Niacin (Vitamin B3): Flushing Away Heart Disease. [4 Studies]

[@joshhart8722]

There’s zero doubt in my mind that niacin works. I’ve been taking it daily for about five years and my lipid profile has completely transformed. My PCP actually asked me what I was doing because she’s never seen HDL levels as high as mine in someone my age.

[@4x4fronsc]

what dosage?

[@joshhart8722]

@@4x4fronsc I take Inositol Hexaniacinate 500mg twice daily. The amount of niacin is 400mg per dose, so 800mg per day.

[@amgis5218]

Absolutely spot on. Niacin increase NAD levels in the blood and muscle tissue, leading to body reshaping, with less abdominal fat and more muscle. It’s the most effective and cheapest supplement I’ve ever taken, with visible improvements and blood panel improvements.

[@dwdwone]

Didn't he say slight improvement if you were healthy?

[@bscsmscs1578]

what was your LDL 5 yrs back & what is your number now?

[@jeremiahcourter8352]

I take niacin with magnesium before bed and it GREATLY improves my sleep.

[@defractelasticity]

Niacin also gives me insanely amazing sleep. Unfortunately is messed up my stomach the next day and also makes me lethargic and depressed. Such a bummer because I love the burn.

[@infosplus1772]

What dosage you take please

[@defractelasticity]

@@infosplus1772 issues arose after a few days of use. Doses ranged from 500mg to 1500mg. The lethargy and depression was likely caused by it causing me to over methylate. I’ve heard low doses can “borrow” methyl groups and prolong use could result in under methylation, and high doses can act in a way to cause over methylation. Feeling sick to my stomach was also the worst.

[@defractelasticity]

@@MsJayski see my reply to the other person

[@TreeOfWisdom2]

@@MsJayski lolz, 250 mg to 500 mg. It can hurt your liver, if you take too much. Take some tryptophan too.

[@sherylfetik4126]

When you take Niacin, you can actually feel the effects of your blood vessels dilating. It sometimes causes redness, or flush. I gave Niacin to my mother, and believe that it helped to improve her circulation to her legs and feet. I believe that Niacin helps me. I usually take 500 mg. per day.

[@emlane-zz6zb]

thank you for sharing. I'm gonna try a supplement

[@charlieparkeris]

500mg would turn me into an itchy tomato.

[@klecoxs2]

@@charlieparkeris😂😂😂

[@klecoxs2]

Is that in one dose ?

[@sherylfetik4126]

On most days, I take 500 mg in a one dose pill, with food and some other supplements. Generally, I buy it from Swanson vitamins. I gave this also to my mother, who lived to be 96. The flush, and occasional itchiness lasts for a few minutes, and goes away. I would suggest not rushing to use heavy equipment, immediately after taking Niacin, as you will feel it working. I believe that it is an aid to healing, as it increases circulation to the extremities.

[@elainep8873]

You need to redo this and separate niacin from niacinamide, the non flush form. The flush form has great support in the literature, while the non flush form is hepatotoxic and has poor cardiovascular results in studies. They're two different molecules with very different outcomes

[@MrTea7]

Looks like the literature about damage of liver regards very high doses like 3 grams/day. Apparently this even applies to regular niacin. Lower bound for safety seems to be 5oo mg-I know when I took 500 mg of niacin I got massive flush still got some flush in range of 250 mg. But then some advise the flush shows you needed it' there does seem to be some habituation effect regarding the flush. Maybe 500 mg niacinamide or lower would be the safe option.

[@standunitedorfall1863]

@@MrTea7 I get the flush @ 100 mg. I welcome it.

[@dukeyaka]

My problem with a lot of niacin studies is they use laropiprant to control the flush. I believe the laropiprant is what blunts the benefits of niacin. The vasodilation effects of niacin are a positive.

[@jamescalifornia2964]

I agree. Ford Brewer MD points this out as well ... 💊

[@profdrlt]

Agree. Newest form of Niacin - Inositol Hexanicotinate allows you to take high dose without flushing, but it has not been trialed.

[@jamescalifornia2964]

@@profdrlt / There is sustained release form niacin that many use 👌

[@senorpepper3405]

​@paulpellico3797 who's brewer?

[@kasiar1540]

No-flush niacin isn't as effective and is linked to liver damage

[@TheTrock121]

I stopped taking Niacin or Nicotinic Acid about 3 months ago when I ran out of my first bottle. With no other changes to my diet I quickly gained about 5 lbs. I'm ordering more right now!

[@susannahwhite7561]

What brand?

[@TheTrock121]

@@susannahwhite7561 The brand doesn't matter, but you want the kind that causes the flush, i.e Nicotinic Acid. This time I ordered time release capsules so I won' feel like my hair is catching fire.

[@Rocky7729]

You can get niacin with red meat

[@Fearzero]

​@@Rocky7729Ya along with saturated animal fats, heme iron, cholesterol and neu5gc all highly correlated to shorter lifespan in 50 plus year studies.

[@luzponce9630]

What Niacin brand do you use? Thank you.

[@JCPProductions01]

I take 250mg with flush every 2 or 3 days. I got blood work before and after supplementation, and my triglycerides cut in half, and my hdl is very favorable. The flush also has helped resolve some discoloration under my eyes as well.

