No more myths. Saturated fat and keto diet

0:00 - What Saturated Fat Myth?
0:24 - 1) Effect Magnitude
1:16 - 2) The low-carb lipid ‘triad’
1:37 - 3) Inverse association between BMI and LDL-C on low-carb
2:13 - 4) High LDL-C on low sat fat diets, and the converse
3:46 - 5) Meta-analysis of RCTs
OreoVsStatin video: • Oreos are the Most Pot...
OreoVsStatin paper: www.mdpi.com/2218-1989/14/1/73
Meta-analysis video: • NEW STUDY Proves it's ...
Meta-analysis, Soto-Mota et al: www.sciencedirect.com/science...
Interventional Trial, Cooper et al: www.frontiersin.org/articles/...

[@brucemoose926]

You guys are blowing up the American Heart Association cholesterol guidelines! Thank you.

[@wesleyogilvie8105]

People have been eating steaks, bacon, eggs, and butter for thousands of years, and nutritionists and doctors decided that they were suddenly bad for you?

[@thisguy2085]

Well yeah….. how else are they going to sell you prescription drugs?

[@henrytang2203]

Conversely, highly processed breakfast cereal has been around for 100 years and somehow it gets 5/5 for a health rating.

[@PudgyCurmudgeon]

Nick, you are giving the statin mongers agita and serious migraines! I'm proud of you. Keep up the good work.

[@efsmiley1995]

😂😂 this is fun! Nick's gotta be loving this if he ever gets a chance to read all of the comments! He's poking that hornet's nest quite nicely!

[@stevesummers955]

www.ncbi.nlm.nih.gov/pmc/articles/PMC3594115/

[@danloomis]

I don't understand; he doesn't make a statin claim in this video, other than a small amount of carbs can reduce LDL-C in some people. What's your point?

[@barneyfyfe8313]

I find ice cream a good treatment for agita.

[@Isaac5123]

What are Oreo cookies made of ?

[@jennifermarlow.]

It makes me so happy to see young scientists/doctors like you (scientist currently in med school, right? It's only my 2nd video) that give me hope for the future. I've watched medicine turn into a farce in my lifetime, damaging so many more people than it heals. It's disheartening. Keep up the good work, so great! Now, this old woman is gonna settle in to enjoy this video I've been waiting to see. Your research is just so fascinating/logical/necessary. from Canada x

[@lachlanscanlan5621]

pertinent remark

[@arnoldfrackenmeyer8157]

I remember 1972 when the public was told steak, bacon and eggs, and butter cause heart disease. So "Mother Nature" did her TV advertisements for Chiffon margarine. People bought Margarin as a butter substitute so they wouldn't clog up their arteries. But it was just hydrogenated oils. kzbin.info/www/bejne/nXXOmqRrn6lofsU

[@darylaarons6625]

I can still remember the day my mother came home with margarine and threw out the butter because of the scare back in the day. She thought she was making a healthy choice for the family. 50 years later, she still uses margarine because he doctor told her to. She’s on a fairly high does of statins because of “high cholesterol”.

[@Truth15freedom]

Yep, Mother Nature warned us not to fool her.

[@arnoldfrackenmeyer8157]

@@darylaarons6625 Thank you for sharing that. I look back on the pictures from the 70's. We were a very skinny nation back then. A lot of people had Mic Jagger's build. I certainly did. To think the worst year for heart disease in the US was 1968 when we were a skinny nation.

[@AntisocialRedNeckNerd]

Yes, the “experts” got it way wrong!

[@AntisocialRedNeckNerd]

Two questions, what was the HDL/LDL ratio in these people with low body mass index? Is LDL really the problem or was that correlation to heart disease not an indicator of cause?

[@MrTantriq]

Bro, you are such a welcomed and needed addition to this space. Thank you and your friends for doing this work.

[@Johnny-gm9wo]

I'm so sick of seeing the word "space."

[@nicknorwitzPhD]

Appreciate it bro!

[@jasoncdebussy]

​@@nicknorwitzPhDGood video but please note that neither LDL nor HDL are cholesterol - they are different molecules

[@ArcoZakus]

@@jasoncdebussy, It is like someone saying "car-people" or "bus-people" if they are talking about things that transport people, if I understand it correctly. I am still trying to educate myself on this stuff and find it very confusing for people who know so much more about it than I do to speak about it that way.

[@jasoncdebussy]

@@ArcoZakus That is an absolutely ridiculous and nonsensical analogy! Did you think it up by yourself? 🤣 These are all different molecules and have different functions. There are so many myths, lies and much propaganda around nutrition - it's important to be scientific in order to get to the truth

[@user-yz7oi4hi7e]

I have had 5 great aunts die in the past 20yrs. They all were in their mid to late 90s. They were all active until right before they past. They lived their lives on a Southern diet, high in fat, eggs, vegetables.their ldl was high, but had no heart disease,or other disease. Just arthritis from old age & working forever. My doctor doesn't believe that would work today as its a different time. My diet is like theirs , but no vegetable oils used, just butter or bacon fat. It seems to work . My ldl is elivated but not high. My aunts swore by collard & turnip greens. So do i.

