NMR spectroscopy visualized

NMR is a widely used spectroscopic method to deduce chemical structure. It has become a central tool for chemistry, medicine, materials science, and engineering. This animated video shows the behavior of nuclei in a magnetic field, magnetic resonance, and explains how the NMR spectrum is used to understand chemical structure. Rather than go into the quantum theory and mathemantics of NMR, the goal of the video is to provide a visual model to help students and life-long learners gain a deeper understanding of NMR. It should be noted that the animation of the continuous spin state transitions is not representative of the actual quantized behavior of the spin states. For viewers interested in further exploration of NMR theory, please refer to textbooks or on-line sources such as:
en.wikipedia.o...)

[@suranga4030]

The best fundamental NMR video I have ever seen.Everyone can very easily understand what is going there🤩🤩🤩 Thank you very much❤️

[@ScienceSketch]

Thank you so much, Suranga. Very kind of you. Be sure to check out ScienceSketch NMR spectroscopy two.

[@janecarville7210]

👍 x

[@hectorgonzalez485]

One of the best videos I've watched on NMR! Thanks a lot for the great explanation.

[@ScienceSketch]

Thank you very much!

[@mhamadkhedro1620]

Vfhnmd

[@ZazaMasta]

This was incredible explained. I try to keep an eye on the effectiveness of visuals I come across in my educational experience and I must say this is up there with the greats. You have definitely thought about this video and it paid off. Thank you very much!

[@ScienceSketch]

I am glad to hear that it was helpful. Thanks for watching!

[@yuguo8884]

Very well made! The professors should use this video clip to introduce NMR. It will be much easier for the students to understand. Hopefully, there will be more visual teaching materials like this one in this channel and more professors and students can find these clips here. Thanks for making this video!

[@giuseppejuniormosca6152]

I think everyone interested in spectroscopy should see this video once. It is simple, clear and gives an overall understanding of the NMR experiment. It's so unfair that it has not the right visibility.

[@ScienceSketch]

Thank you very much, Giuseppe. I hope that the video will get more views and help more students of spectroscopy.

[@davidhaller6079]

I read books, I read online articles, I read wikipedia to fully understand NMR --> but this video IS IT. THANSK A LOT. Amazing video.

[@ScienceSketch]

Thanks, David. I really appreciate your kind words.

[@ankitasaraf2656]

Best ever video of NMR Spectroscopy

[@ScienceSketch]

Thank you very much, Ankita.

[@dr.emanmoussa2291]

best video I seen so far explaining NMR concept .. Thank you very much

[@ScienceSketch]

Thank you very much for your kind comments!

[@butterfish2]

This is great. I was introduced to NMR 30 years ago and could interpret spectra well enough, but I never understood what was happening until now.

[@gabrielle9191]

Oh, if you don‘t mind answering, what is/was your job?

[@butterfish2]

@@gabrielle9191 I'm a scientist still, but I hadn't thought about NMR since graduating, until last year when I suddenly needed to know about it again.

[@nayananayakac34]

There could not be any better vedio than this for NMR. Thank you for making it..

[@PuifaiAojanepong]

Thank you so much! The video that makes me understand the topic the most so far🥰. I can't express how much I feel grateful for this🤩!

[@mexheix]

This is much better than the other video I watched on youtube explaining NMR!

[@gracemaryvarghese6619]

Hey! I was really confused about the spinning alignment of the nucleus in the presence and in the absence of B. Ur video gave me a good clarity about that Thank you so much 😃

[@martincaceres2336]

agradecido de poder tener este tipo de videos tan informativos detallados y gráficos, gracias

[@ScienceSketch]

Estoy agradecido por sus generosos comentarios.

[@SukhwinderSingh-oi2xi]

Thanks a lot to the channel members. A perfect ever explanation given for NMR. All the deep concepts shown perfectly. Please make more videos on Mass spectrometry, Chromatographies and more spectroscopies. This video is very useful. Thanks.

[@stephaniemcmichael]

This is the best video on NMR spectroscopy. Thank you, i'm really grateful.

[@ScienceSketch]

Wow, thanks very much for your kindness. Please check out NMR spectroscopy two!

[@najiali1068]

Fantastic demonstration of NMR. Really appreciate your neat work providing such educational content.

[@nxise823]

Best explanation I've seen on KZbin! Nice work, thank you so much!

[@kep444e]

preparing for the school olymp and finally found this video, tysm

[@majdoleanzuraiki7036]

I studied the material and he put everything in perspective visually and great way of explaining everything. Great video !!!

