Olink Podcast | Ep 18 Pan-cancer blood proteome profiling with María Bueno Álvez (SciLifeLab)

Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources from this episode:
Published study of primary focus
Álvez MB, et al. Next generation pan-cancer blood proteome profiling using proximity extension assay. Nat Commun. 2023 Jul 18;14(1):4308. doi: 10.1038/s41467-023-39765-y. PMID: 37463882; PMCID: PMC10354027. pubmed.ncbi.nlm.nih.gov/37463...
Laboratory, first author, and corresponding author of the study
• SciLifeLab, a collaborative resource for life scientists located in Sweden: www.scilifelab.se/
• María Bueno Álvez (first author), PhD student, Science for Life Laboratory (SciLifeLab): / mar%c3%ada-bueno-%c3%a...
• Dr. Mathias Uhlén (corresponding author), Professor of Microbiology, Royal Institute of Technology (KTH), Leader of the Human Protein Atlas, Founding director of the Science for Life Laboratory (SciLifeLab): www.kth.se/pro/sysbio/uhlen-g...
Olink tools and software
• Olink® Explore 1536, the platform that measured proteins in this study with a next-generation sequencing (NGS) readout: olink.com/products-services/e...
• Olink® Explore HT, Olink’s newest solution for high-throughput biomarker discovery that measures 5300+ proteins simultaneously with minimal sample consumption: olink.com/products-services/e...
• Olink® Insight, an open-access resource to accelerate protein biomarker discovery: insight.olink.com/
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date
• Published article: Styrkarsdottir U, et al. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. 2023 Apr;75(4):544-552. doi: 10.1002/art.42376. Epub 2022 Dec 28. PMID: 36239377. pubmed.ncbi.nlm.nih.gov/36239...
• UKB-PPP website: www.ukbiobank.ac.uk/learn-mor...
Analysis of UK Biobank proteomics data from cancer patients, with co-authors including Ruth C. Travis, Karl Smith-Byrne, and Joshua R. Atkins
• Preprint article: Papier K, Atkins JR, Tong TYN, Gaitskell K, Desai T, Ogamba CF, Parsaeian M, Reeves GK, Mills IG, Key TJ, Smith-Byrne K, Travis RC. Identifying proteomic risk factors for cancer using prospective and exome analyses: 1,463 circulating proteins and risk of 19 cancers in the UK Biobank. medRxiv 2023.07.28.23293330; doi: doi.org/10.1101/2023.07.28.23.... www.medrxiv.org/content/10.11...
U-CAN Biobank, a prospective biobank of cancer patient biomaterial in Sweden
• Glimelius B, et al. U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta Oncol. 2018 Feb;57(2):187-194. doi: 10.1080/0284186X.2017.1337926. Epub 2017 Jun 20. PMID: 28631533. pubmed.ncbi.nlm.nih.gov/28631...
Galleri GRAIL test, a blood-based test that detects a biosignature shared by over 50 cancer types: grail.com/galleri-test/
Genotype-Tissue Expression (GTEx) project, a biobank and open-access database to study tissue-specific gene expression and regulation: www.gtexportal.org/home/
Human Protein Atlas (HPA), a Swedish-based program with the aim to map all human proteins using an integration of various omics technologies and provide these data freely available to the scientific community: www.proteinatlas.org/
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In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here: bit.ly/3Rt7YiY
For any questions regarding information Olink Proteomics, please email us at [e-mail] or visit our website: www.olink.com/
WHAT IS PROTEOMICS IN PROXIMITY?
Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.