Oreos Lower Cholesterol More Than Meds | Educational Video | Biolayne

  Рет қаралды 46,302

Dr. Layne Norton

Dr. Layne Norton

Күн бұрын

Survey paper: pubmed.ncbi.nl...
Case study: pubmed.ncbi.nl...
Oreo vs. Statin case study paper: pubmed.ncbi.nl...
Triglycerides are a risk factor for Heart disease: pubmed.ncbi.nl...
Insulin can lower LDL: pubmed.ncbi.nl...
LDL is a causative risk factor for LDL cholesterol in Mendelian randomization trials: pubmed.ncbi.nl...
Small LDL particles more easily penetrate the endothelium but they deposit less cholesterol, LDL particles still penetrate the endothelial but deposit more cholesterol. The net effects is no difference in atherogenesis: pubmed.ncbi.nl...
Get my research review REPS:
biolayne.com/REPS
1 on 1 Coaching www.biolayne.c...
Get my new nutrition coaching app, Carbon Diet Coach: onelink.to/9h4d62
My research based supplements: www.outworknutr...
Get my books on how to lose fat: www.biolaynesto...
Take my online course "The Science of Nutrition": chfi.click/lay...
Get Custom Workouts by me for $12.99/month:
biolayne.com/w...
/ laynenorton
/ biolayne
/ biolayne

Пікірлер: 527
@jordanmcneely95
@jordanmcneely95 7 ай бұрын
Skipped the video, went straight to the grocery store. Thanks doc!
@TheFracturedfuture
@TheFracturedfuture 6 ай бұрын
Lmao funny.
@realDaveFeldman
@realDaveFeldman 7 ай бұрын
Hi Layne - thank you again for your interest in our research. While I’ll do a more thorough breakdown at a later point in time (currently on a research trip), I would like to again emphasize a crucial component of the LEM is that both higher VLDL secretion is *coupled* with increased lipoprotein lipase turnover. Triglycerides are indeed a good proxy for VLDL that has yet to be turned over. But the LEM isn’t looking to only greater secretion, it is emphasizing the extremely high relevance of the turnover itself which is part of why you see higher HDL cholesterol as well. Again, we would love to come on and chat about it more at length to better explore this model for what it proposes.
@classicgameplay10
@classicgameplay10 7 ай бұрын
What in blazes does that even mean.
@donwinston
@donwinston 7 ай бұрын
You are out to lunch.
@Sam-jn1fz
@Sam-jn1fz 7 ай бұрын
Thanks for all you do Dave! Can't wait for lmhr study this year on plaque.
@scotbradesteems
@scotbradesteems 7 ай бұрын
What about LEM decreases the risk of ApoB? Even if turnover of any given particle is higher, endothelial intrusion is a diffusion process so concentration dependent, not dependent on the lifecycle of any given particle (the probability is not dependent on the history of a particle).
@realDaveFeldman
@realDaveFeldman 7 ай бұрын
@scotbradesteems The LEM is seeking to explain this phenomenon in the context of high LDL/ApoB where seemingly metabolically healthy, fat-adapted. The specific risk association of high LDL/ApoB in this context is what we're researching with the LMHR Study out of Lundquist.
@billiecomeaux
@billiecomeaux 7 ай бұрын
I watched Nick Norwitz's video on this. It that this was done specifically to start a conversation among researchers at large.
@ArcoZakus
@ArcoZakus 7 ай бұрын
It seems to be doing that. ( 4:16 )
@ArcoZakus
@ArcoZakus 7 ай бұрын
@@erastvandoren, "… then he can show us his biomarkers." He did show us the only one he was interested in for this experiment -- LDL-c. It took less than "at least a couple of weeks on Oreos" to see the effect on that one, so why should he be concerned about any others? If he was not, why are you? (Have you even seen his video explaining what this was all about?")
@ArcoZakus
@ArcoZakus 7 ай бұрын
@@erastvandoren, So design and conduct a study to show the effects you are interested in. I would still suggest that you watch (or re-watch) Dr. Norwitz's video where he explains his intent for his experiment.
@justinkoeckritz8273
@justinkoeckritz8273 7 ай бұрын
​@erastvandoren you must not be a LMHR, it's okay fatty
@jimmymuthami7130
@jimmymuthami7130 7 ай бұрын
there is nothing to watch in Norton's videos then. Firstly, Layne himself admitted to errors while replying to this and suggested it's because he was dealing with his mother's surgery. Which is awkward because he sells Data>Feelings and yet he uses feelings to try to explain his deficiencies. As someone who follows the science myself, there is a reason why I follow both these guys, because getting 2 opposing views is essential for science. In fact I got to know Norwitz because of the study, bravo to him for using Oreos, that was provocative of him and it brought out the attention. Norton refusing to debate Norwitz is proving frustrating because I need to hear both opposing views with arguments for each. I didn't want to say this, but on this, as even Layne points out so clearl, Norwitz has his science and data correct, and we science followers should try to see beyond the superficial data and get beyond. Because that study raises more questions. And I appreciate even Layne saying the study raises questions. If Layne and his character sees the study as important, I wonder what type of person you are, really.@@erastvandoren
@dpandey5560
@dpandey5560 7 ай бұрын
All this suggests that there is some aspect of the lipid metabolism mechanism that is currently not understood. Developing that understanding may help develop for the whole population, not just the lmhr, more optimal treatment options and nutrition.
@ArcoZakus
@ArcoZakus 7 ай бұрын
Yes. It seems odd that so many people would be so resistant to that.
@srleplay
@srleplay 7 ай бұрын
My insurance won't cover Oreos, thanks Obama
@JoeS97756
@JoeS97756 7 ай бұрын
need to get a prescription from your doc ;-)
@saintjulien6126
@saintjulien6126 7 ай бұрын
​@@JoeS97756😂😂😂He is joking about insurance.
@saintjulien6126
@saintjulien6126 7 ай бұрын
😅😅use Medicare!
@SandyBee21
@SandyBee21 7 ай бұрын
😂
@JoeS97756
@JoeS97756 7 ай бұрын
@@saintjulien6126 I know, as was I. lol
@AaronWilton
@AaronWilton 7 ай бұрын
Thank you for the balanced review and the ability to say "I don't know," it's why I am a big fan and keep coming back to this channel!
@christopherhansen3449
@christopherhansen3449 7 ай бұрын
Just wanted to thank you. I am a senior at UNLV in Nutrition/Dietetics field. Trying to take on a second major in Biochemistry. Everytime I feel overwhelmed by the stuff I am learning, or the stuff I feel like is way over my head to learn. I watch one of your videos and realize this is how it is done and it is going to take me a while to learn how to get to this point. Thanks
@caseykellyfit
@caseykellyfit 7 ай бұрын
I find this video extremely interesting because I would actually have been eligible for the study. Got bloodwork 1 week out from my show last April around 6-7% body fat and had been on extremely low carb for many weeks prior (obviously). Total cholesterol was near 400ng/dL
@caseykellyfit
@caseykellyfit 7 ай бұрын
mg/dL*
@1996sarvesh
@1996sarvesh 2 ай бұрын
Yea buddy, I think eligibility criteria also includes you need to be "natty". You cholesterol is sky high not because you're a LMHR, you're using PEDs 😂
@athiker111
@athiker111 5 ай бұрын
This was a sensible response to this study. I fit the LMHR profile after being low carb high fat for about two years. Started out this journey obese with diabetes. Eating this way has put my diabetes into remission but my LDL is over 200. Adding back carbs will probably drop my LDL but push my glucose levels back up. Seems like a no win situation.
