Ozempic, Wegovy, Semaglutides: What You Need to Know BEFORE You Get Pregnant - Dr Lora Shahine

In this video, we take a closer look at Ozempic and its potential impact on fertility. Ozempic is a medication used to treat type 2 diabetes, and it works by regulating blood sugar levels through mimicking the hormone GLP-1.
We'll discover some common side effects of Ozempic and explains how it can potentially help individuals struggling with obesity and PCOS, which can negatively and/or positively impact fertility.
I'm also sharing some of the research I found on the potential benefits of Ozempic for individuals with infertility issues. Finally, I'll share my recommendation on the use of Ozempic for fertility treatment.
Overall, this video provides a valuable overview of Ozempic, its mechanism of action, common side effects, and its potential use as a fertility treatment.
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ABOUT : Lora Shahine, MD, is a double board certified reproductive endocrinologist and OBGYN currently practicing at Pacific NW Fertility in Seattle, WA. Originally from North Carolina, Dr. Shahine graduated with a Bachelor of Science in biology from Georgetown University in Washington, DC, and completed her training in medical school at Wake Forest University School of Medicine, residency in obstetrics and gynecology at the University of California at San Francisco, and fellowship in reproductive endocrinology and infertility at Stanford University.
As Clinical Assistant Professor at the University of Washington and Director of the Center of Recurrent Pregnancy Loss at Pacific NW Fertility, she is committed to providing excellence in patient care, teaching the next generation of women’s healthcare providers, and continuing research in the fields of fertility and recurrent miscarriage. She has published over 75 peer-reviewed research projects and is an active member of the American Society of Reproductive Medicine, Seattle Gynecology Society, and the Babyquest Fertility Grant organization. Dr. Shahine is an accomplished author including 'Planting the Seeds of Pregnancy: An Integrative Approach to Fertility Care' and best-selling book, 'Not Broken: An Approachable Guide to Miscarriage and Recurrent Pregnancy Loss.'
Whether through her research, books, lectures, or active social media presense Dr. Shahine is passionate about educating on reproductive health and supporting the feritlity community.
DISCLAIMER: The content contained herein is provided for informational and/or entertainment purposes only and not intended as a substitute for advice provided by a healthcare professional. Use the provided information at your own risk. If you have or suspect that you have a medical problem, please contact your health care provider.
#ozempicweightloss
#fertilitytreatments
#weightloss
Chapters
0:00 Intro
0:30 Video overview
1:16 What is Ozempic
1:46 Celebrity talk
1:59 Jimmy Kimmel
2:06 Celebrity before & after
2:22 How does Ozempic work?
4:20 Wegovy
4:55 Common side effects
6:31 Obesity and fertility
7:07 PCOS
7:32 TikTok
7:47 How I talk to patient
9:38 Research
12:08 Recap
14:00 Outro

[@abigailgilligan8980]

3 years unprotected and never conceived. 2 months on ozempic and I found out I was pregnant (I have PCOS). Delivered a healthy baby girl 5 months ago. I am convinced I got pregnant due to this medication! Was never heavily overweight but had super irregular periods - this regulated me to a perfect 4 week cycle. I would take this medication again in a heartbeat when I am ready for another kid!

[@drlorashahine]

We still have a lot to learn about this medication - especially for people trying to conceive but SO HAPPY for you!!!

[@jenniferluna105]

I also struggled with getting pregnant, and I’ve been on Ozempic for 2 months and just found out im pregnant! Did you have an easy safe going pregnancy? Im freaking out and don’t know what to expect

[@shaylawilliams7033]

This is exactly the result I am looking for. 10years unprotected and nothing. I'm hoping this helps, as my time is running low! Congratulations!

[@shaylawilliams7033]

Congratulations....I'm hoping for the same results.

[@abigailgilligan8980]

@@jenniferluna105 I had no complications other than the normal pregnancy woes of being uncomfortable. Best of luck to you!

[@AussieAdventures77]

Facts are more important than peoples feelings This is how they got here. You need to be firm on patients, If they’re serious, they’ll listen.

[@user-sabeanarenee]

Metformin along with diet and exercise seems to be a safer alternative if you are planning to conceive and breastfeed. Save all the injections for later when there are more studies and research on this 😅.

[@user-cl3ym4nx3q]

Thanks Dr. Shahine! Great information

[@drlorashahine]

Most welcome! Thank you for watching.

[@guirandarhin6162]

Thank you for this video!!!❤

[@drlorashahine]

Thanks for watching!