[@larryc1616]

The required dosage is 1200-2000mg/day in split dosages

[@JCPProductions01]

@larryc1616 the required dosage lmao. Okay. I'll stick with my dosage that's been working. I have a prostaglandin sensitivity. Too much niacin I can'tbreatheh for a short period. It can stimulate the same response as asthma patients with inhaler because of the prostaglandins

[@Zoso449]

250mg/day is optimal for me too. Minimum effective dosage

[@ash9x9]

and they say 1200-2000 mg!? That is crazy@@Zoso449

[@alexsaraceno6144]

Hey bud, what's a flush ?

[@ianrichardmorrissey6082]

My combined cholesterol number has always been around 275, I started taking 1 x 500 ml no flush Niacin morning and night and after 2 months my cholesterol dropped to 195. I’m 69 years old and due for a bloodwork test at the end of December so I’m really itching to see my test results. For the record I eat a very healthy well balance diet, limited alcohol and do not smoke, hike, bike and walk my dogs 3 times a day.

[@twoissas]

Sounds like a great combination!

[@leonardwebster8236]

​@@twoissas de

[@lawnmower11]

I had similar 30% reduction using flushing niacin NA in the past year

[@veronicav1779]

Niacin no flush doesn't have same beneficial effect as Niacin flush so don't know how you improved your numbers, good news for you anyway

[@harrytoyshirt4146]

Cholesterol isn't bad.

[@theancientsancients1769]

I took Niacin for my Long covid palpation issues in 2021 and surprisingly my cholesterol dropped from 215 to 170 or 5.7 to 4.5 the palpitations reduced too once cholesterol went down

[@ShowMeWhatINeedToKnow]

HOw much did you take?

[@heromiIes]

To those asking how much did he take, the recommended dosage is 500-1000 mg daily. That's what I take. No palpitations.

[@marcelguldemond2523]

I’m trying niacin for LC as well, but I’m currently taking 200mg because the flushing I get with 500mg is insane. Trying to work my way up.

[@kasiar1540]

Look into magnesium and mg deficiencies

[@theancientsancients1769]

@@DeusExMachina50 150 to 300 . I reduced it later to 100 to 150 . Niacin can increase homocysteine levels of the heart which was not mentioned in the video. So taking TMG mitigates that .

[@gtau3144]

After an inner ear disorder that stressesd my brain enormously, affected my walking talking and vision I tried every thing to improve. I found any thing that increased methylatiom made me worse so I started on Niacin to decrease methylation and improved . It was a life saver. There are studies going on with respect to genetic repeat ataxias.

[@stevenabeles616]

Seems to help with meniers disease.

[@kylelochlann5053]

What protocol did you use?

[@gtau3144]

@@kylelochlann5053 I take 1g per day of Niacin, in 3 doses after food. Niacin amide does not help. Kind of used to the flush now as I started in 2019.

[@kylelochlann5053]

@@gtau3144 Thanks, perfect. Few people realize the significance of the form of niacin.

[@Always-xl9db]

1g of Nivotinic acid daily? Thats quite a bit. How is ur liver function? Any affect on glucose levels?

[@amgis5218]

You are missing the biggest benefit of niacin (the type that causes flushing): it significantly enhances NAD levels, especially in the older populations. Many studies exist showing how NAD levels increase multiple fold in muscle tissue with 1 g daily dosage in older adults. These adults experience higher muscle mass, lower abdominal fat, and better physical health because of niacin. I can vouch for its effectiveness in body reshaping as a man in my late forties. If I had to choose just one supplement to take, it would be niacin. Yes, I saw dramatic improvements in my blood lipids. But it was its positive benefits on my body composition and huge improvement in the gym that I noticed the most. It’s better and much cheaper than NMN, with the same outcomes.

[@ShowMeWhatINeedToKnow]

HOw much did you take?

[@amgis5218]

I take 1 g daily, which is much lower than the dosage recommended for lipid remodelling (usually 2 g daily). I am taking niacin to increase my NAD levels, which 1 g daily is more than enough for. Even 500 mg daily will increase NAD significantly. But even at 1 g daily, it has increased my HDL (best ever result in my life) and lowered my triglycerides (again best ever number in my life). And at 1 g daily, it's very unlikely to have any negative effects on blood glucose control. I have experienced no side effects, except for the flushing, which I have now gotten used to. @@ShowMeWhatINeedToKnow

[@LTPottenger]

you only need 250mg

[@ldjt6184]

To achieve what? @@LTPottenger

[@amgis5218]

@@LTPottengerall the clinical trials use 750 mg to 1 g for boosting NAD+ in skeletal muscle tissue. Not one study uses 250 mg. Not one. And for lipid management, it’s 2 g minimum per day according to standard clinical practice. I don’t know where you pulled that 250 mg number from. You just talking whatever.

[@orion9k]

Take this every day, 500mg pure powder, the flush effect is so wonderful, a bit pricky and stingy on the skin at times but I really enjoy it 🙏

[@jamescalifornia2964]

The " pins and needles" effect ... 😳

[@cater4anytink45]

​@@jamescalifornia2964me too I love the warn feeling

[@ldjt6184]

I'm glad you enjoy. I do not.

