Old Pill, New Trick

[@SciShow]

Thank you to GiveWell for sponsoring this video! GiveWell is matching donations from first-time donors’ dollar for dollar up to $250. Click on bit.ly/31r9i20 to donate and be sure to use the fundraiser code SCISHOW at checkout to make sure your donation gets matched.

[@eSKAone-]

1:51 Maybe it's not the drug but the sexual activity 💟

[@Direblade11]

I'm very happy that you managed to fit in a "Nice" after saying 69%

[@Direblade11]

@@eSKAone- nah, pornstars get alzheimers too

[@eSKAone-]

@@Direblade11maybe only 30% as much

[@jesipohl6717]

how was their error correction in this fishing expeditiion, did they use every test performed in calculating false-positives?

[@IceMetalPunk]

Hank: "69%" Me: "He's not going to say 'nice', this is a mature and educational channel." Hank: "Nice!" Me: "NICE!"

[@EyesOfByes]

0:47 Hard topic..

[@QoiBoi]

I love Hank even more because of this moment.

[@ochadeshita]

i had the exact same reaction

[@ianmacfarlane1241]

Nice.

[@dynlenoir]

🤭

[@masonjohnson4310]

Viagra is just a drug that keeps giving. First, heart disease, then ED, and now possibly Alzheimer's.

[@Matys1975]

But I thought 💭 everything that big Pharma creates is bad ?

[@RoyeReedBenjamin]

@@Matys1975 I believe most of the complaints about big Pharma center around price gouging rather than their creations.

[@aftersexhighfives]

@@RoyeReedBenjamin unless we're discussing opiates.

[@MrRizeAG]

@@aftersexhighfives Even then, said opiates have plenty of legitimate medical uses. It's the purposeful overuse of them that has caused the problem, and pharma corporations are absolutely to blame.

[@TheSuzberry]

I’m assuming that the stats all come from men.

[@ijusthatedmyoldhandle]

my mom is in the mid to late stage of alzheimer’s and her mother had it too, even younger than her, and ever since she was diagnosed i’ve been having panic attacks about getting it myself (it’s worse because i’m a primary caretaker and have to see every day what it does to someone) and even though this isn’t much yet this news was such a relief to me that i shed a few tears

[@messyties]

Take the vaccine

[@soggybiscotti8425]

You're going to get it. Nightmare nightmare NIGHTMARE!

[@csanadpinter9436]

Bb.((

[@damagecontrol7]

you've got some *hard* times ahead of you

[@vysharra]

Get enough sleep, exercise lightly every day, and never ever stop learning something new each day, these are the existing factors believed to keep people mentally “young” as long as possible.

[@Stonewren]

The entire concept of aging would be a heck of a lot less scary in a world where we could prevent and treat Alzheimers. Godspeed, science nerds

[@OGSumo]

Completely agree. My body doesn't make me, my mind does. Losing the former is inconvenient and scary; losing the latter is debilitating and *terrifying* .

[@MaekarManastorm]

If nothing dies nothing new can be born .

[@RainebowEvee]

@@MaekarManastorm i think the point is that losing all sense of self is what is most terrifying about aging, not the dying part...

[@ianh1504]

itd be nice if it was for everyone and not the fabulously wealthy

[@doitallYT]

I'd really recommend looking into the research done on psilocybin in this regard, there's some seriously promising potential with it's effects on alzheimer's, as well as dementia.

[@ayhams]

"Viagra is good for both of my heads" I REGRET NOTHING

[@Al13n1nV8D3R]

"I REGRET NOTHING" was the "CLIMAX" of the comment.

[@ayhams]

@@pan2aja Of course I never do anything prematurely

[@eddieyeoh4098]

🤣🤣👍🏻

[@corvoattano9303]

You are all Gods. All of you 😆

[@tonyanthony5105]

What an amazing coincidence that the ED meds would even appear to be 69% more anything than other drugs

[@GABEGRAPES]

It’s fun too lol

[@deanspeer1]

I also found that suspicious. Perhaps this research was published April 1st?? Viagra reduces occurrence of Alzheimer's disease by 69 percent....sure not satire at all.

