New Study Says Protein Causes Heart Attacks? | Educational Video | Biolayne

MToR Activation in Monocytes: pubmed.ncbi.nlm.nih.gov/38409...
High Carb Meals Increase Inflammation & Oxidative Stress:
pubmed.ncbi.nlm.nih.gov/22474...
High fat meals impede flow mediated dilation & endothelial function:
pubmed.ncbi.nlm.nih.gov/35665...
High protein diets can help lower body fat & improve blood lipid CVD profile
pubmed.ncbi.nlm.nih.gov/34579...
pubmed.ncbi.nlm.nih.gov/19179...
pubmed.ncbi.nlm.nih.gov/33502...
High protein diets do not increase CVD risk in humans:
pubmed.ncbi.nlm.nih.gov/36986...
pubmed.ncbi.nlm.nih.gov/23587...
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[@espenstoro]

Worrying about minutiae is gonna give you a heart attack.

[@Oldmonstrosityshop]

Paralysis by overanalysis

[@jaymills1720]

The ending was HIGHLY validating - the messaging. The rationale as to why people freak out over the headlines. Good video Uncle Layne ❤

[@kimdecker8901]

Beautiful explanation of complex biochemistry! Thank you! Gonna go listen to it again!

[@arnaudgolenvaux299]

Excellent educational video Layne! Thank you so much. Very informative and clarifying.

[@ryandalessandro4139]

Was waiting for this one. Thank you!

[@Romero610]

Thank you Dr Norton. I heard about this study on the way home from work. I said to myself, i hope Dr Norton does a podcast on this and helps clear some things up. Once again thank you so much.

[@Blah115]

You have new one with him on a channel called Diary of the ceo

[@ProdigalSunTzu]

I think it was Red Fox who joked " they say i cant eat butter, no sugar.... Imma feel like a damn fool when im dying of nothing"

[@rm06c]

He also said "imagine if the Pilgrims ate bobcat with the Indians. We'd be eating pu**y every Thanksgiving." 😂

[@gwenlauterbach2706]

Love it! Thanks Layne for always breaking down pubmed-stuff for us 🙂

[@nikoladjordjevic-kisacanin2777]

Love the video and the channel! I wonder if there are any graphics and animations you can show while you’re explaining some things. It can be hard to understand what exactly is going on.

[@rebeccaaksdal5840]

Thank you for this. Can’t say I understood all of the technical parts, but your interpretation and comments eased my mind about my high protein diet.

[@jiujitsujunkee]

Thank you for making this so simple. I'm an exercise science student and used to get so caught up in mechanisms, and your explanation of mechanisms vs outcomes in human trials changed my view on everything.

[@rm06c]

It's very applicable to all of science. Like Richard Feynman once said (paraphrasing here), it doesn't matter how wonderful your idea and your model is, if it disagrees with experiment then it's wrong.

[@_MrTV]

Always good info and content plus commentary for AL

[@carlag147]

Love the citing of the research!

[@staceyg1719]

Great video and final message 👏

[@dreckigerdan8257]

Thank you for that video, my mum sent me a news article about that study and I couldnt wait for an expert to talk about it.

[@king-yq5xj]

Thank you for clarification.

[@radvel5916]

So much valuable data. Loved it!

[@blainebowling3303]

I was very interested in hearing your analysis. Thank you FTA!

[@ellefson1]

Thank you for cutting through the hysterical headlines with solid logic. I appreciate the way you explain the study, both how it was constructed and how to interpret it.

[@marsh8417]

Thanks @biolayne1 I saw this study and knew that you and Arnold would cut through it all for us mortals to make sense of it.

[@DDHS_Podcast]

Hi Dr. Norton, really well explained and also the biochemical/ molecular biology aspect. Could not do it better! I wanted to read the study for myself, unfortunately I do not have access through my institutitons. I would have loved to see some proteomics data on this as well. Since the mTOR pathway seems to upregulated, it would have been amazing to see the transcriptomic and proteomic response to it. Maybe the pathways involved would not have lead to the notion, that high protein diet leads to heart disease. Thanks again for your effort on debunking the current news articles so we all can have an extra protein shake now for our muscle gain 🙂

[@JOHNNY34A]

I knew you would do a video on this. You explained it best

[@Anusdeur]

Thank you for digging into this and explaining it here🙏🏽🙏🏽🙏🏽👏🏽👏🏽👏🏽

[@NofirstnameNolastname]

Just for the people who don't speak dutch I will translate this user's name. It says "Anus door" Don't ask me why though.

