Regulation of Blood Sugar

[@nourishedbyscience]

Small correction: At time point 7:10, I say that "In liver, muscle, and fat tissue, insulin binds to the insulin receptor on the surface of cells, and that causes a specific glucose transporting molecule called GLUT-4 to be transported to the cell membrane". This is not correct, because GLUT-4 doesn't play a major role in glucose transport in the liver (where it's other glucose transporters such as GLUT-2). In muscle and fat tissue it is GLUT-4, however, so that part is correct.

[@fanonberhe9116]

❤❤❤❤❤❤😊😊😊😊❤❤❤

[@ataho2000]

Another correction would be: Mono - a prefix that means "unique" or "single." Not "One."

[@atoms.channel]

@@ataho2000 hahahahaha, you're joking right? If not, rule #1 of correcting people is to actually be correct. You got us though, I'm still laughing... 'mono' can't mean 'one', hahahahhahahahha.... nice mono, uh, I mean nice one.

[@ataho2000]

@atoms.channel I don't know Greek but they told me that they use "ena" for one and "mono" for single. Care to teach Greek People how to speak Greek? I don't know what to call this, Ignorance, arrogance or .........

[@ataho2000]

@@atoms.channel On second thoughts, my mistake. English people have the tendency to take words from foreign languages ad bastardize them to their harts content so you can use the word "mono" any way you want.

[@jacobgnanapragasam929]

I am 72yrs. Old and 20yrs. T2 diabetic. This channel is the best for diabetics. Excellent presentation. A big thank you.

[@nourishedbyscience]

Thank you, Jacob!

[@soumyendughosh5999]

Truly Best

[@mirzamanmirzaman1482]

Very clear and understandable information. I am watching videos like this and try to manage my food and activities for better health. In about 8 months I lost 52 lbs and I maintained the new weight for tw years. Now after two years my Hba1c dropped to 5.2 and am really happy because I am no more a pre diabetic person. Eat twice a day and walk about 4 miles a day.

[@nourishedbyscience]

Congrats! That's great to hear. I really do believe in the power of taking responsibility to ones own health, rather than thinking about health care only as something that is done to us. Cheers Mario

[@lynlawley8903]

That's fab it's great to here positive out comes

[@MaSa-bp5qe]

Would you mind sharing what you eat?

[@beautifulrose8619]

wow. excellent

[@pjm7879]

I'm on the same path. 18 months, 40 pounds, 5.6-5.7 A1c. Recently started 10,000 steps/day. Hope to get to 5.2 like you. Your story encourages me.

[@vegrunner6688]

An excellent and informative video...thank you. I think part of the reason you were able to impart so much information in a relatively short video is that there was no "bloat"...no excess words or personal asides. Very helpful content!

[@janelensch6168]

I am 71 yrs old, very active, slim 5'10". T2 for 15 yrs. Never knew about IR. Had T2 hubs so very little extra calories like gravy, biscuits etc. He followed ADA diet so had normal carbs with lunch & dinner. Was a pharmacist, checked his blood 8 times a day, and diabetic for 63 yrs. Had limited activities therefore, he had every complication. I can not do this to my family. My a1c always 7.3 & 7.5 and I must get into 6's. CGM last year & I love it. My numbers spike with many meals and trying to fast more. Always eat 1/2 restaurant meal. I am emptying my garage and doing way too much lifting, painting, cleaning, moving fridges and I just lifted 5 drawer tool chest. I just do not expect good numbers anymore. I joined hiking club and never walking on level ground. Loved it. I am desperate to save my organs. On 5 glucose meds & Toujeo insulin. Just sharing as there is something I am missing. I will never give up. Love water & coffee all day. Only eat berries, little carbs and love protein & salads & green veggies. Thx for this training 💪

[@okundola9388]

​@@Franklin-pc3xd She said she is a slim 5'10"

[@prabhakar0076]

Anxiety may be the issue, just meditate and do yoga, SUN SALUTE aka SURYA NAMASKAR , if u want to 😊

[@yangtse55]

@@okundola9388 TOFI ?

[@okundola9388]

@@yangtse55 What is TOFI please ?

[@Chris-tw8fu]

Thin on the outside fat on the inside……TOFI

[@johnchardine1886]

The best explanation of this subject I have ever watched. Many thanks and keep up the great work!

[@fraumahler5934]

I agree. He is very clear

[@msims1910]

This is absolutely the BEST content on this topic!

[@lestereo]

Thank you for this. This is amazing content. Please keep it up. My GP doesn't even come close to explaining things in this level of detail. Your work is very important for patients. How are we supposed to take care of ourselves if we don't understand our condition?

