Pentose phosphate pathway - Cyclic structures and anomers | Biomolecules | MCAT | Khan Academy

[@lakshyajeetvirdi4186]

Don't listen to some of the people here, I love your voice.. and helpful video.. Can you make a video which connects all the cycles of the metabolism of glucose.. Like glycolysis, gluconeogenesis,glycogenesis, glycogenolysis and some of the other cycles idk which all connects to which one.. it would be helpful in understand everything altogether

[@therambler3713]

where would I be without you khan academy, I will definitely mention you at my graduation speech)))

[@nawwarrashed1781]

I was thinking about that rn

[@chell6022]

Same

[@davidn4408]

So did you do it?

[@h.o3575]

@@davidn4408 🤣🤣🤣🤣

[@davidn.2555]

@@h.o3575 Guess he didn't do it. It was all 🧢

[@davidadams255]

Something else of note: the rate-limiting reaction/enzyme is glucose-6-phosphate dehydrogenase. The enzymes for rate-limiting steps of glucose metabolism are often tested on the MCAT.

[@princessfittja]

I really found the video useful! Thank you :) I also didnt find her voice annoying at all, in fact i actually enjoyed it lol. Maybe because i am british, and its not everyday where i can get to have someone teach me something in that accent. It made me pay more attention to what she was saying :D

[@bonbonpony]

princessfittja She sounds a bit like Bernadette Rostenkowski from the TV show "The Big Bang Theory" (which is quite an interesting coincidence that Bernadette is also into biology ;) )

[@venezuelaavi]

great vid a lot of haters on here that probably don't have a grasp on the concepts you presented if they have a problem tell them to go buy lippincott biochem book. keep up the good work from one future doc to another

[@tylzz94]

Her voice might be slightly annoying but she's so smart tho..I'm learning so much from this ...thank you :')

[@backstreetfan2887]

This video was very helpful for me. I feel so very grateful to Khan Academy for providing this fee resource.

[@jeremyhudson7204]

Im in medical schopl learning about metabolism and this helped me out! Thank you!!!

[@Schulemachtmuede]

Great video, I really like how you point out which molecules are important and why and also what the point of it all is My textbook just tells you about all the details first and its hard to focus on the small steps when you have no sense of why its important in the first place Thank you!

[@dimkacracker]

One thing to note: There are 4 different paths that PPP can take. 1. NADPH needs exceed ribose-5-phosphate needs, 2. ribose-5-phosphate needs exceed NADPH needs, 3. NADPH and ribose-5-phosphate needs are equal, 4. NADPH and ATP are needed over ribose-5-phosphate. Depending on whichever, PPP will choose to take different conversions.

[@heylollipops]

Very helpful! Listened on 2x speed and you have a lovely voice.

[@MCouary]

although it lacks some depth, it is very well explained in a more general sense. Congrats, i like it.

[@GaurMansi]

y your voice is so shivery !!!!! just cant concentrate. it sounds like u are in a constant pain n cant speak.

[@abraxadabra4224]

I wish this was an actual in-depth lecture, with formulas and all ..becaue this teacher's voice is hypnotic! It's weirdly high-pitched but calming at the same time. So makes me alert in a curious way.

[@feisalMussaa]

thank you so much I really had no idea about the PPP before watching this video thanks a lot

[@LuftwaffeRommel]

3 stages to PPP pathway; oxidative decarboxylation, isomerization, and sugar rearrangements. Also the most important reason PPP exist is to provide the precursors for RNA/DNA biosynthesis, NADPH is tertiary, erythrose is second. For those reviewing concepts of the PPP for Microbial Metabolism anyways! Only the first 2 minutes is all you need the rest is good but not for this section.

[@abdullahksa1430]

thank you very much, it's really helpful

[@terencecamilon7800]

Thank you for making this so much easier to see!! Also, I'm convinced Jasmine Rana and Drew Barrymore are the same person

[@hawraalsofi4795]

Really thank you for your amazing explanation of it 👏👏👏 I have exam and I understand it finally 😆😅 really good +khan academy

[@todaXPTO]

If you are at 3:30 forward to 8:10

[@FarhanShares]

got it :)

[@JawHacks]

disagree. i think one of the major challenges of PPP is understanding "what's the point?" the discussion during this time helps with that. also, conceptual context helps with memorizing these pathways.

[@noxusfumes3628]

@@JawHacks true

[@gracewang2804]

thank you so much, it is really helpful

[@mo-jl8im]

شكرا جزيلا لكي 😍😍😍😍

[@ceestudy5898]

ma'am, you're the best!!! Your voice is so soothing 🌺

[@sciencenerd7639]

Wow, this was super helpful, thanks so much!

[@nrlacomba1]

Nice introduction of the pathway. It could be more helpful if you can make a video interconnecting the intermediates of glycolysis and the pentose pathway.