@tarahines993
@tarahines993 7 ай бұрын
I used to do low carb (and I was one who thought it was "magic" somehow). Luckily, I have a super smart doctor (happens to be a powerlifter, too) who geeks out on nutrition and studies as much as I do. For the past 6 years or so, he has done lipid panels on me every three months, and back when the lean mass hyper responder stuff was trending and the small vs. large particle cholesterol was a big thing, he even checked my particle size. No matter what I did, even at a healthy to lower weight, my cholesterol was just high (close to 300). Consuming less saturated fat in favor of olive oil, etc. didn't help much. His advice was spot on, I think-- if I stayed at that level for a short time and being low carb helped me lose weight, it was okay. But I shouldn't stay there long term because high cholesterol is a proven mortality risk factor. He suggested I go up to moderate carb-- just taking carbs to around 100 instead of 20-40, and that significantly dropped my cholesterol levels. It's anecdotal, but I 100% believe that eating more carbs is what dropped my cholesterol levels. I'm not sure why, but it made a huge difference for me. I haven't done low carb in about three years. Now I track and eat a "balanced" diet. Not everyone is like me, but I'm definitely healthier for it. My cholesterol, while still on the high side, is not dangerously high and not high enough for a statin yet. Thanks for the video-- I'm sending it to my doctor!
@taylorhillard4868
@taylorhillard4868 7 ай бұрын
I wouldn't be surprised if it was because of fiber. Soluble fiber is useful for the body to shed excess cholesterol. And high fiber diets are often considered to be overall quite healthy.
@jrennickemd
@jrennickemd 7 ай бұрын
Sounds like an awesome doctor!
@jassy0903
@jassy0903 7 ай бұрын
Thank you for your comment! I'm a nutrition student and we have spent a lot of time on this issue. The fiber found in carbohydrates have a wonderful ability to help lower LDL by binding to it so it can be excreted from the body. That's likely what happened for you. I'm glad you were able to find a good balance.
@carinaekstrom1
@carinaekstrom1 7 ай бұрын
There are so many vegans with LDL of 50-70. So carbs definitely help.
@SandyBee21
@SandyBee21 7 ай бұрын
@@taylorhillard4868I agree. My TC was 8.0 ( New Zealand values). 1 month on high fibre foods with very low saturated fat and it dropped to 6.6. On whole foods. No statin yet ( I do have Pattern B) and hope its continuing its downward trajectory
@naelna
@naelna 7 ай бұрын
I was LMHR. LDL 400. I just added some carbs, remained low carb but not Keto, LDL dropped back. I think this is the way to go if you don't need Keto for a medical condition
@Hinz2005
@Hinz2005 7 ай бұрын
I am fit the LMHR description to a "T". I was VLC/Carnivore for several years. I am lean (F/40 with bicep/shoulder vascularity, approx 18% bf). My triglycerides were well below 70 (usually 45-50), HDL sits around 108, but my LDL was creeping up, up, up; eventually hitting the high 300's. I track macros (using Carbon), so I flipped the fuel from fat to carbs and my LDL dropped so fast! Within 3 weeks, I was just a few points over the high end of ref range. My fasting/am BG barely bumped up from high 70's to low 80's and I feel more secure with better numbers. Also, my trigs and HDL have stayed the same. I agree that this possible phenotype may do perfectly fine on a LC diet, but I argue, much like Layne does here, that the shifting of fuel sources may serve us well. I'm enjoying the rice and bread, I must say.
@bcjammer87
@bcjammer87 7 ай бұрын
I fit LMHR as well after years of high fat keto/carnivore diet. 37 year old male very muscular and fit with 10% BF. Blood markers very similar to yours. I’ve tried reintroducing carbs around workouts with some success but beyond 100g/day gives me awful brain fog. I just feel so damn good without carbs I’m torn on this. Really hope some more conclusive data comes out soon.
@Eric3Frog
@Eric3Frog 7 ай бұрын
Has your weight training performance increased since you brought carbs back in?
@RomDoctor
@RomDoctor 7 ай бұрын
Can you say something about your performance and hormonal levels? Did they change? How do you feel better?
@RomDoctor
@RomDoctor 7 ай бұрын
@@bcjammer87can you say something about your performance and hormonal levels in both situations? How do you feel about?
@nobodysfan
@nobodysfan 7 ай бұрын
@@bcjammer87have you tested possible food sensitivities? Not all carbs are equal.
@dkeener13
@dkeener13 7 ай бұрын
so, I come from the low-carb tribe, but this discussion is actually very well done, very fair, and one of the best layman's explanations of this topic I've heard.
@rixxlx
@rixxlx 7 ай бұрын
You mean, Layne-man's explanation! Aha! 😂
@mochageico
@mochageico 7 ай бұрын
nice one bro hah@@rixxlx
@slavbarbie
@slavbarbie 7 ай бұрын
You mean explanation to a layman? Because Layne-man is not a layman.
@_negentropy_
@_negentropy_ 7 ай бұрын
THIS WAS AMAZING! I have a wicked nerd-on. Also I think your response to the hot takes is closer to “data + feelings”…I’d buy that t-shirt in a heartbeat.
@kathykennedy6137
@kathykennedy6137 7 ай бұрын
I have very weird digestive issues. I am extremely intolerant to starch and complex carbs are almost as problematic. We are talking massive blood loss. Trying to eat a “heart healthy” diet and resulted in my weight dropping down to 99 lbs, hair falling out, restless legs, and extremely low tissue iron. I went low carb once I realized starch was the main problem. At one point my cholesterol was over 500 when I was very low carb, almost carnivore. I had my arteries scanned four years ago and my calcium score was ZERO. I got concerned when my triglycerides were high a few years ago. I weigh 120 lbs now. Gastroenterologists were ridiculously unhelpful and I figured this out on my own. Like Layne said, some of us are just unicorns and standard advice makes matters worse. Last fall, I reluctantly tried a statin, and even on half the dose, I felt like a zombie, so I stopped. I added simple carbs, mostly in the form of honey and maple syrup. Occasional coconut flour and wheat bran,but I eat very little fiber and feel better that way. I am not into any nutritional dogma or diet culture. I will eat anything that I can digest without symptoms. I can’t tolerate “healthy” fats like nuts, avocados, olive or canola oil. I cut back on added fat in general, but do full fat diary because my mood and energy suffer if there is nit enough fat in my diet. My total cholesterol last time was 300, HDL and triglycerides both were 70. At age 66, I strength train, walk, and run as much as my twitchy insides allow, and consider myself very healthy.
@kathykennedy6137
@kathykennedy6137 7 ай бұрын
Dairy, not diary. Oops
@kostisapostolidis1821
@kostisapostolidis1821 7 ай бұрын
Calcium score is a late-stage finding. If you find calcium you are very close to a hear attack.
