Patrick Holford - 'What’s driving Alzheimer’s?'

[@Terrierized]

It's the guidelines, upside down pyramid, and the denial/ignorance that we're being set up to fail

[@bikegirl649]

0⁰000⁰0000ppppppppppppppppppppppppppppoooooooooooooooo0w😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊

[@sebek12345]

🎯 Key points for quick navigation: 00:24 *📚 Patrick Holford has written 46 books, including "The Alzheimer's Prevention Plan" in 2005, advocating that Alzheimer's is largely preventable.* 01:20 *⏱️ Every 3 seconds someone is diagnosed with Alzheimer's, with 790 people diagnosed daily in the UK alone.* 01:48 *🧠 Changes in cognition that lead to Alzheimer's diagnosis occur 40 years before the actual diagnosis.* 02:30 *🔬 Alzheimer's diagnosis requires both loss of cognitive function and shrinkage of the medial temporal lobe, visible through MRI scans.* 03:12 *🧪 Homocysteine levels above 11.5 are associated with accelerated brain shrinkage, a key factor in Alzheimer's development.* 04:20 *📈 Small increases in blood glucose within the normal range confer a 15% increased risk of dementia in young adults (35+).* 05:42 *🧬 Contrary to popular belief, only about 0.5% of Alzheimer's cases are due to causative genes, not 30-50% as commonly thought.* 08:02 *🥗 A study of 29,000 people showed that those with a healthy diet were 7 times less likely to have age-related cognitive decline and 9 times less likely to develop dementia than those with an unfavorable diet.* 10:52 *👂 Sensory impairments like hearing loss and vision problems are risk factors for dementia, highlighting the importance of sensory stimulation and an active lifestyle.* 13:23 *🔬 A meta-analysis of 396 trials concluded that homocysteine-lowering treatment is the most promising intervention for Alzheimer's disease.* 15:39 *🐟 About one-third of Alzheimer's risk is attributed to two factors: omega-3 deficiency and B vitamin deficiency (related to homocysteine levels).* 18:51 *💊 A study showed that high-dose B vitamin supplementation (B12, folate, B6) significantly reduced brain shrinkage in people with mild cognitive impairment, especially those with high homocysteine levels.* 24:42 *🧠 Brain shrinkage observed in people with B12 levels within normal range, suggesting current reference ranges may be misleading.* 25:21 *🐟 Recent study shows 20% reduced dementia risk for those with high omega-3 levels from supplements or fish consumption.* 26:29 *🔬 Study found 73% less brain shrinkage in participants with highest omega-3 levels when given B vitamins.* 27:50 *🤝 Synergy between omega-3 and B vitamins highlighted, with combined supplementation showing significant cognitive benefits.* 29:38 *💉 Discussion of anti-amyloid injections for Alzheimer's, comparing their effects to B vitamin and omega-3 supplementation.* 31:27 *📊 Criticism of recent anti-amyloid drug trials, noting potential unblinding issues and minimal reported improvements.* 33:30 *🔎 Raised homocysteine linked to increased risk of cognitive deficit and cerebrovascular effects.* 34:10 *🍎 Four major preventable drivers of Alzheimer's: sugar/carbohydrates, lack of omega-3 DHA, B vitamin deficiency, and insufficient vegetables/fruits/antioxidants.* 35:33 *📱 Introduction of "Cognition" program to help individuals change behavior and reduce dementia risk.* 37:38 *🏥 Launch of pilot program targeting GPs to track patients' progress in reducing dementia risk.* 39:25 *👨‍🦳 Case study of Noge, diagnosed with mixed dementia, showing significant improvement after implementing lifestyle changes based on Food for the Brain recommendations.* Made with HARPA AI

[@Corolla97ww]

Thanks for summarizing main points with time marks

[@craftycalley]

Brilliant. Going to the website now.

[@patricksullivan3919]

Sugar and refined carbohydrates. Plus poisonous seed oils. Corn, soybean, canola, cottonseed. Anything invented after 1890.

