Peptic Ulcer Disease Pathophysiology

Lecture on the pathophysiology of peptic ulcer disease, including an introduction to the physiology of acid production and mucosal barrier defences in the stomach.

[@MrVladalv]

This is so interesting... I am in the 5th year in Romania, and this is very useful to me. Tomorrow I have a lab exam at gastroenterology, and I must say... NO ONE explained this better than what I've seen in this video... and teachers are paid to do that (not paid enough). Thank you so much.

[@HealthEdSolutions]

Glad you found it helpful! Thanks for watching.

[@omarmasri123]

Sir i've been watching ur videos since 2012 they are rlly helpful, i got high grades thanks to you )!I'm a med student on my 4th year now and with every new course i have to check one of your work before i even open a book ;) thanks for putting the effort and god bless you

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@henningviljoen124]

I absolutely cannot without your videos sir Wolf. Greatly explained in detail. Thank you very much

[@HealthEdSolutions]

Glad you found it helpful!

[@nikaarsenidze5977]

this is quite seriously probably the best, simple and very clear presentation i've seen on youtube. lots of compliments to you!!!

[@HealthEdSolutions]

Thanks so much! Glad it was helpful!

[@aashraybhavsar6963]

Thank you for the knowledge you hav provided me with...i hav to give a seminar on dis topic tomorrow in my class, it's very helpful. Thank You for the efforts. Looks like I don't need to do anymore research. I have everything I need. Even my reference book doesn't tell me this much. Thank You Again.

[@HealthEdSolutions]

Glad you found it helpful!

[@TheSocialSmilingMonkey]

Thank you for a very detailed and insightful look into physiology and pathology of peptic ulcers . Ive been very interested & studying gastroenterology along with histology and this puts it in perspective for those who want to look deeper into the mechanistic pathology ❤🌅❤

[@rebeccafernandes6415]

Thank you so much for making this topic much easier for me to understand. It shaved off so much time in my review for upcoming exams. 😊

[@HealthEdSolutions]

Awesome feedback Rebecca!

[@whatzupU]

Thank you for this informative and educational piece on Peptic Ulcer Disease! It was very helpful and easy to understand.

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@stephaniesandor458]

Thanks for an excellent presentation. Very clear, informative and easy to follow. I appreciate your revision at commencement.

[@HealthEdSolutions]

Appreciate the feedback! More lessons coming soon to our channel.

[@space1oddity]

Great explanation,. Though I think gastric ulcer and duodenal ulcer pathophysiology should be explained together + duodenal ulcer is more common, so I would appreciate more details about that too, since it's important. Thanks anyway for this! :)

[@HealthEdSolutions]

Thanks for taking the time to comment and watch. Appreciate the input!

[@francyellefernandez4531]

THANK YOU ANDREW! Your presentation is always super informative. It is helping a lot with my NP degree

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@anasamelymaria8106]

Thank you so much for your time and dedication!

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@HD-dd5yr]

Great video. Would appreciate a picture of the whole flow chart for easy revision

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@ivoaprilov8692]

All day I'm watching ur videos :) and I'm very grateful...best medical media !!!

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@justingriffin6356]

Great video ! Thanks for the breakdown!

[@HealthEdSolutions]

Thanks Justin!!

[@christinesanborn5101]

Thank you for all that you do.

[@HealthEdSolutions]

Glad you found it helpful!

[@a7mad9999999]

im 4th year med student, study in romania, the teachers are useless. what i learned from you in 29 min is much more than what i've learned through the whole digestive stagiu

[@HealthEdSolutions]

Glad you found it helpful! Thank you for watching.

[@professoreltayebabusin2920]

amazing video so helpful for my pharmacy course!!!

[@HealthEdSolutions]

Glad you found it helpful!