[@nourishedbyscience]

Thank you for the kind comment, Luiz. Appreciate you taking the time.

[@yoya4766]

um, let the pharmaceuticals make money from it.

[@ritamorelli3869]

Sure

[@ritamorelli3869]

@@yoya4766❤

[@mikerudd4943]

I really appreciate your "recaps" toward the end of the videos. And they are easy to understand

[@uguree]

Best diabetes and insulin resistance explanation on the Internet ever.. I have watched Dr berg and many others, and they explain things well too, but not as clear, simple and effective as this one.. I think lecturing is a skill, this guy with his presentation and also how he goes into details are perfectly balanced.. I didn't have a professor in uni who can tell topics as effective and as simple as this guy, thanks

[@kimberlywhidden6966]

I’ve had Type 1.5 diabetes for 20+ years and I’ve learned something new. I’m now a subscriber and can’t wait to binge watch your channel.

[@henkwerner]

Thank you very much. This is by far the most understandable explanation I have ever seen on the topic.

[@nourishedbyscience]

Thank you so much. It's always challenging to know how detailed these videos should be, so I appreciate the feedback.

[@00spillai]

What a great video by a responsible clinician. What clarity!

[@varunmc001]

This is hands down the best explanation of what causes diabetes I have seen so far in my quest to understand the disorder.

[@rabidwolfie]

Looking forward to the content on stress effects on blood sugar regulation, particularly if you could touch upon elevated lvls of cortisol! Thank you for this concise and informative video :)

[@eugeniebreida]

Ditto!

[@Heilungshilfe]

Your videos are so well explained and extremely helpful. And btw - your English is perfect. Greetings from Austria.

[@armandzottola1626]

Excellent presentation. Diagnosed as T2 at age 45. Panicked…ignorant…250 lbs. my endocrinologist is excellent . Now almost 84…185 lbs….A1C between 6.2-6.5. Feel wonderful….no complications. But…a long road of exercise, dietary education and discipline. Lucky guy.

[@nourishedbyscience]

Congrats for controlling your T2DM so well. And thank you for the kind feedback. Best wishes, Mario

[@elhombreloco3680]

I'm looking forward to your videos on dietary interventions! I've had type 2 diabetes for 21 years now, ever since I was 17. I had an A1c result of 13.3 recently, and was finally fed up and switched to very low carb + intermittent fasting (~19+5). In about a month I'm down to an estimated average glucose of ~90 (according to my calculations). I'm always in the 70-110 range. I still take metformin and occasionally a tiny dose of a sulfonylurea, but I'm slowly trying to phase those out and see how I do.

[@nourishedbyscience]

Wonderful, and congratulations. Thank you for sharing. I cannot give any personal dietary or medical advice here, but if this was my situation, now that blood glucose looks like it's mostly under control, I would now work with my primary care doctor to focus on other risk factors for chronic disease (serum lipids, blood pressure, biomarkers of inflammation, micronutrient status) to make sure that my dietary changes have not created unwanted problems elsewhere.

[@gloriasaliba3395]

I recently did the same and brought my AIC from 8.2 to 5.9 however I reduced my inflammatory levels from 27.1 to 5.1 in just 6 weeks - I’m still taking 1,000 mg daily Metformin- how much do you take?

[@elhombreloco3680]

@@gloriasaliba3395 I've been taking 2,000 mg a day. Half in the morning, half in the evening. My babe right now are walnuts. I could eat those until they're gone. So I try not to get too many... Overall, it's going well. Minor setbacks hete and there but the general trend is improving

[@liferidar9554]

@@gloriasaliba3395 how did u manage your A1C and Inflammatory levels? can u please share ?

[@gloriasaliba3395]

@@liferidar9554 removed most processed carbs sugar and grains - focussed on good quality protein, good fats, salads and vegetables - ate within a 6-10 hour window - skipped breakfast most days - first meal at 12.30pm-1pm, ate large volumes of salads vegetables - drank 3 litres of water every day, walked 5-10,000 steps and did resistance training twice per week - also started taking supplements - Vit D3, K2, multivitamin, magnesium and collagen - drank back coffee tea occasional Diet Coke - allowed myself 1-2 glasses of wine when dining out and sharing a dessert, certainly not every day

[@samuellaysico541]

I've been following a few podcasts regarding blood glucose and insulin resistance. This video really made me more understand in details the mechanism of blood glucose level and insulin sensitivity. You, Dr Mario and Dr Ben Bikman are excellent teachers on these topics. Thank you so much for your dedication and hard work.