@troy3423
@troy3423 7 ай бұрын
You should probably go see a Dietitian
@kathykennedy6137
@kathykennedy6137 7 ай бұрын
@@troy3423 LOL. Go to a dietitian? Wow, I NEVER thought of that. Or probiotics. Or prebiotics. Or fiber. Or yogurt. Or butyrate. Or kombucha. Or other fermented foods. Or FMT. (Fecal microbiota transplant) Or low salicylate. Or SIBO. Or bone broth. Or any other suggestion that presumes I am uninformed and have not already tried everything and was left to manage this problem with no assistance from “experts.” Because someone has an RD after their name, are they gonna wave a wand and render me able to suddenly digest the things I cannot? Telling me to eat things I cannot digest won’t fix the problem. I once asked a dietitian for help with a low FODMAP diet and she had never heard of it. Fired more gastroenterologists than most people have seen, because the only thing they do is give you the same canned advice, over and over again, even after you have reiterated that you have ALREADY TRIED THESE THINGS and THEY DO NOT WORK. The worst was the time I was in the ER for uncontrollable hemorrhaging and the advice was to “eat more fiber”. Or perhaps the time a doctor put me on medication for intestinal cramps and I could not swallow as a result, and when I reported that she said she hoped I would not stop the drug because that was not a side effect. I stopped the drug, regained the ability to swallow, and needless to say, didn’t waste my time with her again.
@kathykennedy6137
@kathykennedy6137 7 ай бұрын
@@kostisapostolidis1821 my score was zero.
@BrainsandGainsPodcast
@BrainsandGainsPodcast 7 ай бұрын
LMHR here. LDL went to 200+ on keto and 300+ on carnivore. HDL, trigs, etc were perfect.
@BestLifeMD
@BestLifeMD 7 ай бұрын
Eat some carbs
@MmartinL
@MmartinL 7 ай бұрын
It is not shown whether this high LDL is harmless. Maybe it is healthier if you had a lower LDL by eating some carbs.
@BrainsandGainsPodcast
@BrainsandGainsPodcast 7 ай бұрын
@@MmartinL I think that is likely correct. I do not eat this way now, I was just experimenting with those diets to see how I responded.
@TravisH-nm9fy
@TravisH-nm9fy 7 ай бұрын
@@MmartinL The lower you can get your LDL the better.
@matthewtrout1440
@matthewtrout1440 7 ай бұрын
@@MmartinL On the other hand, if some carbs lead to elevating A1C, that could be bad too. It'd be nice to have low glucose/cholesterol/triglycerides, but it seems nearly impossible for some people to get all three in the low range unless they have great genetics. I can choose to lower either cholesterol or glucose, but not both. Triglycerides are low no matter what.
@jassy0903
@jassy0903 7 ай бұрын
I have also seen a scenario like this with someone that had low triglycerides, highish HDL, high LDL, lean and fit that worked out. She was in my ER having a massive MI. Seeing skinny "fit" people having heart attacks made up my mind about LDL a long time ago. I can't for the life of me understand why anyone can sit with these numbers and feel okay with it
@LucidAmethyst
@LucidAmethyst 7 ай бұрын
That doesn't mean the high LDL caused the MI. That's like saying you can't be involved in a car accident if you're not in a car. The idea of the study is to eventually disprove that LDL is a factor with the calcification of arteries leading to heart disease. There are many factors that can lead to a heart attack, and it isn't just heart disease. As there are other studies that show high LDL is associated with longevity, I am very interested to see where this study of LMHR's goes.
@cantstopthefunk22
@cantstopthefunk22 7 ай бұрын
Did she happen to be vaccinated
@jj900
@jj900 7 ай бұрын
​@@LucidAmethyst that wasn't the point of the study. Its stating that there is a subsection of the population, lean people on extremely low carb diets, who use LDL as a transporter in the lipid energy model. There is a hope that that does not lead to coronary plaque. However we know for certain that LDL is involved in the pathogenesis of coronary plaque development. It's not the only factor I agree.
@InfiniteQuest86
@InfiniteQuest86 7 ай бұрын
@@LucidAmethyst You are wrong. I don't think they have any intention of trying to prove anything like that. They only care about LMHR. I'm also unaware of any study showing high LDL is associated with longevity. If you mean that there is data collected where old people developed high LDL and then died because of a ton of other factors, then yes that probably exists. Did they have high LDL their whole lives and that's why they lived long? No. Just look at people with Familial hypercholesterolemia. They tend to have cardiac events very young. They did not live extra due to high LDL. They died very young. It makes no sense to say high LDL is associated with longer life when all the data shows otherwise.
@TasteOfButterflies
@TasteOfButterflies 7 ай бұрын
​@@LucidAmethystafaik the association between high LDL and longevity is due to diseases like cancer, hepatitis, malnutrition etc which among other symptoms cause lower LDL. When researchers take care to exclude subjects with undiagnosed diseases from prospective studies, the association between high LDL and longevity disappears.
@hanvo3522
@hanvo3522 7 ай бұрын
I'm a physician, and this is my 2 cents based on what I know. LDL-C, VLDL-C, and even ILD-C are all just circulating lipids on a spectrum with different sizes and compositions, but in essence they are all just 1 apoB particle with different lipid composition. And there are people with low LDL-C on treatment but still have a residual CVD risk, and these in patients the residual risks are somewhat explained when used nonHDL-C or apoB (there are studies if I remember correctly). There are also patients who are insulin resistant who have low LDL-C because this population has very small lipid particles rich in triglyceride. What I think happened in this study is that person increase calories and carb intake, which elevated other components of his lipid profile (triglyceride in particular), causing most of his lipoprotein particles to become smaller and shifting the cholesterol concentration into other non-LDL particles. I think additional information about his total cholesterol and non-HDL-C will probably help, both of which I think will either elevate or stay the same (meaning same CVD risk). I would love to hear your opinion about this hypothesis.
@reynmike
@reynmike 7 ай бұрын
Layne, please don't lump Nick and Dave in with all low carbers. Your video is implying that Nick/Dave are recklessly going rogue and making firm conclusions out of this. I think you know better. Nick and Dave have many of the same concerns.
@robert111k
@robert111k 7 ай бұрын
For those LMHR individuals who are concerned about their high LDL, this information comes from another case experiment (mine). A minimal dose of Rosuvastatin (5 mg) along with a minimal dose of Ezetimibe (5 mg; in my country, they only sell 10 mg dose pills, so I have to cut them in half) reduced my LDL from around 220 to around 40 mg/dL (the actual numbers were 218 and 43). Initially, using Rosuvastatin (10 mg) alone, I reduced it to 121, and in a first attempt of combining Rosuvastatin (5 mg) and Ezetimibe (10 mg), the resultant LDL was 38. BTW, I suspect that LMHR individuals are not so much 'unicorns'. I, who am not a particularly social person, know several.
@robertdaymouse3784
@robertdaymouse3784 7 ай бұрын
I do similar, 7 mg simvastatin and 3mg Ezetimbe and 500 mg L Carnitine (for LP(a)). But I do not get anywhere near the reduction you do, I am at about 60-70mg/DL LDL. Mine started at 60 then bounced up to 70 six months later, I would expect yours will do the same.
@robert111k
@robert111k 7 ай бұрын
@@robertdaymouse3784, maybe the Lp(a) is the point. Mine is below 1. Or maybe not. I have bloodwork scheduled for next week. We'll see.
@robert111k
@robert111k 7 ай бұрын
@@robertdaymouse3784 Maybe the point is the Lp(a). Mine is below 1 mmol/L. Or maybe not. I have blood work scheduled for next week. We'll see.
@Chris_P_
@Chris_P_ 7 ай бұрын
I’m curious why you’d want to take the statins, but not just increase carb consumption a bit?
@robert111k
@robert111k 7 ай бұрын
@@Chris_P_, two reasons. The first one is a matter of control. When you start being permissive with something, at least in my case, it's very easy to slip down the slope. The second reason is that I had digestive issues (gastritis, GERD) that have improved significantly. Besides (I don't know if this is real or just suggestion, but just in case), my concentration and memory have also improved. I don't want to take risks. I'm not afraid of statins and have no side effects, apart from a couple of points increase in AST and ALT, but both are still below 24.
