get through medical school without you Zach! Thank you so much for teaching and sharing your knowledge - I literally don't know how to thank you enough

[@H-ton-R-tonSN7893]

You're absolutely an amazing instructor, who feeds the whole world with knowledge through social media..

[@sabaripaulmajumder5196]

Love from INDIA

[@Destinyschild777]

Same bhai, best teacher in the world

[@piyushgadegone5107]

Ye Ranveer Allahabadia jaisa dikhta hai kya dosto?

[@aaronstephen482]

@@piyushgadegone5107😂😂😂😂😂abe bhai

[@azmeelmohammed3802]

@@piyushgadegone5107 beer biceps without workout😂😂

[@spanishlatteMD]

so happy for you guys for what you have accomplished over the years! been here since 1st yr med school and I still am now that i am a graduating medical student! keep rocking you guys!

[@obedbagona7402]

Regards to MSU Med! - From ADZU School of Medicine

[@danielpa8644]

In the MASS part of lecture - LMN lesions cause less protein synthesis (more protein degredation) then at 23:30 the muscle responds to a decrease in Acetylcholine by synthesizing more nicotinic receptors. How are new receptors being created when protein degredation is going on with a LMN lesion?

[@honeybadger1621]

hi,I'm type 1 diabetic 46 years old 15 years have neuropathy. I broken my tibia bone 4 screws and rod in my leg now. my question diabetic people's fracture healing? also neuropathy can made problem for healing process?

[@sudeeptalapatra3982]

@@danielpa8644 great qs Daniel.!..even when protein synthesis is less due to less Ach cell will try to make new and more nicotinic receptor so as to increase muscle pr synth with whatever protein the cell from the very beginning of UMN lesion and even in late phase it will destroy it's organelles To make N.receptors because it is the only means to maintain homeostasis for the muscle cell.

[@britneyidapaulus750]

This was aweeeesome😭 I am basically hours away from facing my end of term internal Med exams and this was so useful 💡, the light to the end of my tunnel 💗

[@daniaizzah4335]

last year med student here and your videos are god-sent!! thanks Prof! Many loves from malaysiaaa

[@scottwilson7633]

Thank you for what you guys do. I've been using your videos all through undergrad and now in medical school, and I can honestly say that you are one of the main reasons I (and likely many others) have been able to make it this far. Ninja nerd will have a big donation coming their way after residency!

[@neelamjha7955]

Ahhh!!!!! The most awaited video is here....🤩 Thank you Zach....I respect You and your work a lot...I really do...🤩🍰

[@jeffreyrayner5235]

Thank you Zach. I have been recently diagnosed with MND and a fell into a dark space. Your lecture has clarified my case such that I can understand what I may or may not have. This allows me to understand and deal with what could have been a total despair.

[@melissamonreal9486]

BLESS YOU!! You explained UMN vs. LMN in the first 5 min of this video better than my grad school professor did in a full semester. Thank you!!

[@VERA-jo3ev]

THIS IS LIFESAVING, i have a neuro class in 2 hours and this just was PERFECT!

[@lollolez7147]

Can't express how thankful I am, Appreciate the time you spend to teach us in such an efficient easy, and fun way.

[@guarkenchiman4427]

His spirit challenges every mind to thirst more for knowledge. Thank you for your energy and time

[@Thefirewithin1233]

Man, that was the best teaching about UMN and LMN lesions I've ever had

[@evelynperez2486]

I just wanted to say that I freakin love your videos! You truly helped me pass advanced anatomy in my grad program! You have a gift of teaching things very clearly something some professors do not know how to do!!!!

[@lifeingreatmoment5654]

The best teacher I am eagerly waiting for him twice in every week

[@aakashkumarsah8616]

Neurology seemed so tough to me.You made it so easy zach🤗🤗. Thank you ninja nerd team❤🇳🇵

[@andydonham8612]

Should be mandatory viewing for new PLS and ALS patients. Cleared so much up about the affliction. Thanks so much.

[@manishaprja]

Thank you so much for this. Best teacher! No one taught this in so simplified form in medical school. It helped me a lot.

[@humanbeing3177]

What an extraordinary lecture you have prepared and made it available for free for real. I am so thankful to you.

[@SF-es3ff]

So much respect to you, attempting to get into PA school and discovering how hard that can be! Your videos provide an in-depth understanding that I probably couldn’t get elsewhere this easily! May God bless you for all your efforts!