[@mrofnocnon]

Me too!

[@gtbigdog3507]

I don’t mind pain and I hate it

[@BenOchart]

I used to get hive rashes. Red itchy rashes. I took 100mg of raw niacin and got a massive hive break-out ... I never had another hive rash again. I consider niacin a miracle vitamin. Not the toned down niacinamide but raw real niacin.

[@dearartms]

we need more videos on most known vitamins, they are so helpful

[@benroberts1446]

agreed. Right now I'm taking a derivative of B1 (Thiamine). It's helping me deal with an issue but I'm concerned of what the health implications are of taking it long term (maybe there is no downside though/only benefit?). Derivatives aren't the same as the typical form too.

[@FrenchViking466]

I have a bit of an issue with everything synthetic, my body doesn't seems to like those type of supplements.

[@Always-xl9db]

Are u taking TTFD form of B1? Or Benfothiamine?

[@aurapopescu1875]

Watch Dr. Peter Osborne's channel, he has extensive courses on all vitamins and much more.

[@aurapopescu1875]

​@@FrenchViking466Eat lots of meat, no need to take supplements.

[@calvinpurdy2668]

I have been taking 3 grams of "flushing" Niacin after dinner for several months now, and my blood lipid profile improved dramatically. I'm staying with it, not only that, but at almost 70 years of age, I have noted a remarkable reduction in age spots on my face and hands.

[@theworld9272]

Can you provide a link to the niacin you bought?

[@MrCeo1978buddy]

​@theworld9272 I just looked it up on Google and it said niacin flush

[@theworld9272]

ok,thanks@@MrCeo1978buddy

[@luzponce9630]

What Niacin brand do you use? Thank you.

[@esteraustria6386]

@@theworld9272w

[@Bodtec66]

Niacin, including Inositol Hexanicotinate, has long been known to be a terrific antihistamine which we know has a great deal to do with other heart disease effects like very painful variant angina, which I have experienced hundreds of times. Certain triggers, for example like MSG, aspartame, caffeine, etc...might trigger the coronary arteries to constrict whereas Niacin, prophylactically or even during acute attack, can and does dilate those vessels. I have done this in practice for myself hundreds of times and for clients in my previous life, hundreds of times very effectively and obviously very safely as the amazing Niacin genius, Dr. Abram Hoffer would attest Niacin is for so many things from heart disease to schizophrenia and from histadelia to "allergies". All The Best, T

[@sueyu3603]

Different types but it can rise bilirubin n does with me Gilbert’s

[@michaelcox1071]

He means a previous profession or stage of life.

[@manicniceguy2341]

Damn was wondering why I could smell better. I just started taking Niacin today. Along with my Magnesium and Fish Oil Tumeric. I don't think it has any side effects at work where I picked up a Bottle at Walmart.

[@papazjose1274]

@@michaelcox1071 Sad that in 2023 you have to clarify what this means

[@danielmoser2741]

Yes Dr. Hoffer is wery good i read the Book

[@trinispur3787]

I started taking Niacin about a year ago. At that time my overall cholesterol levels were very good ~120 total, 42 HDL, ~120 Tri, ~70 LDL and lower amount of VLDL. I had been on Crestor for many years. However I was still having a lot of heart problems and I could never get my HDL up or my Tri down. So having seen a few videos on Niacin I decided to take it starting with 500mg once a day. Because of the flushing effect I moved to taking it at night just before I went to bed. Within 6 months my Tri had come down to the 80s and my HDLs into the 50s. In December I increased my intake to 1000mg per night and last month my blood work indicated my Tri in the 50s and my HDLs in the low mid 60s. This was the first time my Tri to HDL ratio had gotten below a 1:1 level which is the current gold standard for a lipid profile. My LDLs increased about 10% during that time but is still in the very acceptable level. I have recently halved my statin dose and will monitor how that affects things within the next 3 months. Overall I’m very happy with the results so far. Do your own due diligence as this is not intended to be medical advice or a recommendation as each person will have different outcomes.

[@Libertas_P77]

I’ve been taking Niacin (flushing version) at 1g daily for 7yrs, because of historical studies going back DECADES (before big pharma with a vested interest in us taking their statins over a cheap, off label vitamin), that show substantial long term health benefits. There’s some legacy papers from the 1970’s where they followed a group beyond the original study, and the ones who stayed on it showed substantial reductions in various degenerative age associated conditions. It’s to me a no brainer alongside 1g of NMN, because Niacin utilises the Preiss-Handler pathway.

[@Physionic]

That study you’re referencing is called the ‘CDP’ study. It’s a big one.

[@hrabmv]

thank you for your experience! i took 200 mg for 2 days and my skin improved overnight so that i am scared how good this works...there must be some bad side effect to it, i was thinking....my skin REPAIRED in 2 days...from being red for few years now since covid basically! niacin is good for bones too!! for eyes, yes i did notice i crave sugar bit which i did not have before!