[@willemvanriet7160]

and now Bill Gates is manufacturing butter from carbon extraction... Let's skip the next round of UPFs

[@TommyJerry-bs6ui]

@@willemvanriet7160 IF that manufactured artificial butter turns out to be just as healthy nutritious as ordinary butter, then there's no problem. I think the company is called Savory Butter. They are mimicking the fatty acids from the ordinary butter and makes it from yeast. Its very exciting. Seed oils are unhealthy cause they are prone to oxidiation, and becomes rancid during the manufactering. And margarine is unhealthy cause of trans fats.

[@angelawilliamson6765]

Life-changing information 🎉 Massively appreciated 👍🏼

[@scoobtoober2975]

Dr Grant is right up my latest alley. I've been routine basking in sun, shirt off as much as possible. I truly has helped metabolic health and visceral fat, it's shrinking my insides and makes me feel well adjusted. Love you and i haven't heard of him. Nice to see no shill college folks on this panel. Love rob lustig, he saved my life and my families. No doubt about that. I was very ignorant and resistant to change. Until he said its the sugar stupid and low fiber.

[@DandoPorsaco-ho1zs]

Alley is a narrow passageway. The word you're after is ally.

[@jimw6659]

Wonderful talk. Thank you.

[@joannekerr8839]

Absolutely awesome video - thank you.

[@jamieparr6962]

Fantastic listen 👍👍

[@petercyr3508]

I think he is missing the mark here a bit. Our huge brains REQUIRE ketones along with glucose from birth to develop and be fueled properly. Yet we spend our lives blocking ketone production eating the crappy recommended diet full of sugar and junk starches. So this begins the first time a baby is given sugar. Then the brain is starved for decades. Your liver makes all the glucose you need. Any you eat is extra and blocks ketone production, also by the liver, while your body deals with the unneeded glucose. If you constantly eat carbs, you constantly block ketone production and starve your brain. So prevention is to be in a well fed ketogenic state. It will also improve your vit B levels. Lots of info out there on how to do that.

[@kevmuso4336]

Exactly my reaction to this!

[@itwillbenicewhenitsfinished]

No no no, Dr Here did strict keto for long time, developed many metabolic problems. I need some dietary glucose, there’s some genetic differences between Europeans and eskimos - less able to use peroxisomes etc etc, (we have salivary amylase for a reason)

[@porkpie2884]

@@itwillbenicewhenitsfinished The dietary requirement in humans for carbs is exactly ZERO. May be there's something wrong with your liver?

[@fiddlerJohn]

10:49 " in other words it's not just about having a healthy brain it's not just about having a good sort of metabolic Supply if you don't use it you lose it ."

[@terfalicious]

excellent speaker

[@Annalwayslearning]

Fascinating and funny! Great presentation, thank you 😊

[@peterpan6821]

All of this seems obvious to me but it's nice to know I'm right. Eat and live as our ancestors.

[@sharvo6]

Many decades ago Robin Morgan's book, the descent of woman, theorized that Early humans evolved as partially aquatic.

[@dormasterous]

Interesting talk, thanks 👍

[@jimw6659]

A link to the cognitive website would be useful.

[@j.p.8248]

Can someone please post the TL;DR (a summary of key points) for lay people?

[@hmbdata]

You should take omega 3, eat fish. Avoid too many carbs (presumably highly processed); keep low levels of homocysteine (take B vitamins; leafy greens, fish. Keep good vitamin D levels.