@qe9933
@qe9933 7 ай бұрын
This was one of your best videos yet on an extremely weird study and result!
@omi6816
@omi6816 7 ай бұрын
I think is a pretty Bad one, that on this one he basically tried to insult someone who actually wanted him to collaborate on a ver interesting research. Layne showed that he has no scientific mind on this one . Layne showed that he is too, a zealot
@EpicMotorcycleAdventures
@EpicMotorcycleAdventures 7 ай бұрын
“Supplementation with Oreo cookies” a sentence is never thought I’d hear 😂😂
@robertdaymouse3784
@robertdaymouse3784 7 ай бұрын
The commentary on carnivore channels surrounding these studies is so over the top. And Norwitz does nothing to counter the disinformation, while at the same time marketing directly to those same people.
@ladagspa2008
@ladagspa2008 7 ай бұрын
Feldman and norwitz are grifters
@carolfox4454
@carolfox4454 7 ай бұрын
I think I may fit in this group. I went keto 6 years ago to keep from converting to a full blown diabetic. My LDL went into the mid 200s. Needless to say my Dr. freaked. He has been trying to get me to go on a statin ever since. This year he ran every cardiac test offered in our area. All were normal. Once every two weeks I eat more carbs so that I don't lose my ability to use glucose. Checked my lipids during this time and my LDL was lower as was my HDL. Trigs went up.. '
@stellasternchen
@stellasternchen 7 ай бұрын
If your TG went up significantly in response to carbohydrates maybe you have not fixed the problem with insulin resistance yet. You just treated the symptoms. Which is ok, that‘s what meds do as well. We know that diabetes remission is not caused by cutting out carbs. It has been done on various diets and even happens after weight loss surgery. It is probably due to loosing fat. Why are you so sure your high LDL-C is not harmful and your doctors worries are nonsensical? What harm would be taking meds to be on the safe side? That‘s what I don‘t get tbh. I think it is dangerous to put a study, that excluded every LMHR with plaque and also is lacking a control group above randomized controlled trials and mendelian randomization studies. There needs to be more research to come to a proper conclusion and definitely of higher quality. One big question would be how many of the LMHR do not develop plaque and how many do not and if it’s more then people with low BMI and normal or slightly elevated LDL-C not on a low carb diet. There are people that do get no cardiovascular problems despite high LDL-C and not being metabolically healthy. My grandma for example. LDL-C in the 300eds elevated TG‘s and fasting glucose. No heart disease with 88. So should we not care about LDL-C and metabolic health then? There are always outliers. And a study cherry picking what might be outliers is largely used to depict all of the group. I see that very critical. What‘s also stange is you could predict their studies outcome - plaque does not build up over one year, but several or even decades. Don‘t get me wrong, I‘m fascinated with the phenomenon. But I do not think the lipid energy model is correct. It makes no sense. It proposes that LDL-C is high because of higher traffic of Triglycerides in LDL particles. But triglycerides are very low in LMHR and they do not have much small LDL typically carrying TG’s. No it is the reverse cholesterol transport, that is the issue in my opinion, where HDL but mostly LDL is involved. Both HDL-C and LDL-C increase in LMHR, indicating they are full of cholesterol. Reverse cholesterol transport is increased in fat loss, as not only the stored triglycerides leave the cells. This happens on low carb/keto more then on a carb rich diet. Fat tissue somehow protects from high cholesterol. If you look at BMI and LDL-C, you see only a rising linear relationship up to a BMI of 30, and then even a drop. I bet there is something wrong with the fat tissues in LMHR.
@qdmudong
@qdmudong 7 ай бұрын
Been waiting for this video, thanks, Layne
@AZ89231
@AZ89231 7 ай бұрын
I mean, you know it’s Nick, right? Did you even read the study?
@stargazerbird
@stargazerbird 7 ай бұрын
He was being professional
@AZ89231
@AZ89231 7 ай бұрын
@@stargazerbird or stupid and he didn’t even read the study fully.
@jan1agush
@jan1agush 6 ай бұрын
I tried this myself and it was consistent with their results. On keto I had trippled my LDL and after starting sugar/honey my LDL dropped significantly (almost to baseline). I am relatively lean.
@danielcordeiro6003
@danielcordeiro6003 7 ай бұрын
The definition provided for a Lean Mass Hyper Responder (LMHR) is often misunderstood. It is crucial to clarify that an LMHR is characterized by specific lipid metrics: LDL-C ≥200mg/dl, HDL-C ≥80 mg/dl, and TG ≤ 70mg/dl. This definition is independent of Body Mass Index (BMI) and dietary patterns. Although LMHRs typically exhibit lower BMI and carbohydrate intake, which may intensify the phenotype, per the LEM, it is important to underscore that neither BMI nor diet are criteria for the LMHR definition. Concerning LDL-C exposure, the assertion that solely the exposure to LDL-C or APO-B containing lipoproteins leads to endothelial penetration raises questions. It is essential to consider whether arterial interaction with these particles, potentially for repair purposes, also plays a role. The context of elevated LDL levels in all studies does not account for individuals without lipid metabolism dysfunction. For instance, conditions like reduced LDL receptor activity or impaired APOB100 recognition. However, the individuals in question do not exhibit these dysfunctions. The LEM paper offers an in-depth analysis of this phenomenon. Nevertheless, the absence of studies specifically addressing LMHR individuals leaves a gap in understanding their risk for Atherosclerotic Cardiovascular Disease (ASCVD), a critical concern for those on ketogenic diets for medical reasons, seeking assurance on the relative safety of increased LDL levels. The critique regarding triglycerides (TG) is well-received. While I am not an authority on this subject, I look forward to the authors' response and the ensuing discussion, as they are known for engaging in insightful dialogue. One point to note from this LEM: it identifies three factors that can elevate your LDL levels: 1) Depleting liver glycogen stores. 2) Increasing energy expenditure. 3) Reducing body fat. In essence, possessing a lean physique, consuming minimal carbohydrates, and engaging in extensive physical activity are conditions that elevate the likelihood of higher LDL cholesterol. However, experiencing just one of these conditions may not necessarily lead to an increase in LDL.
@erastvandoren
@erastvandoren 7 ай бұрын
Endothelial penetration? 😅 🤡 Transcytosis of LDL is absolutely normal and happens in everyone.
@davidflorez1196
@davidflorez1196 7 ай бұрын
​​​@@erastvandoren Layne says it in the video..... aging Is normal and happens in everyone, but who wants to accelerate that process??
@yoso585
@yoso585 7 ай бұрын
@@erastvandoren so then, every ldl that passes through is detrimental?
@erastvandoren
@erastvandoren 7 ай бұрын
@@davidflorez1196 yes, we don't want to accelerate LDL transcytosis. That's why we need to keep inflammation, blood glucose and pressure down.
@erastvandoren
@erastvandoren 7 ай бұрын
@@yoso585 Every LDL that crosses endothelium can be gulped down by a macrophage. As far as I know, this process (fluid phase macrophage pinocytosis) is unregulated. We also know that inhibition of LDL transcytosis prevents atherosclerosis completely.
@intro...101
@intro...101 7 ай бұрын
Thanks for your take on this, Layne. And thank you for disclosing bias. I wish all influencers did that.