[@hsmith1180]

you get a lot of love in these comments and it's well deserved. I rely on these vids so much to supplement my "scholarly readings" because you break it down into much more comprehensible language. I'm not exactly sure how you do it but you make it so much easier to grasp. I watch bits over and over to make sure I have the idea correct. You are a legend

[@Iminoamino]

Being a medical student the respect and love I have for this person is inexplicable! Thank you

[@granitklippa]

Best teacher ever! My wife has recently been diagnosed with Progressive Bulbar Palsy and this video really helps me understand the symptoms. I am a Nurse anesthetist by training, but never really paid attention to this topic in the past. Thank you for posting, keep it coming

[@fatemahh9459]

Oh my God I have a neurology exam in the morning, you couldn't possibly have had better timing! I might cry with sheer relief and gratitude 🤧 Your videos are the only reason I'm surviving and feeling smart while doing it 😂❤️ Thank you soooooo much! I cannot possibly ever express my gratitude. You are a real inspiration!

[@mosab_emad]

I swear this is the best lecture I have see in KZbin ,, Sincere love and respect Doctor ,, YOU ARE AMAZING!!

[@alih6953]

Zach you are helping millions of people. I am praying for you and your family so that God grants you with health and wealth. Thanks

[@setarehabdoli3115]

You are literally amazing,for years as a postgraduate specialist I was struggling for this topic,,,,,if there is a magician,its you❤

[@sudeeptalapatra3982]

understanding Mechanism behind all these hyper reflexia and hyper Tonia makes it easy to memorise.... also gives an enjoyment 9f understanding the actual concepts behind...Kudos to your team sir for gifting such an amazing lecture.❤️

[@EmmArwen]

oh my god! i can not stop watching your neurology classes. i am a resident 5 th year in the neurology department. It is fascinating me after seeing you explain this staff!

[@kyongvincent4385]

Love his lectures. How he can remember that much info. Genius

[@Azikiwe-qi6jd]

I regret to have wasted many years reading huge books trying to understand upper and lower motor lesions, and crashing nothing, little did I know ninja is the solution.

[@amelonlord654]

Liked it and enjoyed it, definitely. I am so thankful, I was always very interested in neurology but found it quite complicated. You make all the complicated concepts seem understandable. I coudn't ask for anything more. And you even tell everything with such a spark that makes me want to binge watch your neurology playlist! Who would've thought..

[@eman-ne2ng]

42:33 that smile on your face made me smile, Zach. You love to teach and it shows, always! Appreciate everything you do :)

[@malihahoque5460]

The way you connect physiology with medicine ; damn I'm in love !

[@itssuhaibalrumi]

We must protect this man at all costs.

[@arijoybhattacharjee6039]

I love you Teacher ❤️... From India 🇮🇳

[@cleopaschisanga5355]

You deserve tones of awards... This makes so much sense when examining CVA patients thanks so much ninja nerd🙏❤️

[@ifrahakbar2283]

One word for you: KING!

[@atlantic7949]

I have tried to understand why UMN lesion causes hyperreflexia, not even my teacher explained this in the lecture in our neurology block. But, I am glad we have you. TBH, We all need to fund this guy to open his medical school.

[@prasannabharathi2019]

You make the topic more interesting by saying the word "beautiful " again and again 😍😌😍

[@cinnamonbun5530]

I'm coming and thanking you in person when I graduate. Lifesaver you are. Thanks for saving me from hating medicine. Turns out it's just poorly taught in uni.

[@sandrak4032]

Amazing! I understood so many things in depth that I had been taught couple years ago

[@kelechi2352]

what a time to be alive.. I am blessed to have found this channel

[@jyotisamanta4997]

Kudos and all the best wishes. This solved my never solving confusions ❤️

[@neliakalenga2462]

Literally the best teacher anyone could ask for! My Med school life saver!

[@mrindian5908]

Thank you for the most woderful lecture with brilliant simplification of a complicated topic. I have one doubt - the inhibitory tracts from Medullary reticulo spinal nuclei are descending ipsilateral where as excitatory cortico spinal tracts are coming from opposite side of brain, so how these inhibotory tracts are damaged to produce hyperreflexia in UML when the UML lesion is actually on the opposite side of the brain. Pl clarify, thank you.

[@hannahunt1175]

Your enthusiasm is infectious

[@marianapereira5370]

Amazing lecture as always! When are you guys releasing the video about the physical exam? Btw love your videos, been watching them since my first year in medschool and I'm in my fifth now, and it's a lot thanks tou you! Keep up the great work!!

[@thanujathilakawardana4143]

When I search a topic I always want ninja nerds to have it . because ur lessons are the best ones .Thank you

[@obaidkhan2278]

Pure class of love 😍😍❤️❤️❤️❤️

[@RailingMedia]

I'm doing an elective, only a first year unit, and I have close to 5,000 words in notes from various sources on ALS. In absolutely none of them (and I'm talking books devoted to ALS) do they describe it anywhere near as clearly or sequentially as this video. What an amazing teacher, you're now bookmarked next to 2-minute neuroscience videos... I'll be seeing you along the rest of my psychology degree pathway :D Now to find suitable academic texts to reference for the knowledge that you shared in this video.