[@rowslynch6342]

​@@Physionic HELP Please ??? So a 35% reduction in LDL along with a 35% increase in HDL. Isn't that a POSITIVE outcome for combating Inflammatory processes ??? HELP !

[@Stanley_Baby]

@@rowslynch6342 Yes to a very large extent

[@00Tenrai00]

What variant do you take ? Nicotinic acid? Please get your liver function test done. Niacin >500mg/day causes liver toxicity…

[@agballew-solutions]

I’ve been a big fan of Niacin for years, especially it’s positive impact on brain health…!

[@Mellon-Musk]

What effects did you get. Thanks

[@luzponce9630]

What Niacin brand do you use?

[@blueskyvibes]

Brain health?? Tell us more 😊

[@Vegguit]

I have been taking 1250mg of B3 in the form of nicotinic acid (niacinamide does not work) for 35 years, I started after reading the '8-week cholesterol cure' in the late '80s I am 61 now, have a cholesterol level of over 300 but have a CAC score of zero. I have had a CAC twice in the last three years and both times had a zero score. which is rare in a man my age. Also, B3 is now know to be an NAD+ booster similar to NR or NMN. Just me 2 cents

[@redberries8039]

Good to hear. I've been on about 500mg per day for about 10 years

[@genomedia44]

Do you break that up into smaller doses? Given that most people experience the flush as low as 30-50mg

[@jamescalifornia2964]

@genomedia44 / I use the sustained release kind. Also a TMG supplement. There are some studies that show niacin can lower CV inflammation. Interesting supplement ... 👌

[@redberries8039]

I also take with TMG (as per a poster above)

[@Always-xl9db]

How is your glucose and liver function?

[@TheFirstManticore]

I am a 76-year-old female. I take about 250 mg. Niacin daily- or just enough to get a flush. I take it for "sense of humor," as I hear reports that it is helpful for this. I tend toward depression, and anyway, a sense of humor is good for everything. I take Niacin, not Niacinamide. One can, in time, develop a tolerance to Niacin such that there is no flushing, but this has been very slow to arrive; a few years ago I only took 125 mg, and I am now considering taking 375 mg. Even this is not a huge dose, so this therapy is pretty cheap. Years ago I took statins, but my doctor has not been prescribing them lately, so the Niacin may be a factor in this also.

[@JerryWDaviscom]

I'm 66 and take 500mg almost daily, and another 500mg at night sometimes to give me a deeper sleep.

[@maodanz1672]

Me too i will take 1500 mg or more spread out if im sick or cleansing with vit c ref .dr hoffer . Dr saul

[@ollymounara605]

@@JerryWDaviscom is that niacin or niacinamide? Because I flush so hard if it take my B complex without food that only contains 10mg that I can't imagine what would happen by a high dose like that. I do have niacinamide at 500mg, but that will get me a headache if I do not take MethylB12 and or TMG along with it as it uses up methylation.

[@1flybyguy]

@@ollymounara605I take 500mg niacin (not niacinamide) daily and some days won't get a flush and some days the flushing will make me red from head to toe and blotchy rash on the chest and back, hot and tingly. It lasts less than an hour, but I'd take it when not having to go out in public if that redness would cause embarrassment. Wondering if my not experiencing the flush on some days is tolerance, but I still get it so can't figure that one out.

[@evelynmitchell2888]

I have read that Thiamin vitamin B-1 is also mood elevating.

[@Vinnie-cv5qv]

Another great analysis. Now my son watches your posts. He has a degree in bio/chemistry and is a true geek who loved his Organic Chemistry 3 class. He said no thanks to med school and loves teaching chemistry hoping he can encourage his students to pursue careers in the sciences. He is asking his students to watch your channel.

[@Physionic]

That's really wonderful, and thank you to you and your son, Vinnie.

[@MostAlpha]

Chemistry Wizard indeed.

[@lorddouglas6659]

I have been taking 250mg/daily Nicotinic Acid (Niacin with Flush) for 2 years. My Triglycerides went down from 251mg/dL to 115mg/dL. My HDL rose and my LDL dropped. You have to take the flushing type. Taking non-flush Nicotinamide does not reduce the Triglycerides.

[@digitalbath6057]

Is it prescribed or you took it on your own?

[@carmella88]

I'm so scared to do this bevause I already have anxiety I heard it can cause panic attacks

[@TheJaYSolo]

do you believe the niacin was what made your triglycerides go down that much? Is there anything else you did for your triglycerides?

[@superdavedfw]

I've been taking niacin over the past +/- 6 months and I have steadily reduced my total cholesterol count by about 20 points. From about 250 to about 230, which doesn't sound like much, but the bigger improvement is my LDL (the bad) went from 158 to 131 and my HDL (the good) went from 38 to 55. My Doctor has been trying to get me to do statins for a while and I've been fighting her on it. I started out doing 300 mg a day (3X100 mg) and now I'm doing 800 mg a day (1X500 & 3X100). Best to take with a meal to help avoid the itchy, red skin and flushing, but in time, you will build up a tolerance to where it's less irritating. Still a work in progress that seems to be working!

[@nirajshuklaNL]

Downloading this to watch on the plane tomorrow. You're so consistent with the great info.

[@Physionic]

Have a safe flight!