[@stathisapostolou2630]

Excelent content. I knew a lot of what you have mentioned, but this video helped me to connect the dots and get a spherical understanding. Please keep up with this series.

[@samiraba1]

This was by far the best video I watched in this topic. I watched it twice back to back! Thank you so much for your effort ❤

[@nourishedbyscience]

Thank you for the feedback! It's always hard to know how deep to go without boring everyone, so it's good to get this kind of feedback. Cheers Mario

[@momezart]

Glucose effectiveness is intriguing. Your channel is one if the credible/trusted source in the area of nutrition. Wish you can do it more often. 🥰 Greeting from Thailand.

[@nourishedbyscience]

Thank you. I took an (unplanned) pause this summer due to some personal reasons. I am planning to post more regularly going forward.

[@fareedahmed2302]

This is mind blowing content! The simplicity and effectiveness of this video is really beyond words! Hats off Sir.

[@nourishedbyscience]

Appreciate your feedback. Glad you found it helpful. Cheers Mario

[@msims1910]

Amazing illustrations, breaking this complex topic down so well, to the lay person! Thank you, Dr. Kratz!

[@chiuchan4432]

Excellent explanations ! Now, I have a clear understanding of diabetes that I cannot get anywhere. Thank you!

[@briankellner970]

The glucose effectiveness section at the end was really interesting.

[@ceciliachen2084]

Awesome explanation. I am now watching this channel frequently. Thank you!

[@dmk1913]

Such clarity, comprehensiveness in the video. Can't wait for other videos in the series

[@nourishedbyscience]

Thank you!

[@Minisquid100]

Such valuable information all in one place that I've been trying to piece together for years. Thank you!

[@PBandJbros]

LOVED THIS and I've been a very studied Type 1 Diabetic for 23 yrs!! Thank you!! (Wish I could find an educated Endo like you!!)

[@Sheyz123]

I've had to go over this a few times but you have explained in detail all the questions that I have had about this subject. Thank you so very very much. It helps me in my quest to reverse my insulin resistance

[@chutneymasala1]

Well done Clearly explained Amazing Thank you

[@SPUJALT002]

Thank you so much for this. Please keep it coming! Can you provide some input on perimenopause and insulin resistance and why can be done to help our bodies.

[@geoffreyclarke8110]

Thank you so much for a very detailed and well explained presentation. A first class example of teaching to me and fascinating new information. I'm looking forward to your other videos.

[@meep0meep]

Thank you for this video. It’s one of the best diabetes videos I’ve seen. Clearly & methodically explained- the summary was excellent. All in all, Very helpful for those of us struggling w/insulin resistance. Appreciate it & Look fwd to your other presentations on this topic.

[@chazlon5061]

awesome to see you posting again. always gems from this channel. :D

[@nourishedbyscience]

Thank you. And sorry for the extended pause.

[@chazlon5061]

@@nourishedbyscience you're welcome and that's understandable!

[@joannazaras8144]

I can't wait to see your next videos. They are very informative and helpful. I appreciate the effort put into providing professional and in-depth knowledge and at the same time making the information understandable to everyone.

[@stefanbuscaylet]

Let you a bigger comment, but wanted to send my thanks for giving me data both technical but also understandable by someone not with a degree in endocrinology. Keep up. Linked, subscribed, saved, commented.

[@nourishedbyscience]

Thanks, Stephan! Greatly appreciated!

[@johannel8104]

Mind boggling. 5.4 grams of sugar in your entire bloodstream at a fasting state of 90 mg/dl. The human body is amazingly efficient and an absolute technical marvel!

[@MsQ275]

The work of God ❤🙏🏻

[@satishramakrishna1]

Thanks! Very well described - could you also describe something called the Dawn phenomenon, which increases fasting blood glucose levels?

[@nourishedbyscience]

Thank you. Appreciate the support. Cheers Mario

[@bedi3yamida870]

make a video on how to avoid insulin resistance

[@philippabrealey1310]

I am following a programme to counteract obesity and pre-diabetes. I am 72 and unfortunately became decidedly undisciplined about eating in lockdown. I studied biochemistry and food science in the early 70s and again in the late 80s but have now forgotten much of the detail, and of course, I am desperately out of date. The theory aspects of the programme I am following are dumbed down for the non-scientist so much that I find myself utterly confused. Thank you for this perfectly pitched series. I have watched 3 videos at a sitting, must now let that sink in and go and choose a suitable breakfast. Thanks. See you again soon (literally). Phinna.