[@fatimausman6695]

You explained everything very well

[@drlorashahine]

Thank you!

[@arizalba7021]

After real bad side effects with metformin and having no luck with pregnancy these past years my OBG is recommending ozempic and birth control for 6 months and then try for a baby. But she doesn’t recommend taking while trying to conceive. She believes I’m a good candidate for Ozempic to try and control my pcos and help regulate my hormones. It’s kind of a last resort in my case fingers crossed it works.

[@AshleyHitsman-dk7gj]

love your videos!!!

[@drlorashahine]

Thank you!!

[@seydiparada2540]

I know that we shouldn’t be taken semaglutide while being pregnant bc my provider for the medication of semaglulitide let me know that the moment I know that I am pregnant I have to stop but now I am confused bc I went for a pap smear this pass week n I spoke to my provider and let her know I was on the medication and she said that it was not good that I was am suppose to be on birth control while taking any weight lost medication but I continue to explain to her that I have pcos n I don’t have regular cycle and that I needed help on tracking cycles n she didn’t give no help at all or explication so how can I even trust about the weight lost medication what would u recommend?

[@LizWalker-gx6ts]

So torn weighing out the pros and potential cons. Do you still recommend discontinuing Ozempic even if it’s treating insulin resistance in Type 2/ PCOS? Seems like that could interfere with the ability to conceive but also, malformations are scary 😧 Any idea if the fetal malformations were with normal doses or potentially related to decreased food intake vs the medication?

[@drlorashahine]

Best for the patient to review and weigh all pros/benefits with cons/risks with their doctor who knows their personal situation ❤️

[@laurenleigh3221]

Some additional thoughts… given the half life of a week, it takes semaglutide approximately 5-7 weeks to no longer present in the circulation. Likely because of that, the manufacturer recommends waiting at least two months after stopping semaglutide before trying to conceive. It sounds like from what you said some providers prefer to be more conservative, which makes sense. I also got the impression that as of now it’s unknown if the fetal effects were due to the medication, or from weight loss during pregnancy. I am going to go ahead and assume there won’t be a trial in pregnant women in this space, but I imagine we will get more observational data with time … the manufacturer has a registry to monitor outcomes in pregnancy as well which providers can reach out to.

[@drlorashahine]

Thank you

[@tiffanycalestina3853]

@@drlorashahine Thank you for this video. I have PCOS as well as Endometriosis and my significant other and I had been trying to have a baby for several years. I got pregnant and found out because I had an appointment to see my OBGYN for a regular annual, which for me includes ultrasounds. I didn't know I was pregnant at the time. The ultra sound tech kept trying to say something, but the doctor didn't tell me I was pregnant. Instead, he handed me birth control pills and told me to start them right away. The tech finally said aren't you going to tell her about her "mass"? He said oh it's nothing to worry about. She came running out as I was leaving and said go to the hospital now and gave me a copy of the report. I looked up the "mass" and it was a baby... I went home and took a pregnancy test and it was positive. I texted the OBGYN and sent him a picture of the positive pregnancy test and said its a good thing I didn't start taking the birth control you gave me. Nevertheless, we ended up miscarrying at the end of the first trimester. In addition, my cousin and his wife were trying for 7 years. They tried everything, IVF anything they could. The doctor finally told them to stop. That it wasn't going to happen for them and they should look into adoption. My cousins wife has some health issues and they told her to focus on that and losing weight to get healthy. She was put on Wegovy and within 2-3 months not only did she lose weight... SHE WAS PREGNANT and in her 40's. That gave me so much hope. Baby Carter was just born on 7/20/2023, at 7 lbs 6 oz. What a blessing, her sister said that she knows about 5 other women that had fertility issues and other health issues and once they started Wegovy they all got pregnant and had healthy baby's. So, I definitely think there's something to it. All on Wegovy though.... none on Ozempic. I hope others feel hope from this as well.

[@torrigraham7168]

Hi! I have Type 2 Diabetes and am taking 1000mg of Metformin (500 at a time, 2xs during the day), and also take Rybelsus 7mg 1x a day. My husband and I go in for our IVF consult next month (we have male factor infertility, my tests all came back normal and I had 1 successful pregnancy in the past). Do you feel it would be okay to continue these medications for someone attempting IVF in the near future?