@yoso585
@yoso585 7 ай бұрын
Nothing has been established about lmhr aside from a definition and basic baseline data. The Oreo experiment may apply to all lmhr. Though interesting, and not clear if response is from carbs or is from over feeding, it can remove one from the lmhr category. But what this has to do with demonstrating anything counter to the current ldl cvd relationship is absolutely nothing.
@erastvandoren
@erastvandoren 7 ай бұрын
💯
@jackynikola
@jackynikola 7 ай бұрын
I don't think you have carefully examined the study. As far as I remember, the researchers conducted a Calcium Score on the participants, and the results showed that they had almost zero, which is less than people with normal LDL. Therefore, it is unlikely that if they had lower LDL, they would have a lower risk of cardiovascular diseases. It seems like you are biased, my friend. You always have the same perspective, which is why you have problems with the majority of researchers and doctors on social media.
@horatiumarian2934
@horatiumarian2934 7 ай бұрын
i've been doing keto diet for more than 3 years now, and i have the same problem, high LDL all other markers are fine, or in the limits, i'm feeling better overall, have lost more than 25 pounds but i don't know why my ldl is so high and if i need to be concerned...from what i saw in the keto community most of the ppl have high ldl ...so maybe the entire keto community is a unicorn community...maybe in the future, more studies needs to be done on the keto community/low carb....to figure this out
@ladagspa2008
@ladagspa2008 7 ай бұрын
Of course you need to be concerned. Literally every study has shown that high LDL is bad. The keto grifters won't tell you this
@Santa-ny1yp
@Santa-ny1yp 7 ай бұрын
That answer is simple. If you are low carb and find out you have high ldl, eat some damn oreos and retest.
@azdhan
@azdhan 7 ай бұрын
Sadly, I can just see makers of oreos taking this study out of context and falsely using this to further market the sales of oreos
@ladagspa2008
@ladagspa2008 7 ай бұрын
Only thing this study is being falsely used for is by the ketotards who are now claiming statins are useless, and that high LDL in keto is safe.
@SandyBee21
@SandyBee21 7 ай бұрын
Anticipating the buy in from legacy media
@azdhan
@azdhan 7 ай бұрын
@@SandyBee21 Lol, I can just see the new marketing label. “clinically proven to reduce high cholestoral” with a big asterisk. Then, further super fine print somewhere on the bottom or back of the package somewhere referencing the asterisk stating: “ Individual results may greatly vary and results were based on a N of 1 study. We do not endorse our product as a substitution for medical advice, prescribed treatment or the consumption of oreos to prevent or treat high LDL. Please consult with your doctor.”. Having said that I have to confess as a side note, I am super jealous of the LMHR phenotype. I love me oreos, but cannot stop at one only, so find I need to totally avoid them. If I could eat 13 Oreos a day with impunity. Now, that would be heaven,,and a dream come true 🙂
@elhant4994
@elhant4994 7 ай бұрын
FDA won't allow it.
@MichaelGGarry
@MichaelGGarry 7 ай бұрын
Doesn't this study just show that......carbs are good? LOL
@ZRogers91
@ZRogers91 7 ай бұрын
I just googled “Do Oreos lower cholesterol?” like just a minute ago. I go on KZbin and bam, this video pops up. Trippy
@bluecrewfan88
@bluecrewfan88 7 ай бұрын
I'm almost in the camp you described. Without a statin, my LDL runs close to 180 (about 100 with 10 mg of Lipitor). Last I checked my HDL was 69, and triglycerides were 50. I'm thin and athletic, and work out quite a bit. It seems to me like the logical thing is to keep doing what I'm doing as far as exercise and diet are concerned, and keep taking my low-dose statin. The possible side effect is higher blood sugar levels, but my fasting glucose is still high 80s, and muscle pains, which I don't have. Why the aversion to statins in this scenario?
@egdm1235
@egdm1235 7 ай бұрын
I'm glad to hear you get such significant results from a reasonable dose. At my last physical I found myself in nearly exactly the same situation (LDL 180 and everything else pretty good). I'm currently at the end of a six-month test to see if I can get results with 10 lbs weight loss and a higher-fiber, lower saturated fat diet, but I'm expecting to have to start statins next month.
@brucejensen3081
@brucejensen3081 7 ай бұрын
Cognitive function I guess. I did try a statin for a while and my feeling was decreased Cognitive function, so much so, I couldn't compile data. Lol. I used to get gout bad. Meds looked like a life long thing, so I made better connections to what was good and rectified the issue. A side effect was much better numbers with ldl, hdl, triglyceride. Old habits started coming back and the numbers got worse again and that's when I tried a statin. Since then I have tried to make better habits easier to follow from making even better connections. I actually have optimal metabolic health now. If you can, it is clearly better to work with nature than fight against nature, such as using a statin. Not going to be possible with everyone, I guess.
@davidflorez1196
@davidflorez1196 7 ай бұрын
There's concern about mental cognition if you have familiars with Alzheimer's disease bit if not I think your safe
@Butmunch666
@Butmunch666 7 ай бұрын
I'm glad you're solving your statin deficiency so succesfully. Layne is truly an amazing guy right!
@ThomasAT86
@ThomasAT86 7 ай бұрын
Be right back buying Oreos and stopping my medication without talking to my doctor. (I'm joking, PLEASE DON'T DO THAT)
@kevinmoore734
@kevinmoore734 7 ай бұрын
Layne could you look at the recent U of Pittsburgh study linking high protein with atherosclerosis?
@condoriris6286
@condoriris6286 7 ай бұрын
This video is above my scientific abilities.
@balkibartokomous
@balkibartokomous 7 ай бұрын
"Full disclosure, I have beef with guy, and this guy, and this guy, .... "
@robbanks1436
@robbanks1436 7 ай бұрын
Yep, so true
@SullivanKelly85
@SullivanKelly85 7 ай бұрын
Full disclosure: Layne is on statins
@brownshit1
@brownshit1 7 ай бұрын
​@SullivanKelly85 so are a lot of cardiologist and longevity Drs...
@SullivanKelly85
@SullivanKelly85 7 ай бұрын
@@brownshit1 the irony there is not lost on me 😆
@LowHangingFruitForest
@LowHangingFruitForest 3 ай бұрын
All the choppiness at the intro just shows how difficult it was for him to not throw a ton of shade lol
@rjvsmb
@rjvsmb 7 ай бұрын
The study and the 1-of-1 experiment are points of entry for further discussion and studies. They are not meant as a final word. This has been expressly state by those involved with the study. This is important to disclose in this commentary.
@WholeCosmos
@WholeCosmos 7 ай бұрын
You forgot to mention the one data point guy lean mass responder who ate the oreos has Crohns disease or Celiac disease or some food allergy to Carbohydrates that's why he was on a ketogenic low carb diet to begin with....to cope with a disease. He had diarrhea the entire time he was eating oreos, he admitted this in an interview so he likely did not absorb all the fats he was ingesting..... they were just passing right through his small and large intestines without being absorbed. Also the saturated fat in oreos are either partially hydrogenated soybean or palm kernel oil . Both have zero actual cholesterol in them as plant based saturated fats and again they were just being passed right through due to his gastrointestinal disease. LOL I'm willing to bet blood lipid markers go down for anyone having chronic diarrhea. It's well known people loose weight due to malabsorption when having diarrhea. The immunological inflammatory response he has to the wheat and or carbs makes this one study meaningless because it throws yet another variable into the lean mass hyper responder phenotype. Diarrhea DATA. LOL
@stargazerbird
@stargazerbird 7 ай бұрын
That’s an excellent point
@stephanjaure3344
@stephanjaure3344 7 ай бұрын
Around minute 8, you say that the genes that affect ldl do not affect anything else in the metabolism. Are you certain this is true ?