[@LowCarbLowDrama]

Nick, you've done an excellent job. When I started keto for diabetes, I did not consume fatty meats, dairy, or high-SFA plant oils and lost a lot of weight. My LDL skyrocketed. A year later, I started adding fatty meats and dairy, and my LDL hardly fluctuated.

[@LowCarbLowDrama]

@alchemy1 I ate lean protein and burned my own fat, and so was ketotic.

[@KetoTibet]

Well done

[@user-kk4ix9uv9v]

Love your handle- so true- so simple

[@LowCarbLowDrama]

@user-kk4ix9uv9v I'm glad you liked it. It reflects my health transformation on lowcarb, and I now have much less health drama than I ever did when I was plant-based.

[@LowCarbLowDrama]

@@alchemy1 I know I'll be dead without my cholesterol.

[@JonStielstra]

Thanks for packing a lot of valuable, pertinent info into 5 minutes. Much appreciated!

[@Truth15freedom]

In the early 80s I read an English study that showed heart disease in the north was higher than the south with the diet was margarine in the north and butter in the south.

[@tomlauris]

Also see "Israeli paradox"

[@LakeOuachita]

Lies we were told, with absolutely no real clinical studies done. 🤦🏼‍♀️🤦🏼‍♀️🤦🏼‍♀️

[@forester057]

All so big pharma and medicine could save you with their pills, surgery and their “life saving” stents. If you had dropped the carbs/sugar and kept the butter, beef and eggs you wouldn’t need them. Follow the money. The corruption is pervasive in our society.

[@juliawigger9796]

Have you seen the ingredient label? Pure poison. Why would you eat it?

[@zombieapocalypse3837]

@@LakeOuachita Actually there was a clinical trial conducted by Ancel Keys, but it was never published "Minnesota Coronary Experiment In 1968, about ten years after the beginning and two years after the first publication of the results of the Seven Countries Study, Keys and Ivan Frantz initiated a large randomized control trial, replacing saturated fats by food items with naturally high or artificially raised content of linoleic acid in an intervention group. The randomized and blinded experiment ended in 1973. Results were not published until only much later in form of smaller excerpts as part of conference talks or doctoral theses. The raw data and analysis were discovered in 2013 in the estate of the principal investigator, Ivan Frantz. The study shows no positive effects of the altered dietary intake. Cardiovascular mortality of patients over 65 years of age increased by the replacement of saturated fats."

[@mikeg5413]

My whole way I view LDL has changed. I don’t believe a word that they say about it and don’t fear it … to the point that I don’t even care what mine is. So many of my health issues have been resolved since going on keto that I will never trust our medical & pharmaceutical industries ever again.

[@amyfu2047]

This one earned my subscription. I hope this channel explodes in popularity.

[@jayhoggard92]

😊😊😊

[@anotherviewofthings]

I just checked you OREO-Statin study. All I can say is that I wish you a long and fruitful science career. You deserve it. And humanity deserve it (if you stay at hospital/university and do not sell yourself to the "industry"). Congratulations. The results are so staggering, that an RCT should follow. I think some guys in Australia have a group of high LDLs that are keto/low carb long-timers.

[@nicknorwitzPhD]

I want those RCT $$$! And thank you!

[@AnneMB955]

I have so much more faith in the young, up and coming scientists now that you’re here Nick.

[@pamisntcraiganymore]

I found you recently and really enjoy your content. I kept keto for a long time then careened into a pile of processed carbs I could not get out of. I need inspiration and you provide it with easy to understand information

[@GameofTrees]

Home run Nick, nicely done.

[@trentriver]

Great work - you and a couple of others are the reason that I come to You Tube. Please - keep up this great work - real, unbiased science rules!

[@keto-rl2ce]

Great vid, short, clear & on piont! 🎉

[@cates_keto]

This is so interesting! Keep up the good work!! ❤

[@jimlofts5433]

A younger Dr Sumner Miller asking "why is it so " Well done Nick, so many questions and now we need the answers

[@antoniovelarde392]

Yeah, we need to know why.

[@amgis5218]

Great clip. Edifying and more entertaining than your other clips. Might I suggest you produce more of these clips, with 10 minutes being the maximum length? Humor, brevity, conciseness-this triad opens the door to YT success. Helpful work and research-thank you.

[@tal8871]

you are a motivation to other researchers! fascinating stuff

[@GougedandLeft]

Earned my subscription brother. Good work.

[@H4KnSL4K]

Dude, you are on your way to becoming a KZbin superhero

[@arnoldfrackenmeyer8157]

He already is a youtube superhero.

[@Cenot4ph]

With what 😂 providing more nonsense about LDL as an issue, it isnt. Let's move to the real issues here such as carbs

[@baccaratfitness2360]

It’s important to note (which Nick has in other videos) that this hypothesis doesn’t apply to those with familial hypercholesterolemia or familial hyperlipedemia or FH. In that population (of which I am a member) we have a genetic disorder where we don’t have enough of or have faulty LDL receptors on our liver. It affects about 1% of the population.

