Phases of Insulin Secretion (PART 1) | CDE Exam Tips

This is a series of 2 seperate presentations.
PART 1 - PHASES OF INSULIN SECRETION
PART 2 - INSULIN RESISTANCE
PART 1 - This presentation provides information on BASAL/BACKGROUND insulin secretion. Also discussed is Phase 1 & 2 of insulin secretion in regards to meals (ie:PEAKS) and the mechanism behind this.
Explanation of the mediators and pathways for insulin secretion in relation to Phase 1 & 2 is also discussed.
THIS VIDEO WILL ALSO HELP IN UNDERSTANDING PART 2 - INSULIN RESISTANCE. CLICK HERE FOR PART 2: • Phases of Insulin Secr...
Check out our videos on:
-Insulin Synthesis/Secretion - CLICK HERE: • Insulin Release (PART ...
-Insulins effect on target tissue such as the muscle, adipocytes, and liver. CLICK here: • Insulin's effect on Mu...
Here are some references for further reading:
[5] Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26(2):19-39. www.ncbi.nlm.n... [Last accessed Oct 14,2021]
[6] Henquin J., Dufrane D, Nenquin M. Nutrient Control of Insulin Secretion in Isolated Normal Human Islets. Diabetes Dec 2006, 55 (12) 3470-3477; DOI: 10.2337/db06-0868. diabetes.diabe... [Last accessed Oct 14,2021]
[7 ]Sprague JE, Arbeláez AM. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-475. www.ncbi.nlm.n.... [Last accessed Oct 14,2021]
[8] Ramchandani N, Ellis MK, Jain S, et al. Basal insulin requirements on continuous subcutaneous insulin infusion during the first 12 months after diagnosis of type 1 diabetes mellitus. J Diabetes Sci Technol. 2010;4(3):610-614. Published 2010 May 1. doi:10.1177/193229681000400315. www.ncbi.nlm.n.... [Last accessed Oct 14,2021]
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[@lexilopez100]

This was so helpful! Thank you!

[@cdeexamtips]

Thanks for watching. Glad you found it helpful. Please Share

[@momezart]

Thank you so much. The video animation and how you explain with short, sharp and clear message make the video not only educational but also pleasurable. 🥰📌🥰

[@cdeexamtips]

Thank you. Glad you liked the video

[@anastasyahutapea694]

excellent explanation, thankkk youuu so much

[@cdeexamtips]

Glad it was helpful

[@blackbeltendcrinology]

Thank you so much!

[@cdeexamtips]

Thank you for watching

[@fidalathifah7288]

Hello. Thank you for making this video. Great explanation. I was wondering, would you mind to share you references number 8? I couldn't find it on the footnote. Thanks.

[@micro2159]

is there treatment to restore insulin secretion? insulin resistance is already reversed

[@cdeexamtips]

Great question..... The pancreatic beta cells that do not produce sufficient insulin in people with T2DM are not permanently damaged during the early stages of the disease and can be restored to normal function through the removal of excess fat in the cells. There was a study called “Remission of Type 2 Diabetes for Two Years Is Associated with Full Recovery of Beta-Cell Functional Mass in the Diabetes Remission Clinical Trial (DiRECT).” It showed about one-third (36%) of the patients who took part in an intensive weight management had remission of their T2DM after two years. The study found, that beta cells are not permanently damaged in early T2DM and can be “rescued” by removing the metabolic stress of excess fat within the cells. More info here: diabetes.org/newsroom/insulin-producing-beta-cells From the Diabetes Canada CPG there is an article called “Remission of Type 2 Diabetes “ And it highlights that reducing liver and pancreatic fat content (along with substantial weight loss when following very-low-calorie diets), this may be linked to normalizing blood glucose. Also, the data highlights that some residual beta-cell function is required for a person to achieve T2DM remission, which supports the notion that T2DM remission is more achievable for individuals who are relatively newly diagnosed or who have sufficient beta-cell function. More info here: guidelines.diabetes.ca/cpg/special-article-remission-of-type-2-diabetes Interms of medications, Metformin exerts protective effects on insulin-targeted tissues as an insulin sensitizer and may also help restore insulin secretion and protect the pancreatic β cells from lipotoxicity or glucotoxicity. Here is the full article: www.sciencedirect.com/science/article/pii/S0925443916302435 Other studies of interest for further reading: -Restoring Insulin Secretion - Adult Medication Study (RISE Adult Medication) repository.niddk.nih.gov/studies/rise_adult/ -Stem Cells Restore Insulin Production and Control Blood Sugar in Type 1 Diabetes www.connectedinmotion.ca/blog/promising-breakthrough-stem-cells-restore-insulin-production-and-control-blood-sugar-in-type-1-diabetes/ -Novel approaches to restore beta cell function in prediabetes and type 2 diabetes link.springer.com/article/10.1007/s00125-018-4658-3

[@micro2159]

@@cdeexamtipsThanks for information. hope I will achieve full reversal of diabetes my HBA1C came in normal range my FBS came in normal range the only thing out of range is PPBS