[@ritamorelli3869]

I feel that this video is informative After suffering with diabetes and monitoring my own numbers I have noticed that protein eaten together with carbs produces a lower number

[@tuppercareyd]

Excellent video thank you This is so important to understand as diabetes is becoming so common

[@Health-And-Diabetes]

I got T2 in 1984. 40 years later , i am managing with Metformin and jardiance. Meals are mainly legumes, lentils, cowpea and soybean. A1c 6.9 . My previous wife is a Doctor, but that didn't help to stop complications and triple bypass. Now i am my own guru. Search, research, listen, test, test and follow.

[@Health-And-Diabetes]

I am 69.

[@nourishedbyscience]

That's great. Legumes are a great food for people with glucose intolerance. If you can, include a lot of fiber-rich non-starchy vegetables and a portion of additional protein in each meal, and may should see some additional improvements. Keep your doctor in the loop, however, as your medications may need to be adjusted should your glucose tolerance improve.

[@aarondorn6568]

Thank you. For the last year, I have been trying to understand and do anything I can to reduce my insulin sensitivity. I am anxiously awaiting your videos on how to improve it. That said, this is the first time I have ever heard of glucose effectiveness even after years of research. I am intrigued to see anything I can do to improve that aspect of sugar metabolism as well. I say all of this to say that the information you provide and the fashion in which you provid it is the most helpful I have ever found including all my conversations with physicians, nutritionists, and personal research. Thank you so much for putting it all out there.

[@nourishedbyscience]

Thank you for the kind feedback! Best wishes, Mario

[@tomcaron9113]

Wonderful information! Tells me I’m on the right track with my new CGM Libre 2. A1c has bounded all over, not anymore. 20 years as diabetic, no adverse effects to date, want to keep it that way. Just subscribed! Thanks to you and Dr. Fung!

[@Sophal27]

Great video as always. Could you talk about the effect insulin and insulin resistance on fat metabolism?

[@nourishedbyscience]

Yes, I will for sure, and also the other way around (fat effects on insulin metabolism), because it seems to me that most people mistakenly think that only carbs have a negative impact on insulin secretion and action. Cheers Mario

[@lindaliestman4397]

Thank you for your content! You are easy to listen to and to understand, and a great help to so many people!

[@dimitrikorsakov2570]

Very happy to see you're back!

[@keekiatchua447]

This is by far the most informative channel that i have come across in this domain. Thank you so much and looking forward to more videis!

[@annaopoku9074]

You are a very good teacher. Your explanation is very clear. How you speak is soft and it helps to hear well. GOD BLESS YOU

[@AlecLittle-r1x]

Thank you for explaining insulin sensitivity and the regulation of blood sugar levels in such a way that is easy to understand. One thing I have been wanting to know is did I do anything in my earlier years to cause my diabetes such as drinking too many sugary drinks. Hopefully you can answer that question in a future video or reply to my comment. Thank you again. Your videos are very informative. 34:34

[@dodyh657]

Yes.. eating/drinking too much sugary foods in a long term make insulin resistance. It takes around 10-15 years to a diabetic condition from pre-diabetic condition. So if you got diabetic condition at 40 yr old, then perhaps you have pre diabetic condition at 25 - 30 yrs old. Change your diet and intermittent fasting will improve your diabetic condition. I hope that help.

[@janowen5946]

I would love to see the video that says --- you have a body that is glucose intolerant - these are the daily habits one must do to move the body back to insulin sensitivity and glucose tolerance.

[@45876]

My family doctor only tells me to lose weight after seeing my blood work. He didn’t bother to tell me why and what happened. I have to google each test to find out what exactly are these but I still don’t understand what I see. This channel helps a lot. I don’t blame the doctor since he only sees me once a year for 5 minutes. I am the one who should be taking care of my body but I didn’t. Thanks for the education and with your information, I am determined to get my health back.

[@impulsemail]

Thank you, this was much needed and very enlightening.

[@yropez]

Excellent! Can’t wait to see more from your channel on this topic!!

[@nourishedbyscience]

Thank you, Yoshiko!

[@marynguyen6417]

I ve learnt lots on this topic from Dr. Ben Birkman, but I still enjoy your very educative video. I am looking forward to seeing more videos from your channel. Thank you!

[@nourishedbyscience]

Thank you, Mary. Appreciate your feedback. Cheers Mario

[@gloriasaliba3395]

It’s Ben Bikman he’s awesome

[@mgmovassaghi1733]

Very clear and informative presentations thank you so much

[@adrianmihailescu5255]

Extremely clear and concise! Can’t wait your next post!