[@drlorashahine]

This is a great question Torri. I would advise you to consult your medical provider, as I can't give medical advice to personal situations on social media. I have a lot of content on the subject on this channel, website drlorashahine.com, KZbin and Instagram account @drlorashahine that are great sources for you

[@biancacimpean2991]

I am taking Saxenda, at the recommendation of my cardiologist and my diabetologist as I have an IMC above 40 and high blood pressure. As Saxenda contains Liraglutide, I would like to ask you if there are any risks in case of conceiving a baby while taking Saxenda. Thank you.

[@drlorashahine]

This is a great question. I would advise you to consult your medical provider, as I can't give medical advice to personal situations on social media. I have a lot of content on the subject on this channel, website drlorashahine.com, KZbin and Instagram account @drlorashahine that are great sources for you

[@leniuskareina6879]

Hi i got pregnant and i have been taking phentermine for 3 weeks and i took my semaglutide shot yesterday but I'm afraid to have the baby for risk of any congenital malformation. I don't know what to do

[@drlorashahine]

This is a great question. I would advise you to consult your medical provider, as I can't give medical advice to personal situations on social media. I have a lot of content on the subject on this channel, website drlorashahine.com, KZbin and Instagram account @drlorashahine that are great sources for you

[@JenniferMontebello-pw9gr]

Amazing video. For women with obesity that are going through IVF- What about using ozempic to lose weight for a few months prior to IVF egg retrieval and then stopping 2 months before embryo transfer? Or is there thought that it may reduce response to IVF stimulation?

[@drlorashahine]

This is a great question. I would advise you to consult your medical provider, as I can't give medical advice to personal situations on social media. I have a lot of content on the subject on this channel, website drlorashahine.com, KZbin and Instagram account @drlorashahine that are great sources for you

[@user-bc2oi7ks9u]

When they say you shouldn’t take this when trying to conceive do they just mean the pregnancy part? I’m considering doing IVF to use my eggs but would then use a surrogate. Do you think it would be safe to use ozempic in that case?

[@drlorashahine]

Great question - one issue to consider is these meds slow gastric emptying- important to tell your doctor and anesthesiologist if you’re taking - may increase risk of aspiration at egg retrieval

[@melissasnailjourney9719]

I got pregnant while on ozempic and ended up losing pregnancy dr said it was because of ozempic

[@melissasnailjourney9719]

I lost pregnancy

[@allisonremi5450]

I'm 13dpiui and positive. I'm only been on for a month .25mg - now that I'm pregnant and I'm freaking out. Please let me know if it's okay

[@drlorashahine]

This is a great question. I would advise you to consult your medical provider, as I can't give medical advice to personal situations on social media. I have a lot of content on the subject on this channel, website drlorashahine.com, KZbin and Instagram account @drlorashahine that are great sources for you

[@AshleyHitsman-dk7gj]

ozempric most insurance will decline if you don't have type 2 diabetes I am on wegovey.. my doctor said I have to lose 70 pounds in order to do ivf so for now I have to do this to get it off me and learn new food options and portions but super stressful ps I've is our only option.

[@drlorashahine]

Thank you for sharing your experience with us! I wish you all the best on your journey! Thank you for watching!

[@tiffanycalestina3853]

Does your insurance pay for the Wegovy?

[@BubbleheadOMW]

Does it not bother anyone that Ozempic carries a black box warning for thyroid cancer?

[@drlorashahine]

Good reminder that these medications are relatively new. Long term data on risks not available yet.

[@BubbleheadOMW]

@@drlorashahine That, doctor, is the most irresponsible comment I've ever heard. Stuff people full of a money spinner ( yes, for doctors, too) before the black box warning is confirmed? Shame on you.

[@a-terrible-fate532]

It's just a stop gap measure like steroids. Once you get off them there's a good chance that you will rebound back up, after the appetite suppressant affects wear off.

[@drlorashahine]

It’s true - it’s my understanding that these medications only work as long as you keep using them

[@Franciellestephanie]

What about breastfeeding? Is it okay?

[@drlorashahine]

I am not aware of any studies in this particular question❤️

[@AussieAdventures77]

Poison

[@rosylemons]

This would have been useful and helpful but your transitions every 10 seconds were very annoying and distracting 3/10 video couldn’t watch it through entirely. You should rethink this. Highly distracting in a BAD way

[@drlorashahine]

Well noted. Thank you for watching ❤️

[@nadiatheprettyflamingo6528]

If you do t have anything positive to say…. Don’t say it at all. How about you go make some videos and see how well they do? It’s the information that is important NOT the editing. Please go make a video if love to watch it