Parkinson's can be detected through skin, study says

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@MissEAG 9 ай бұрын

Wasn't there a nurse that could smell Parkinson's too? I read somewhere at some point, that Parkinson's patients had an overgrowth of a certain type of yeast in their brain.. not sure if that led to anything.. but you know how bread yeast has that smell.. I wonder if that yeast they found in the brain has its own distinct smell and is throughout their bodies and giving them a smell, that can help it be detected. Remember that yeast is classified as a type of fungus and 'they" are now saying that fungus could be our next big problem.. but maybe it already is... but we haven't been paying close enough attention to it.

@dianeyoung8068 9 ай бұрын

Some dogs can smell Parkinson's.

@LeafBurrower 9 ай бұрын

A lot of people can 'smell' Parkinson's--I swear I can. My mother had it and I have a couple of friends who have it, too. The smell is slightly metallic, how can you describe a smell? If I smelled it on a person without knowing they had Parkinson's I'd definitely recognise it, but that has never happened and of course I've never tested it scientifically. I think I'd have to be specifically thinking about it to recognise it, which may mean it's psychosomatic I suppose. As for the yeast thing I think you're confusing a couple of things: Parkinson's, along with some other neurodegenerative diseases, is characterized by accumulations of a particular protein ( _alpha-synclein_ ) in the neurons of the brain stem ( the _substanta nigra_ ) which produces the neuro-transmitter _dopamine_ . These protein clumps (called _Lewy bodies_ ) cause cells in this part of the brain gradually to die off resulting in progressive physical and mental issues related to ever-reducing dopamine production. This is why Parkinson's patients are prescribed synthetic dopamine agonists which are quite effective but come with their own raft of side effects, there's nothing like the real thing, as they say. Scientists have found that this _alpha-synclein_ protein causes cell death in yeasts, too, and oddly enough there are similarities in certain chemical pathways that both yeasts and human cells utilize, so by experimenting with agents that can *_block_* these pathways in yeasts they have developed protocols that can prevent Parkinsonian symptoms in various animal models. I don't know how far they've come with this since I last was up to date with this stuff 10 years ago when my mother was still alive, but there was a lot of excitement about it at the time.

@MissEAG 9 ай бұрын

@@LeafBurrower My uncle also passed from Parkinson's a year ago so maybe you aren't aware of newer research. I just looked it up again.. there is lot's if you search for the fungal genus Malassezia, which causes an increased prevalence of Parkinson's, along with the bacterium Helicobacter pylori, and the hepatitis C virus.

@LeafBurrower 9 ай бұрын

Hospitals and clinics should have Parkinson's sniffer dogs. Some sort of program should be devised whereby the dog gives a sign to the handler and they in turn alert the medical staff who would then consider recommending testing. I don't exactly know how you'd do it, but there must be a way dogs could be utilized since they, too, are supposed to be 85-95% accurate diagnostically, and you could potentially screen large numbers of people for a pretty small cost. Otherwise you're still relying on a symptom to trigger this skin test and by that time it could be quite late on in the development of the disease.