[@NiekLodewijkx]

high carbs

[@grunklebob9009]

Walking on uneven terrain is the hands down BEST brain exercise you can do! Get your sleep and have a good diet and you won't have to worry about this :)

[@AnneMB955]

So do I now go and get a blood test to see if I’m getting enough B vitamins and Omega 3? Would taking supplements be okay even if I feel I’m eating the right foods? Certainly want to avoid Alzheimer’s that Dad had. Great talk. Did the test: 2 green, rest yellow. (68 years)

[@fiddlerJohn]

7:58 "In the British medical jour 29,000 people and what it found is that uh those who had a healthy diet were about 7 times less likely to have age- related cognitive decline than those with an average diet and nine times less likely to develop dementia than those with an unfavorable diet and one of the things that was quite interesting in this and this is not because I'm not a fan of exercise I totally am uh but the effect of the diet was was about twice as important as the next biggest risk factor which was exercise whether or not you had apoe4 made absolutely no difference at all the other big trial that's going on that is multifactorial and very respected and very well done is the finger trial and uh they're changing lots of different factors that are risk factors but once again whether or not your apoe4 makes no difference ."

[@joseftraunmueller3844]

The question is, what odes BMJ consider a healthy diet, and how did they ask the question?

[@Krunch2020]

Doctors don’t know what a healthy diet consists of. Make your personal guess and give that a try. Good luck.

[@AnneMB955]

So what is a healthy diet?

[@AthleticHobo-br4qh]

Almost certainly a diet primarily full of vegetable whole foods (this does not mean a diet primarily consisting of grains). i.e Mediterranean, Okinawan, pescetarian, whole food Vegan diet.

[@fiddlerJohn]

23:07 "Indian J Dermatol. kind of helped the Clincher on this because he said human babies are born with a waxy waterproof layer the vernix. I have never seen a vernix in any land-based mammal. I wonder if the same thing occurs in the sea mammals like seals and sea lions you probably know that dolphins have every bone in our hands and arms in their flippers. So if you watch their fetal Evolution they're like us, but they're just sort of shrink and sure enough a French Canadian marine biologist took this up and it is true. Seals and sea lions have exactly the same vernix us humans do. No land based mammals have this. The point of this is one has to assume the Pavan man was burning off at least double the calories hunting and Gathering and what that would mean to today is that half of our entire diet would have to be marine food to get the same kind of intake of Omega-3 DHA of phospholipids of B12 of iodine of selenium of zinc and other such essential brain nutrients. In other words Evolution has driven our brain and in fact it is that combination of phosphorilated DHA attached to phospholipids that is such an Exquisite predictor of the risk of Alzheimer's disease ." Vernix caseosa, or vernix for short, is a white, cheesy-looking substance that coats the skin of a baby while in the uterus." www.ncbi.nlm.nih.gov/pmc/articles/PMC2763724/

[@pureabsolute4618]

Nice reference to application of the vernix!!

[@OGPedXing]

I enjoyed the lecture except that I was surprised by this part. The aquatic ape is generally considered psuedo science. It makes claims that are very complicated, explainable by other hypotheses, and is essentially unprovable or testable. High omega 3 diets are easily achieved from a diet consisting of large ruminate mammals. Sea food is not required. Also bipedalism likely started prior to coming down from the trees more than 7 million years ago, not via wading as is claimed. Having vernix at birth is protective against pathogens for a hairless infant. It need not have anything to do with semi aquaticism. It is just as easy to say that sea lions have human like vernix indicating a land based hairless evolutionary past.

[@genuineimpulse9134]

A diet made of grains= sugar+ statins. Babies have a high cholesterol, almost like it's a needed thing in the body. It's important in nerve sheathing and the brain. What could possibly be wrong with making 50 billion a year to screw with nerve function.

[@HaHaroni]

Great research but I believe this guy needs to talk to Dr Knobbe.

[@Fire_of_Heaven556]

Statins and poisonous food

[@ostinspace]

Just eat red meat and eggs get out in the sun you should be right :)

[@zorabw8948]

That is what I do. My B vitamins in the bloodwork are excellent.

[@ekondigg6751]

Definitely. But Dr Holford says that Vit B complex often starts to become malabsorbed when we age, which means that for some older people, they can't absorb enough B vitamins from meat and eggs, even though there's enough present in the food. It's those people who should be supplementing.