[@cesargutierrez8165]

Layne, this video was very very difficult to keep up with. I can usually keep up with your educational videos, but this one was tough. Can you please try in the future to simplify them as much as possible as if you were talking to elementary students in science. I know you have to be very thorough with your explanation, but not all of us are experts in your field. Not trying to be rude, just trying to understand the logic and explanation in someway behind the topic. Thanks Layne, love The Coach, it has made me learn more about my body and metabolism than I could have ever imagine. Thank you to you and the team for creating such an amazing and unmatched nutrition app.

[@heathergant0819]

Ty for this one!!

[@cybervoid8442]

Nutrition made simple made a great video regarding this too

[@user-lb5yf1by7s]

Thank you.

[@thinleylama6257]

I love your advice or information ❤ always watch and listen thank you

[@gifridge]

So glad you talked about this study, as I knew the internet was going to crazy over it.

[@lastfirst7512]

1. I love you 2. Long time follower 3 these new videos exposing or analyzing new studies are awesome 4. The ones where you show discuss these new stupid fitness fads like seeds oils are bad 😂 are awesome.

[@AdamScottfit]

Another great one. This was a prime example of mechanistic data and, like you said, not focusing on the outcome based studies. This is what the bioquakers have done for years. Looking at mechanistic data and fully ignoring what the outcome based studies say.

[@helencantimagine]

Thank you, Dr. Layne, for your dedication to health. I've been a subscriber for less than a week. I found you through your interview with Doctor Mike. Watching your videos makes me feel like I'm learning a new language. I also feel like one of the Charlie Brown characters listening to the adults as they talk-womp...womp. I keep listening because I know I'll catch on to all the science. I appreciate you.

[@Judgement220]

Awesome video my friend. You know your stuff.

[@cherylnielson4710]

Even when Dr. Norton talks in an alphabet soup of technicalities I learn something. Glad he looked at this particular study.

[@Sjs9000]

Fantastic video! I felt like I was in cell biology class again.

[@mikewalkow1860]

So glad you covered this idiocy!

[@noreturn4396]

Simple diagrams might be helpful for the uninitiated

[@ruthannlewis6471]

Enjoyed ❤

[@user-ls1zs7lz7l]

thank you

[@wroilly]

6:20 Makes sense. Isn’t this why body builders eat protein every few hrs? To keep that rate limited process less rate limited? Just so happens it could also be facilitating sustained mtor activation.

[@cyclobenchaprine]

In theory, yes, but evidence no longer supports this. The real utility of eating frequently is ultimately getting enough food in without needing inedibly large portions

[@TheHivefl]

I was waiting for this one

[@user-ip9mw8yg9o]

Thanks

[@simonoregan4744]

Sits down with a huuuuge grass fed steak to watch this

[@jacobdebernardi4385]

This vid is the first time I heard about the ApoE knockout caveat. Holy moly

[@kestag2110]

Good stuff. Nutrition made simple Dr Gil talked about this yesterday too. 👍

[@erich7301]

Carbon...Go use it. Game changing for me. I love it. I'll be a lifetime subscriber to it.

[@MrGrateful1]

I do exactly what he said towards the end. High fiber, lots of veggies, moderate amount of lean protein sources, along with resistance, and cardio training. Don’t smoke don’t drink in excess. I also spend a lot of time outside.

[@br6768]

According to the FDA and the World Economic Forum.. I'm supposed to be eating mostly round-up infused corn flakes and.. insects I think? So I'll just continue to eat what makes sense to me. A balanced whole food diet.

That is is simply untrue and made up dude. Try to be a little bit more critical.

[@sudhanvakashyap297]

link?

[@elijahcaraballo2903]

It’s not made up.. go look it up on their website!

[@br6768]

The FDA thing was a bit of a reach but glyphosate is actually in our foods that isn't a lie. The FDA, USDA, DOH.. one of those expensive, tax funded governing bodies have to know because I and other people know. They just let it slide on though to the supermarket shelves. The WEF is pushing _"bug based food"_ that isn't a lie either. Their thought process is it would be a solution to starvation. They are worried of potential livestock shortages in the future due to human overpopulation. I'm not sure how KZbin handles external hyperlinks but a quick google search "WEF insects" and "Glyphosate quaker" you can see for yourself.

