Nobel Prize Winners Dr. Katalin Karikó and Dr. Drew Weissman | The Story Behind mRNA Vaccines

This is the story of how Nobel Prize winning scientists Katalin Karikó and Drew Weissman became mRNA vaccine pioneers, helped develop the first COVID vaccines, and are changing the future of medicine.
For years, Katalin Karikó, PhD and Drew Weissman, MD, PhD worked in their Penn Medicine lab, trying to figure out what made mRNA so inflammatory. They did experiment after experiment, examined the data, and refined their approach based on the results. Then in 2005, they discovered the solution they were searching for: By encapsulating the mRNA in a certain lipid, it prevented inflammation and allowed the fragile mRNA to go to work without interference.
When the COVID-19 pandemic hit, it propelled Karikó and Weissman’s mRNA technology into the mainstream, where it became the foundation for two COVID vaccines. The critical discovery and success of the COVID vaccines kicked off a flurry of mRNA vaccine research, had has led to the development of vaccines for conditions like HIV, herpes, sickle cell anemia, influenza, peanut allergies, and even cancer.
Karikó and Weissman have received the world’s most prestigious awards for their discovery, including the Lasker-DeBakey Clinical Medical Research Award, the Breakthrough Prize and the Albany Medical Center Prize in Medicine and Biomedical Research.
Learn more about mRNA vaccine history and breakthroughs at Penn: www.pennmedicine.org/mrna
#nobelprize #mRNA #mRNAVaccine #COVIDvaccine #PfizerVaccine #ModernaVaccine #pennmedicine
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[@Ksaw32]

Incredible congratulations to Dr. Karikó who was demoted by Penn for not winning enough grants but persevered through their short sightedness. She is a true inspiration.

[@vecernicek2]

Grants are often a lottery

[@cherrybeach01]

When Dr. Kariko said, " To be a sceintist is a joy.", that brought tears in my eyes.

[@naytewilson]

It sucks there are so many people who act as if they’re more intelligent than them and downplay their success.

Thank you Dra. Katalin and Dr. Drew, in name of humanity and health care workers. Congratulations!!!

[@kapildev4738]

Actually they deserved more than Novel Prize. Saving millions lives in a hopeless condition such a phenomenal human wellfare act. An act towards humanity services through your sacrifices, endless efforts, and dediction are greatly appreciated more and more ...God bless you both and wish you all best for your future endeavors. A big salute to both of you!

[@untergehermuc]

There not „more“ than the Nobel price.

[@Ashishkumar-id1nn]

I love this statement "To be a scientist is a joy". Wonderful work!!!

[@zoltanczudar5886]

I feel so proud of her.

[@mbbsboi7248]

I cannot imagine the dedication and effort put in, bravo and congratulations!

[@TubeYouTakashi]

Amazing & will respect your work. Dr. Katalin Karikó and Dr. Drew Weissman.

[@lucyaudrey733]

the kind of people that inspire me. I am close to tears because I can imagine how difficult it was, the late nights, the fails but then when you do something you love it fuels you each time

[@cosmicwarriorx1]

Congratulations 🎉 and thanks you to both.

[@dr.ejazkhan7227]

I loved the energy of Dr. kariko. 😊 Thank you to the government, universities and scientific community and last but not least, the people, that still fund us to find everyday new in science. Dr. Ejaz Khan

[@Bullet-007]

i want to teach my kids about science, friendship and perseverance for 27+ years. what better way to do it than with this video

[@qd4051]

Thank you for helping humanity with your work!

[@moonlitSapphire3691]

Thank you so much both of you❤.

[@katherandefy]

This made me tear up. Thank you to both❤

[@ichinichi2009]

Thank you for all your hard work. You're both a blessing to the world. May all your endeavors succeed as well 👏👏

[@dentoncaballero9465]

A MILLION THANK YOU Sir and Ma'am.

[@sreeram483]

Scope of observation from A to B in paths of deviations between sound journey vs light energy along with mechanical energy calculations is a great study Mam

[@marymushinsky6291]

Penn may not have appreciated Dr. Kariko, but we do, as well as your colleague Dr. Weissman!

[@xieluyanlouise4327]

Incredible congratulations to Dr. Kariko. I'm so proud of you

[@user-nx1jk3ym4l]

This is incredible and truly motivating...

[@Mikupigeon]

Just bloody awesome!

[@lenapham9377]

Admirable, truly grateful!

[@alainaaugust1932]

Dr. K and Dr. W, thank you, thank you, thank you. The Nobel Prize is not nearly enough. I pray some billionaires grant millions to your institutes, to your work, to your training young scientists to extend your work for humanity. May heaven give you brilliant angels in abundance to inspire your minds. From heaven only is a reward commensurate with what you’ve done for humanity possible. Blessings.

[@peterrice365]

Just a big thank you, may your future research be successful.

[@user-jm3ub4ny9i]

Congratulations both of you ❤❤❤

[@Cgv69]

Congratulations to both of you.