[@Sharkyktc001]

I was going to like this comment but leaving it at 69 is the right thing to do

[@ThreesiXtydegreeS]

nice

[@nakdea]

i think that walking around with a 4 hr erection isn't such a bad trade off if it allows you to remember why you have one

[@seasonofthewitch4209]

LMAO ✌😎

[@shieh.4743]

😆😆😆

[@LordDark102]

It doesn't really work this way. I'm a young man and use it recreationally and you have to be aroused for it to work. But yeah 4 hour boner is true lol

[@MJorgy5]

I got 3 times the mileage trying one for fun. Thought it was going to have to be amputated.

[@hughdanaher2758]

I was trying to work out a comment to say the same thing. Thanks.

[@tedium37]

My elderly father has fairly advanced dementia. The idea of giving him this med is a little scary but if all it accomplishes is making him smile for a few hours its well worth it.

[@FaultAndDakranon]

I was scared I was getting early onset dementia. Turned out my undiagnosed adhd was just kicking my ass. I'm so glad that a treatment might exist for other people with memory problems.

[@cartermclaughlin2908]

OMG. I wasn't undiagnosed, but i had been off meds for 25 years. 3 months on meds has made a world of difference.

[@FaultAndDakranon]

@@cartermclaughlin2908 I'm so glad you've found an effective treatment. Vyvance is my saviour.

[@exosproudmamabear558]

It was my hyperthyroidism. I was literally forgetting and denying that even happened (A very specific thing for Alzheimer's) even doctors were surprised since they were expecting hypothyroidism to be related to forgetfulness. Also, I have ADHD too but since it is a normal occurrence for me to forget it didn't bother me.

[@exosproudmamabear558]

@@cartermclaughlin2908 Lucky you my ADHD meds trigger my mania so I can't use it except on special occasions like tests and exams.

[@ZOB4]

You know those researchers were super pumped to get to that 69% figure.

[@cvspvr]

the researchers were pumped in more than one way

[@estergrant6713]

“hey bob” “thats doctor bob to you intern” “okay dr bob, the results of our study show that 68.998% had reduced chance of alztheimers” “hmm i think you mean 69%” “sir i dont think..tha-” “whos the head researcher here?” “sigh, you are dr bob” “nice”

[@melody3741]

It was probably 70%, and then they fudge the numbers, of course against their favor so they're not really committing a crime or anything, just to make it 69. I would do that.

[@nickwarner8158]

Hey, before you just go around making jokes you should consider all the LONG and HARD hours of dedication to the job went into DEEPLY studying all of this. Interns were walking sideways in the first week but I'm sure morale in the lab was rock solid

[@Hasenlordify]

Got the 69th like, nice

[@brucepaterson6961]

Complex organisms (hydra, us and everything in between) have specialized cells. All the cells have the same genes but each specialty has its defining epigenes. The evolution of complexity evolved when a gene (Hox) evolved that when the cell divides at a specific time (or after a certain number of divisions) gives 2 daughter cells that differ in their epigenes at a specific location, producing a cascade that gives 2 different cell lines. We do this many times, hydra only does it a few. Because hydra does this so few times it has also evolved the ability to reverse it, then reinstate it to regenerate any lost part and reproduce by budding.

[@tim40gabby25]

Nice.. a pill that gives you a night you can remember :) The hydra section was remarkably succinct. Great video.

[@LetsTakeWalk]

It might be the best medication ever invented. Good for the heart, good for your lovelife, good for memory.

[@jacobeys1966]

I 100% believe this I was taking sedinefil (sorry misspelled) for blood pressure and ed and I definitely noticed my mental focus and short term memory was working in overdrive! I was having vivid memories from my past that I used to not remember. Crazy!

[@UniqueornBacon]

My dad used to exercise 3-4x a week and always took his vitamins. At around his early 70s he stopped working out when his gym closed and it wasn’t easy to drive out of his way to another before work every day. Within 5 years he had to quit his job because of his deteriorating cognitive function and by 78 he was in a wheelchair because he had a tendency to fall and lose balance. After falling at the top of the stairs twice we had to ban him from his own room on the second floor to avoid a fall down 2 flights of stairs. He died shortly after his 80th birthday. “Age related dementia” but never outright called Alzheimer’s. Also possibly Lewey body syndrome.