[@sam14796]

yes... video is awesome and i do love voice of narrator...good job

[@katjau_]

Thank you! It really helps to hear something explained with different words and slightly differently!

[@omerhudaibengi6595]

U're my guardian angel :)

[@graceshryack5446]

I love your breakdown and assortment of everything. So helpful.

[@brideepdeka9619]

her voice is like magic....wao

[@summerbreezenight]

Glu is the abbreviation for glutamic acid. Glc is better for glucose. It's a small point, but the beginners get easily confused.

[@AbuAl7sn1]

“ Gluc “

[@ZikryYaar]

Absolutely Amazing... Thanks

[@tolu.writes]

This made my reading so much easier, thank you 🥺

[@gerardine3]

much much help

[@FarhanShares]

u might want to skip 3:30 to 8:10 if you already know the differences between NADH & NADPH.

[@sofia_m762]

Thank you so much ❤

[@daniellekernan2052]

You need to be careful writing things like "Glu" and "Gly" because those are short hand for glutamate and glycine!

[@Niggaman51]

Womp Womp

[@xIFearlessPups]

Absolutely amazing, wonderful video!

[@smokymiaw]

Great explanation!!!! Very easy to follow along :) Thank you!

[@jamalnasirmls]

All that helped was subtitles. Thanks for the subtitles.

[@asas-tc6kr]

I finally generally understood this pathway. Thanks a lot I was really struggeling with it.

[@palshah3509]

If confused here @ninjanerdscience does a very good job in explaining this

[@woloabel]

(On Saturday of February 18, 2023). On the Matter of Pentose Phosphate Pathway (PPP): 1) Substrate of Glucose-6-Phosphate (Glycolysis Product); 2) Enzymes Therein And (Oxidative Phase Enzymes and Non-Oxidative Enzymes); 3) Products Therein of Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NADPH, Reduced Form and/or Reducing Agent in Metabolism) and Ribose-5-Phosphate (Nucleic Acid Synthesis); 4) Biological Chemicals (Nicotinamide, Phosphate Subgroups, [Carbohydrates and Amino Acids] Redox Reactions Therein; PhD Jasmine Rana, es sehr gut zu lernen und lehren Lebenbiosynthese und Chemie daran. Heil!

[@Ash-cz4xv]

tmrw is goin to be my exam passin it or not i enjoyed studing with you guys, lots of love

[@janjamesramos247]

This helped me to understand more of the bigger picture of PPP. Thanks!!!

[@nahuyblyat]

this was very helpful, thank you!!!

[@reneho9189]

During the COVID-19 pandemic, it’s better to watch this video than to take school lessons online and have no idea what teacher was talking about.

[@AlKhttabAlSaqri]

thank you Jasmine Rana. This is awesome !

[@jinx2873]

thank you

[@yourfuturedocburenbeiya]

Great content as always! I hope they don't take away the MCAT resources after September!

[@santiagomelendez8771]

THANK YOU! :)

[@karenjose2509]

Thanks for helping me. :)

[@banizzile]

Thank you!!! Amazing video

[@matthewlee4834]

Good video as always

[@deveshyadav6283]

Thanks very helpful

[@tusharchopawar8255]

Very helpful...thnks for sharing..

[@basketballtim2009]

Excellent video. Wonderful job connecting this pathway to others. I found it very useful.

[@puriezeondy9425]

Can I just say that the first PRIMARY product of this reaction is RIBULOSE-5-PHOSPHATE and not ribose-5-phosphate. Just for those that might be revising for medial or biomedical exams, you need to be accurate!

[@puttatidam.1819]

actually she is correct. Ribose-5-phosphate is a primary product (---> nucleic acid) Ribulose 1-5, diphosphate is also made, these two are two different things.

[@lissa7052]

Thank you!

[@melissamcfadden3728]

Love your videos! Thank you!

[@remi742]

I like your voice, very cute. Keep it up

[@medschoolradio]

Fantastic! Very helpful indeed!!!!!!

[@zSchreckensszene]

your voice is fine, for the record. thanks for breaking it down!

[@mohammadadnan6374]

helpful thank you ❤

[@Rabiecakes]

great vid. very lucid

[@benjaminmasara7935]

Great

[@sujith2074]

Thank u

[@EDUARDO12348]

So interesting what cells can do... in this example a delicious meal can be broken down in glucose which can serve to build cellular software called DNA.

[@reinemachefrau8633]

Very interesting Eduardo... very interesting. I can hardly think about something more interesting 😂

[@ricexzeeb]

great explanation, thanks

[@tonyperuano]

thank you for clarifying the pathway, in class this pathway had me confused on which direction it goes

[@theclassroomdoc]

Thanks so much and agree with Jeet, ignore people who focus on your voice (beyond me how they can be so ungrateful!!!). Had a question. The supplement d-ribose often recommended for fibromyalgia is often touted as something that helps energy for muscles (implied is more ATP). Obviously this is not correct. What do you think is the reason this may help chronic muscle pain or with angina (muscle pain again). Thanks so much for any help!