[@kishan4264]

Great video. Would appreciate a picture of the whole flow chart for easy revision. Also h2co3. Again, great video. Thanks

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@nataliacarbonell8764]

Hi, today I had an exam and the question was “how does alcohol affect the mucosal layer for gastric ulcer making?” So I talked about the surfactant. My teacher said that there’s no evidence of that on the GI track, just on the lungs. So I wanted to know what was the biography of that statement.

[@mckaciesoobrattee2972]

Excellent lecture. Very helpful. I realize though that you did not say any thing about how stress and sympathetic stimulation causes stomach ulcers. Do you have any video on that deal with it ? If so please let me know .

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@roseoconnor8766]

Please put subtitles on this video that are accurate, trying to learn key terms from this video is improssible when they arent spelt correctly.

[@MAla-zt7gn]

Amazing, Thank you! 🎉

[@geetanarvekar4044]

It was great help ! I wonder if you do videos on the pharmacology of the drugs based on the pathophysiology of the diseases?

[@nellyhoffman6194]

+Andrew Wolf THanks mr andrew

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@enno5030]

watch in 1.25 speed!

[@shivampatel6795]

En No I am watching it in 2x. #LoL

[@quadtos857]

LOL! Thanks.

[@ramlahaji7891]

Lol

[@HealthEdSolutions]

Thanks for the feedback! Many people prefer it slow so they can take notes - a number of our viewers are students:)

[@HealthEdSolutions]

Thanks for watching:)

[@NhungNguyen-ej4po]

Thank so much

[@sam4594]

You are a life saver . THANK YOU MUCH

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@vyjayanthi6775]

your videos very helpful andsuperb

[@HealthEdSolutions]

Thanks for your feedback and thank you for watching :)

[@crisderez]

thanks for making it easy to understand

[@HealthEdSolutions]

Glad it was easy to understand!

[@anwarmusa3626]

Hi thanks a lot for the educative information. it really prepares me for my exams. Would you please inform me more about the pathogenesis of the disease. is it just through the same way as the peptic ulcer disease

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@omosuyiademola8088]

Thanks so much

[@HealthEdSolutions]

Thank you so much!

[@esrabulankoglu2625]

thank you so much it was so easy explanation 👏🏻👏🏻👏🏻

[@hashimsalim5966]

thanks alot dr. realy i understand it very well... god pless u

[@HealthEdSolutions]

Glad it helped!

[@chigozieokoye8222]

Great

[@rowenaescoto8143]

a very well said dr! thanks a lot!

[@HealthEdSolutions]

Thank you so much!

[@Urosurgeons]

I like the video. Very informative. A bit long for my taste.

[@HealthEdSolutions]

Appreciate the feedback!

[@xBassel92x]

Why didn't you mention the role of prostoglandins when you talk aboit the protective mechanisms ?

[@HealthEdSolutions]

Thanks for your input. We've passed this along to our medical review board. Sorry for any delay as these comments all went to spam.

[@zeesho3105]

Informative Thanks :)

[@vikramjitsingh7679]

Simply amazing...!

[@md.tarequrrahman7230]

Thank you Mr. Wolf. Your videos are amazing and so simple :)

[@HealthEdSolutions]

Keep watching, we appreciate the support!

[@metalica732]

Mr. Wolf, isn't the point of having enteric coated Aspirin to prevent digestion of the aspirin in the stomach, but rather in the small intestine? I saw you mentioned that as one of the etiologies of PUD. Wouldn't uncoated tablets cause more harm?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@kasainelankoi845]

great explanation

[@HealthEdSolutions]

Appreciate it!

[@sofianetrifi9562]

Excellent presentation

[@HealthEdSolutions]

Thank you!

[@NiharMeshram]

Helpful lecture,Thank you!

[@HealthEdSolutions]

You're so welcome. Glad the lecture was helpful!

[@love19398]

enjoyable teaching

[@HealthEdSolutions]

Thanks for the support!

[@elisele9851]

Thank you so much!

[@HealthEdSolutions]

Thank you Elise for watching!