[@allboutthemojo]

​@Physionic I am generally healthy and fit ( play sports and exercise 4 to 5 x per week) but my ldl is very high, hdl is good, triglycerides low and lipoprotein A very high. My doctor has been trying to convince me to start statin. I didn't because I'm not totally convinced about statins. I started Naicin ( sustained release, not the flush free kind) and Garlic pills. My hdl increased quite a bit, ldl dropped by 20 percent, triglycerides went even lower but I still have to get my Lipoprotein A measured, which the doctor says is the main concerning marker of all. Unfortunately, there just aren't enough videos about Lipoprotein A. Any suggestions on how to learn about it and your opinion? Thanks

[@JH-yu6yf]

I took 500mg of normal nicotinic acid (niacin), not slow release, for a month. I took it with 2g vitamin C, and did that at least once/day (before bed). My LDL went down 100 points, from 150 to 50, and my HDL went up, in just one month.

[@alineharam]

new study of dangers with Niacin. Please give us an update to this wonderful episode.

[@ThomasConservative]

Great video, answers a lot of questions I never thought to ask but needed to know.

[@Physionic]

Glad it was helpful! And, thank you!

[@Mike-hr6jz]

I am a type two diabetic and it had no effect on my blood sugar and believe me I test constantly and I took niacin for at least four months straight and because of the ketogenic type diet I am on my A1 C has gone down to 5.5 and it had been as high as 11.3

[@Emivioricomex]

Woow thanks for sharing.. How many mg did u take???

[@keng7758]

Your reviews and detailed analysis are quite awesome! Love your work!

[@CrustyCrip]

My former GP puts all his patients on niacin (as nicotinic acid), for cardio health. I've been using three 500mg sustained-released tablets daily, for years. Appears to stabilize, and possibly reduce, calcium deposition in arteries.

[@pondboy3682]

Physionic: "What is niacin being compared against?" Ad interrupts: "Grass fed butter!" Me: 😂😅

[@Physionic]

Hahaha!

[@AnonMedic]

😂😂😂 lmfao

[@Funsoul8]

GRASS FED BUTTER IS HIGH IN VITAMIN. K2 ..❤

[@jrb_sland]

Aging [75] Canadian man here. I've been consuming 2500 mg of niacin daily for the last 30 years every since I complained to my GP about the high cost of the Zocor [a statin] that he had recently prescribed & which had shown positive benefits on a recent before/after set of blood tests focusing on cholesterol levels. He suggested I try niacin but warned me about the well-known 'niacin flush' side effect. I made the switch, adapted to the flushing, and so far, so good. My blood numbers are routinely well within currently recommended levels. But I'm still waiting for compelling evidence that lowering cholesterol is long-term beneficial, however...

[@teddybearroosevelt1847]

You can also take it with chia seeds dissolved into water. The chia seeds multiply in size thereby acting as a buffer and this lets the niacin get released over time, thereby getting rid of the flush.

[@Birdylockso]

I always check the Conflict of Interests at the bottom of each research paper. You never know who is sponsoring these things.

That's incredible news to me! Thanks for the awesome video, as always!

[@Physionic]

Thanks, Andre.

[@Draziell]

Dr. Hoffman e posteriormente o William Walsh usavam altas doses de niacina para tratamento de esquizofrenia e outras patologias mentais devido os efeitos nas histonas (transcrição gênica).

[@manrodstrupe7312]

​@@PhysionicB3 = PP ?

[@srmitch9260]

Niacin (nicotinic acid) completely “cured” my acne. I have had acne for many years well into my 20s, I’m not 26 completely acne free. The transformation since taking 500mg daily of flush niacin, my skin has DRASTICALLY improved. Fascinating substance

[@luzponce9630]

What Niacin brand do you use? Thank you.

[@followthepinkline]

​@luzponce9630 I use NOW brand. I'm not the person whom you responded to initially, just thought I'd help. Got mine on Amazon, just started taking 500 MG today. Avoid "non flush" niacin🙏

[@infosplus1772]

The very crucial infos are peoples comments what they have experienced with B3, Thank you so much for very useful video please make an update

[@HoodLivin]

Thank you for muddying the water. I still consider it a miracle supplement.

[@susan174]

something i didn't hear is information regarding form of niacin, dosage of niacin, and frequency and duration of use.

[@doctorrobert60]

In addition to the risk of elevating blood sugar one must avoid extended release niacin that some people try to limit the flushing. Extended release niacin has the risk of hepatic inflammation. Love your video by the way!

[@CaptnYestrday]

From what I've gathered in the studies and meta studies, high dose(500mg-1g+) niacin flush should be taken once a day after dinner. This takes advantage of the first couple hours of carb sugar clearing effect and avoids the dangers that niacin introduces to blood glucose and insulin resistance during the 3rd through 6th hour window after ingestion. 😅 Just no snacking after dinner!! An interesting question to pose would be " when after dinner? Immediately following or just before bed. "

[@mrofnocnon]

True but only a very slight risk.

[@Coasterdude02149]

@@CaptnYestrday What if your snacks are usually celery sticks, cherry tomatoes and cucumbers? Yes, I am serious.