[@jimsturt]

No - it's the same. high LDL is bad for anyone and causal of atherosclerosis. Hopefully you are on a statin and PCSK9 inhibitor - it's realistic to treat to normal levels now.

[@baccaratfitness2360]

@@jimsturt Wrong. High LDL is correlated with cvd not causal. Come on man, we’ve been eating and thriving on meat for over 2 million years. It’s why we were able to grow our big brains and it’s why our digestive system shrank from one of fermentation to one that took a lot less energy so our brains could utilize the extra energy. Now all of a sudden we can’t tolerate LDL particles? Or is it that with the advent and over abundance of processed foods with sugar, refined flour, seed oils and artificial ingredients NOW we can’t handle ldl. Do you not think that the processed foods and sugars and seed oils cause oxidative stress, inflammation and glycation? Ridiculous.

[@jimsturt]

@@baccaratfitness2360 okay. good luck.

[@jimsturt]

My best friend has FH - no diabetes, not overweight, never took the statins his doctor told him to start in high school. Hear attack last year at age 34 with two arteries over 90% blocked, ended up with 4 stents. you can shout oxidative stress or whatever other BS you want but at the end of the day it is simply LDL levels.

[@baccaratfitness2360]

@@jimsturt People with FH have the propensity to clot which contributes to the dilemma. They’re different than LMHR’s in that they have the receptors to remove excess particles from the blood. It sounds like your friend may have the homozygous form which can affect kids.

[@susanbeever5708]

Great job Nicholas! Saturated fat does not stimulate glp-1 production that leads to insulin secretion but PUFAs do as they stimulate TRPA1 in the intestines a known receptor that stimulates glp-1 production that then stimulates the glp-1 receptor that is a g protein coupled receptor that lowers the threshold of TRP receptors TRPV1 and TRPA1. This leads to the neurosecretion of insulin in the pancreas and hormone secretion in the hypothalamus and pituitary.

[@shawshank6015]

😂🧐🥱😖🙈🙉🙊 Tf with this Science carry on... 🤨

[@susanbeever5708]

@@shawshank6015 if you do a simple google search you will find research articles that delineate everything that I have stated. Not all neatly described in one simple to comprehend remedial place but reported in incremental steps per article. Obviously a challenge for some to comprehend. The science over thirty years since Dr. Julius discovered human TRPV1 has been enormous and has led him to sharing the Nobel Prize in 2021 with Dr. Patapoutian who discovered the piezo-1 channel, in the category of physiology and or medicine.

[@LawrenceAugust_]

I had to consult ChatGPT for this, lol "The statement you provided contains several elements related to fat types, GLP-1 production, and insulin secretion. I'll break down the components to provide some clarification: Saturated fat and GLP-1 production: The statement suggests that saturated fat does not stimulate GLP-1 production. While it's true that different types of fats may have varying effects on GLP-1 secretion, the relationship is complex and not solely determined by the saturation of the fat. Dietary fats, including saturated fats, can influence GLP-1 release, but the mechanisms are multifaceted and may involve factors beyond just the type of fat. PUFAs (Polyunsaturated Fatty Acids) and TRPA1 activation: The statement implies that PUFAs stimulate TRPA1 in the intestines, which then leads to GLP-1 production. However, the direct connection between PUFAs, TRPA1 activation, and GLP-1 secretion is not universally established. While there is research on the effects of fatty acids on various receptors, the specific pathway mentioned may not be widely accepted or fully elucidated. GLP-1 receptor and G protein coupled receptor (GPCR): The statement correctly mentions that the GLP-1 receptor is a GPCR. Activation of GLP-1 receptors can indeed lead to various physiological responses, including the modulation of other receptors. TRP receptors (TRPV1 and TRPA1): The statement suggests that GLP-1 receptor activation lowers the threshold of TRP receptors (TRPV1 and TRPA1). The intricate interplay between GLP-1 and TRP receptors is an interesting concept, and there is some research on the interactions between gut hormones and TRP channels. However, the details and mechanisms may not be as straightforward as described. Neurosecretion of insulin and hormone secretion in the hypothalamus and pituitary: While GLP-1 can stimulate insulin secretion from the pancreas, the direct involvement of TRP receptors in neurosecretion of insulin and hormone secretion in the hypothalamus and pituitary is not universally accepted or well-documented. In summary, the statement outlines some interesting concepts, but the relationships between dietary fats, GLP-1 production, and the mentioned receptors are complex and may not be accurately captured in the presented sequence of events. The field of research on these topics is continually evolving, and new findings may provide more insights into these mechanisms."