[@shadilali7308]

what does mean of apical adaptation ...? tell clearly about mucosal barrier how it protect and how it induce to cause peptic ulcer ...?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@josephnathan6132]

Hi, great video - you really simplify and present it in a clear way. I have 2 questions: 1. From what I read H pylori decreases acid secretion, as opposed to increase in acid secretion as you mention. 2) I did not find a recent article supporting the surfctate layer, can you please send a few studies about this? Thx!!

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@MrEvanston]

Hello Andrew Wolf: Thanks for this fascinating video. I remember from my lecture days in nursing school. One question: do you have any information on gastritis relating to diabetes? Also, can you discuss the chemistry related. Thanks again.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@shirtsguitar]

nice one ! thank u ! 😀

[@HealthEdSolutions]

Thank you!

[@shanthala1345]

Thank you sir🙏

[@AnthGott]

Hi thanks for an interesting and informative video. What treatment would you recommend for h pylori?

[@hadihajjar332]

Omeprazole (Proton pump inhibitor)-decreases the stomach's production of acid, and two antibiotics

[@kailashagrawal8433]

great

[@HealthEdSolutions]

thank you:)

[@SandhyaRamachandran]

gud video ! Is it that the most potent stimulus for H+ secretion is when the food reaches the antrum (G cells)....but the parietal cells are mostly in the body ? so how does it help?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@nitsanshevach1827]

thank you! awesome vidoe

[@HealthEdSolutions]

Thank you for watching! Glad it was helpful!

[@SandhyaRamachandran]

Did i get this right ? Hp causes inflammation ..the same infly cells stimulate G but destroy D cells?

[@HealthEdSolutions]

Thanks for your question Sandhya. We have passed it along to the Health Ed Solutions medical review board. Thanks for watching!

[@dreynasaurus]

How bout vids on Pharmacology also? :3 Anyways, thank you and cool vids! Have learned more than when I am in class!

[@HealthEdSolutions]

Thanks for the feedback! We will be rolling out new lessons soon. Thanks for watching.

[@akhtarhusenada6711]

give a video for pharmacotherapy nd treatment with site of actions including side effects and precautions plzz..

[@HealthEdSolutions]

We will be rolling out new lessons soon. Thanks for watching!

[@ashieducomfort]

Please, what is the difference between pathophysiology and pathogenesis?

[@ayanidal8910]

Mr. wolf, about somatostatin does it inhibit G-cell OR Parasympathetic release of ACH as you said?! and thanks in advance

[@HealthEdSolutions]

Thanks for your question Aya. We have passed it along to the Health Ed Solutions medical review board. Thanks for watching!

[@mohammedmusa9836]

Awesome👍🏻

[@HealthEdSolutions]

Thank you for the kind words!

[@boymore-handsome1959]

thanks alot doctor!

[@HealthEdSolutions]

Thank you for watching!

[@srajah3]

Very helpful video. Thanks a lot :D

[@HealthEdSolutions]

Thanks for watching!

[@SciSciToys]

Ive been on Prilosec and Paxil for 21 yrs and recently have tapered down on both and my duodenum/small intestine aches, maybe ulcer so I may have to go back on the normal dose, seeing as Ive been taking Prilosec for 2 decades Im worried about Gastrin levels and stomach cancer risk from taking PPI's long term and yet when I reduce slightly my proton pumps awaken and my duodenum doesnt like it one bit, I was thinking about taking DGL, cabbage juice, yoghurt etc whilst Im coming off Prilosec to protect the stomach/duodnum lining, are there any other things |I can do to help the stomach/duodenum to adjust to stopping PPI's, I thought maybe start taking Gaviscon which coats the lining? Thankyou.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@kelvinlim4573]

great videos but alot of spelling errors, students who have not studied GIT may think that all the spellings are correct.

[@HealthEdSolutions]

Thank you for the feedback! We will be releasing a new and improved version soon. Thanks for watching.