[@btudrus]

@@zorabw8948 Exactly. And meat & eggs will provide enough methionine and choline for glutathion to work properly.

[@stuarthutt3740]

It's very eloquent but I suggest you look at brain biopsies and aluminum poisoning as per Dr Christopher Exley.

[@seanmurphy1704]

Is there a liposomaly encapsulated version of b12 as there is with vitamin c, for much better absorbtion, ie passing through the blood brain barrier?

[@btudrus]

red meat 🙂

[@305Alligator]

Statin use ‼️

[@petermadany2779]

I guess chocolate chocolate chip ice cream is low in DHA and high in carbohydrates, not sure about B12.

[@btudrus]

zero B12

[@versewriter8123]

Surprised to hear him mention folic acid. It is now known that this synthetic non bioavailable supplement has a deleterious effect on those with the MTHFR snp. Up to fifty percent of the world population has this mutation. If supplementing it's safer to do so with either methylfolate or Folinic Acid (not the same as folic acid) which are both biologically available & don't depend on a cell enzyme to convert them in order to affect the methylation cycle.

[@MrSillenomis]

Seed oils? Processed food? Artificial sweeteners?

[@porkpie2884]

carbs

[@scoobtoober2975]

I did the food for the brain test. I'll check in with it when you want me too. I think it sends an email. Cheers.

[@Vova3iLvova]

so the tldr is..... eat eggs? full of omega 3 and vit B

[@ekondigg6751]

Eggs are certainly better than nothing for DHA, but very little compared to sea food.

[@btudrus]

and red meat and avoid sugar and carbs...

[@HB-iq6bl]

No carbs.

[@j.taylor3670]

The fish oils cause stroke, increasing the risk of vascular dementia and heavy metals like mercury are another cumulative problem. There has also been an up tick in ALS in humans and cases of dementia in dolphins (!) linked to blue green algal blooms due to global warming and the cyanobacteria contained therein, so they should find a way to get the homocystein down without seafood. Immediately.

[@ekondigg6751]

Problem is that we need DHA. The only abundant source of DHA is seafood.

[@ThanhNguyen-wn5cz]

Take Krill oil supplement, eat sardine.

[@gardenwatch3754]

So, Alzheimer's should be much higher in vegetarians and vegans - is there any data to support this?

[@suthish123]

Great presentation - looks I Am the first to comment?😂

[@1timbarrett]

It’s a good thing China is leading the way on ALS research, given the incoming “silver tsunami” there…! 🌊

[@Maintain_Decorum]

Calling my doctor for a homocysteine test!!

[@Maintain_Decorum]

My doctor told me I didn’t need it. I’m 65. I insisted. I’m glad to report my levels are normal. 😊

[@Mat_Gallusman]

​@@Maintain_DecorumSo you did not need it 😉😁

[@tonybennett638]

Too many carbs for Joe ?

[@jujumaccas]

Ice creams….

[@Mat_Gallusman]

And he’s on statins.

[@Ariella-mx3xq4cw6n]

We were never apes DNA is only 70% that of humans. A banana has 50% the same DNA. Quote from Evolutionist Professor Jerome Lejeune, in a lecture given in Paris on March 17, 1985, translated by Peter Wilders. “We have no acceptable theory of evolution at the present time. There is none; and I cannot accept the theory that I teach to my students each year. Let me explain. I teach the synthetic theory known as the neo-Darwinian, for one reason only; not because it’s good, we know it is bad, but because there isn’t any other. Whilst waiting to find something better you are taught something which is known to be inexact, which is a first approximation …” . There is another, which does fit the bit of evidence we do have. Creation.

[@danielmogos8990]

How can a scientist speak about evolution and being an ape with such certainty? This is really disturbing, especially considering that he is someone who claims that he has a good understanding of the world and who tries to convince me that he is right in what he says. I withdraw my patreon support.