[@susanbeever5708]

@@LawrenceAugust_ very interesting and entertaining coming from a bot. Nice way of starting to think about things. At least there is thinking. The neurosecretion of insulin affects the pancreas via glp-1-> its GPCR receptor the glp-1R that lowers the threshold for TRPV1 on the nerves that stimulate the pancreatic beta cell tissues. The glp-1 RA such as semaglutide folks utilize this. The glp-1R in the paraventricular region of the hypothalamus lowers the threshold for TRPV1 and activation of TRPV1 leads to stimulation of the pituitary to release antidiuretic hormone. This can lead to hyponatremia, hypoosmolality and stimulate TRPV4 seen in active, inflammatory atherosclerosis. Glp-1R lowers the TRPA1 threshold in the hypothalamus that leads to suppression of appetite. This is what the glp-1 RA drugs such as semaglutide folks are so excited about. Fat stimulation of insulin is minimal as anyone wearing a continuous glucose monitor will attest however looking specifically at glp-1 secretion by enteroendocrine cells lining the gut PUFAs stimulate TRPA1. This is seen when people eat the TRPA1 agonist cinnamon also. Capsaicin a powerful TRPV1 agonist is taken in capsules as a diet supplement too but beware it can cause heart failure at high doses. My point is that TRP receptors are key to understanding the relationship between what is ingested and how insulin is produced. We do not yet know the complete answer how glp-1 rises so quickly after eating and there are more TRP channels such as TRPV2 and TRPV4 associated with glp-1 release. When we have hyperglycemia and the cells become resistant to the insulin receptor high insulin stimulates TRPV1 to get glucose out of the blood and into the cell because TRPV1 does not need the insulin receptor. TRPV1 utilizes GLUT4 without the insulin receptor to get glucose into the cell. Who knows this? Force feeding cells glucose-> too much oxidation-> oxidative imbalance while TRPV1 on mitochondria also -> too much reactive oxygen species in excess of antioxidant supply. This all leads to lipid oxidation and inflammatory damage of the mitochondria, cell and other tissues. So not including TRP channels is a disservice to our understanding of the serious metabolic health issues we face.

[@susanbeever5708]

@@LawrenceAugust_ here are a couple of nice articles: Stimulation of glucagon-like peptide-1 secretion downstream of the ligand-gated ion channel TRPA1 G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei - serpentine gateways to neuroendocrine homeostasis Yes, they are working out testing techniques however the glp-1R is there as are TRP channels.

[@MrSevam]

Brilliant Nick , as always. Concise data, diligent research, facts, facts, facts. An excellent counter to all the spurious ' opinions ' out there.

[@BossInVegas]

my dude is based and gonna grow this channel super fast. thanks for the quick summary

[@kenmarriott5772]

Bravo. A real scientifically minded medical student.

[@thenext9537]

I’m still navigating here. 237/170/54 (total cholesterol, ldl, hdl in 2020. Now I’m 170/91/68. What did I do? Statins already but added ezitimibe. That made a bit of difference. What I did though after made the most and my other changes were same. Fiber, I was hitting 120% of daily soluble fiber for 6 months and that made a bigger impact it seems. I’m agnostic to everything, open to anything. We’re all trying to live our best life here.

[@yottawatts9470]

Get a scan of your arteries for a blockage and if you have little to none you don't need any statins at all

[@bkarabin]

Reason 4 reminds me of "The Science and Art of Low Carbohydrate Living" by Volek and Phinnek. Iirc they say while in a ketogenic state ingested saturated fat becomes the preferred field (as opposed to your body's stores). So is the reasoning basically not investing saturated fat -> higher LDL to supply energy around. Increase saturated fat intake lowers LDL since now there's less reason to take it from internal sources. This is why the Feldman protocol of increasing saturated fat works?

[@lvrichardson7966]

The information was good, but background music was too loud, making it hard to track along with the argument presented. Dial back the music, please.

[@TomSmith-cv8hk]

I have tinnitus, background noise I already have, Nick's in a race, play him at 0.75 speed.

[@shawshank6015]

And the Speed at which he's speaking

[@LawrenceAugust_]

Can slow speed and turn on captions. ✅

[@LakeOuachita]

Beg to differ, music, was NOT too loud, not too fast...I can follow Nick just fine...the pace and the music.

[@VeganV5912]

Cancer tumors, 95% eating animals. Peer reviewed scientific fact. Actual photos : kzbin.info/www/bejne/oHvKZoFulsSXh68 .. That’s why I’m Plant-base/vegan. kzbin.info/www/bejne/pna0aaKon76BhqM !!

[@AE_IAF]

Loving your work Nick! It'd be great if you could talk with Dr. Malcom Kendrick.

[@MattCardJacket7]

NICK!!!! You're a stud!

[@hyperTorless]

Talking about LDL without mentionning PUFA oxydation or LDL particle sizes is like talking about diabetes only evoking blood sugar.

[@naaras]

Hi! I just watched a video about your study and if I understood correctly when you were on statins exercise increased your ldl, is that true? Does that apply generally if there isnt enough carbs in circulation?

[@pattyogden5788]

I am new to carnivore and watching lots of videos- one of them mentioned you and I was so excited to hear of a smart young man searching for the truth about food and going into the medical field!❤❤ I noticed your two beautiful dogs in your video and I wanted to ask how you feed them. I know it’s off topic but it’s been really bothering me for a couple years that my dogs’ food is just processed fake food. I’ve been giving a little less portions and adding whatever meat I’m eating that day into their food. Thoughts?