[@PossibleBat]

Yeah most likely Lewy body syndrome, it’s a way more aggressive and fast "version" of Alzheimer’s… my step-grandfather died of it and in like a year he went from normal to not even remembering his wife, children and grandchildren as well as his own name, birthday, he literally was decaying alive. It was truly horrible to see and I cannot even imagine to suffer

[@vicariouswitness]

Research earthly conditions before investing in space.

[@ianmacfarlane1241]

I get prescribed a drug that's usually used for Parkinson's (Ropinirole) for my nighttime leg cramps - it's amazing how drugs can often have different uses.

[@tribiz6762]

Zolpidem, which is a sleep medication, has been documented to restore consciousness, in permanently vegetative states. Yes they have an IQ in the 60s but bringing someone back from permanently brain trauma induced unconscious is amazing. Look up the Ambien effect

[@ConnorNolan]

I know! I take blood pressure meds because they lower my blood calcium, therefore slowing the formation of my calcium oxalate kidney stones.

[@src3360]

Low dose lithium causes improved brain function and brain markers for memory. And I take it twice a day!! Lol

[@S8tan7]

I know someone who takes the antidepressant Sertraline to treat their IBS due to its side effect of bunging you up xD

[@kimmium]

What if it induces withdrawal Parkinsons? What about permanent Parkinsons after prolonged use, will it still seem a good idea

[@meggiem4685]

New rule: if Hank wears a t-shirt underneath a jacket or a similar garment, thus obscuring the graphic displayed on said t-shirt, he has to show the whole thing at the end of the video so that people like me can stop trying to figure out what the graphic is and instead pay attention to the content 👍🏻😂

[@ashleydeen5490]

If it helps is a pizza john shirt so only a few options

[@girthysmurfster]

Wait. You were focused on the t-shirt instead of googling where to buy a NASA themed Members Only jacket?

[@antispeedrun]

LOOOOOOLLLL I didn't know if this channel would drop that "nice" in there or not, and I'm so happy that it did. Thanks, Hank.

[@xanderellem3646]

I was very disappointed that you didn't acknowledge the 69, but then you brought it back around and hit us with the "nice!" Thank you Hank for managing to drop a sex joke in an otherwise serious science video, you're one of the good ones.

[@leftward_hoe]

leaving it until the end of the paragraph will absolutely be enough to fly over the heads of all Sweet Summer Children in the audience. definitely happen to me in life, after re-watching some old childhood cartoons and still catching new jokes :)

[@myuu22]

Wasn't sildenafil a drug for ED in the first place?

[@rediius]

@@myuu22 It was a high blood pressure medicine first, and only later did doctors realize that it dropped high blood pressure by redirecting it to your penis.

[@kennedy6971]

I thought the same thing.. Followed with "thats what she said"

[@robertgotschall1246]

Thank heck indeed. I'd really like to know about downside effects of Viagra, though.

[@Yojimbo711]

Thank you for your everlasting work Sci-Show

[@kioshekat7931]

I learned a lot today. and I can't wait to start an argument with someone that hydra are real and explaining them without the context that they're marine microorganisms.

[@worfoz]

Hydra's ARE real, they ate all the mermaids, so the lack of mermaids is clear proof of the existence of the hydra's. If you want to argue that, start by showing proof that mermaids still exist.

[@midnightrambler8866]

I really wish they would hurry up with effective treatments for alzheimers I'm not getting any younger and it runs in my family.

[@samanthateoh320]

I strongly encourage you to read a book published by prof Dennis crouse

[@simpleasmed2341]

It is a hard task! Alzheimer's disease envolves multiples factors like the deposition of amyloid, immune system, cholinesterase, etc. We made pretty good advances over the years though.

[@平和-v1z]

This channel is outstanding.

[@alexoolau]

Another possibility is that finding signs of the mental decline that comes with Alzheimer’s may be particularly hard in people with autism, especially for those who might already be functioning at a lower intellectual ability, Westmark says. “It’s a really novel idea, that autism could be protective,” she says. However, she adds, “I think that someone could probably write an equally convincing paper on the opposite.” This channel reveals that more dendritic branches are good against dementia. Autistic patients are born with more dendritic processes than normal people. This discovery really connects the dots about the role of neural dendrites in dementia.

[@LordBlackNephew]

Please hurry, this information is needed, would help love ones tremendously. BX STAND UP!!!

[@Corteum]

This is good. Thank you for this report.