[@User-to7nb]

Just here to leave a like and a comment for the algorithm

[@lisamoore8858]

Wow! I had a Thalamic stroke and have suffered with CPS, Ataxia, Spasticity - debilitating pain, arms stuck and not able to move for hours, neuropathy from the top of the left side of my head down my torso to my left leg. l was very much uneducated about the brain and pathways until I started watching you You are a wonderful teacher and explain in such detail. Thank you

[@balavantbhaipatel1969]

My teacher is back.....whoooo

[@NinjaNerdOfficial]

[@qamaruddinkhan3847]

Best teacher for understanding concepts 💞 kindly at the end of every lecture, cover the whole board so that we can take screen shot as well for memory

[@akatodemyrus6077]

I wish I could draw like him...

[@simplyy.lylaa7]

Wow, you should honestly be a teacher! This is amazing!!!

[@SameerShaikhAdventures]

FIRST ONE TO COMMENT. HUGE FAN OF YOU SIR. LOVE FROM PAKISTAN❤ do reply to me 🤒😂 Stay Blessed❤

[@NinjaNerdOfficial]

Thanks so much!!!

[@Desert-123]

This is the best video on the internet . Thanks for being short and so comprehensive !❤

[@christybiji1433]

You always manage to explain something so complex so well! Thank you!

[@obiesielawrence7658]

I have never seen motor neurone lesions this explicit. Good one ninja.

[@vinayakkapatral4246]

My Zach doze for the day! I was reluctant to see neurology classes but .... now I am hooked! Zachcellent!

[@farangaisjinasaidi6271]

The most fantastic video ever to describe UMN and LMN.

[@Neemo-ps7sg]

Thank you so much, my medical school journey is so much more enjoyable and comprehensible because of you.

[@haleeyzkhair4121]

I have waited all day for this. Thank you Zach you are the best of all.!!!!

[@lukeorison5418]

This was a great breakdown of each type of motor nerve and the lesions. It brought a much firmer foundation of understanding for me. Thank you!

[@camrynpierce1461]

agree. thank you Luke and thank you ninja nerd

[@NinjaNerdOfficial]

Glad it was helpful! - TG

[@mashudurebeccamulangaphuma8649]

Thank you so much. I spent 4hrs trying to understand my lecturer's notes on UMN and LMN. Should have came straight to ninja nerd. You made things easy for me

[@rwuthenow]

That was amazing. Just basically taught about 400 pages of exam prep. Thanks for doing this. You have really exemplary teaching skills. I wish I could half as good a job.

[@DOT368ER]

Best to explain MND! My dad passed away from ALS a few years back started with the bulbar. I’m having symptoms of LMN with fascinations. This definitely give knowledge to determine what one has!

[@judithumeadi2704]

Great revision session. Excellent teacher, delivered at just the right pace. Easy to understand and follow. Thank you!

[@adeyemialexandra209]

Sir, you are blessed with intelligence and the gift of teaching. Thank you for breaking down these hard topics

[@sunnyrajpoot6526]

Love from INDIA ❤ VERY THANKFUL FOR MAKING MY CONCEPT EASY LOVE U MAN ❤

[@tabitha2540]

Amazing teacher! Your enthousiasm is contagious to understand this. You are brilliant as a teacher. Thank you soo much.

[@chansaclive]

went through this video 2hrs before my exams yesterday and it came exactly about this .thanks ninja nerd

[@garycovington7925]

As someone diagnosed with PLS (Primary Lateral Sclerosis, UMN) over 29 years ago and heavily involved with PLS email groups then Facebook PLS groups (1400+ members) for around 25 years that's the best explanation I've yet seen! Thank you! 👍 The only thing I have issues with is the explanation of fasciculations as being LMN. Almost every one of the 1400+ PLSers in our Facebook group, including myself, have fasciculations yet I'm sure after 31 years from first symptoms I have PLS with UMN symptoms only. The connection between fasciculations and fibrillations measurable on EMG seems tenuous because most of us with serious fasciculations have had EMGs which show no LMN involvement.

[@drshuvochakravorty7017]

Best explanation ever about UMNL & LMNL

[@musicbeachdance]

Saving my entire existence in Neuro thank you for explaining the findings for fasciculations!! So easy to follow!

[@julieforsyth4349]

I finally understand WHY we have the signs and symptoms of UMNL vs. LMNL! Thank you!

[@madeleinemei-ling5625]

Studying anatomy should be all videos - I kept trying to read the textbook to visualize but you explained it so clearly thank you!

[@sheliapdd758]

Really help me to understand neurology class clearly. Thank you Zach. You did it great!

[@josetrujillo738]

Awesome Teacher! And great Camera skills! Thank You Zach and Rob. Shout out to Kristen! Ninja Nerds Science!