[@papazjose1274]

@@Coasterdude02149 Then change your diet because if you are fat eating celery sticks, cherry tomatoes and cucumbers, you got a bigger problem that Niacin can't correct. Also, no healthy person should be snacking. Just pure logic, nothing personal,

[@flatty9159]

Helped my ED for sure.

[@tylergates4075]

How long did it take to notice results? Dosage?

[@chuclkles58]

​@@tylergates4075 IIRC a study used 1500mg p/d over 12 week period

[@donnolsen]

This is difficult to grasp without knowing the Niacin dosage of the studies.

[@venom999333]

1000-2000mgs Take a 500mg in the morning & 500mg at bedtime Add a 3rd pill in the afternoon if you want but more than likely 1000mgs should be enough. If you want do a random 3rd pill a few times per week. Flush isn't a problem. First time yes. Second time, not so bad. Eventually it's barely noticeable most days. So, take a vitamin B3 to help save your life or rely on pharmaceutical chemicals that cause you numerous harmful side effects. B3 side effect...flushing. Difference here is adult or a child? Which are you?

[@gz625]

1,5-2g rectally

[@Technichian462]

And that makes it a usless study. But such is the way of epidemiology, USELESS IN SCIENCE.

[@venom999333]

@dr.robertjohnson6953 not when you know that the dosage is 1000mgs to 2000mgs. Doctors study medicine & don't usually bother to learn what healthy eating & nutrition can do. Because why would they? They treat the symptoms with medicine. Their whole purpose in life. Most won't treat the route cause if it doesn't involve some type of medication. No money in that. Someone comes in with heart burn issues. Scope then it's either a pill for rest of life or surgery. No other options. Forgetting to mention that losing 10lbs would also cure the issue. No need to mention that part because no money to be made there! 😉

[@mrmcallister]

@@gz625😂😂😂😂😂😂😂😂 omg. Are you serious ?

[@michaelrredford]

Thanks!

[@Physionic]

Thank you!

[@pwlacombe]

You do statistical analysis of people watching your videos. You can't get enough.

[@mossrun]

I am 77yo. I take 3000mg niacin daily. I can't take statins. I started and stopped taking niacin many times in the past, because of the flush. You have to approach niacin the way you would a rattlesnake, slowly and at a distance. I found that; if I started at a low dose of niacin 50mg first once and later 3 times a day. I found you can build up your bodies flush resistance to niacin. Slowly, over a period of months I was able to increase my daily niacin to 3000mg. After reaching that daily amount for 6 months I found that thaking that amount in 3 seperate 1000mg doseage thoughout the day that I rarely ever experience any flushing.

[@arnoldfrackenmeyer8157]

Bravo! Excellent video! I have learned from failed research and development just because a substance favorably alters blood lipids, doesn't mean it prevents heart attacks and strokes. I was hoping you would include Absolute Risk Reductions and Number Needed to Treat to avoid a CVD event with Niacin.

[@papazjose1274]

Have you checked out the rest of his videos series on Niacin yet?

[@arnoldfrackenmeyer8157]

@@papazjose1274 No, this was the first I had seen.

[@mystrength5640]

The raised Glucose/ insulin is a concern, looking forward to more info! Thank you great Video!

[@Meadows191]

Chris Masterjohn, PHD says don’t eat carbs for 3-6 hours after taking niacin

[@bobbob-ph9xd]

It's ridicolous. They focus on the negative because big pharma WANTS YOU TO BE SICK. IT'S LITERALLY THEIR HOPE IN ORDER TO SELL YOU THEIR CRAP . They cannot patent vitamins

[@MMimi-mg4qt]

It cured to me something that looked like the begining if the arthritis. A friend of mine had nasty hip pains and now she is cured.

[@lindaabernathy4876]

Thiamine is very interesting. Especially the lipophilic forms. And how about nicatinamide/niacinamide?

[@orion9k]

So you basically spend 14 minutes explaining that niacin has no positive nor negative effects on health according to studies 😅 It's still one of my favorite supplements, way better than nmn for energy boost, it really wakes me up if the flush hits hard 🙏

[@jamescalifornia2964]

Live for the flush 😊

[@Riley512]

You are the only one (and me) who noticed this. Also not much criticism of the studies, although most people here chiming in provides contradictory results.

[@orion9k]

@@jamescalifornia2964 Oh yea! Sometimes I will even do it twice per day, once for breakfast in my smoothie and once for 10min before workout.

[@Needless2say]

Perhaps the work of Dr Abram Hoffer is in order. He once told Dr Linus Pauling that he was only one letter off C>B.

[@MrSeanyGee]

I wonder, would taking b3 in conjuction with berberine or metformin enhance the lipid clearing effects.

[@Always-xl9db]

Very good question, wondering as well.

[@avoycendeether8869]

This is a good one. I've probably spent at least an hour listening to this while reviewing those papers....I only ever tried niacin in acute doses before hot ~hour endurance events (crit, sprint triathlon, 10k, etc) with the idea that skin flush dumps heat quicker and improves performance...so a little niacin and greenleaf/sims sodium loading. Never knew niacin had an impact on blood lipids. Crazy.