[@sylar010]

Thank you! Your videos are really helpful! So do NSAIDS increase the risk of an upper GI bleed as they can cause peptic ulcers, or is there another way that they can cause it?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@irvinreinel]

hey, ive read in my book that one cause of PUD is the back diffusion of HCl? Can you elaborate on this more please. I don't understand where HCl diffuses back and what the book means by back diffusion. thanks.

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@seni701]

thank you very much sir. u are my star :-)

[@HealthEdSolutions]

Thank you for watching!

[@saraahmedtanveer4668]

I think you explained Delta cells wrong. They are stimulated by inc pH

[@HealthEdSolutions]

Thanks Sara, we've passed along this feedback to Dr. Wolf. Thanks again!

[@fatimaexo1043]

Thank youv💜

[@draselaprathnayake768]

thanks

[@HealthEdSolutions]

You're welcome and thanks for watching!

[@teateao]

Very informative ..... Thank you.

[@HealthEdSolutions]

Thanks so much!

[@beastmode7107]

nice

[@laraibajrar737]

I want refernce material of this video

[@HealthEdSolutions]

Thanks for watching! We've passed this on to our medical review team.

[@maryamdashti8650]

Bless you

[@HealthEdSolutions]

Thank you so much Maryam

[@momen222003]

please i did not understand about the mucosal barrier ????

[@HealthEdSolutions]

We will be rolling out new lessons soon. Thanks for watching.

[@jayantamajumder9916]

That was a great video.. Butttt. Why u talk so slowly and suddenly become louder!!!that was irritating

[@HealthEdSolutions]

Thank you for the feedback! We will be releasing a new and improved version soon with improved sound quality.

[@delsol7878]

So... PUD = Gastric ulcer disease = duodenal ulcer disease?

[@isnajiaffarjanjalani7445]

delsol7878 exactly

[@charleskamandaCK222]

+delsol7878 PUD=gastric ulcer+duodenal ulcer....

[@HealthEdSolutions]

Thanks for the question. We've passed it along to the Health Ed Solutions medical review board.

[@HealthEdSolutions]

@@isnajiaffarjanjalani7445 Thanks!

[@HealthEdSolutions]

@@charleskamandaCK222 Thanks for the input!

[@rangariraichihowa4247]

nyce

[@majuthomas7090]

👍

[@HealthEdSolutions]

Thank you for watching!

[@sanovarfakir]

👏🏻👏🏻

[@motazali8129]

doc hi nice information i have a question if activation of parasympathic nerves system lead to release more of ach and we know the parasympathic are activate under relax time sleeping time but how stress can give ulcer too

[@jehadalhashem8849]

sorry dr.andrew ... i'll answer this for you ... stress will cause significant reduction in the brunner's gland which also produce mucus-rich with bicaronate .. it's in the duodenum so in case of stress it's always duodenal ulcer

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@HealthEdSolutions]

@@jehadalhashem8849 Thanks so much for chiming in!

[@robertholley2560]

I thought COX 3 isn't functional in humans?

[@HealthEdSolutions]

Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!

[@learnpubhealth]

Wonderful lecture... bt u change your tone n pitch after every few seconds.. dat becomes bit irritating n caues loss of interest...

[@HealthEdSolutions]

Thank you for the feedback! We will be releasing a new and improved version soon. Thanks for watching.

[@XHUMBITO1]

Good information! But you talk very very slow, try to talk more enthusiastic next time, maybe?

[@HealthEdSolutions]

Thanks for the feedback, appreciate it!

[@78divyasadiya]

Sir you are ready lazy to talk...it interrupt the understanding 😞

[@sydneyturner1187]

Lk NH i

[@kulejoseph8766]

Boring lecture

[@HealthEdSolutions]

Thank you for the feedback! We will be releasing a new and improved version soon. Thanks for watching.

[@bomhayhay]

thanks

[@HealthEdSolutions]

Of course!

[@bomhayhay]

​@@HealthEdSolutions after 5 years u reply me of course! Wow ... thanks again ....

[@HealthEdSolutions]

@@bomhayhay so sorry for the delay. We are actively managing the channel now:)