[@okundola9388]

Thanks so much.👍 Please continue the technicalities, it helps to understand more. Also include full names of acronyms used to demystify them & help to understand their functions & activities. Apart from the fact that I'm a Pharm. by training, the current trend as you know is patients' involvement in their own health management & many patients conduct researches on their health issues even without medical training. So it's good to get comprehensive information from honest forthright experts like you whose primary motive is health, wellness & correct understanding, treatment & management. When a presentation is accurate /factual, the length will not matter to a patient who needs the knowledge to understand their situation & help in their own health management. In conducting researches, many patients have fallen victims to wrong information from people who just want to be heard & make money from the little & inaccurate knowledge they have. This is your 3rd presentation I have seen recently. Very well appreciated ❤

[@nourishedbyscience]

Thank you for your feedback. Just looking at my own comment section and e-mail inbox I can certainly tell that many people have fallen prey to almost cult-like diet tribes that perpetuate dangerous misinformation. Cheers Mario

[@ashokkammila8752]

Very informative. Which we understand the basic information regarding insulin for non medical people. Thank you.

[@fla8731]

thank you for making these videos. very well explained.

[@theresaotoole9141]

Thanks for a well presented lecture on this issue, as a I am a new Type 2 Diabetic (6 months now). As is my nature to not just follow what my Doctor says alone - but to try to fully understand what the reasons are he is prescribing a particular treatment and why. Unfortunately Doctors only have 6 to 10 minutes per visit for a standard fee and it is insufficient to explain what he knows - So instead I just get told what to do. To counter this I have been exploring everything I can get on KZbin and I have learnt a lot these past few months. But your presentation was brilliant - in particular the supporting diagrams used - which really helped to explain the process. I have just now subscribed and look forward to learning more ...

[@okundola9388]

You are so very right. It is same scenario in my country 🇳🇬. Doctors are anxious to push you out of the room when they feel they don't have any new developments \ information to gain from a patient to help them pass their exams for higher qualifications, write thesis\journals etc. for their promotion. They don't make effort to research to help patients when they feel they already have the ready made textbook prescriptions & they make the patient feel like a pest.

[@EA-ck4so]

Amazing presentation! Very informative and clearly explained.

[@lynnpep6962]

Mario, I just listened to Nutrition Made Simple, that you were on. You made me feel so much better, thank you.

[@thedesihobbit]

Thank you so much for this excellent video.

[@stefanbuscaylet]

Thank you very much for this. I’m a technical guy but just not in the field of medicine or body function. It’s been difficult to find diabetic info that doesn’t overly simply this for non-technical people or the material requires a PhD in biology to understand. This struck a great response. Just a feedback which had my eye twitch, you showed graphics of glucose over time to a GTT and pretty much showed it fully recovered in 2 hours but you then stated that even a a healthy response measured 2 hours later could be as high as 50% more. Otherwise great job. I’m 60 years old now and was diagnosed about 12 years ago, but there were so many signs in reflection that i was going from healthy to pre-diabetic to full diabetic that were missed by both me and my doctors and I’m dealing with neuropathy consequences that seems like i should have been able to have addressed earlier. My father, me, and my daughter all grew up with hypoglycemia and me and my dad both have transitioned to full diabetic. At least now I’ve been able to coach my now 33 year old daughter to watch and potentially mitigate her insulin sensitivity and hopefully mitigate well before irreversible consequences such as neuropathy and other organ damage occurs. Thanks again for the great content.

[@nourishedbyscience]

Hi Stefan, Thank you for your feedback. To clarify the twitch-inducing issue 🙂, the official guidelines by the American Diabetes Association and other national diabetes organizations say that a 2-hour glucose value in a 75g oral glucose tolerance test needs to be under 140 mg/dL to qualify as 'normal'. First, 75g of pure glucose in a liquid form is a hefty dose, and more of a challenge than almost any solid meal I can think about. Second, in healthy people with 100% normal glucose tolerance, glucose may peak around 140 mg/dL even in response to that 75 g OGTT and be back to baseline at the 2-h mark. So the graphs I drew for normal/healthy people were more in line with what a healthy person's glucose levels after a meal and even in an OGTT would actually look like. Sorry to hear about your neuropathy. I am hoping that my upcoming content about additional measures people with manifest diabetes can take will be helpful to you and your family. Cheers Mario

[@lotfibouhedjeur]

Excellent presentation. Love your straightforward approach. Binge watching your videos.

[@patmuscarella8279]

I just found your channel an I will be a constant follower. You explain things well enough for me understand somewhat. Thank you.

[@luisclementemesquita5511]

Great presentation. Many concepts are presented very concisely, logically and informatively.