[@br6768]

The FDA thing was a bit of a reach but glyphosate is really in our food supply that isn't a lie. The FDA, DOH, USDA.. one of our many expensive, highly staffed, tax payer funded, governing bodies has to be aware of this long before I was. Still these products still end up on our supermarket shelves 🤷‍♂️. The WEF is pushing for insects as food. This is very true. They believe the human population is too high and we can't supply enough meat for the entire population. This is their solution. Bug based food. I'm not sure how KZbin handles external hyperlinks. If you google "WEF insects" and "Glyphosate Quaker" you can see for yourself.

[@tamago84]

do the one with the diet soda and afib

[@Nothingmuch1039]

I thought I was going to die the first time I drank a Boost shake...

[@francisproulx9669]

Depend of what *boost* we are talking about 💉💉

[@liamturner-beauchamp1570]

@@francisproulx9669the booster juice 😅

[@Nothingmuch1039]

The little old people drink from the grocery store.

[@GutCheck777]

If you want to Ensure your Boost is more satisfying, mix it with bourbon.

[@francisproulx9669]

@@Nothingmuch1039 yeah I know it was just a silly joke on my part

[@pelonete5000]

You only forgot at the end to say ,"limit your intake of processed foods".

[@jarlwhiterun7478]

Greek yogurt, beans, tuna, peanut butter, tofu, cereals are all processed. You gonna avoid all those foods?

[@davorzdralo8000]

Literally everything you eat besides raw fruit and some rare veggies that are also eaten raw, I'd processed.

[@BelindaEmanuel]

I lie down on the earth and take a big breath in, that is to be happy and calm. I eat a balanced high protein diet full of fruits vege, plant and animal protein. That is to keep me alive! Keep up the good analysis Layne. Thanks.

[@NofirstnameNolastname]

Wow never seen a video appear yet from Layne when it had 0 views. #likecommentforthealgorithm before I even watched. Did hear about this study though, was waiting for this vid thanks as always for staying on top of this ! :) Looks like I'm actually the first real human to comment because Chasidy qs8xb and tammykacyee with underwear profile pics(not that I'm complaining) and generic comments seem sus ;P

[@bogrunberger]

I think all health studies should come with a Biolayne video attached.

[@factbots]

just one for the algorithm 🤣 Man I even understand chemistry when Layne explains it, fancy words simplified for the masses 💪

[@Billybear185]

You should really consider writing a book that connects philosophical logic and human health! I'd buy it!

[@efo19wire]

lmao thanks biochem degree for carrying me through the mtor activation process 😂. i study bacterial kinases in my grad program rn and it’s nice that my signaling cascades are so damn short haha

[@carperdiem8754]

I hate your videos because you are more buff than me.. keep up the good work

[@ozzybeloiu466]

Kinda Richard Simmons bro😂

[@BertoniCostales]

Taking into account the study and your comment that a high-protein diet could potentially decrease body weight, perhaps an approach focusing on sources low in the amino acid Leucine could be a correct approach to decreasing cardiovascular risk, low in saturated fats, and low in sugar.

[@RandomHuTaoSimp]

You don't need to lower saturated fats. A meta analysis of all the data on the highest level of data on this compound was conducted and they wrote a paper that their was NO correlation between saturated fat and negative health effects. Literally no data in the literature proves saturated as being harmful as a standalone compound, and NO it does not cause diabetes. All it does is make you sugar intolerant which is a protective mechanism in adaption to low carb diet. So don't fear saturated fats in any amount, mainly if you're low carb.

[@D.Fay_Coe]

with this video, Layne Norton, today, wins the internet.

[@jakubchrobry3701]

The researchers said their studies demonstrates a mechanistic basis. They made no claims about actual health outcomes in humans. Plus, they said risk might begin at protein levels over 22% of calories or 1.55 g/kg. There are not too many people eating this high of protein, especially in the elderly. The 95th percentile of men over 50 is about 21% of calories.

[@Klaudiuszeg]

Tell that to people who listen to Brad Stanfield or follow keto and carnivore diets.

[@defeqel6537]

I wonder if other macronutrients affect things as well; we know they affect autophagy at least

[@danielbrown001]

Any evidence-based fitness enthusiast is probably eating over 1.6g/kg of protein due to the most current evidence on muscle hypertrophy. So that’s why people in these comments care a lot.