[@mjr7991]

I’m a good example. Age 52, I went on keto, but didn’t increase my consumption of saturated fat. All I did was eliminate chips and sugary snacks and added veggies. My hdl and triglycerides improved but my ldl doubled (80 to 160). This is freaking out my doc who now wants me on a statin. But I lost 30 pounds in 3 months. My bmi fell from 28ish to 25 and working on getting into the low 20s (probably another 10 to 15 pounds). I did all of this with zero exercise. I’m now adding weight training to hopefully get my ldl down so my doc gets off my back about going on statin. Hopefully my further leanness doesn’t worsen my ldl. I have no plans on following my docs advice to go on statins. I will do calcium scores every year if necessary (last one was zero). Don’t smoke or drink either so see no need to go on statin. It’s funny that I lost weight and technically eating much healthier but somehow that makes me a candidate for pharmaceutical intervention.

[@alchemy1]

Why is KZbin cutting out people's comments? Your comment ends like this: " I did all of this with zero exercise. I'm now...." My own comment up there also cut no matter how many times edited it or re-did it. . Weird if you ask me.

[@mjr7991]

@@alchemy1 did you click on read more?😉

[@alchemy1]

@@mjr7991 Right. For some weird reason I don't see "more" at all. Crazy alright. Oh, wait a minute, more weird stuff. My comment has been moved down below and there I do see "read more". Now I also see yours. I refreshed the page. But that is still totally nuts. 🙂 Aside from that, the main theme of my comment is that to those of us whose cholesterol shoots high it is not due to eating meat and fat and also has nothing to do with being lean, not lean etc. No relevance to any of it. It is in fact caused by burning body fat. So what does this translate to if I may? It has two causes. 1. It is genetics. 2. It is caused by fasting. In other words, just fast and your cholesterol shoots sky high. So what is happening is that keto/carnivore imitates fasting as far as your body is concerned. And of course, also some folks, their cholesterol goes way way higher than the others. Not every one of us is the same. However, it does level off. It won't just keep going up to 10000. So meat, no meat. lean, not lean. So long as you are burning fat for energy, that is the cause. That wraps it up. But what i find rather puzzling is why no experts clearly mention this. Notice how the dude Nick just by eating cookies his cholesterol dropped. Well, that is because when he eats the carbs, he no longer is burning fat. Plain and simple. That is all. Notice with you? When you begin to lose weight, your cholesterol shoots up and when you eat meat, it has nothing to do with it. In fact, if you exercise, fast, eat meat.... Whatever it takes, the minute you run out of carbs your body begins to use fat for energy, your cholesterol shoots up. Nobody actually clearly sees this. It took me a while to see it. I tell you what. Once you get the weight you want, balance your diet and you will see your cholesterol subside. Just eat carbs to keep you out of ketosis and no more. Because if you eat more then you will gain weight. As your body will turn the extra carbs and stores it as fat. My personal opinion is 100 grams of carbs a day is a good place once you reach your weight loss goal. But you just have to experiment.

[@jakubchrobry3701]

Calcium scores are useless. Once they move off zero, it's probably too late.

[@mjr7991]

@@jakubchrobry3701 I think that’s a bit of an over simplification. Similar to stating higher ldl alone with no other data will absolutely result in heart disease.

[@kinpatu]

I’m curious if in your research you’ve looked at any lean mass non-responders (I made up term) as comparison points against LMHR. My BMI is 21 and heavy exerciser. Saw no increase in LDL-C going to ketogenic diet; in fact LDL-C reduced ~20% and trigs decreased >90% compared to whole foods plant based.

[@Frostbiker]

What do your fasting triglycerides look like? What about your fasting insulin, or your hba1c? Do you consume any carbs before/during exercise?

[@kinpatu]

@@Frostbiker Trigs a little under 40mg/dL. A1c 5.3~5.4%. Haven’t tested insulin in a couple years but it was quite low. Can’t remember the number now. Exercise is always fasted, first thing after wakeup.

[@keto-rl2ce]

What % of PUFA, MUFA, SFA do you consume?

[@stargazerbird]

This is a very good question

[@johntatman9168]

My wife falls into your category and I fall into the LMHR on the exact same diet. One thing we have noticed however she gets sick a couple of times a year and I have not been sick in over 40yrs. Not sure why but my theory is the high LDL seems to be pretective.

[@slightlyopinionatedjay]

Great video Nick 👍

[@robyn3349]

Thank you!

[@capnkirk5528]

What is the risk if you aren't particularly a LMHR but get the same response to ketosis? I USED to be an LMHR, but age and Covid have taken a very nasty toll (mostly Covid / Long Covid). My BMI is right around 25, my A1C is right around 5.7, my BP is fine but managed by medication (for 25 years due to a different condition). My LDL shoots up if I fast and get into solid ketosis. I WANT to use fasting to try and end LC, but am concerned that my LDL rises substantially with fasting and ketosis, so I am trying to guesstimate which is worse for me. (If I was SURE that fasting would improve LC, I'd take my risks with the LDL). Anyone have info?

[@bereal2366]

Thank u so much for this very informative video 💙💙👌👌

[@grahamosborn-yj3vx]

Hi Nick ,on you Oreo experiment what happened to your triglycerides and HDL ? I would guess triglycerides went higher and HDL lower? I am a LMHR with a ldl of 380

[@scottstevens6380]

Thank you.