[@margaretwuellner3761]

Wow! Fascinating information and well presented . Thank you!

[@aminsinichi]

This is gold. Amazing job!

[@ellas6101]

Great explanation, I have learned a lot

[@inte7189]

I was watching this. And wondering about this crazy amazing process nothing short of divine i think. And then he says MIRACULOUS.

[@debschwartz7211]

Excellent presentation of the material! Thank you so much for doing this!

[@hughtubewatcher]

I just watched this video for the second time. It is so well done and so informative that it should be required viewing for every diabetes educator and diabetes patient. I have a follow up question. The video highlights three major factors affecting the body’s ability to manage blood glucose: (1) insulin sensitivity,(2) insulin production (i.e., beta cell function) and (3) glucose effectiveness. Are there ways to test each of these three functions for a given individual? Using a personal example, I was diagnosed as having type two diabetes based on an A1c that was just over the type 2 threshold. I adjusted my diet/exercise, lost some weight and started wearing a Lingo CGM. I am now able to maintain my blood glucose within the range of 70 to 140 97% of the time, with an average daily glucose of 95 to 100. In other words, I am able to maintain blood glucose levels below the even the prediabetic threshold. However, I don’t know my insulin sensitivity, my ability to produce insulin, or my glucose effectiveness. At this point, I haven’t learned enough to know exactly how that information would help me. But I think that information might be valuable as I continue to learn more about diabetes. If this question is answered by one of your other videos, please let me know and I will watch them next. Thank you for all your outstanding work.

[@nourishedbyscience]

Hey Hugh, Great question. And congrats to what sounds like reversing your diabetes! First, now that you learned about glucose effectiveness, for practical purposes, move that onto the backburner. That is because while it's extremely important for blood sugar regulation, we have no clinical test to measure it, and we currently don't know how to improve it. In other words, even if you could measure it, it would not be actionable knowledge. However, glucose effectiveness is an important part of several insulin-independent mechanisms through which blood sugar can be cleared from the blood. Another one I wish I had mentioned in the video is that muscle tissue can take up glucose from the blood in a way that is independent of insulin, so exercise acutely lowers blood glucose levels when they are elevated, and going for a simple walk after a meal can be an effective way to lower elevated blood glucose levels. (Don't be confused that exercise when done fasting can also raise blood glucose levels; that's not a bad thing and should not discourage exercising, because exercise is extremely important for metabolic health). Second, there is an easy measure of insulin resistance called HOMA-IR that I recommend you could get. I talk about that here in this video: Measuring Insulin Resistance: kzbin.info/www/bejne/hYvXqaKaprR1mNksi=qaaNZ2y8cXNcojeD In general, glucose tolerance is the product of your insulin sensitivtiy and your insulin secretion (beta-cell function), and often, improving insulin sensitivity is the easiest way to improve glucose tolerance. It is important to understand the root cause of YOUR insulin resistance if you are insulin resistant. I talk about the 16 main causes here, in these videos: Causes of Insulin Resistance: The Personal Fat Threshold: kzbin.info/www/bejne/mYGYaKKDbdF1l7csi=NTZ82Rue7mVP3-7p Insulin Resistance: Top Causes & Contributing Factors: kzbin.info/www/bejne/forXn5-IeNZradUsi=2GgrTvMRBfmumBl4 Often, you'll hear general statements online such as "do x to improve insulin sensitivtiy". These sometimes work, but I feel strongly that the better approach is to identify specific causes of why we personally are insulin resistance, and then address these. And third and lastly, poor beta-cell function is often genetic in nature, and seen in people who have a family history of type 2 diabetes. That doesn't mean that it cannot be influenced. Similar to HOMA-IR, there is a measure just based on fasting glucose and insulin called HOMA-B, so if you get HOMA-IR measured, you can use the fasting glucose and insulin data to also calculate HOMA-B. It's a rough estimate of beta-cell function, but it can give one first indication. CGM data in response to high-carb meals can also be useful to detect poor insulin secretion, particularly if there is a very rapid spiking pattern. More precise tests are very involved and usually never done in clincial care. I haven't made a video about beta-cell function yet, how to measure it and how to improve it, but I think I'll do that soon. One factor that we know reduced insulin secretion is fat in the pancreas, which is a form of ectopic fat. If we lose weight, we tend to lose some of that pancreatic fat, and the insulin secretory capacity of our pancreatic beta-cells improves. We also know that - temporarily - doing long fasts and also a low-carb or keto diet will reduce insulin secretion, particularly the first-phase insulin secretion. In other words, if you have a habit of intermittent fasting or longer fasts, or if you are generally on a low-carb diet, make sure to re-introduce carbs slowly after that. Hope this is helpful. Happy to talk about any of these things in one of our upcoming Patreon calls. Cheers Mario

[@hughtubewatcher]

@@nourishedbyscience This is extremely helpful. I will watch the videos cited and discuss the testing that you mentioned with my PCP.