[@jakubchrobry3701]

​@@danielbrown001 If you're in your 20s or 30s and a lean healthy bodybuilder, go for it. 2.2 g/kg is likely fine, but you're not likely going to see any significant (noticeable) gains from eating more than 1.6 g/kg due to the diminishing returns of the concave-down curve of muscle gains vs protein. It's best to put your efforts into an optimal training program and recovery (yeah, the hard stuff) rather than focusing on the easy stuff of eating more than 1.6 g/kg of protein. Yes, people should care. Once you get in your 50s, fitness enthusiasts begin to think more about longevity and disease. Then it comes down to: why take the risks when you're not going to get benefit from eating over 1.6 g/kg. It's no longer about ekeing out every additional nanogram of muscle mass. There's plenty of research showing protein has a negative impact on all nine aging pathways, plus negatively influencing disease. You can gamble by believing this is all bunk, but to what end? Concerns about sarcopenia in the elderly? Research shows that the additional protein does not help in the elderly. They need to lift weights. Period. 1.2 g/kg is enough, when half are not even getting 0.8 g/kg.

[@jakubchrobry3701]

@@danielbrown001 Yes, people should care. Once you get in your 50s, fitness enthusiasts begin to think more about longevity and disease. Then it comes down to: why take the risks when you're not going to get benefit from eating over 1.6 g/kg. It's no longer about ekeing out every additional nanogram of muscle mass. There's plenty of research showing protein has a negative impact on all nine aging pathways, plus negatively influencing disease. You can gamble by believing this is all bunk, but to what end? Concerns about sarcopenia in the elderly? Research shows that the additional protein does not help in the elderly. They need to lift weights. Period. 1.2 g/kg is enough, when half are not even getting 0.8 g/kg.

[@senditcody3130]

ok so the mrna is translated in a ribozone where it latches to mrna and protein and is the assimulation of emis4f then acts as a scaffold to attach to the mrna. THen releases into ef4e then into ef4if, then to mtor. Ok got it. Wait... I lost it. lol

[@billleach7915]

Truth!

[@bobbysmith5320]

Great video! I have protein and drink amino supplements everyday! My arteries are all good. If we can’t eat Carbs, protein or fats, what are going to eat? 🤷🏽‍♂️

[@pieman8705]

Are you going to post a reply to Norwitz latest video about your video on the oreo research?

[@NetanelLiftzshitz]

love your face dude. 😂 great video, loving the stupidity on the internet being ripped apart to shreds

[@annamokrushina9228]

Please address the “Sailing La Vagabonde” recent “fasting retreat” video. This is insane

[@Gruso57]

I find it really strange they used ApoE knockout mice knowing they have high ldl cholesterol.

[@kiwimaccomboattack9765]

I heard lettuce is good to use as an ice pack? Do you use lettuce instead of an ice pack?

[@kiwimaccomboattack9765]

Oh, you deleted your response Layne, I wonder why?

[@gridrunner1319]

Spot on advice

[@Isaac5123]

What is the advice ?

[@morpen1234]

​@@Isaac5123look for the bigger picture stuff instead of mechanisms

[@gridrunner1319]

See Layne’s advice startling @ the 11:47 minute mark

[@Isaac5123]

@@gridrunner1319 and you think this is good advice eat your greens and fruit ? 😂 I'm a carnivore I know better 😂 good luck

[@Snerdles]

If leucine is what truely drives MPS then would't ir make sense just to eat a moderate protein diet and simply take something like 3g of leucine per meal? It's super cheap, so at 3g per meal or 9g per day a one month supply would be about 30 bucks. You would likely lower your overall protein needs for similar growth and save a ton of cash on protein bars and powders (and meals too).

[@SexyMFPoker]

I need to take the prerequisites before watching the rest of this video

[@TheSfajacks]

FTA! “Stared at the food pyramid for 6 years” 😂

[@muneebmashhhgaming]

There was a study that showed spot reduction is possible....

[@Melesniannon]

Anyone else immediately glanced at the clock when he said "Get enough sleep"?

[@NoLegalPlunder]

Time to become a breatharian.

[@zach81210]

In the mouse arm of the study, what exactly is the purpose of the apoE knockout? Wouldn't this just make it more difficult make applicable to humans?

[@DDHS_Podcast]

Hi, they used this type of mice since it has been shown that these mice can form plaques similar seen in human. Therefore this would help to study the outcomes in the disease context, here cardiovascular diseases. Of course even having such a mice model, it is hard to translate every finding into human trials. Hope that helped. (References: Pendse AA, Arbones-Mainar JM, Johnson LA, Altenburg MK, Maeda N. Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S178-82. doi: 10.1194/jlr.R800070-JLR200. Epub 2008 Dec 5. PMID: 19060252; PMCID: PMC2674752. Lo Sasso G, Schlage WK, Boué S, Veljkovic E, Peitsch MC, Hoeng J. The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction. J Transl Med. 2016 May 20;14(1):146. doi: 10.1186/s12967-016-0901-1. PMID: 27207171; PMCID: PMC4875735)

[@BigBrownTruck22]

That "no alcohol" recommendation is kind of difficult

[@mikekdawgman1]

This does make sense as I have started resistance training to build muscle and increasing my protein intake about 150-200 grams per day and over the course of a month or two of consistency, I feel like I’m having a heart attack post workout (very hard to breathe and relax like I’m having a heart attack).