[@dylan-howell]

Does the driver of the high LDL matter, or does the long term high LDL remain a significant risk factor?

[@eagleeye9549]

Dude, you're awesome!

[@user-pv6xo1ti4c]

Hi Nick! Did you track blood LPS, blood TMAO, leaky gut (Cyrex Array 2), and activity of Human herpesviruses in your personal case study of you on a ketogenic diet? The foods used on your ketogenic diet may have increased LDL cholesterol due to an immune response to LPS, etc. Children with certain active infections will have greatly increased LDL.

[@faylouise8169]

good one! did your papers look at vldl 1 and vldl2 as metrics?

[@LakeOuachita]

Thank you for your continued videos on this. As i near my BMI, my LDL shot up, and doc thinks i have FH...😂😂🤦🏼‍♀️🤦🏼‍♀️..yet, have no family history of this...

[@willbrink]

An interesting discussion worthy of pursuing but will be taken wildly out of context by 99% of viewers.

[@mjs28s]

ok, but what happens on a population scale rather than small studies or looking at a specific subset (hyper responders)?

[@mhadden]

looking forward to Nick at Physionic also covering your interesting topics.

[@lewis-mindscrambler987]

same

[@fractalbeans9513]

Thank you! In other words, stop blaming saturated fat for what carbs did...

[@Kermit_T_Frog]

I am very definitely in the lean mass category of fit people. I cycle on and off on ketogenic diets. I have high LDL. VERY low triglycerides. High HDL. Abnormally LOW BLOOD SUGAR. Still, I am not going to discount that research that LDL is bad for you. I don't think this is well enough understood. I am going to stick with the theory that too much of anything is BAD.

[@_________9996]

What did 'carbs' do exactly? Which form of carbs? Which quantities? Do you think that a high %E intake of saturated fat plays no part in the progression of disease?

[@RomanticSlob36]

How did you come up with the "dosage" size of the Oreo cookies (one sleeve/day, I believe)? Based on my blood test results after nearly a year of carnivore, my total cholesterol is at 228. I'm definitely not an LMHR, but it would be fun to see if I could get my total cholesterol below 200 simply by eating the occasional orange or banana. I don't want to over-do it, however.

[@dctrex]

I'm on a ketogenic diet and my BMI is perfect for a man of my height. Consequently I'm pretty sure I have higher cholesterol. So is this support research paper and KZbin video suggesting that to lower this LDL count one should consume saturated fats such as butter?

[@leoderiviere1685]

What do you think about the studies that have been done in regards to Apoe4 genotype where they analyzed how Saturated Fat and NonSatured Fat have different outcomes on Alzheimer irrelevant of plaque. They do conclude Saturated Fat is a major impact. I know you know this but i want your opinion on that! Thanks

[@marilynmetzger5821]

I have the same question!

[@brandonjones2348]

Great content man I found this very informative, I think the background music is a tad too loud, just some feedback all love

[@MikeDirnt78]

I've been following your research. My BMI is on the low side, I'm lean and physically active but my cholesterols are not under the LMHR category. LDL has been volatile over the years ranging from 82 to 180. I don't follow the keto diet. More towards the Mediterranean diet. Now I'm experimenting with increased carbohydrates intake to see if my LDL can push lower. Last LDL = 123 on 8/Feb. Will report back my finding if I can achieve under 100s again.

[@user-tp8sr3mr6k]

So basically the liver produces high ldl on a low carb diet when the body detects depleted serum blood sugars from inadequate carbs but as soon as the carbs are restored the liver down regulates the production of ldl. This still doesn’t answer if it is healthy or not for the liver to produce high levels of ldl or whether moderate blood sugars in the blood is healthier ?

[@Justinegallows]

There is 600 years of nutritional science that says high ldl is no good.

[@zlmdragon.]

no one has that answer, just guessing

[@grummelameise]

the blood sugar levels in a good functioning body are always the same. i dont think ldl production is damaging your liver, never heard of that.

[@YamatoForever]

This is why he dropped his LDL when he went on his cookie diet.

[@konradx498]

Are you syre you want to hear the answer to your question? Countless studies have shown that *high LDL in metabolically healthy people is a benefit, not a liability,* especially in older people. It dramatically reduces all-cause mortality.

[@DJ-Illuminate]

I run 6 miles a day 5 days a week and I have high LDL, High HDL and Low Tri. My doc wants to put me on statins. I saw that low tri hints that LDL is mostly good LDL otherwise the tri would be also high. I eat a meat once a day but otherwise avoid most dairy (I have a dairy allergy). So do I get a CT Scan?

[@tlewis5901]

Dr. Nicholas Norwitz you are thee most thought provoking scientist of this new LMHR awakening. This is taking off astronomical, may you be super successful in your endeavor to get doctors and scientist to sit down and have conversations ! 👏

[@janiceg7661]

What about endimorph post menopause hashi hypo types? What do we do to lose thar last 20 lbs and drop LDL?

[@Bartospeed]

Tack!