@stargazerbird
@stargazerbird 7 ай бұрын
FHC includes higher clotting.
@clintwalker7095
@clintwalker7095 7 ай бұрын
Thanks for helping sort this out. Its Interesting for sure
@Keepitcurious1685
@Keepitcurious1685 7 ай бұрын
This video exemplifies why I keep making time to listen to and work to understand Mr. Norton's content. Im gaining real scientific knowledge and becoming more intelligent along the way. I can't thank you enough!
@Roberto-cg2gr
@Roberto-cg2gr 19 күн бұрын
Why are you hiding discussion with Nick Norwitz
@wtssmaller
@wtssmaller 7 ай бұрын
Would have been nice if he took fruit instead of oreos. Whole foods Meat + Fruit would be a very fun diet that also allows to stay lean.
@f.-j.j.5738
@f.-j.j.5738 7 ай бұрын
As a breastfeeding mom, oreos are a staple in my diet. They are rich in calories, calcium and a chemical called sunflower lecithin. Sunflower Lecithin is an emulsifier which means it liquify the fat in my milk and makes it easier for it to flow from my breast to the baby or the pump. Our milk supply is crucial for us breastfeeding mothers so yes! We love oreos 😊
@SebastianFernandezAlberdi
@SebastianFernandezAlberdi 7 ай бұрын
The study also doesn’t say if this is just a temporal effect.
@kenthomas2427
@kenthomas2427 7 ай бұрын
I don't get these extreme diets. They can't be healthy in the long run, and are nearly impossible to maintain. I just went to a balanced diet with reasonable portions. Try to limit added sugar, saturated fat, and sodium. Added veggies, including spring mix each day. I actually eat plenty of fat, but its mostly healthy fat, such as nuts, and Olive and Canola oil (here comes the mob). I have maintained it for 2.5 years. I have lost 110lbs, and am still losing. Have about 40 more to go. Went from prediabetic to very good glucose levels. LDL dropped to the 70s, HDL 67, and Triglycerides at 51. (I do exercise a lot too). This feels so much easier to maintain than carnivore, high carb, paleo, etc. I think a big key for me is tracking everything I eat and sending it to someone to look at each week to help with accountability.
@carlosjosejimenezbermudez9255
@carlosjosejimenezbermudez9255 7 ай бұрын
If you want to know why a mob against seed oils exist, just look up a video of how they are made, it doesn't have to be a keto propaganda style video either. A simple "how it's made" should be enough. Extreme heating, chemical bleaching and extreme heating once more is enough to make seed oils useless from the moment they are packed and sold. This is something Layne didn't cover in his video about seed oils, which was more of a pot shot against certain groups than his usual education videos I believe. The reason seed oils (sunflower, canola or rapeseed, soybean) weren't harvested historically and why they are a modern invention is because it is impossible to harvest them without the industrial processes we have in place in modern times, which, as I mentioned before, oxidize them before you get to even taste them. Sure, mob mentality is annoying, and my idea is not to push the way some zealots do, but there is a reason why seed oils are hated across different dietary social groups, and it is not garbage.
@brucejensen3081
@brucejensen3081 7 ай бұрын
Ok, but why rapeseed over other oils
@brucejensen3081
@brucejensen3081 7 ай бұрын
​@@carlosjosejimenezbermudez9255I think people have been harvesting sunflower seeds for 5000 years. Probably best eaten whole. At least for now, there are no gmo varieties
@kenthomas2427
@kenthomas2427 7 ай бұрын
@@carlosjosejimenezbermudez9255 I have watched these videos. I was concerned... for about 5 minutes. I also saw that there are many studies that look at the results of consuming them, and they all show neutral or positive results. They have a good fat profile. When I cook, I use Olive Oil. However, some of my favorite products in the store have canola oil, and all my markers have improved during the period that my consumption of it went up. That is probably not the reason why, but it doesn't seem to be hurting.
@kenthomas2427
@kenthomas2427 7 ай бұрын
@@brucejensen3081 I don't buy it or cook with it. But I don't shy away from products that have it.
@PT121551
@PT121551 7 ай бұрын
I disagree with your assessment of the topic because I think your argument is based on lipid hypothesis, ie,higher the concentration of LDL’s , higher the risk for atherosclerosis whereas the other side’s hypothesis is based on lipid energy model- see Dave Feldman’s explanation why people who are on ketogenic or carnivore diet have high LDL.
@user-ef2gw5yr2j
@user-ef2gw5yr2j 7 ай бұрын
can you make a video on high protein diets and liver diseases like nafld . seems like there are many conflicting viewpoints on this topic and some people say high protein diets are good and other says they are bad for liver disease.
@BO2trickshoting
@BO2trickshoting 7 ай бұрын
so you’re saying in the context of that one person, they would be better off eating the oreos than not eating them?
@MmartinL
@MmartinL 7 ай бұрын
Not necessarily, maybe it would be better for that person not to eat oreos and having high LDL. It is not exactly shown that such a high LDL in the context of LMHR is less healthy.
@fran6b
@fran6b 7 ай бұрын
All this suggest to me that carbs fuel some important fonctions in our organism, other than the already important one of providing energy.
@michaelblacktree
@michaelblacktree 7 ай бұрын
I remember clicking on a video titled "Are You a Lean Mass Hyper Responder?", expecting a video about hypertrophy. Boy was I wrong! LOL 🤣
@bzbernier1
@bzbernier1 6 ай бұрын
Although there was an intervention, this appears more mechanistic to me. clinically, most physicians who work with diet commonly see a greater physiological response with food than medication. I usually give most of my patients 1 month to drop their LDL by 30% in 4 weeks after we discuss a plan absent any statins. That period is too short for us to retest after prescribing statins other than assessing for side effects. Why statins didn't work as well? Assuming perfect adherence - it could simply be an absorption issue with the statins. The lipid profile may impede statin pharmacokinetics, this happens sometimes with diabetic patients and there is a lot of research about which statins are better to use in diabetics for this reason. Clinically, more health gurus are gonna claim statins are trash, high LDL is fine, and low carb is the best way to go now, so yay, work just got more fun because they guy who eats bacon and weighs 300lbs at 5'6 is gonna tell me his diet is scientifically proven to be heart healthy by adding in Oreos.
@Munky-vj1nz
@Munky-vj1nz 7 ай бұрын
I’m only going to watch the first 10 seconds of this video and assume it’s fact to help justify the sleeve of Oreos I’m about to smash. Thanks Layne!
@DDHS_Podcast
@DDHS_Podcast 7 ай бұрын
Hi Dr. Norton, really interesting study and thanks for presenting it in such a fantastic balanced way. I was reading a bit into LDL and PCSK9 mutations (heart-1 trial from Verve therapeutics, Crispr trial for knocking out PSCK9 mutant in liver cells as a first trial for gene editing for familial hypercholesterolemia) and was wondering, if the study considered the genetic background of these specific people? I could imagine, that these people might have a different compensation mechanism, where low carb actually leads to increased LDL, since they might lack a specific enzyme or have lower levels of it. Moreover, I was wondering if they also checked the plaque formation/ degradation in the context of the diet. Thanks again for this amazing video and your honest style! Love it. Keep this great work! Many greetings!
