Part I - Mucosal Immunity

[@armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓 youmakr.ai/test-playground/questionnaire/673d5055859b9c170836f1b1

[@crimson_auror]

This man single handedly taught me immunology as an undergrad because my professor was terrible. Now I’m in med school and he’s still helping me.

[@bittersweetspn]

my teacher was like: lamina propria ...peyer's patches ...& i was like :whaaat?!! it was latin indeed,to think that you actually managed to explain everything in like 30min ...REALLY IMPRESSIVE ,THANK YOU !!

[@endangeredspecies1744]

Amazing, you have helped me with my personal research

[@josef994]

The scintest who detect that was a genius ...and your explanation was excellent thank you

[@Monmize]

You are a legend sir.

[@sankalpspatil4890]

Holy cow the body is so complex

[@susanlee5690]

This is very very helpful.. Thanks a lot!

[@lancejohnson108]

Awesome diagrams... wish I could draw like this on the marker boards when teaching. Have you thought about doing these on a marker board? That way you could erase sections instead of redrawing.

[@manueleliseo4233]

I guess it's kinda off topic but does anybody know of a good site to stream new series online ?

[@magnusrayan498]

@Manuel Eliseo flixportal :)

[@manueleliseo4233]

@Magnus Rayan thanks, I went there and it seems to work :) Appreciate it!!

[@magnusrayan498]

@Manuel Eliseo no problem :)

[@yuliannad4252]

as far as I know, M cells present the antigen to macrophages not to dendritic cells.. dendritic cells can catch the antigen of the lumen by themselves without leaving the peyer's patches

[@Neyliz123]

+Yulianna D M cells, located on the peyer's patches, transcytose Ags to the underlying DC which are in the peyer's patches. There are also Dendritic cells in the lamina propria.(Con. Tissue) where the dendritic cells can extend their processes though the gut epithelium and capture Ags on their own :)

[@garytucker5748]

Endorphins stimulated.

[@LuisMi_inmuno]

Excelente trabajo, muchas gracias por compartir, saludos desde Mexico DF ( Excelent video, thanks!!)

[@akshayshelar3969]

Sir pls make vedio on vaccines.

[@MrSTANDup92]

Great video thanks man!

[@laisaraujo1290]

thank you so much for this video!!!

[@khsagar]

can you please cover autoimmune and immunodeficiency????

[@vikki12307]

Really impressive but you talk and go through it so fast.

[@neil7090]

But they're punchy and that keeps his tutorials short. They're really good that way. Pause and take notes, that's what I do.

[@isesdealmeidaabrahamsohn1358]

There are serious conceptual flaws in this material by Armando Hasudungan ! Plasma cells do not circulate to other tissues to there produce antibodies and do not have Ig on their surface. B cells originate in the bone marrow, populate the secondary lymphoid organs and tissues and are the ones that have Ig on their surface and recognize Ag. They do not circulate as much as T cells. They need help from T cells to synthesize most antibodies. The differentiation towards plasma cells occurs in the secondary lymphoid organs and tissues . The bone marrow is not a major source of Ab-producing plasma cells except in some domestic animals. Most actions of Antibody to eliminate bacteria or antigens does not occur in circulation. T killer cells are seldom called that nowadays - better T cytotoxic cells. There is no explanation offered on the subpopulations of Th cells and how they appear. The name Th1 cells appears suddenly and certainly their funcion is not only to produce Interferon gamma; TNF-alpha may be secreted by Th1 but they are no t the major source of this cytokine. Several important participants of Innate immunity are not mentioned f.i. activation of the inflammatory cascades by interaction of TLR receptors and NK cells Conclusion and advice to potential viewers: Get yourself a basic immunology book in paper or via internet and learn correct basic concepts. Ises A. Abrahamsohn, MD , PhD. Professor of Immunology. University of São Paulo, Brazil.

[@AmirAbuleil92]

All what you are saying here Armando explained it in details in previous videos ,, check out the immunology map videos

[@projectfortatjana]

+Ises de Almeida Abrahamsohn please check other videos!!!!

[@nellyhoffman6194]

Come explain to us then you MD PHD =Pizza hut delivery

[@TribaI_]

I believe you are being quite harsh as Armando Hasudungan hasn't gotten his basics wrong. - Plasma cells can circulate to tissues such as in this case in the Lamina Propria - B cells do populate secondary lymph organs which is why we see them in Peyer's Patches which is a secondary lymph organ. - Correct T cells circulate more than B cells (around a 80% to 20% divide) - B cells don't need help to synthesize ABs but need additional signals to become activated. 3 signals in fact: from T-helper cells as well as cytokines and binding to the cognate peptide that is specific to the binding groove of B cell receptors. - Yes differentiation does occur in secondary lymph tissues which as I said Peyer's patches are thus Armando Hasudungan is correct. - Most of the time in the adaptive immune system when B cells become activated in lymph nodes they move back to the bone marrow to either differentiate to memory cells of plasma cells where they secrete ABs. - Armando Hasudungan never mentioned elimination in the circulatory system. All of what he said was in secondary lymphatic organs or lymph vessels. -It is not wrong to call Tc cells T killer. This is still taught today and there are many names for multiple things in biology. - If you watch the other parts of this series you would know that Armando Hasudungan would explain the sub populations of Th cells. - Your next statement is confusing why are you mentioning INF-gamma then T?NF-alpha. -I would agree with Armando Hasudungan and leave out the innate immunity as this video was specific to the adaptive immunity of the mucosa. One thing Armando Hasudungan could have done was include the job of T-reg cells and their important function in regulating the inflammatory response which if not present could lead to Inflammatory bowel syndrome. On the whole I believe Armando Hasudungan did a fantastic job in explaining this confusing and difficult subject. I do not envy your patients or students who are in your care at University of São Paulo.

[@saraaMoh]

I find the zooming in and out VERY disturbing