[@nicknorwitzPhD]

Super! Very generous!

[@forester057]

I have to ask. What is the thumbnail supposed to be? As a guitar player it looks like a guitar pedal made from butter, which is amazing. I’ll have one of those please. Great buttery tone.

[@ArgoBeats]

Thanks Nicholas, but at this point what could be the driver of high LDL in a low carb diet? The 2 biggest culprits have always been saturated fats and/or carbs (sugar).

[@Part_121]

I'd like (someday) for someone to be able to clear up, at what point are we talking about BMI measurements in LMHRs? For example I started my keto diet at a BMI of around 32, with type 2 diabetes and an LDL in the 60's. 80 lbs of weight loss later, on keto, and type 2 diabetes was reversed but LDL more than quadrupled to the 270s (this while on a statin). I'm now in the triad with trigs of 49, HDL of 98 and LDL of 275 and a BMI of 24. Is there such a thing as a Fat-to-lean-mass hyper responder? The other thing I'll throw in is that, as a kid, I was always extremely lean to the point that it was difficult to purchase clothing that would be long enough, yet skinny enough. No one checked cholesterol in the 1960s, especially in children, so I have no idea what my blood work would have been like back then. Perhaps once a LMHR, always a LMHR, even it you get fat and diabetic? I'd almost rather go back to eating pizza, bread and pasta again, just to relieve the brow beating I get from my doctors, none of whom can even spell lipid energy model. Thank you for looking for answers!

[@melissag3005]

I'm going to be curious in June I get my blood work again, but back when I was BMI over 35 on keto my blood work looked great. I went off keto and maintained bmi 24 but the brain fog and the stiff joints returned so I decided to go on it again and sure enough brain fog gone and joint pain/stiff even only a couple weeks, much less. Awesome to be able to jump out of bed or get out of the car without having to take a moment. I can't wait for this comparison study. I know I have mild calcification just from a generic ct scan of my chest, that makes a TON of sense with my prior life, thankful it is still "mild". I'm also on a cancer med that could raise it. I may not live long, but I feel great. Quality over quantity. Thankfully I know what is on the other side for me so this is all just interesting to watch play out. I'm expecting my cardiologist to freak, but it will be interesting.

[@COLLAR01]

Do the LDL's increase so the lipids can try and scour more sugars in the blood in the absence of glucose??? trying to procure "easier" energy

[@rokmin8550]

another good video!

[@sdjohnston67]

Good stuff!

[@johntrujillo7001]

So is high LDL good or bad in lean hyper-responders?

[@FutureLaugh]

I am lean, I have now triglycerides, great HDL and elevated LDL. I have always thought my ratio was excellent, but my doctors have all told me that high LDL, despite of the ratio, will give me plaques. I started doing keto 7 years ago to maximize my health, now i dont know what exactly the direction i want to take. I did paleo diet for 8 years prior, its hard for me to rationalize eating all sorts of fruits again. I am considering my long term health into account and I know that mediteranean diets have the best optimal levels of success for longevity- but I just havent found a good fit just yet. Will eating more carbohydrates (from real whole food sources) decrease my LDL? I dont want to eat oreos, but how much carbohydrate is actually necessary to reduce the LDL? Will my body be flexible enough to metabolize the carbohydrates and the fats or will i be out of energy all the time transitioning from not enough of the two?

[@alpineflauge909]

world class content

[@gummiesrule88]

What if any is the correlation between saturated fat intake and apoB, in various human groups. The correlation between high apoB levels and cardiac risk is pretty strong...

[@slowphil]

But what is the arterial plaquing situation in folk on low carb who have high LDL and low BMI?

[@martarico186]

So does having 700 ldl on lean massive responder will lead to heart disease with time?

[@stanleybridge]

Why in this scenario would HDL, LDL and TRIGLYCERIDES all increase as in my case? Hadn’t had carbs to speak of for months prior to the labs.

[@kaychesnut2898]

So glad to know I can figure out my BMI by testing cholesterol. Seriously though, thanks for pursuing this. I am also interested in those who are lean who are not hyper responders.

[@luchiayoung]

Then they are not hyper responders

[@kaychesnut2898]

@@luchiayoung right!

[@donnatarallo5502]

I am one of those LMHR, 5'0" 105#. Went on Keto lost 22#. My lab work was all red showing I was in the High end of most tests. Would my ApoB, Ldl medium, Lp PLA2 activity, non HDL Cholesterol also be high?

[@Takkaho]

i'm the same, 5'-6" 145lbs. doing carnivore. feeling good, hair skin and nails feels good. hdl up, tri down, but ldl sky rocketed. my doc want to put me on statins. i don't think i will ever take it.

[@bshul10]

There's a connection between High LDL and Dementia. Can you explain this away?