[@ScienceSketch]

Glad you enjoyed it!

[@Ismael-im9in]

Great video. This helps a lot. Should be shown before teaching an NMR unit.

[@Olivia-W]

This is amazing and finally makes more sense.

[@samuelmcdonagh1590]

No doubt this was the best video I've watched thus far on NMR. However, I would've preferred more mathematical depth, perhaps covering the quantum mechanics involved.

[@sidewaysfcs0718]

I'm not sure individual spins actually behave like shown at 2:01, they can only precess along the Z azis, the incoming radiation simply flips them from +1/2 to -1/2 and induces some coherence between their precessions, the following decays of the precessional coherence (T2) and the decay of the non-equillibrium population of -1/2 oriented spins (T1) together give rise to the collective FID behaviour of the global magnetization vector. As i understood it, it's only the global M vector that has this "classical" decay evolution that we detect as a FID signal, the vertical component of the magnetization being purely a result of the populations of +1/2 and -1/2 orientations, and the x-y component evolution of the M vector being the desyncronization of precession of the entire population of spins.

[@ScienceSketch]

Thank you for your thoughtful comments.

[@adriaanberger1930]

This is also how I understand it. It would be responsible if the creator made a note in the description that the animation of the spin state transitions as continuous is not representative of the salient quantum-mechanical model required to predict MRI phenomena.

[@ScienceSketch]

Hi Adriaan, thanks for your input and absolutely correct. My intention with the video was to create a visualization of the decay of -1/2 spins in T1 to give the observed FID behavior. I urge the viewers to delve more deeply into the mathematics and quantum theory behind NMR. I will take your advice and add a comments to the description. Thanks for subscribing!

[@niloonilase1616]

It was a very good and simple explanation of NMR! I learned and enjoyed. Thanks😊

[@ScienceSketch]

You are welcome!

[@yomeyo6622]

Incredible explanation! The best I 've found so far! Thank you!

[@loulouparis_]

Excellent explanation! Thank you so much!

[@lkcreativethoughts7255]

Best explanation on KZbin

[@davidkellen8044]

Oh man... I am currently studying the NMR part for my thesis defense and was studying it through two recent papers... However, it is very hard to understand without a visual representation. Your animations pointed my in the correct direction!

[@ScienceSketch]

Thank you very much!

[@litebrite3163]

Awesome visualization of complex phenomena!

[@mauroariascontreras9284]

how I admire you, this is so pedagogical! thanks a lot

[@ottoeuller8604]

ngl, this video goes hard. excellent explanation, amazing visual to go along with it. wish my professors had shown me this along with their lectures!

[@lucysnowe9974]

Wonderfully explained; thank you.

[@joyfun5664]

The best presentation I had ever seen

[@Phosphoenol_pyruvate_CK]

Awesome visuals along with concise explanation of NMR jargons 💯

[@hafsaiqbal1074]

Best video which clear all concepts

[@muhammadumarsotvoldiev8768]

Thanks a lot. Very clear.

[@akhurairah599]

Tnk u Sir ! Awesomely described and visualised ❤❤

[@ScienceSketch]

Most welcome 😊

[@weskeralbert5564]

best video i have ever seen to explain the theory,good job

[@ScienceSketch]

Thank you very much. I like your channel!

[@Sagivbh]

Amazing! I see bright future for this channel.

[@dragondrago1740]

I have an exame of structure determination and was looking for some basic principle of HNMR and then I found this amazing video wich made me see the complete picture of NMR, thank you for that!

[@ScienceSketch]

Glad it was helpful!

[@mediwise2474]

How to earn structure elucidation

[@goozhaojian5193]

very clear video on NMR spectroscopy i found Thank you so much

[@philidor9657]

Really good explanation!

[@RaffayMalik-hs8cd]

Brilliant explanation

[@prawinbharat]

That's a Fantastic Visuals!

[@ScienceSketch]

Thanks very much.

[@tacefairy]

There is so much info here, thank you!

[@wulf_bang3728]

Thank you for that perfect video!

[@hedgehogelite8573]

amazing explanation, thank you for the video. would have liked some elaboration on why frequency and shielding relate

[@ScienceSketch]

Thanks very much, Hedgehog. The relationship between shielding and frequency depends on the Larmor equation. The higher the magnetic field around the nucleus (less shielding), the higher the frequency. More shielded nuclei will experience a lower magnetic field and will have lower frequency. Stay tuned for NMR II coming out soon.