[@jtleon7086]

I wish i was smart enough to follow this in depth lesson, information overload. I'll have to rewatch.

[@nourishedbyscience]

Sorry ... I admit, the body is complex. However, the information is IMO critical to really understanding diabetes, and what can be done about it. So, I think it's worth the effort, but then ... I am biased ...;-) Cheers Mario

[@sueturnerhc9321]

Thank you so much for this information.i have type 2 diabetes. Struggling to keep good numbers. Probably could lose 10kg max but not huge. Controlled well for first 2 years but not so much now. I believed that because I had so severely reduced carbs, once I did eat them, blood sugar would skyrocket. I was m8serable, missing the foods I love as I am a “feeder” and love to cook. No rice, potatoes, pasta, bread to name a few, I was miserable. Who satisfies their desire for a biscuit with their morning to a 1/4 a biscuit - not a happy way to live. Will watch your videos over and over to give me a quality of life. Thank you. Diet generally salad and egg, cold meat for lunch, meat and veg, excluding potatoes for dinner.

[@nourishedbyscience]

Here is an important point to consider: if we generally eat a low-carb diet, that is fine and maybe even disireable if we have type 2 diabetes. However, a low-carb diet lowers what we call the first-phase insulin response, i.e., the amount of insulin the pancreas can secrete in the first few minutes after eating a meal that contains carbs. This first-phase insulin response consists of pre-formed insulin that is stored in the beta-cells and can be released into the blood within seconds of eating carbs. The reduction in the first-phase insulin response is an adaptive response to eating no carbs, because the body simply doesn't want to keep pre-made insulin stored in the beta-cells if it never is needed because we are not eating carbs (this is similar if we fast for an extended period of time). This is temporary, and if you were to start eating carbs regularly again, your first-phase insulin response would recover. However, what this means is that you want to keep your carb intake roughly steady from meal to meal. If you eat a low-carb diet, make every meal low-carb. If you eat a normal mixed diet, do that every meal. Aside from this, I feel that it is critically important to figure out WHY you are glucose intolerant. The first step is to figure out whether we are insulin resistant: Measuring Insulin Resistance: kzbin.info/www/bejne/hYvXqaKaprR1mNksi=C681vsKNjXqWJSMq If we are insulin resistant, then the next step would be to think through the most common causes of insulin resistance to identify potential reasons for OUR insulin resistance: Causes of Insulin Resistance: The Personal Fat Threshold: kzbin.info/www/bejne/mYGYaKKDbdF1l7csi=eK6OeDRpGNpPzOqW Insulin Resistance: Top Causes & Contributing Factors: kzbin.info/www/bejne/forXn5-IeNZradUsi=kfHudBNBlFN1NlzU To understand why insulin resistance is damaging to long-term health: Insulin Resistance Syndrome: A Neglected Risk Factor for Chronic Disease: kzbin.info/www/bejne/fJiWn2Csnpenabssi=Cob6H4vwk6yCz12F Wearing a CGM can also be useful to identify early signs of glucose intolerance and insulin resistance: How to Interpret Your CGM Data: kzbin.info/www/bejne/eoexdWxmq7Zjrqssi=vpLTb-bAIvenYWjB And once you have identified potential causes or contributing factors to your glucose intolerance and/or insulin resistance, you can address these specifically. It’s important to be clear that while excess visceral and ectopic fat is a common cause of insulin resistance and glucose intolerance, it’s not the same for all people. Others are insulin resistant because of low muscle mass, chronic stress, chronic sleep deprivation, or micronutrient deficiencies. Hope this helps. Best, Mario P.S.: This is not medical or medical nutrition advice, as I don't know your specific situation, incl. your medication and medical history. I recommend you look though the videos, and if you have any questions, discuss them with your doctor or nutritionist.

[@ksappani]

Thanks

[@nourishedbyscience]

Thank you.

[@nilodeguzman4436]

Will it help taking pancreatic enzymes supplement to improve sensitivity

[@bettieivy4873]

Thanks!

[@nourishedbyscience]

Thank you, Bettie! Wonderful to have your support! Cheers Mario

[@clarkkent7973]

At 29:52, you discuss GIP and GLP-1. The new drugs Wagovy/Ozempic are essentially adding more long-lasting GLP-1 hormone to your body. The new drug Mounjaro is essentially adding more long-lasting GIP and GLP-1 hormone to your body.