[@zojal]

THANKS!!

[@theclassroomdoc]

I'm quite confused about one matter. First, thanks sooo much for the great video. There is a supplement called d-ribose often used to treat fibromyalgia and its described mechanism is that it helps replenish ATP. Given that you have specifically noted here that the PPP is not involved in any production of ATP I cannot explain the theoretical use of d-ribose for increasing ATP other than the fact that it shuttles off at some point to enter glycolysis... in which case why not just support glycolysis. Appreciate any thoughts!!! #gratitude

[@gibranmir1776]

SHUGGARRR.... 🧡

[@dr.tariqmerestani3027]

non-oxidative phase doesn't produce ribulose-5-phosphate. it's actually produced in the oxidative phase. Non-oxidative reactions:are series of carbon-shuffling steps during which three-, four-, five-, six-, and seven-carbon monosaccharide phosphates are produced

[@dimkacracker]

yup, in my book it says oxidative phase ends with production of ribose-5-phosphate.

[@dr.tariqmerestani3027]

@@dimkacracker Thanks for bringing me back 6 years!

[@juxsoundz4822]

This girl goes to Harvard Medical School? This kind of reassures me that even people at the highly esteemed schools are not necessarily on a higher level of education than the rest

[@bmx687]

JUX SOUNDZ agreed. An education is an education and a person can get an education that is on par with the IVY schools without attending one

[@bonbonpony]

JUX SOUNDZ That's because education is one thing, and knowledge & understanding is another thing. It doesn't necessarily come hand in hand. But with Jasmine, she's dealing very good with this scientific stuff. Sure, not *perfectly* good, but good enough for most people's purposes.

[@AhmedGamalMedicine_gets_easy]

Thank you for that video :) It really helpful and Pentose p pathway became more easier Thank you :)

[@chell6022]

I love your voice, and find it soothing actually, lmao Never listen to other comments Also thank you for the amazing explanation

[@deveshyadav6283]

Need 2nd part of this video

[@adventureinashell8438]

saved my life :)

[@conniedelacruz2749]

Prayers

[@pedroferrer1117]

those rogue oxygens are out to get us

[@DrMohammadArifulHoque]

Quick , run an hide!!

[@traciprovins3221]

7 minutes in and I still haven't found out where this takes place or what it's purpose is. But 3 minutes differentiating between NADH and NADPH...

[@عيادةالدراجاتالنارية]

Traci Provins occurs in cytosol of the cell in areobic or non aerobic and the purpose produce NADPH and ribose 5 phosphate which is inportant for nucleotide synthesis then for DNA and RNA synthesis

[@therambler3713]

lol, seriously, she clearly explained these things

[@solo7843]

Traci Provins facts

[@huntersikari]

6:27 "The breakdown of glucose accepts the electron and it does not donate them", You said it wrong, didn't you?

[@Dimplez2388]

Yes, She said it wrong and you are correct.

[@hyderali692]

I know I am dumb... But please answer my question....if free radical have an extra electron , why will antioxidant will donate more electron to stabilize it?

[@mbakhil6050]

your voice😍😍😍

[@lizzychan844]

Why is the glyceraldehyde-3-phosphate produced after the first transketolase reaction isn't fed into glycolysis and then both it and the sedoheptulose-7-phosphate go down the pathway to give G3P and F6P?

[@s101077]

U have a sweet voice

[@bonbonpony]

Is this pathway somehow related to the Calvin Cycle's RuBP regeneration phase? I see it produces some of its intermediates, such as xylulose and erythrose.

[@lordmasterization]

I wish Sal could do biochem videos.

[@mbakhil6050]

such voices are the reason to start loving teachers 😍

[@kaylanyoungman5517]

A little too far there.

[@Eric-sq4hd]

she has a great voice

[@olivia2528]

really sounds like Amy Adams!

[@olivia2528]

Also very helpful, thank you :)

[@todaywerebel]

Lol at the second comment 😂

[@GoodKnight5252]

Only issue i have is you don't really explain the pathway...

[@CB0ZZ0]

Wasn't very KHAN Academy!

[@ghsh21]

Glucose doesn’t have a 6 carbon backbone? It has 6 carbons, but it’s not the same as a cyclohexane!

[@godrianmbaulu2089]

At first was lecturing well because she was explaining step by step but got lost on non oxidative phase because she stop explaining step by step but just started talking about important things which is slow learners can't understand

[@ndrgzmnify]

Lighten up everybody and turn on the subtitles. You'll thank me later :P

[@sajilmalla7316]

Nobody have thanked you till now.. Liar

[@MyPratikrocks]

Lol

[@DollyDomDom]

Sigh.... first she said NAD/ NADH donates electrons and then she writes NADP/NADPH donates electrons :(

[@pimpmurray]

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