[@angelinasouren]

Ha! So enjoyable ! Congratulations to both of you. I think that people who believe that there's something seriously wrong with you (not said as a joke, but seriously) if you are still up at 2 or 3, working on something, need a mental health checkup. One of the most hurtful or insulting things ever said to me was about the fact that I sent someone a mail or left voicemail or whatever in the middle of the night because I was working on something. I didn't expect the other person to be up but I didn't expect people to make a major fuss out of it either. They didn't accuse me of anything but they seemed to have made a major fuss about it. That's insane. I think it had something to do with physical chemistry; it was a long time ago and I've forgotten the details but the flabbergasted feelings remain. If you don't want anyone who's driven, then don't hire someone who's clearly highly driven. End of. I wish that I had simply said in response that at the time.

[@evamagyari6113]

Thank you so very much to both of you! i don't think we know the hole affect of your dedication!! Thank you again!

[@kxwx2682]

Thank you Dr. Kariko and Dr. Weissman

[@sanaamazhar5398]

My hero!!! Both of you!! You guys inspire me!!!

[@loiruckgodwin2372]

Thank you for all your amazing work

[@atropine7574]

Thank you doc🎉

[@minad3643]

Thank you❤

[@saifurrahman6453]

Thank you. We are blessed to have 'angels' amongst us, still. Their humility is amazing.

[@xiechenyue]

amazing work, amazing story

[@nattawatkantitham3791]

🤍All the best and million thanks for your endless dedication to save lives for humanity, you save the world. Utmostly, you are deserved to recognise for this medicine discovery of Nobel Prize, Congratulations.

[@TON-vz3pe]

This is the pinnacle of being a human being.

[@artivalys]

Congratulations Dr Kariko and Dr Weissman and many thanks from World

[@nancychauhan1188]

To see such passion! ❤

[@nasrulhoda7331]

Pressure of Extramural Funding on every scientists by the institutes is indeed a “death valley” for good science and good scientists in the USA. I see it now as an alarming sign of the dark side of future good quality science in the USA.

[@richardong5501]

Thank you, Dr. Katalin and Dr. Drew!!! Without your prior work in mRNA vaccines, we would not have been able to develop a vaccine for COVID-19 in a mere 2 years, and have saved a countless number of lives not just in America, but across the world! These people are incredible and the timing of when they finished their work in creating mRNA vaccines was SPOT ON. Years and years of work and clinical trials, and when COVID-19 broke out into the world, they already had the tools and ideas necessary to develop a COVID vaccine in 2 years. Incredible job, guys! You deserve this Nobel Peace Prize! 🎉

[@SreejithSathyan-pp9cw]

Such a big inspiration to see them talk. Thank you to them , god bless them 😊😊😊

[@CarolR-uy6jc]

Much congratulations. I love her positive spark.

[@zoologyngshindekjs7376]

Thanks Dr. Katalin & Dr. Drew for Extraordinary work for Humanity & mankind🙏🙏🙏

[@AbhishekKumar-rw9iy]

Our real superheros❤ love from India 🇮🇳❤

[@jorgesilva6675]

Katalin e Drew, muito obrigado pelo seu trabalho. Espero que vocês continuem nesta emocionantes busca pela vida. Talvez na eternidade vocês tenham a capacidade de entender a grandiosidade de sua obra, quando as vidas salvas podem ser contadas em milhões. Que toda a luz divina possa afugentar a escuridão da ignorância, que a capacidade de entendimento tenha o caráter da humildade do recomeço e aprimoramento constante. Escrevo do Brasil, meu país sofreu muito e posso garantir que se hoje eu voltei ao meu cotidiano trabalho, foi graças ao trabalho de seres humanos com vocês. Muito obrigado.

[@specialforce8486]

Two great minds making a great change. Find your other half.✍️🧠

[@KumarKumar-fn4sx]

I now my head to your exemplary work for the well-being of the mankind. May god’s blessings keep you healthy and joyful and your life becomes a celebration

[@tfla10]

Two incredible human beings! You not only made history but both of you became immortal! BRAVO!

[@JorgeRamos-xw6dy]

Katalin and Drew, Thank you for your commitment and passion.

[@sushilapatel2127]

Proud of her!!

[@yash1071]

I clapped for you in my room. Thank a lot.

[@petalsoflife]

Congratulations👍🏼

[@sahinmondal8691]

Inspiring ❤❤

[@BadAss_691]

Without having a cracked mind ( different mind) amd this level of passion, you don’t achieve these monumental feats

[@fekadufeye1379]

Congratulations you made history by saving millions life from catastrophic death.

[@MichaelWlliamRay]

Awesome video!

[@Sagnikmay1]

Life should be like this, or nothing!

[@lindacoffin5110]

Joy to the world!

[@user-rg3eu8lk4j]

One of the few scientist who inspires me to do quality science 😊 . Many people do science, publish results and they forget about it. But some scientists just stick to one thought and an idea.