That was extremely helpful and visual. Thank you!

[@johnathanmarcucci8255]

this explanation is awesome! thanks

[@julians6392]

The animations really helped! Thanks for explaining

[@khanphysics8209]

Waow such good video

[@PallasTurrets]

Awesome vid! Been struggling to understand this topic for a whole, this certainly cleared things up a whole lot

[@ScienceSketch]

Glad it helped!

[@heinrichburmeister1291]

Awesome visual explanation, well done and thank you!

[@kaushalyakumarihami1394]

amazing vedio

[@fjs1111]

You did really excellent describing this!

[@bx1186]

Very good explanation, I personally would find it better if you could talk a little slower :) (but I am not a native speaker)

[@karthikr3044]

Fantastic video and thanks a lot.

[@fjollaamiti2628]

Wow this was soo wonderfully explained , thank you sooo much dude.

[@thanoszobrist6730]

Concise and Complete.great explanation.

[@ScienceSketch]

Thank you very much, Thanos! I appreciate your support and encouragement.

[@Hamzakhan29592]

admirable

[@samusaran13372]

5:01 How do we know which protons are close enough so as to raise the multiplicity?

[@ScienceSketch]

A neighboring proton has to be within three bonds to cause spin-spin coupling (also known as J coupling). For more about coupling and multiplicities, see NMR spectroscopy 2. kzbin.info/www/bejne/eoGuaZuwrcqXZ9E

[@jesusdacoast872]

Nice explanation

[@toyganyilmaz]

Extremely good explained,

[@MrArunavadatta]

Excellent

[@vigneshk1033]

Amazing 😍.Make more videos like this we can visualize the concepts better..

[@michaelfuxeklint4909]

Indeed, thank you very much 👌👌

[@monalisamallick9426]

great video

[@priyanshugupta521]

Amazing....I was thinking about why nucleus precesses...you nicely explained, moreover, you explained about doublet etc. What made us to think nucleus as top not like a (hard)sphere.

[@rh.5304]

Thank you so much, finally get it, happy :)

[@lynj-c9153]

Excellent!

[@user21XXL]

1:54 - does this pulse have to be mached exactly to rotate the nuclei? Is it possible that in a given molecule some atoms that are strongly shielded / deshielded would be too far of the tune to be rotated by that RF pulse? Or simply the pulse contains a spectrum of frequencies and all nuclei will find matching tune to rotate?

[@ScienceSketch]

Thanks for your question. You answered it in the last sentence. The short Rf pulse has a spectrum of frequencies and will excite all the nuclei.

[@dgwparfitt]

Could you possibly explain why the deshielded proton has a higher frequency than the shielded one, but its Fourier transform peak is at a lower frequency than that of the shielded one? Many thanks.

[@ScienceSketch]

Hi David, Thanks for your question. You're completely right: it seems wrong. The peaks to the left are actually higher frequency than those on the right. The X-axis in ppm goes UP as you go to the left and DOWN to zero as you go to the right. I know, this seems wrong and is in conflict with any other graph that you have seen. The X-axis of the NMR spectrum is expressed in ppm (parts per million). The chemical shift (the resonance frequency of a nucleus) is defined as the resonance frequency minus (the frequency of the instrument) divided by (the frequency of the instrument) times 1 million. Please see this reference: chem.libretexts.org/Courses/Western_Washington_University/Biophysical_Chemistry_(Smirnov_and_McCarty)/05%3A_Nuclear_Magnetic_Resonance_(NMR)_Spectroscopy_-_Introduction/5.03%3A_Chemical_shift_in_units_of_Hz_and_ppm

[@dgwparfitt]

@@ScienceSketch That makes sense, many thanks for your detailed explanation (and for the videos).

[@abhishekthechoudhary]

Beautifully explained. loved the explanation!!!

[@ScienceSketch]

Thank you very much, Abhishek.

[@brurida3328]

You are the NMR-god!

[@oliverwho6195]

Well said!

[@mehmoodhassan7065]

Wow wow really wonderful explanation ... Thanks thanks.. best ever explained than my professor

[@ScienceSketch]

Thank you very much for your kind comments.

[@jeydeang7890]

Could anyone help out? The powerpoint of my spectroscopy course mentions that the RF pulse is meant to perturb the equilibrium magnetization to set the nuclei into precession. My understanding however is that the RF pulse is meant to flip the already-precessing nuclei and not induce the precession itself?