[@EyesOfByes]

0:47 Pun unintended.. 2:01 *Nice.*

[@norgporg8370]

Post bac Tau researcher here: cool thing in the literature that’s got the spotlight is tau’s physical relationship with ribosomes. Since de-novo protein synthesis is important for memory formation/dendritic spine development/maintenance, tauopathy is the next big candidate for an Alzheimer’s treatment drug. Cool stuff came out recently in nature communications, worth a read if you’re in the field!

[@tomcurl8034]

My grandmother died of Alzheimer’s and I hope that this new discovery helps other people not suffer as much

[@davidgrech4574]

Thank you for sharing your insights and your positive energy and hope you know how much I appreciate your channel 👍

[@GMPOFloyd]

If a pill like that weights 8g, that’s the densest pill I’ve ever see

[@squimmysquam]

Just pointing out that the preview image says 8000mg. 8 grams of Viagra when the dose is 50mg is going to be an interesting time for sure.

[@csn583]

*Side effects may include death.

[@thermitebanana]

"this treatment is experimental, we'll have to find the right dosage" "I think 8000mg should be enough" "Are you sure?"

[@RebelAlliance42]

My mum passed in May after 10 years "living" with Alzheimers and Dementia. This is awesome!

[@mem1701movies]

Help me! My mom has been acting strange for awhile.

[@SuperManning11]

So sorry for your loss. My 84 year old mother just came to visit us. She has always been so sharp, but this visit I noticed a big decline in mental faculties, and an increase in forgetting what she’s already said. But then I feel like my mental faculties have suffered over the last couple of years as well, so maybe it’s just worse when you’re in your 80s. How do I tell the difference? I am very worried about her, but she seems to think she’s fine.

[@SuperManning11]

Sorry, didn’t mean to dump on you. I’m just very concerned. I hope you have been able to find peace in your mother’s passing, may she Rest In Peace.

[@Praetor_Fenix420]

I'm so sorry to hear about your loss. I know where you are coming from my mother passed from Alzheimer's on May 11th this year. Tonight would have been her 80th birthday. This is awsome! Finally researchers are going alll in to fight that awful disease.

[@RebelAlliance42]

@@SuperManning11 my mum was only 59 when she was diagnosed, 69 when she died, so it was glaringly obvious. It's pretty normal at 84, I wouldn't worry too much if I were you ❤

[@catherinegasiorowski8216]

Donated to GiveDirectly. Thanks for sharing the information

[@Al13n1nV8D3R]

This drug makes your heart happy, makes your brain happy and makes your wife very happy. 😂

[@seasonofthewitch4209]

😁 ✌

[@theabristlebroom4378]

Well, I would say it makes Mr. HAPPY happy. 🤣

[@zahirmurji]

The wife would be happy if she took the same drug, otherwise she won’t know if anything happened.

[@MaryAnnNytowl]

Nice, Hank. Nice. 😁 Great jumps forward in two different big questions! 👏 👏 👏 👏 👏 News like this makes me happy to hear, and I could surely use stuff to make me happy, anymore!

[@spiderman233]

"Is that a banana in your pocket or are you happy to see me?" "Just my alzheimer medicine"

[@montycantsin8861]

Thats an antijoke. Grim.

[@vonakenyon7981]

My father had dementia from Alzheimers which made him even more obnoxious than he had been for 80 years. I was stuck looking after him because our family lawyer refused to help me get him admitted to a facility. I actually envy people who end up looking after someone they loved. At least they have some great memories.

[@andysgreif]

I love that Hank threw in a low key "nice" with the 69% statistic. Noiceee

[@oalfodr]

Congratulations for reaching 6.9 million subscribers. Nice

[@lucidmoses]

If they figure out how they regrow a head then maybe down the road this could help for some politicians. :p

[@montycantsin8861]

Correction: ALL politicians

[@gotaylor]

Hope this works out, one strike against it is that Sidenafil is off patent so no big pharmaceutical company will step up to fund a multi year study costing tens of millions of dollars.

[@willkelly86]

One minor nitpicky detail, but the blue pill in the thumbnail has 8,000mg stamped on it which is 80 times the maximum dosage for Sildenafil and likely enough to cause blindness, cardiovascular events and/or death.