[@edbenfield4199]

Best explanation of diabetes I have seen. excellent addition to info from my doctor(s). Very clear and easy to understand. Am forwarding a link friends with diabetes. Thank you.

[@nourishedbyscience]

Thank you for your kind feedback, Ed. Best, Mario

[@aditya_in_wild]

Thank you for clearly explaining how IR works. Looking forward to more videos and learning how to manage effectively.

[@yazminmojica4458]

Excellent presentation, clear and to the point. 💯❤️

[@jerrywilhelm5122]

Brilliant, the clearest explanation I have seen on this subject. looking forward to learning more.

[@uhadonejob]

Good information. I am surprised you didn't mention urination as an insulin independent removal mechanism.

[@nourishedbyscience]

Technically you are correct that glucose can be excreted through the urine, but this doesn't occur in meaningful amounts at glucose concentrations below the renal threshold of glucose, which is at about 180 mg/dL (10 mmol/L). And blood glucose does not exceed 180 mg/dL under physiological conditions, i.e., in people who are fully glucose tolerant. But, you are correct, it is an insulin-independent mechanism of removing glucose from the blood in people with diabetes. Cheers Mario

[@cliffgrout9577]

Thanks so much for the best information on blood sugar regulation I have found 🙏

[@wordysmithsonism8767]

These explanations are the best I have seen.

[@davidbird9423]

Absolutely best reporting of body function from glucose intake

[@chanwaileong9880]

Keep up the good work. One of the most informative videos that we ever had. Though some of your talks are a little hard for the layman to fully digest, they are incredibly eye opening. Perhaps, we just need to go thru the videos several times to digest the messages.

[@okundola9388]

Yes

[@samanya_manus]

Sir you have shared very valuable information with us we are thankful and God bless you for your hard work and dedication. Love from India

[@jamesmcmahonii8433]

Blows my mind many of you have been T2D for 10s of years. I'm barely preD for 1.5 years and already lost and arm and leg.

[@Teal_Seal]

😢

[@Ahmed-px1zf]

Thank you very much for this very informative highly science based podcast. Simply fantastic

[@nourishedbyscience]

Thank you for taking the time to provide feedback. Best wishes, Mario

[@VicknairD]

Very nourishing! Filled with useful information delivered in a conversational style. And not overly long. Thank you! Can wait to digest other videos. We have a health related small group at our church. Your video on How to Avoid Blood Sugar Spikes is already on the docket for a future group discussion.

[@nourishedbyscience]

Thank you for taking time to leave your kind feedback, David. And what a great idea to have a health-related group at church. I am honored to make an appearance there. Best wishes, Mario

[@joanneclark8256]

Is this a group online?

[@sanadaunauda9620]

Thank you very much for your video - with a plethora of videos on the subject and a lot confusion and lack clarity on what sugar is ?? in simple term that a layman like me can understand and came across your video by accident! looking for a video on Hebrew language and yours pop up !! why?? don't know! and I am not complaining either but I was very happy to listen and it was refreshing and clear!! Thank you looking forward to the next one.

[@SPUJALT002]

Thank you!

[@georgekaw3235]

Thank you for sharing your knowledge and expertise to the many people that are prediabetic or Diabetic, and more important, bringing to attention the problem of metabolic desease not many people are aware of. I have viewed many of your videos, I turned 70 yrs old last May, I have an A1C3 of "5.7%" last April, I'm skinny, 5' 6" weigh 112 lbs, but Asian, by nature we're small, 80% vegetarian, and exercise and go to the gym 2-3 times a week since young, although I am lacking some exercise outside those days I am sedentary. I would appreciate very much if you can inform me the areas I need to improve so I can be Insulin sensitive, thank you so much!

[@nourishedbyscience]

Can I suggest these videos here to figure out if you are insulin resistant and - if so - what the cause of that may be: kzbin.info/www/bejne/hYvXqaKaprR1mNksi=n33oxruPIh4lz68r kzbin.info/www/bejne/forXn5-IeNZradUsi=zstOCLv04NcS6ECF Cheers Mario

[@NimarkFarmS]

Thanks for this information, kindly do a video on how to reverse prediabetic with low BMI... Any dietary suggestions?

[@chrisbishop251]

Thank you very much. After watching numerous videos, this was one of the most informative I seen on the subject and touched on completely new areas which I was not aware of.👍

[@sheila7814]

Best discussion on the internet! Thank you