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Calcifications-
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Calcifications refer to the accumulation of calcium salts in body tissues, which can be a normal physiological process or an indication of disease. In pathology, calcifications can help diagnose various conditions.
What are Calcifications? 🤔
Definition: Calcifications occur when calcium builds up in body tissue, leading to hardening or stiffening of the affected area.
Types of Calcifications:
Dystrophic Calcification: Occurs in damaged or necrotic tissue despite normal serum calcium levels.
Metastatic Calcification: Results from elevated serum calcium levels, affecting normal tissues.
Causes of Calcifications ⚠️
Dystrophic Calcification:
Tissue injury or necrosis (e.g., from infections, tumors).
Chronic inflammation (e.g., in conditions like tuberculosis).
Metastatic Calcification:
Hyperparathyroidism (overactivity of parathyroid glands).
Chronic kidney disease (leading to imbalances in calcium and phosphate).
Vitamin D intoxication.
Common Locations of Calcifications 📍
Vascular Calcifications: Hardening of blood vessels due to calcium deposits, seen in atherosclerosis.
Breast Calcifications: Detected during mammograms; can indicate benign or malignant changes.
Kidney Stones: Formed by the accumulation of calcium and other substances in the kidneys.
Lung Calcifications: May occur due to previous infections (e.g., tuberculosis).
Diagnosis and Imaging 🩻
Imaging Techniques:
X-rays: Can show calcifications in bones and some soft tissues.
CT Scans: More sensitive for detecting calcifications, especially in organs like the lungs and kidneys.
Ultrasound: Useful for detecting calcifications in soft tissues.
Treatment Options 💊
Depends on Underlying Cause:
Dystrophic Calcification: Often requires addressing the underlying tissue damage or inflammation.
Metastatic Calcification: Focus on treating the underlying metabolic disorder (e.g., managing hyperparathyroidism).
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