[@TheYeetedMeat]

ok

[@SuLokify]

Also for 8 grams that's a super dense pill

[@popcorn200213]

I had to pause the video to laugh when Hank said Viagra reduces the risk of developing Alzheimer's by 69%. Because I am, in fact, still 12 years old in my soul

[@dawnofapril3055]

I want to know where Hank got that jacket. It's really cool!

[@martinbremer2164]

Sent this to my mom bc my grandma has Alzheimer's. Now I'm thinking she's gonna be pretty confused by all the stuff about hydra

[@ryanmcfall1127]

69%? you can't make this stuff up ;)

[@aaronadams376]

Nice

[@kataseiko]

Alternative interpretation of the data: People who have errectile dysfunction have a lower chance of developing Alzheimer's. Also likely: The number is possibly lower than 60% due to people forgetting to place insurance claims.

[@unclescar5616]

Viagra: Healing two heads with one pill

[@WesNoStress]

I’m weak 😂 😂🤣

[@PrivateUsername]

Hail Hydra! Also, Nice.

[@Virtuous_Rogue]

I want a SciShow episode explaining Hank's NASA jacket.

[@kaypgirl]

It's on his Tiktok. He got it from someone on TikTok, whose dad designed the jacket for NASA, and they got some and had an extra. She (daughter) follows him on TikTok and offered it to him.

[@Virtuous_Rogue]

@@kaypgirl Thanks!

[@kalvinlabuik3366]

Oh yes I remember studying Hydras when I was kid in school

[@MandrakeFernflower]

It's also used for treating severe altitude sickness

[@stonerman15]

Interesting!

[@OtakuUnitedStudio]

So it's panacea for the Mile High Club?

[@csn583]

@@OtakuUnitedStudio Only if your airplane has depressurized, in which case you should probably make good use of the time you have left!

[@somnorila9913]

Talking about hydra that regrows their head made me remember that Men in Black part with the alien pawnshop owner who regrows his head when they shoot it off. Could be interesting a movie around that kind of idea where some aliens called "hydra" have imbedded in human society or something.

[@ryanryan3220]

I hope Sildenafil is a 1st step to treat Alzheimer's disease.

[@mashobane9982]

Having your mind fully working blood pressure low and erectile dysfunction gone sounds like a good combination to me

[@h7opolo]

0:40 "this is medication for ED, one reason it's hard..."

[@brettbreet]

No more sitting on Grandpa's lap!

[@hpdftba]

My good friend lost his wife to Alzheimers when she was still in her 40s. It sucked to watch him go through that

[@simpleasmed2341]

It can be really though for the family. In such young patients it may be genetic alzheimers, it manifests in younger persons and the family can have multiple cases.

[@selfdiscardedkingofruin7291]

Who says you can't teach old pills new tricks?

[@MeanBeanComedy]

I wonder if this also works for Tadalafil and Vardenafil.

[@scotlandghost]

When you think that you've clicked on the video's thumbnail because you expected a video entirely focused on the thumbnail image.... And end up realizing that it is a lot more complicated than that.....

[@sebastiannitu6928]

So viagra, first used as a medicine for blood presure and now a pill for getting it hard, could be used for alzhimer's? So old people could get a 3 in 1 pill?

[@poietes7337]

That is an incredibly well executed study. Speaking only for myself, with each successive birthday that moves me closer to that dreaded part of life most often associated with alzheimers and other major system disorders, any time I forget a word or why I entered a room, I have a quick moment of dread: Is this the first sign of something worse? It's not a good feeling.

[@briansmith9439]

There's a well-documented study in a convent population (I believe in PA) in which the nuns had an inordinately high amount of plaques and tangles, yet none (pun not intended) showed any signs of mental health problems; on the other hand, there are some patients with a dx of Alzheimer's who have the brain autopsied after death (obviously) that don't show either change ... I think that one-third of people diagnosed with Alzheimer's don't show plaques or tangles either as found on observational studies (or, that's the number around 1995) ... so your comment about doctors not knowing the cause certainly is correct.