[@mikewalkow1860]

Obviously it the protein LOL

[@rgh622]

Ok, hear me out. Lane said, "Hit the like button and leave a comment for the algorithm." After that I didn't understand a word he said.......my brain exploded...

[@Hexomickey]

My mom definitely brought this up to me the other day haha. Thanks for the vid!!!

[@lonestarpatriot876]

So in a nutshell, we are not like genetically modified mice! Got it. Good to know.😂

[@Gr33n0ni]

For the algorithm, by the way I need to say earliee on in my life I was not focusing on eating enough protein throughout my day. I wasn't even eating 70 G on average but in abundance of extra calories

[@gizmomagoo]

Love you

[@brandonotoole4374]

For my nutrition degree we stared at myplate for 4 years, not the food pyramid. Showing your age Layne.

[@karynstouffer3562]

Not necessarily, it also depends on the university, and the teaching program, plus the professor's preference.

[@johannesvenezian642]

I am sorry, but the caveat regarding the mice strain being ApoE knockout is wrong. They compared the plaque levels between different diets in the same strain, so the results are very much valid. Also, the following point you raise also makes no sense, given that at the diets they provided with lower ratio of protein, the rest of the calories came from either carbs or fats, but they didn't measure an increase in plaque formation (it was over the course of 8 weeks, so not immediate response only in mice). In Fig. 8b,c you can clearly see correlation between increased leu intake and higher plaque build-up and lesions. It is important though that indeed given the knockout, it is very much possible that in the WT the ApoE mechanism can get over also the higher amounts of protein, meaning you won't see the deleterious effects.

[@marcdaniels9079]

Outcome > mechanism

[@bohonutrition8247]

Yessssss!

[@mike8725]

Us all being here is a sign it doesn’t give heart attacks

[@chrisbeerad8835]

There are some credible people looking for face up debates layne . I think you have good arguments to a lot of it but not all , be great for us , "the dummies' to settle it once and for all . especially the sat fat / lipid science/ inflammation debate .On a personal level i saw a cardiologist post cac / blood , ct angiogram and have no cvd , no calcification and thats in the presence of hypercholesterolemia , Ive eaten a gram of protein per pound of bodyweight or more for 14 years now so that may be in the moderate group who knows but ol doc was stoked with what he found in a 54 year old heart for a change .

[@cookinthekitchen]

I have to find your videos debunking some of Thomas DeLauers statements, he certainly throws a lot of science out there that may or may not be accurate

[@Santa-ny1yp]

Thomas focuses on mechanisms, Layne focuses on the end product.

[@Eaw13]

Hi,KenDBerryMD just put YT video on about - 7 Things Rotting in Your Colon Right Now. I’m so confused about what to eat and what Not to eat. Your thoughts Dr

[@tallesttreeintheforest]

eat meat and saturated fat and natural stuff your anchestors ate.. do not count calories, do not care about cholesetrol, use your own body and cravings as a compass. if you eliminate all processed foodstuffs, you will start to get much clearer cravings, like waking up in the morning craving whipped cream or fatty beef. and that is great. listen to that and you will be much healthier.

[@Eaw13]

@@tallesttreeintheforest Thank you !

[@andrewboss2018]

How did we go from the argument of high protein potentially dysregulating mTOR expression to saying this paper assumes we shouldn't eat any protein at all and practice fasting. That is a red herring and not really the point of this paper.

[@alexanderabrashev1366]

Monocyte is not a type of macrophage, a macrophage is a monocyte that resides in the tissues.

[@Rob-dp1tt]

Yea its that or the fauchi juice

[@deborahthompson849]

You're this 71 yr old man's go to Doctor for well researched truth. I haven't had Doctor come to my home since U was 6 years old in NYC. Thank You Doc!!!!!!

[@andrewzach1921]

Like others i got lost in the chemistry lesson but if you're not worried then I'm not worried 😊

Doesn't new studies show that protein is effective for many many hours? The new studies about when you should eat protein for gains and all that?

[@vincentninja68]

MTOR has been a misunderstood boogie man for years now. Swig of water is not the same as drowning in it.

[@nekowolf583]

Breatharianism it is then!