[@grantlawrence611]

I believe flush free niacin was used. Niacin in with flushing is what works.

[@KindergentlerMr.Softbelly]

I have taken a gram a day of niacin ( not niacinamide) daily for over 30 years. My calcium score for plac buildup is zero. I take niacin for the flush prior to workouts and take 300 mg aspirin daily also. I take my niacin in pre workout drinks make myself now all,day and feel a light burn that in tolerate well. My lipid profiles change dramatically with diet, down a lot since cutting back veg oils and sugars. Currently all my numbers are optimal but 15 years ago they were way out of tolerance, off the scale out. I think niacin has been very healthful for me. I plan to keep using my bulk powder niacin in my sports drinks. Opens all the capillaries and gets all my vitamins to the muscles.

[@noneofurbusiness5223]

Any thoughts on inositol hexanicotinate?

[@fatboydim.7037]

Niacin is often touted as a NAD booster in Longevity.

[@maj8301]

Does that mean my NADS will get bigger? Is it painful?

[@alejandrososa5146]

@@maj8301slow down, Beavis

[@Stanley_Baby]

When they did studies on NMN and NR, a great deal of NAD in the organs was Niacin derived rather than from NMN and NR

[@mikem2397]

30 days niacin balanced cholesterol for me. Love it

[@haroldgreen1425]

My doctor had been harassing me for a couple of years about my high ldl numbers. He's given me statins multiple times but within a week I have so many joint issues I'm virtually crippled. I recently did an mri stress test scan and it came back negative for blockages. I'm 74 and on 8/1 I had blood work done. Now the figures were hdl 60, triglycerides 60, ldl 196. I tried a niacin a couple of years back and had a really strong reaction to the flushing. I decided to try again but at a very low level. I started at 250 mg per day. After a week I went up to 500, and a week later 750 and finally to 1000mg per day. 11/29 I had blood work done again so we're talking a couple of months of niacin at most. The blood work figures are hdl 80, triglycerides 64, and ldl 148. I was hoping for some improvement but not expecting that much. I will say two things. First I eat a very low carb diet allowing myself 12 carbs per day and have for 30 years now. I put my diet down for the fact that I showed no blockages at my age. Second, I still am having some side effects from the niacin. Itching but no flushing. Irritated stomach and some numbness to my tongue and throat. Far less side effects than I had trying a statin. Will I continue, yes but I may reduce the dose at some point. I've had my triglycerides down as low as 45 in the past and the 60's range I attribute to not being strict enough on my carbs for a few days ahead of the blood work. Almost forgot to mention that my glucose that normally is at the recommended range rose a small amount on the niacin. I hope these figures may help some decide what niacin may be able to accomplish.

[@Luv4life77]

I take full flush niacin for better circulation to all the tiny blood vessels in my body. The effect on triglycerides and HDL is appealing but the lowering of LDL not so much. There are studies coming out that correlate extreme longevity to higher LDL scores. Cholesterol is in every cell of your body and very abundant in our brains. Thus, all the dementia and Alzheimer's nowadays due to low cholesterol and statins. I've been full carnivore now for 20 months and it's become obvious that a high fat, high protein diet is the proper human diet. EVERYTHING has improved. At 64 years old with a 6-year-old daughter, it pisses me off that I had to figure this all out by myself on KZbin but am grateful I finally found the holy grail of nutrition.

[@OfftoShambala]

Glad you are doing well… however there are those doing extremely well, recovered from lots of chronic illness from raw vegan and whole food vegan… but 90% needs to be organic. I think the thing is to stop the sugar, the fake sugar, preservatives, pesticides, various toxins etc that most people eat daily nowadays… meat and non poisoned fresh fruit and veg as Whole Foods… are what we are meant to eat… it’s about getting the toxic food out of your life. Sure, have a brownie for your birthday… or some potato chips w onion dip at a bbq … your body can deal with that most likely… if those types of things are truly rare… it’s about only eating Whole Foods… I don’t like the vaccines they pump into animals… and they are trying to put vaccines into spinach at some riverside university in California. Hope you continue to do well!

[@daveforgot127]

You are nuts

[@King_of_the_slums]

It seems those who follow carnivor always feel great, and those who go vegan claim the same, and the common factor is the lack of carbohydrates

[@bertlindsay]

​@@OfftoShambala agree, they are all elimination diets. But there's definitely benefits is quality grass fed meat consumption

[@Sydopath]

What relevance is the age of your daughter, to your over-opinionated rant about meat? What is “obvious” to you, may not be a factor with others. You should study the enigma of flawed cause & effect claims with uncontrolled in-vivo studies

[@1flybyguy]

I've been supplementing with 500mg of niacin daily for over a year, and indeed, my LDL went down 25% and HDL up 25% on average. My highest level of LDL was 145 mg/dL before niacin, and after, it's been under 100 consistently. As far as elevated blood sugar, I don't know if that'd be shown in my HbA1c, but that hasn't fluctuated by much... pretty steady. I'd do everything I could to not take a statin drug, or any drug for that matter.