[@picksalot1]

Though the tentacle end is called the "head," it is misleading to what is usually thought of as a "head." "Hydras have two significant structures on their body: the "head" and the "foot". When a Hydra is cut in half, each half will regenerate and form into a small Hydra; the "head" will regenerate a "foot" and the "foot" will regenerate a "head". If the Hydra is sliced into many segments then the middle slices will form both a "head" and a "foot"." "The nervous system of Hydra is a nerve net, which is structurally simple compared to more derived animal nervous systems. Hydra does not have a recognizable brain or true muscles. Nerve nets connect sensory photoreceptors and touch-sensitive nerve cells located in the body wall and tentacles." Wikipedia

[@_CinnamonKitty]

*This one neat trick will make your... brain resist Alzheimer's...?* Who's writing this script, anyway!?!

[@nathanramstorf1033]

May show my age a little but I laughed at the irony in posting this video same week Bob Dole is in the headlines. RIP

[@jakuburban6289]

How awkward would it be to pop you Alzheimer’s pills every morning around your family

[@sunny.g5070]

literally had an exam on this today, you could of uploaded this this morning 😭

[@CarolinaBloomquist]

Oh great even more of a reason for my husband to want marital relations more often. 😂

[@devinbramlett9069]

I appreciate the “nice”. Also, isn’t it a bit strange that a drug that helps with erections is correlated with 69%

[@JoeARedHawk275]

It might’ve been off by a fraction of a percent, but 69% is just like the cherry on top lol, easy to memorize

[@MichaelJLong]

You gotta believe when the research team did the math, they looked at each other and said… “nice” 😂

[@brandondavidson4085]

I would like to see how much is correlation and how much is causation. Maybe older men who are more "active" tend to not develop Alzheimer's?

[@2Balls2Furious]

Exactly, men with dementia don’t need sildenafil. Not really a breakthrough. It’s like saying that driving cars is linked to a reduction in dementia risk.

[@framerate3x3]

So you're telling me my bluechew subscription is helping me stave off Alzheimer's and keeps my game turbocharged? Say less

[@BigMobe]

I want Hank's jacket. Did anyone notice the 8000mg dose in the thumbnail?

[@peterjeffery8495]

The lesson here is to not go gently...or softly, into that good night. Rage RAGE against the dying of the light but before you do pass me one of those little blue pills. BTW does Tadalafil have the same benefit/effect? Some of us prefer Pepsi to Coke.

[@ArnoldLayne92]

I love the two-topic videos! I would also love some communication in the thumbnail or title relating to it though, as there are some video titles and thumbnails that wouldn’t interest me (based on the first story only bring mentioned) but I might be interested in the second story!

[@jamesfarrell8339]

I love the jacket Hank Go NASA

[@DemonXeron]

Nice

[@KiwiFrute]

Nice

[@beautruex7012]

Whoa 😳 glasses guy gained some weight! It is bulking season; but I wanna see him SHREDDED by spring!

[@sherry356]

I was scared that I had Alzheimers... turns out it was the long-term effects of taking pregabalin (Lyrica), which destroys your memory and prevents the growth of new neurones and nerve connections.

[@zhadoomzx]

The thumbnail shows an image with a blue pill and the inscription "8000 mg". That's 8 grams. A sugar cube is ~3g. I find it hard to imagine that a pill that small contains 8 grams of an active ingredient.

[@chatheboosted]

hehehe 69% nice! and they threw in the "NICE" meme in there too kekeke

[@MichaelJLong]

“NICE!” 🤣🤣🤣

[@uprightape100]

Harrumph. Hydras deserves their own vid.......hiding them behind some boner-pill clickbait is insulting to ALL Cnidarians.

[@IsomerMashups]

Finding the cure to Alzheimer's will take _long and hard_ work.

[@matthewsimonwilson3]

Sildenafil - treats vasculitis - increases blood flow amyloid plaque due to glymphatic error - blood proteins not being cleared out vasculitis via cryoglobulinemia - unstable blood cells sensitive to changes in heat - increased predisposition to bacterial/fungal infections infections result in toxic levels of Aldehydes which deposit in the brain from the brain stem (blood brain barrier) outward - often mistaken as drug and alcohol abuse also sildenafil may work as a treatment for vasculitis it may also put dangerous pressure on your heart if the underlying cause of amyloid plaque is not considered.

[@Ryalnotch]

What do you mean put dangerous pressure on the heart? also do you think something like vardenafil would work even better considering it being less selective?

