Part I - An Intro to Endothelial Dysfunction and Atherosclerosis

In this first part, I describe the basic anatomy of an artery and discuss the important role of the endothelium for maintaining vascular health and preventing atherosclerosis.
More information can be found in my review paper:
www.ncbi.nlm.n...

[@billkos7993]

Can you do a video on the endothelial glycocalyx? .I feel like that is a video worthwhile and not too many people talk about it. Your thoughts?

[@劉佳星]

Is it possible to have a wearable continuous endothelial function monitor？

[@jamesalles139]

now add the endothelial glycocalyx

[@hero-gl4zy]

Can iopromide cause endothelial cell damage due to toxicity?

[@Yomibee]

Thank you, you're a great teacher.

[@physiologymadeeasy216]

Thanks ShalomChantez. I'm pleased you found the information useful!

[@s9plus603]

So very helpful sir😊😊

[@abuAbduAllah100]

Thank you dr for sharing this, I got a right internal carotid artery stenosis 90%+ decreased to 50%+. It is a construction in the advantage layer at some point of the artery when you look at it in the 3d pictures, and down of it, the artery got into like a balloon shape, looks inflamed or something, but I don't know if this balloon shape part got plaque in it or not, well I got a stroke as well. My question is why would the advantage layer constrict? And is it true that l arginine and l sitruline together in a supplement can produce the nitric oxide which can repair the edothelium of the arteries?! Best regards

[@physiologymadeeasy216]

Hi Khaled, Sorry to hear this. The balloon shape your referring to is likely the carotid bulb. Quite often there can be evidence of plaque here due to greater turbulence in blood flow. I am not sure what you mean by 'advantage' layer, but briefly, when the endothelium is damaged, the reduced NO bioavailability allows vasoconstrictive factors to dominate in the vessel. This obviously leads to reduced diameter and also vessel wall inflammation. There may be some evidence the L-arginine can improve vessel health, but I would discuss these options in more detail with your clinician. From a lifestyle point of view, you need to control any CVD risk factors and also incorporate exercise in to your life. This will have a far better effect than any supplementation. All the best with your recovery and health, Aamer

[@aodhfinn]

Food quality , and the amount is absolutely critical to strongly reducing the risk of plac build up ....the western diet is central to the creation of plac build up ....the western diet , is deathly.....whole food plant based diet the only way !

[@fit4lifesparta]

I am trying to understand exactly how the Endothelial Cells become damaged. I have read that sheer stress increases NO production and thus VD. But sheer stress from high blood pressure "Scratches" the EC? How does glucose or LDL in the blood actually damage the EC? It physically scratches them as they pass by? Thank you for your clarification. Dave from Wisconsin.

[@sreyvanthaaugustfirst1976]

Good teaching

[@onlinecourseinultrasound4712]

Nicely 😊😊

[@pinkypriya5313]

Very gd video...make many thing very clear

[@physiologymadeeasy216]

Thanks Priya. I am pleased the video helped.

[@simonefitganzheitlich]

🤍 Thanks

[@markomeara7962]

Is LP(a) and Lipoprotein Associated phospholipase A2 strong predictors of atherogenisis and poor endothelial dysfunction?

[@pirasanthanrajadurai1183]

Very informative. Thanks for the video Doc

[@physiologymadeeasy216]

My pleasure. Good luck with your studies!

[@chinthakayalakishna2166]

Pleace ట్రాన్సలేట్ తెలుగు

[@firozkhansarvani]

enhlish nerchuko

[@gtm5650]

Since plaque built up takes many years and the blood vessels are constantly taking a beating. The body must have a healing mechanism through nutrition or other recovery methods. What are these healing mechanisms?

[@physiologymadeeasy216]

In brief: 1) Mediterranean diet - helps increase nitric oxide (NO) bioavailaibulity in the vessel; 2) aerobic exercise - increases NO levels and integrity of vascular wall; 3) lifestyle/medical interventions which reduce common heart disease risk factors.

[@alc6799]

Why would some points in the body’s endothelium be more susceptible to ‘damage’ than other parts as for example high BP is the same throughout the body?

[@physiologymadeeasy216]

Good question. The flow of blood through the body is dynamic and differs for pressure, speed, viscosity and other factors. The blood vessel network also has lots of branch points, curvatures, changes in diameter etc. All of these factors and more make the pressure (and potential damage to endothelium) different in different segments of the artery. So, although blood pressure measured in the brachial artery might reflect what pressure the whole system is under, the effect of that pressure on a smaller, narrower and bifurcating vessel might be different than to a larger, straight and non-bifurcating vessel. This is my understanding of what is a complex process.

[@roberth9441]

No, Thank you doc! Your channel is approximately named….You made this extremely easy to understand! Peace&blessings to you.

[@physiologymadeeasy216]

You are very welcome Robert, and thanks for the kind comment. I will continue to take the same approach in future videos too. Take care.

[@amardeepsamar7161]

super thank you sir

[@taveshju8655]

Thank you sir, can you do a video on how obesity can cause endothelial disfunction?

[@physiologymadeeasy216]

Hi Tavesh, I will try to produce a video on this soon.

[@PikesCore24]

Hello Dr. Sandoo, I'm a 57 year old male in excellent health. However, I have rosacea, which is a skin disorder of the face. If flares up when I'm in direct sunlight. It is mostly on my right side. I have a hunch that the capillaries of my skin in this area have been damaged, and that i have endothelial dysfunction in this particular area. I was just wondering if you had ever heard of such a thing?

[@physiologymadeeasy216]

Hi there, sorry to hear about this. This is a helpful summary of the main physiological mechanisms which include neurovascular dysfunction, inflammation and increased vasodilatation ahdbonline.com/payer-perspectives-in-dermatology/1469-article-1469 and www.ncbi.nlm.nih.gov/pmc/articles/PMC5037831/

[@PikesCore24]

@@physiologymadeeasy216 Thanks for getting back to me. That paper is a bit heavy on biochemistry, but I'm going to dive in.

[@Sojourner1]

Fabulous presentation. Thank you. (And no unnecessary background music is an added bonus.)

[@physiologymadeeasy216]

Thanks Sheesh. Background music in educational videos is a particular 'hate' of mine. It distracts the brain from taking in the most useful information (i.e. the verbal narration).

[@aodhfinn]

Thanks for that video ...👍

[@physiologymadeeasy216]

My pleasure

[@kalwantdhesi7710]

How do you reverse atherosclerosis

[@physiologymadeeasy216]

Exercise, good diet, reduced stress, getting good sleep!

[@MarksThinkTank]

Brilliant video, thank you!

[@physiologymadeeasy216]

Glad it was helpful! All the best.

[@shahmirhosseinzadeh3122]

Really good thank you

[@physiologymadeeasy216]

Thanks Shahmir.

[@Omri.Tal.]

Great vid, thanks!

[@physiologymadeeasy216]

Your welcome! I am pleased you found it useful.

[@downbntout]

Wish you had zoomed in

[@physiologymadeeasy216]

Apologies for that. Your right, zooming in would have made it easier to read the words on the diagram. I am learning about video making all the time, so this is good feedback PS: if you zoom your browser view settings to above 200%, you tend to get more clarity for this video.

[@downbntout]

@@physiologymadeeasy216 I'm on my phone, and I wonder how many ppl only get YT on a phone. Thank you for receiving my post graciously

[@GideonStHelen]

Excellent job, sir!

[@physiologymadeeasy216]

Thanks!

[@kholi1240]

@@physiologymadeeasy216 how much take time Atherosclerosis to develop???

[@mtom7889]

Awesome!

[@physiologymadeeasy216]

Thanks!