Physiology of Blood coagulation Animation - Extrinsic and intrinsic pathway

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Physiology of Blood coagulation Animation - Extrinsic and intrinsic pathway
Coagulation Overview
Platelet plug formation is primary hemostasis
Endothelial injury → collagen exposed → platelets adhere to vWF in the subendothelium (adhesion)
Binding of platelets also activates them to release their granules which contain key molecules: TXA2 (thromboxane A2), ADP, Ca2+, and serotonin
Role of ADP in platelet activation: ADP binds receptors on platelet surface, causing insertion of GpIIb/IIIa (fibrinogen receptor) → allows aggregation of platelets
Aggregation is mediated by fibrinogen, which binds GpIIb/IIIa on adjacent platelets
Aggregation is inhibited by endothelial cells that release PGI2 (prostacyclin) and NO
The goal of secondary hemostasis is generation of the fibrin clot
Many reactions in the cascade require Ca2+ and platelet phospholipid as cofactors
Factors X, IX, VII, II (mnemonic "1972") are vitamin K-dependent
Inhibition of the clotting cascade occurs via activated Protein C (APC) and Antithrombin III. tPA (tissue plasminogen activator) disrupts existing clots.
Prothrombin Time (PT) evaluates the extrinsic system: Factors VII, X, V, II and I
The normal PT is between 10-12 seconds.
INR (International Normalized Ratio) is a standardized value for PT that is often quoted when following warfarin therapy. The normal value is set at 1.
An elevated INR indicates relative increase in anti-coagulation (i.e. INR = 2-3)
↑ PT can be seen with warfarin therapy, or any process affecting the synthesis or consumption of coagulation factors (i.e. liver disease and DIC; respectively).
PTT (Partial Thromboplastin Time) evaluates the intrinsic system: Factors XII, XI, IX, VIII, X, V, II and I.
The normal PTT is between 25-40 seconds.
PTT is used to follow heparin but not LMWH (i.e. enoxaparin) therapy.
↑ PTT is seen with factor deficiencies, DIC, vWD and anti-phospholipid syndrome (associated with SLE).
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[@srinatchi3296]

Such a great one i found today...thanking you all ..🙏🏻....helped a lot for my preparation😄😄🙏🏻.....

[@doctorbhanuprakash]

Most welcome 😊

[@srinatchi3296]

@@doctorbhanuprakash 🙏🏻😍🙏🏻

[@buntymaliwad2498]

After watching this video one word circulating in my mind on loop factor factor factor factor factor 😵 are Mujhe chakkar aane lag gaye ab, by the way nice information thank you so much 😊

[@priyanshujain4422]

😂

[@abhishekesport4017]

I am preparing for neet exam and this is very useful for me.thanks a lot.

[@doctorbhanuprakash]

🤝🤝🤝

[@amirakhlak6888]

U dont need to dig this deep for neet

[@mekalaravindra3461]

You don't need this video dear for neet examination you jst go through ncert a many times perfectly this video is recorded mainly for mbbs students

[@abhishekesport4017]

@@mekalaravindra3461 ok

[@prateek_.a]

😂😂😂😂 can’t stop laughing. Now medicos be like ham kha jaye fir🤣.

[@MedWonks]

Somebody plz give the example of extrinsic pathway

[@DrAdnan]

Great overview 👏

[@manjus1986]

Sir u r material is tooo good I just watched 3 days before it was really good sir can u teach me morphology of flowering plants sir please

[@sundusomar1960]

Thnks dr

[@sairagul4824]

how can i use these slides for my power point presentation? any one please guide

[@alekyagude9612]

Prepare more videos like these

[@doctorbhanuprakash]

sure

[@_unknowngirl_9101]

Thank you sir❤️

[@Doctorcorner100]

Thankyou MAM

[@mairakhan1350]

Plx teach in urdu

[@artsyAsh5541]

excellent

[@doctorbhanuprakash]

Many many thanks

[@rgrioff939]

Is it necessary for MBBS 1 St proff examination? Plz reply sir

[@doctorbhanuprakash]

Yes

[@piseytha6478]

Thanks sir

[@cutiebeauty4765]

Thank for your vedio

[@doctorbhanuprakash]

Thank you too!

[@islamislife1780]

This channel is the best.

[@doctorbhanuprakash]

Thank u so much

[@doctorkyrgyz]

Thank you sir

[@ratul498]

Excellent animation, very much informative. Thank you :)