[@matthewsimonwilson3]

@@Ryalnotch both will affect QT interval time

[@matthewsimonwilson3]

look at Long QT syndrome

[@Ryalnotch]

@@matthewsimonwilson3 I can't seem to find any human studies showing effect on QT interval, only one fidning no effect and animal models showing possitive effects of PDE5 inhibition on arrhythmia.

[@matthewsimonwilson3]

@@Ryalnotch probably should have said Both "may" affect QT. Vardenafil has been noted for it it has generally been dismissed for Sildenafil. but I would still issue caution. As a sufferer of Long QT syndrome myself I have to be extra vigilant with medication. Personal experience of Sildenafil producing the same heavy heart pounding that I also experience with Rizatriptan (migraine medication) is the only thing that drives me to issue caution. not to seem extra knowledgeable on the subject. I wouldn't want anyone to have a bad reaction.

[@WoshemenGaming]

How did the study control for depression? I have seen some articles link depression to AD as well.

[@memesoft5604]

A genuine question I have is what is being done about prevention for Parkinson’s disease and the dementia related to it? Theres isn’t a cure, just care, much like Alzheimer’s

[@lohphat]

I’m curious but need to see the hard data. I’ll show myself out.

[@MoritzvonSchweinitz]

Could someone explain to me how this Sildafenil/Alzheimer correlation hasn't been found a long time ago? I would've guessed that we already have a bunch of algorithms trying to find interesting correlations in huge datasets (including medical ones) 24/7 ?

[@jhonbus]

Sildenafil has been around for about 20 years. I guess the main age bracket that gets boner problems is about 20 years younger than the main age bracket that gets Alzheimers.

[@Infernoraptor]

Simple, if we don't know the actual cause of a disease, how can we say that " this person would have gotten Alzheimer's if not for ____". Plus, big data studies are also hard to do quickly. We've only started getting a sense of the potential causes of Alzheimer's in the past decade, let alone any sort of ability to say who is at risk beyond guessing from family history.

[@phenethylamines]

We don’t actually have algorithms doing large scale searches like that because stats are hard. This paper is a collection using a case-control format which is, in the grand scheme of things, quite a weak study design. Studies like this have a easy time finding associations, and a hard time controlling for confounding variables. So for example, it’s possible that this association only exists because people with erectile disfunction have other health problems which could lead to death prematurely to the age they would’ve developed Alzheimer’s. But you’d not be able to know that information due to the limits of the study design. Edit: and I should add, the abstract blatantly states that the investigators are aware that their result is not indicative of a causative relationship, and they recommend a randomized control trial. This is nice and all, but VERY unrealistic; RCT’s are just too inefficient for rare outcomes like Alzheimer’s, it’s almost certain that this is one of those times where you see a video about an exciting development, but never hear about it again.

[@lenabreijer1311]

Studying big datasets is a new thing. It is not easy because the trials are not looking for the same things, use different terminology sometimes and things just don't always mish. Also it requires large amounts of computing power, knowledge of statistics, programming skills and the right algorithms and money, lots of money. Then there are the privacy issues with access.

[@efeghilmffdsee5216]

@@phenethylamines Rare outcome? Alzheimer's disease is most common in people over the age of 65. The risk of Alzheimer's disease and other types of dementia increases with age, affecting an estimated 1 in 14 people over the age of 65 and 1 in every 6 people over the age of 80. It is terrifyingly common for such a debilitating disease. It is also the main cause of dementia in general at around 80% of causes.

[@markmcrae2704]

Hank that jacket is absolute 🔥

[@lordgarth1]

It’ll keep gramps from rolling out of the bed.

[@OtakuUnitedStudio]

Oh wow

[@grrrgrl101]

I have hope❤️

[@clearwater1231]

69% lol

[@aaronadams376]

Nice

[@code6505]

I don’t know... Maybe if they stop ruining our foods.. We wouldn’t have to worry about it. In the end.. ALL ROADS POINT TO MONEY!!!! 💰💰

[@doctorlovera]

So... sildenafil is a molecule made to reduce cardiovarcular risk but now it can make remember easier despite of being use to make something harder??? Just kidding. These are great news. I hope this leads to a real breakthrough. Alzheimer is a devastating desease.

[@spointz8936]

Hm.. wonder if Cialis and its generic variants would have similar benefits 🤔

[@iLoveBoysandBerries]

This is why Hugh Hefner never forgot a thing