[@robertblemings2910]

Gotta love science ❤

[@lucynawereszczynska9537]

Love it!!! Thanks 🧈, 🥓

[@stargazerbird]

So if you do a very low fat high carb diet as a lean person who is very active what do you see? I would be interested to see what the effect of a lower calorie intake plus high carb does. So far the drop in LDL in LMHR occurs when they either add sufficient calories to be in a slight excess or add carbs. Maybe if you switch it to the other extreme of high carb you still get high LDL during exercise or weight loss. That would further confirm the model that it’s the need to draw down fat reserves for energy that is the cause. Deplete the glucogen stores with a sprint or three and then do a longer run and then test. One confounder in your Oreo experiment was you added them onto a stable calorie intake so were in a calorie excess. How did you know if it was the extra calories or the carbs that made the difference? Fasting and quick weight loss will raise LDL. Never get a blood test on a diet.

[@j22dave]

Please slow down your delivery and pause after significant points. I know your excitement in your explanations but its a little tough to follow and digest! Keep it coming!😀

[@jimlofts5433]

Nick is the human energiser bunny

[@mjr7991]

Just set playback to slower speed.😊

[@gloria2340]

A balance is key.

[@johngrener183]

Hello Nick, One thing I haven't seen yet, among those who promote carnivore, is a comparison of why meat fat congeals in drain pipes, but not in arteries. It would be nice to see a study on that. Also, how does hydrogenated fats clog the arteries? Thank you for your videos. They're very informative.

[@Mallchad]

2 reasons. Fairly simple. Fat in drains is just a big lump that cools enough to become solid, it can't mix with water even if liquid so disrupts flow and stuff and can build up over time. In your blood it is small clumps of fat precisely sized by your body's machinery and then packaged in a protein called a "lipoprotein" so it can mix with the water in your blood safely without building up. Second if it did get out for some reason it would be very hot because your body is above the melting point of all fats it will be liquid, then your immune cells can clear it out like any other problem. Hydrogenated fat does not clog arteries no fat clogs arteries, that was an unproven theory that really needs to go away tbh. The thing that causes heart attacks is coagulated blood, a blood clot. The thing that causes narrowed arteries is damaged arteries that need repairing and produce unstable low-density scar tissue. If it is allowed to heal it will become strong arterial tissue and calcified tissue.

[@pinboru_]

Is LDL still considered bad though? It sounds like it’s just a normal body function to adjust as needed.

[@Becky7669]

This makes sense

[@godblessusall7696]

After a year on low carb, I lost 50 pounds. Sadly LDL increased 50%. I am certainly not a LMHR but my LDL must think I am. I heard Dave Feldman mention that the study parameters for the Trig/HDL/LDL might be expanded to include people like me who do not exactly meet the LMHR guidelines? I hope this is true because we, not so lean mass low carb people, need some good arguments to present to our doctors. Doc is happy about the drop in A1c to normal, 50-pound weight loss, higher HDL, and lower triglycerides, but they are VERY upset with me when I say no to a statin increase.

[@acwright]

What are health problems associated with a lean, active person having high LDLs?

[@afaultytoaster]

do you have any qualifications in health or nutrition

[@TheAbsoluteSir]

How about the association between APOB and saturated fat?

[@juanpablosanchezaveleyra6454]

Ok. This one blew my mind.

[@nicknorwitzPhD]

"Mission accomplished" ... I suppose "I understood the assignment" (trying to learn Gen Z lingo so my partner will stop teasing me that I'm an old 28)

[@rkardos4220]

My LDL was 145, HDL 43, Triglycerides 85 in 12/23 blood work so I decided to take prescribed Statin rosuvastatin 10mg + ezetimibe 10mg, and on visit for blood work 2/7/24 my LDL was now 53, HDL 50, triglycerides 74 so I was actually shocked at such a huge drop and thought can this be healthy? My AST liver enzymes also went up from 22 to high range of 50. So, this is not healthy. I have stopped taking statin.

[@ep2223]

Great information. But, how does this relate to heart disease in skinny people with high LDL's.

[@carloslara9976]

How does our bodies produces LDL cholesterol? How do our body regulate their production?

[@islaadele1212]

My LDL was over 500 in my last lipid panel. My TGs were 330. HDL is always over 70. My BMI is about 20. I'm thinking it's because my blood was taken after a 3 day fat fast (nothing except 30-50g butter per day). I didn't fast for a full 12 hours before the test. Also, I drank coffee. I'm thinking maybe I have a coffee sensitivity, or it's the inversion pattern at work. I've decided to buy a decent home cholesterol monitor and start experimenting to see just what affects my numbers, especially TGs, so dramatically.

[@AliceFarmer-bg4dw]

Nick, does heavy exercise reduce LDL?

[@nicknorwitzPhD]

In LMHR would tend to increase. In standard person, depends on body comp as well and baseline metabolic health.

[@larsnystrom6698]

Why is LDL-C such an important endpoint for you? You seem to base your entire reasoning about saturated fat on that LDL-C is so important. In your opinion, is LDL-C a cause of anything?

[@HalfGodHalfBeast]

the real question still remains unanswered: is LDL really the vilain it is made out to be, I have a feeling it is not but would like to know for sure.

[@KenJackson_US]

I feared saturated fat for a long time and ate low fat because "everyone" said that was the healthy diet. But it put me in the hospital with a non-functional gallbladder. Now I'm very pleased to be enjoying cooking everything in beef tallow on keto. I'm quite certain low fat is the villain.