Cell Death: Pathology Hindi Lecture

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺: / clinical.learning
Cell death is a fundamental biological process that plays a critical role in development, homeostasis, and response to injury. It can be classified into two main types: apoptosis (programmed cell death) and necrosis (uncontrolled cell death). Understanding these mechanisms is essential for comprehending various diseases and treatment strategies.
Types of Cell Death 🔍
Apoptosis 🌱
Definition: A controlled and regulated process where cells self-destruct in response to signals.
Characteristics:
Cell shrinkage and chromatin condensation.
Fragmentation of DNA.
Formation of apoptotic bodies that are phagocytosed by neighboring cells.
Functions:
Removes damaged or unwanted cells (e.g., during development).
Maintains tissue homeostasis.
Plays a role in immune responses.
Necrosis 🚨
Definition: An uncontrolled form of cell death often resulting from acute injury, infection, or lack of blood supply (ischemia).
Characteristics:
Cell swelling and rupture of the cell membrane.
Release of intracellular contents, which can trigger inflammation.
Causes damage to surrounding tissues.
Common Causes:
Trauma, toxins, and infections.
Ischemia leading to a lack of oxygen.
Mechanisms of Cell Death 🔬
Apoptotic Pathways:
Intrinsic Pathway: Triggered by internal cellular stress (e.g., DNA damage). Involves mitochondrial signaling.
Extrinsic Pathway: Triggered by external signals, such as death ligands binding to their receptors.
Necrotic Mechanisms:
Often involves energy failure (ATP depletion), leading to a breakdown of cellular functions and loss of membrane integrity.
Importance of Cell Death 🏥
Development: Cell death is crucial during embryogenesis for shaping organs and tissues.
Disease Processes:
Cancer: Dysregulation of apoptosis can lead to uncontrolled cell proliferation.
Neurodegenerative Diseases: Excessive apoptosis may contribute to diseases like Alzheimer's and Parkinson's.
Infection: Necrosis can be a consequence of infections that compromise cell health.
Clinical Implications 🩺
Cancer Therapy: Targeting apoptotic pathways can enhance the effectiveness of cancer treatments.
Neuroprotection: Strategies to prevent excessive apoptosis may help in treating neurodegenerative disorders.
Inflammation: Understanding necrosis and its inflammatory consequences can guide the management of inflammatory diseases.
#CellDeath #Apoptosis #Necrosis #Biology #MedicalEducation #CellularHealth #CancerResearch #Neurodegeneration #Inflammation #HealthScience

[@amolkelkar7231]

Nice lecture

[@medschoolsimplified007]

Thank u