[@ScienceSketch]

Hi JeyDean, one of the possible sources of confusion is that it depends whether you are considering a single atomic nucleus or the average of a multitude of nuclei. If you consider a single nucleus, it will definitely have a spin when place in a magnetic field. It will precess at its own Larmor frequency. But if you think about an average many nuclei, then the average magnetization vector will be aligned with the magnetic field because all the precessions cancel out. THEN when you apply a pulse to the average, the vector will flip down, and all the nuclei will re-align with the magnet at their own rate and precessing at a different frequency.

[@aaronlin4487]

This video is fantastic! thank you a lot!!!

[@abhijitashanbhag]

Thanks for the video, explained really well

[@gamerboyss5310]

yo best lecture ever

[@hyteruna]

I am impressed with this NMR explanation. However I thought the triplet in 5.40 minutes should be doublet of doublet and the quartet should be doublet of triplet, because the geminal coupling much larger then the vicinal coupling.

[@ScienceSketch]

Hi Hilwan, Yes, you are correct. I was trying to simplify the N+1 rule so that two neighboring protons would give a triplet and three neighboring protons would give a quartet, etc. But geminal coupling would most likely result in doubling of the doublet and doubling of the triplet, as you said. Your timing is great because I am in the final stages of making NMR Spectroscopy Two video which will go deeply into vicinal versus geminal coupling. Also I will touch on magnetic anisotropy and how to use integration to assign structures. Many thanks!

[@hyteruna]

@@ScienceSketch thanks for the immediate responses. I will be happy to review your next videos before you publish them.

[@user.w18]

Interesting, so it's H which is measured really in aim to identify C and other connected atoms, am I right? Because, I saw few documentation about its application in energy exploration like with oi, they measure H to identify and quantize the fluids in earth formation matrix.

[@mahmoudmuhammad7525]

Thanks very much for your clear explaining for working principle it was really helpful

[@GiorgiaGranocchia]

thanks, explanation very clear

[@SharonWendyM]

Watching this 2hours before exam and I feel much better about the topic

[@ScienceSketch]

Glad to hear that!

[@hiteshdhamat1671]

Its really helpfull to understanding how nmr spectra obtained... Thnk u...

[@hiteshdhamat1671]

We need more nmr videos....

[@ScienceSketch]

Glad to hear that

[@semb12]

Great video. Thanks very much.

[@BigLoveForRock]

amazing explanation. thank you!

[@samholmes1684]

This is so good.

[@altareb]

Thanks for this explain

[@Superfarmerx]

Thank you very much!!

[@Lithium_exist]

Best video to grab the concept

[@ScienceSketch]

Thanks for watching, Gowri!

[@musikvonpauli]

Thank. You. So. Much. FINALLY I get it :D

[@rachelhughes2837]

i am going to be learning all this in my L5 in uni in sept, so im reading up on this now ready. i didnt understand some of it as i havent learnt it yet but the end part i could see what was happening.

[@ScienceSketch]

Thanks for watching, Rachel. Be sure to check out NMR spectroscopy two. It goes into spin-spin coupling (J coupling) in more detail. kzbin.info/www/bejne/eoGuaZuwrcqXZ9E

[@NICKuuuuu]

This is so great! I am saving it forever lol

[@yohararanasinghe2996]

This is amazing, thank you! Please do some videos on inorganic spectroscopy as well if that's possible

[@ScienceSketch]

Thank you very much, Yohara. Inorganic spectroscopy...do you mean ESR / EPR?

[@yohararanasinghe2996]

@@ScienceSketch yep.. and also in NMR fluxional molecules, F NMR, P NMR ,etc 🤗

[@electronicswithmadhan1052]

Sir here in Larmor frequency relation, whether the frequency 'v' in the LHS is the frequency of the emitted radio frequency by the protons, after the passing of RF waves is stopped or else anything????? Please anyone kindly say....

[@ScienceSketch]

The Larmor frequency is the precession frequency (not a radio frequency) of the protons oscillating in the magnetic field. The excitation of the protons comes from a short Rf pulse. The frequency of the pulse is centered at the middle of the NMR spectrum. A short pulse at a carrier frequency contains a range of frequencies centered about the carrier frequency. The bandwidth is inversely proportional to the pulse duration. This may be helpful: en.wikipedia.org/wiki/Nuclear_magnetic_resonance#Precession_of_the_spin_magnetization

[@maazsyed2240]

Excellent explanation can i get notes for this????

[@jw3983]

awesome, thank you

[@noobMASTERL2004]

Amazing