[@thiruGajanan]

Friendship goals!

[@KK52930]

Congratulations

[@DP52879]

I forget who the Nobel Prize winner that I heard saying that often scientists do not do research with the intention of helping others in mind. They are simply driven by their curiosity. So I am amazed that our genuine curiosity serves goods for our race.

[@saftheartist6137]

Utterly Incredible 😳😮

[@katalinszabo9655]

Incredibly proud of Karikó Katalin, as a Hungarian, makes me so fuckin’ proud of my country

[@zsofiahermann6525]

❤

[@Betterworldforyou.]

Thank you . Your dedication and hardworking has proven to the world that it is worth. We can enjoy now mask free world. Thank you God Bless you two.

[@JonathanXLindqviust]

For anyone who is caught up in the whole "anti"-vaccine political bid, I hope you can look up what it is really about. The proteins, the way they managed to use RNA to recode (faster than usual vaccines that requires us to wait for our body to react to a foreign thing and THEN create the same recode) is fascinating. It has saved literal millions, but I am more hopeful for the future.

[@esragbilir]

She is INCREDIBLE 🌌

[@francescaaiello9427]

GOD BLESSED people.

[@tateyawitz9191]

They are international heroes!

[@mariadelrosariovillanueva8716]

You are both amazing!! Thank you for all the sacrifices that you have both made to make these discoveries possible. Wishing you continued success in making a difference in the world. Thank you.

[@evaszeibert4888]

Gratulalok buszke vagyok hogy ilyen tehetseges emberek szuletnek magyarorszagon...vagy kulhonban..

[@TheSamonex]

Greatest mind ever !

[@chayonsaha3465]

Love ❤🎉 for both of them.

[@nathalieplum2137]

I've been rooting for them for the Nobel even before the pandemic. So very deserve, they've opened up a new world of prevention and treaments. Thank you Dr. Katalin Karikó and Dr. Drew Weissman 👏👏👏

[@sabrinams2325]

😭😭😭😭😭I really wanne be a scientist like you

[@Real_G077]

Leptospirosis, Let Goooooo. Love from Thailand.

[@user-ek5ut6ib4m]

Are you familiar with Acemannan?

[@sreeram483]

Mam mRNA with response to sense alteration is a great study however the other effects need to be more inclined to personal level, how well can it be achieved with a gamble of cash running to take a spot either via any chance?

[@camillekissoonmohammed8664]

👍 She did it !!!!!!!!!!!!!!!!!!!

[@alhaeri1]

they did it

[@camillekissoonmohammed8664]

Oh, now that is exactly why, "she" did it !!!!!!!!!!!!!!!!!!! 👍

[@blinoldluv]

Can't help laughing reading many sarcastic comments.

[@Mau365PP]

Too bad the research for the real problem is not getting the real funding and recognizion: LONG COVID

[@lorill2631]

Congratulations on your massive success ❤ you deserve kudos from the world! Literally saving millions of lives! And yes, the impact of future vaccines 🎉 because of mRNA is so powerful.

[@shankarbalakrishnan2360]

Working at 2 or 3 in the morning❤❤🎉🎉

[@milleniumgenesis]

Felicitaciones a los Pioneros. Genios entre los genios. La humildad de la ciencia es ante todo, asumir que es divertida, muy divertida.

[@vihanduovin8386]

❤❤🙏

[@MossyMozart]

Enthusiastic congratulations to both of these geniuses! They have already been an enormous boon to humankind. It was not trump that created the COVID-19 vaccine possible - it was these two people. To have such scientists in our midst is a joy. Big applause!

[@smestartup8561]

You are a team of heroes. pan-Corona Viraus Vaccine, sickle cell anemia gene therapy, Malaria, Leptospirosis, Vaccines for peanut allergies

[@notsojigglyanymore]

he kind of looks like Gru from despicable me😅

[@helloworld-ow9tf]

I like how she describes it as "an exciting crime story" at 4:13

[@farmasinema]

Thank you.

[@suryarp]

It almost sounds like a movie. So heroic and inspiring! What an impact these relentless, dedicated, humble scientists have made to the world! May these Nobel laureates inspire generations of people take up sc ience as their careers!

[@tonysonglalala]

Thank both of you🎉👍

[@whatsmyusername1231]

I can't imagine what they feel like, coming as close to saving humanity as possible these days. Good work folks!

[@priyanktripathi7665]

Congratulations both of you..and your whole team...🎉

[@solapowsj25]

Now and then, we pass a milestone: Dr. Edward Jenner. 😊

[@tuando-ed9ud]

Thank you so much. Your intellectual is a gift of humanity.

[@MNP208]

❤❤❤❤❤❤❤❤❤❤❤❤❤❤

[@martysmith5260]

Must be nice to be smart. My brain isn't even able to comprehend what they've accomplished!

[@kmahsan]

don't be discouraged by any means. Knowledge is like a house you build it brick by brick. Just gotta start and keep going 😀