@fran6b
@fran6b 7 ай бұрын
Maybe a new mic to celebrate 500 k subs? Just saying, for the algorithm.
@przyczajkaibum
@przyczajkaibum 7 ай бұрын
This is very interesting. I have always been lean, great BMI, reasonable ammount of lean mass, low fat, always had normal cholersterol...and when i started IF a few years ago and migrated towards a low carb diet..my cholesterol went towards numbers such as 250-300 LDL...and none of the doctors couldn't explain it. I am looking forward to more data because it gives me hope.
@itdepnz
@itdepnz 7 ай бұрын
One black swan is sufficient to debunk all swans are white. Right? 🤣
@mikeluhrs4578
@mikeluhrs4578 6 ай бұрын
I disagree with some of your takes, but this was a good video and levelheaded take. Cheers.
@jeffharwood6185
@jeffharwood6185 7 ай бұрын
You didn't address their CTA's would love to hear your thoughts on that.
@classicgameplay10
@classicgameplay10 7 ай бұрын
Its very irresponsible what you just said in 8:40. In the end you are giving what these people need to justify in their heads keeping a very high ldl because they think they fit this lean mass criteria or because they might think they will fit it someday if they keep up on this path. In the end, nothing new this study shows, except that carbohydrates instead of fat lower ldl. Why use oreos instead of lentils though, is a question, so we can also question the real motivation of these reasearchers.
@annoyedaussie3942
@annoyedaussie3942 7 ай бұрын
Really should have used white sugar in water.
@nobodysfan
@nobodysfan 7 ай бұрын
I’m glad you talked about inflammation since it is a big driver towards cardiovascular disease independent of cholesterol. More so in my opinion than LDL. Lower inflammation means less diseases to a certain point. By the way, there are no unicorns. Every person has thousands of people who respond just like they do. Maybe not millions but thousands. There are thousands of lean mass hyper responders in the wild. A minority sure, but not a unicorn.
@erastvandoren
@erastvandoren 7 ай бұрын
It's not independent of cholesterol. It's an accelerator of cholesterol.
@optimistas7
@optimistas7 7 ай бұрын
Another limitation of the case study is that they measured LDL-C and not Apo B. I believe there are about 25 percent of people who can have low LDL-C, but high Apo B and we now that Apo B is more accurate marker of CVD risk.
@voxmor
@voxmor 7 ай бұрын
There might be a problem with the data, when we're talking about 1 person...
@cybervoid8442
@cybervoid8442 7 ай бұрын
"might" is doing some heavy lifting here lol
@dannym8015
@dannym8015 7 ай бұрын
Thanks for a balanced review Layne. Excuse my ignorance as I have no idea how LDL is measured from a blood sample, so my question is probably entirely stooopid… Is it possible that any of the ketone bodies (bhb, acetate etc) could be causing a misreading of the ldl numbers, thus artificially increasing the readings,?
@fcmerces
@fcmerces 7 ай бұрын
I’m kinda like that subject I was doing yearly blood tests in the past, and I got the best results (122 total cholesterol) when I was having soda with deep fried food for breakfast and afternoon snack everyday. It doesn’t mean someone else would have the same results, also it doesn’t mean it’s healthier on the long run for myself. I also used to do an Oreo diet for bulking (super skinny), but nowadays I try to eat more lean and unprocessed food, and my body responds positively to it.
@Butmunch666
@Butmunch666 7 ай бұрын
Actually it does because this lipid energy model predicts exactly what you're describing.
@TangoMasterclassCom
@TangoMasterclassCom 7 ай бұрын
Thanks for your great content!! Best explanation about this study I've seen.
@hiker-uy1bi
@hiker-uy1bi 6 ай бұрын
It's also important to note that Nick's experiment didn't even assess both major classes of statin. It only examined hydrophilic statins (like rosuvastatin), which tend to do a poorer job of LDL clearance than lipophilic statins, which have greater penetration into the liver. It's quite possible such a statin would have done as well as, or at least comparably to, the Oreos. It's a flawed, clickbait experiment that doesn't even demonstrate what it says it does. And it's being used without any context by low carb grifters to engage in further statin and LDL denialism. The takeaway for most lay people, I suspect, is "statins are garbage because they don't even work as well as Oreos!" Then the extremely online 65-year-old with metabolic disease ignores his cardiologist's advice because he heard Ken Berry and Shawn Baker mention this on KZbin. I find the entire online low carb ecosystem to be completely insidious. My takeaway from the experiment, at best, is that (1) these kinds of diets may contain an inherent, and potentially morbid, risk factor for those with this phenotype in the form of extremely elevated LDL; and (2) it's probably a better approach for this phenotype to add at least the number of grams of carbs outlined in the experiment to their ketogenic diet in order to reduce this risk. I don't think the experiment successfully demonstrated that statins would be ineffective for this phenotype because it only assessed one kind of statin, as noted. And it's only testing one person, Nick, and his response could be idiosyncratic. The experiment could have just as easily tested a banana instead of Oreos, but it wouldn't get the headline. A banana would get people thinking they should eat more whole plant based, which isn't what low carb ideologues like Nick want.
@jacobcochrane9069
@jacobcochrane9069 7 ай бұрын
These are not unicorns, and it's not about the people. It's about the model of what metabolism is, and the variety of ways in which it can function. Function in a healthy, natural way. I wonder what the typical LDL levels are for wild cats. I'll be looking into that...
@casnerjablonski4866
@casnerjablonski4866 7 ай бұрын
Dr. Norton, ironically my cardiologist had me massively increase CBH while matching fat and protein concurrently to when Nick did he n=1. Due to autoimmune reactions to almost all CBH sources the only way I was able to do this was via homemade Christmas cookies(if I was gonna feel like shit from CBH, they were at least gonna be delicious) as they allowed me to match fatty acids to my animal-based diet. Anecdotally, I had LDL decrease from ≈460 to ≈230 and TG decrease ≈65 to ≈34. Nick Norowitz explains the decrease in TG because of hyperinsulinemia in a fasted state(he explains better, I’m not a lipidologist lol). Could this be true in the context of a diet that promotes glucose sparing and physiologic insulin resistance? Ergo, with the increase in CBH you see an insulin resistance like oversecretion of insulin? This has been something that I have not been able to get my head around but I am concerned about as my low CBH diet is because of autoimmune issues that take priority to LDL. Thank you, on the off chance you read/respond to this lol.
@Arumenuyama
@Arumenuyama 7 ай бұрын
Interesting video overall, but this situation isn’t nearly as “Unicorn” as author states multiple times. I, for example, don’t fit, as my LDL, even though high, isn’t so MAD high, but that’s because I am not lean: lost about 100 pounds on Keto, but still somewhat overweight. But when I go more strict on my diet and lose weight again, even with less saturated fat, my LDL is aggressively going even higher. And I could pretty confidently predict that at about 15% (even more probable at 12%) body fat I would probably fit into LMHR category…
@nicorellius
@nicorellius 7 ай бұрын
data > feelings !
@davidpope9630
@davidpope9630 7 ай бұрын
High HDL/LDL and low Trig was how my blood work consistently came back when I consistently only ate Red Meat, fatty fish, veggies and fruit. Low blood pressure as well. I no longer eat strictly meat and veggies and my HDL/LDL is back to normal but my trigs hover around 100 and my blood sugar/A1C has been trending in a bad direction. (Typ 1 Diabetic)
@SLude480
@SLude480 7 ай бұрын
Maybe the effect of Oreos was brief and if they continued for 6 weeks vs 16 days they could’ve seen the same rebound as the statin.
