Pharmacology- Histamine and Antihistamines- Autocoids Pharma MADE EASY!

ERROR:
There is an error where I said "MEDIZINE" . It's actually MECLIZINE.
Also, the anti vertigo effect is due to blockade of H1 receptors in the vestibular apparatus.
MNEUMONICS:
-First generation antihistaminics: As I am from the first generation, DIP ME PROperly in CHLORine
-Second generation antihistaminics: CEFELO as in CEPHALO (related to the head), but
remember that although the mneumonic is cefelo, these drugs do not cross BBB (head) and cannot cause CNS side effects.
Histamine and Antihistaminic drug Pharmacology
First lecture in the series of Autocoids and Respiratory Pharmacology
#Histamine
#Antihistamine
#Pharmacology
#review
#easy

[@Easymed101]

After watching this video i just have two doubts, why didn’t i get this before? And why this channel has so less subscribers? Content of this level deserves a lot more

[@easydoctor565]

In vertigo the pathophysiology involves either there is formation of hydrops in semicircular canals, formation occurs either due to increased flow or inflammation. Beta histine reduces blood flow by H3 agonism and anti H4 activity which reduces inflammation. In BPPV there is the salt crystals which dislodges and causes vertigo and resting can help it. There is a role of muscarinic receptors as well in it to cause vertigo. So the drugs commonly used are Beta histine and cinnarizine. Steroids are used as anti inflammatory. Prochlorperazine is used for acute vertigo due to multiple action on histamine and muscarinic receptors. I haven't seen use of TCA ever in vertigo.

[@kashyapsoni9888]

You just explain a whole chapter in a brilliant way...best medical channel so far...I read the textbook after watching this and that really work for me...👍🏻

[@krishna3032]

That picture don't suite for this channel smoking man I think

[@e.y.k.6893]

@@krishna3032 that image is of sirius black. He is a charector in Harry Potter series. The channel name also includes his name 🤣

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[@mitalisahoo5350]

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[@minahilsalmankhan5698]

SO GOOD! keep up the good work! I rely on you for my pharma preparation :3

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Oh my god thank you so much im literally struggling right now cuz they preponed all of our exams thank you i love you i lvoe you i love you

[@muhammedmunavvar6671]

I was very reluctant to read this topic in Tripathi before seeing this video. But this video made me read this topic. Thank you ❤️. It was very useful... Keep going.. we are all with you...

[@myselfvrutik]

Your teaching style is so cool, that smooth lines in between are just woww... Ty✨

[@jemsheenachinju9995]

Ur explanation is so nice . Thank you. But it could have been more better if audio and video is having a sync. Here many at a times what is been written and what is being talking about are different,so I’m getting confused where to focus at

[@MedMadeSiriuslyeasy]

Yes, you are right

[@shahryarahmad1519]

Recapitulation of knowledge.Recalling our pharmacology teacher. New learning is Beta histidine is a histamine.but recently H2 Blockers is banned. I don’t know why! People already consumed last more than 30 years. So it is sad.many wishes.

[@drxravibhardwaj6666]

Hand whriting is amazing

[@Medicos7844]

thanks mam it's an wholesome viedo please be make viedo on H2 histamine antagonist

[@umerafridi9585]

Its really very helpful , and download all your topic document .

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Imma say I love you girl ❤️ you are a huge motivation and my 'go to' videos when I have trouble in pharmac...you are an angel..really!! God bless you as you show the path to many others ✨ Happy revision people ☺️

[@MedMadeSiriuslyeasy]

That’s really kind of you :’)) Thank you

[@musafiz6164]

Im so happy I found this channel. Thanks alot

[@elissesarmiento4789]

Thank you for the lecture becuase we do online class right now. Sir Ash brought me here 😊

[@deginetmathewos9134]

it is amazing lecture i love so much

[@bhargavpatel4024]

Helpful again before the exam😁

[@sabakhogiani580]

Also i m puzzled about that if a group of drugs have similar activities which one we should administer ????

[@iqramalik8869]

At 8:04 u told we give 1st hemeration antihistamin in nausea vomiting with pregnancy bt in start u told it has tertogenic effect ?

[@innovativegiftsandrangoli5652]

Exactly

[@innovativegiftsandrangoli5652]

But it has teratogenic effect in animals not humans..so it's used as antiemetic

[@sabakhogiani580]

Hello mam H1 receptor has positive ionotropic action on heart how can it have negative dromotropic effect ?? You mentioned only 7 anti histamines but there are lots of it could you explain why do I need to memorise all of them or only those which you mentioned ??

[@reshammunafbts7448]

I love ur video it's easy to study after

[@gotampaliwal7217]

Mam* please tell me that is your video is sufficient for subjective mbbs 2nd year paper

[@niranjanpradhan9091]

Nice presentation

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Best one

[@mbbscracker649]

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[@RuwaNyakurimwa]

Actually very good. Keep it up!!!!

[@waleed2980]

Great work sis

[@Princess-cl6tp]

Can you let me know we are giving the first generation of antihistamines to treat nausea and vomiting as it's antiemitic then why in adverse effects it causes nausea and vomit

[@aravindhsharma7774]

So second generation drug only used as a external mam

[@varshilpatel2122]

One question Is CHLORPHENARIMINE is CNS depressant or stimulant ? ..... How CHLORPHENARIMINE have CNS stimulation effect? @medmadesiriuslyeasy ..

[@gotampaliwal7217]

Can please tell me that is your video is sufficient for subjective mbbs 2nd year paper

[@ayush5590]

Was it sufficient?

[@aritrasaha9454]

Also add H2 receptor blockers like famotidine

[@viniljose4303]

Life saver video 😃😃

[@local5ab]

Nice

[@DrRose-sp7bt]

Where r u from??and medical college??? Plz reply ....

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❤️🔥

[@piyushkumar.2400]

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[@nexuschn]

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[@gudiyamaurya657]

Thank you sir

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[@abhishekvishwakarma3446]

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[@yenibera.priscillaJCD]

Thank you 😊 mam

[@MedMadeSiriuslyeasy]

Most welcome 😊

[@subhajitkandar4349]

What is the meaning of Gq ,Gs Gi ??

[@mbbscracker649]

The G protein coupled transmembrane receptors has subclasses . Gq coupled means when this get activated it will incr IP3+DAG concentration into cells and this will further ultimately phosphorylate and modulate different enzymes or proteins. Gs when activate it will stimulate adenyl cyclase enzyme and will rise in cAMP level is blood ultimate rose of Calcium inside cell Gi when activated will inhibit adenyl cyclase and this decreases cAMP concentration inside cells and fall in Intracellular calcium will occur

[@shefinmytheen5450]

MECLIZINE?

[@shailendraingle1993]

"CETIRIZINE" or CETRIZINE

[@aritrasaha9454]

Add levocetirizine

[@MuhammadYusuf-bi3ly]

Q S/E Class 5:14

[@priyankaanil7490]

Somehow you're not very confident today mam

[@priyankaanil7490]

Wow ! Thanks for liking my comment. Really like your tutorials. I am student of MD pharmacology

[@MindMatters-vt2iz]

hahaha..i really like ur lame jokess u must be a humorous person in real