@dkeener13
@dkeener13 7 ай бұрын
the "rebound" was due to the subject testing another aspect of the lipid energy hypothesis, which is that increasing energy expenditure (exercise) would increase LDL-C. He intentionally doubled his steps for that final period and saw the predicted result.
@SLude480
@SLude480 7 ай бұрын
@@dkeener13 why only 16 days of Oreo but 6 weeks of statin?
@dkeener13
@dkeener13 7 ай бұрын
because the docs he consulted said 6 weeks should be a fair "trial" period to see the likely lowering effects of the statin. these LMHR guys know they can raise and lower their LDL at will by throttling carb intake.
@Sam-jn1fz
@Sam-jn1fz 7 ай бұрын
I bought a dozen cases of oreos. Thanks doc! Ill eat a case a day
@erastvandoren
@erastvandoren 7 ай бұрын
It's simple. People on keto: 1) have very low insulin levels 2) they have sky-high insulin resistance So, in people on keto insulin is basically useless. But insulin has many functions, one of them being ApoB degradation. On keto ApoB degradation is not a thing, but if you add some carbs, then insulin is somewhat back to normal, ApoB degradation kicks in, LDL particle number drops.
@Klaudiuszeg
@Klaudiuszeg 6 ай бұрын
Nah, 1k calories in oreos probably just made him eat less fatty meats thats it.
@DixieNormas16
@DixieNormas16 7 ай бұрын
Love Layne’s videos. I literally use every app this man has and everyone of them are golden
@brucejensen3081
@brucejensen3081 7 ай бұрын
Looks like I can keep smoking.
@KendraWest-xk6po
@KendraWest-xk6po 7 ай бұрын
The information should be automatically disregarded because of only one participant in the study.
@Ruudwardt
@Ruudwardt 7 ай бұрын
I was initially hyped about the LMHR stuff, as I fitted into this criteria quite well (IF and Paleo zealot back then). Then I started digging deep in LDL and Apo-B literature - my enthusiasm faded. So the best lifestyle ever: be a KETO LMHR and on truck load of statins and PCSK9i-s. (joke, haha) Great analogy on smoking vs the lipids - I will keep it. All in all I follow their research as it can reveal crucial novel information.
@Butmunch666
@Butmunch666 7 ай бұрын
The biggest problem is that Layne doesn't understand what cholesterol is or what it does. Most doctors don't. It's really sad.
@jonathanclark3107
@jonathanclark3107 7 ай бұрын
Can you do a video on Eric Berg claiming eating eggs increases or even causes your risk for heart disease?
@RobertWinter2
@RobertWinter2 7 ай бұрын
At 13:24 you state that there should have been an increase in triglycerides due to the increase in carbohydrates. From the paper, the subject maintained ketosis during the Oreo arm of the study with exogenous d-β-hydroxybutyrate supplementation. Could that explain the lack of an increase in triglycerides?
@wtssmaller
@wtssmaller 7 ай бұрын
No, triglycerides dont raise in 2 weeks. It takes longer
@muntahafaiaaz
@muntahafaiaaz 7 ай бұрын
You inspire me to pursue a PhD in nutritional biochemistry I'm doing my bachelor's in biochem
@brownshit1
@brownshit1 7 ай бұрын
Get ready for a life of frustration because everyone on the planet thinks they're an expert on the matter. Sorry that's probably just my jaded view and the reason I didn't pursue it after my undergrad.
@braysive4380
@braysive4380 7 ай бұрын
Just put the mic on your camera
@MichaelAmen316
@MichaelAmen316 7 ай бұрын
How do you detox Chlormequat out of your body?
@samuelcakar174
@samuelcakar174 4 ай бұрын
Great video!
@TheDumplingOrc
@TheDumplingOrc 7 ай бұрын
When they create whole body scanners and programs to identify each person’s perfect diet like in star trek, things will be nice.
@K4R3N
@K4R3N 7 ай бұрын
9:50 right this unicorn LDL population is so small and not how most people with broken metabolism behave that it's basically irrelevant. #1SubjectONE
@ArcoZakus
@ArcoZakus 7 ай бұрын
It is not irrelevant to them.
@FutureLaugh
@FutureLaugh 7 ай бұрын
does inflammation need to be present to cause the LDL to penetrate the endothelial walls?
@ladagspa2008
@ladagspa2008 7 ай бұрын
No. The LDL entering the wall itself causes localised inflammation. Watch the video of Gil Carvalho with lipidologist William Cromwell
@sebacatana
@sebacatana 7 ай бұрын
Ooooh I was waiting for this one! Nick just won't stop talking about this. So annoying! THANK YOU!
@markhaubphd
@markhaubphd 7 ай бұрын
Yes, it is interesting he used foods he objects/rejects and is now using them to promote his work/science and popularity. Maybe he finally saw the light and that all "foods" can be incorporated into a healthy diet.
@shiftgood
@shiftgood 7 ай бұрын
@@markhaubphd You... you don't understand whats happening do you?
@robbanks1436
@robbanks1436 7 ай бұрын
@@markhaubphdhe purposely used Oreos because almost no one would think they are healthy at all. Any carbs will cause lower LDL in LMHS.
@lolo20adaify
@lolo20adaify 7 ай бұрын
​@markhaubphd ahh no you missed the whole point, just like 90% of Layne fan base. 😂😂 fucking bots
@onika700
@onika700 6 ай бұрын
What causes varicose veins?
@8_bit_Geek
@8_bit_Geek 7 ай бұрын
I just read about someone this morning who lowered LDL by introducing milk into his diet. Milk is somewhat high in carbs. 5 years from now there will be some good studies coming out Recent study out of Europe I just read about has LDL as a minor risk factor
@dkeener13
@dkeener13 7 ай бұрын
The Mendelian Randomization trials are essentially just measuring a genetic predisposition to high LDL, i.e. familial hypercholesterolemia (FH). FH is indicative of a broken lipid metabolism. It's actually a rather huge assumption to say that, on the one hand, we have this genetic predisposition that raises some blood marker (LDL-C) and indicates risk, and on the other hand we have lifestyle factors (low carb diet paired with low BMI) that raise the same marker, and that therefore this marker carries the same risk in both situations. We know the mechanism causing the high LDL is different in both scenarios, so I'm not sure it makes sense to assume the risk carries over.
Don’t Worry About “Bad” Cholesterol, Says Dr. Paul Saladino
18:57
The Minimalists
Рет қаралды 994 М.
Minecraft Creeper Family is back! #minecraft #funny #memes
00:26
Миллионер | 1 - серия
34:31
Million Show
Рет қаралды 1,1 МЛН
Do you choose Inside Out 2 or The Amazing World of Gumball? 🤔
00:19
Шок. Никокадо Авокадо похудел на 110 кг
00:44
I Was WRONG About Artificial Sweeteners? | Educational Video | Biolayne
21:47
How to grow muscle...According to Dr. Berg -  What The Fitness Ep 39
22:52
Dr. Layne Norton
Рет қаралды 113 М.
Salt Isn't Your Enemy! It's SUGAR! | What the Fitness | Biolayne
12:59
Dr. Layne Norton
Рет қаралды 72 М.
Oreos are the Most Potent Drug for LDL Cholesterol
7:59
Nick Norwitz
Рет қаралды 526 М.
Minecraft Creeper Family is back! #minecraft #funny #memes
00:26