[@terrycameron9728]

Thanks Nicolas, you’re a very gifted natural communicator. I found this to be very clear. I await your further videos on niacin as I’ve been on NMN for about 10 months. ❤

[@mahmodali9394]

NMN is a waste of money It doesn't get into the cells you can listen to peter atia thoughts about that, old school B3 will Skyrocket your NAD

[@nattydred2593]

My Dr and I switched me off Statins to Niacin about 15 years ago, and I haven't looked back. My calcium score actually went down a little the first five years. LDL generally at 75 or lower, HDL around 60. Blood pressure low normal, heart rate reduced to 60. I don't know if it was related but I did start to gain some weight. I address that with a Fasting Mimicking diet once or twice a year, and a restricted feeding window of 11-12 hours.

[@nutterz641]

Thanks for sharing. What dosage are you on?

[@nattydred2593]

@@nutterz641 2000mg SLO-NIACIN (Main pointe Pharma) every morning along with Kirkland fish oil, magnesium, quercetin. We started at 1500, and after about a year of monitoring lipids and liver enzymes, increased to 2000. If I miss a day the flushing the following day is more intense, but for me, manageable. I should add that most days I intentionally walk 7500 steps in about an hour, and switched to a pescaterian diet ( fish 2 or 3 times a week), high in beans and vegetables, with no processed grains or seed oils. EVOO only.

[@ShowMeWhatINeedToKnow]

When you say your calcium score, you mean your coronary artery calcium score? How much niacin did you take?

[@StreetTruckinTitan]

You really dont have to worry about higher LDL. Its HDL and trigs that we should worry about keeping in a healthy range. You need a higher LDL for hormone production.

[@nattydred2593]

@yourDoom8 while that's true, most people find knowing that doesn't help them lose weight. I ate more because I was eating late in the day, which made me hungry in the morning, and then again late in the evening. I ate more because I was hungrier, and I was hungry because my insulin sensitivity has gotten out of whack. Doing a Fasting Mimicking Diet for 5 days got my insulin sensitivity and hunger, back in line. And then reducing my feeding window so that I wasn't eating late, kept it in line, so that I wasn't ravenous at the start and end of the day. Eating healthy foods also helped keep hunger and insulin in line. From my experience, just relying on will power to eat less when you're ravenous, is impossible, and bad for me mentally.

[@fabienpaillusson7390]

I have read the book by Dr Abram Hoffer entirely dedicated to Niacin and its therapeutic uses upon megadosing. It's a mine of information by a doctor who had enough integrity to test the supplement dosages he recommended to his patients before prescribing them. He thought that otherwise he could not relate to how his patients would feel under the potential side effects, including the (in)famous flush.

[@mahmodali9394]

Thank you for sharing your thoughts, i wish more people learn about the late great Abram Hoffer and his work, may God bless his soul in heaven's

[@addams40]

OMG THE FLUSH GOES AWAY WITH CONTINUED USE. READ..

[@tomyhasse]

I read the same book and it is a true evidence that Niacin is working

[@ianstewart8243]

The flush is not a "side effect"

[@fabienpaillusson7390]

@ianstewart8243 it's a side effect insofar as the reason why people take niacin is not for the flush itself

[@evelynmitchell2888]

That flushing is the tiny capillary's opening up permitting blood flow. My reason for using Niacin.

[@transistorradiorecords3661]

I only take Niacin in a B-complex like Garden of Life's- Raw B-Complex. Same with Amino's (same idea of combining), with the exception of BCAA's use for a strain or a pulled muscles. My folks were on Statins and both had muscle problems. Not for me.

[@pattyfluegel7816]

What you are not factoring in and you can find info on if you look is that yes, niacin does increase diabetes/insulin resistance. And by this very action increases adverse cardiovascular health. However, when you study the deeper mechanism by which niacin acts apparently it depends on when you take it in relation to food. Apparently it improves processing of carbohydrates for 2 hours, then for the following 6 hours improves processing of fat and processing of carbs goes all to H*ll. So, if you take it on an empty stomach and don't eat the following 8 hours it ameliorates the harmful effects. I'm not going to look for the studies right now, but they are out there.

[@IchLiegFlach]

Whenever I start with Niacin I get headache after the flush. Also I feel less energetic and even a little bad. I took it because of low HDL Cholesterol. Pretty low dose.

[@Physionic]

Is that why you're always lying down? :) Research indicates it should be taken a particular way; for example, it must be taken with food to reduce side effects.

[@IchLiegFlach]

@@Physionic thanks I will try it with food. I wanted to have a fast onset and took it before eating.

[@synaestesia-bg3ew]

​​@@IchLiegFlachThe first time I took niacin (500mg), I thought I was about to die because of the flushing effect, my hole body was so hot. I was usually someone with cold bands and feet in my 30s. All a sudden i felt an intense blood circulation and felt the urge to scratch my skin became I was very itchy. After 10 minutes , I felt like I did 40 minutes exercise, I was so relaxed, the best feeling I ever felt, without rapid heart bit, just a nice feeling. Plus I had the Viagra effect, my dick was rock hard during 20 or more minutes, if my memory is good. For no appearing reason, it was just the blood flow. Soon after I fall in deep sleep. I used to take niacin whenever I couldn't Americans , but taking it direct guarantee the full 7 hours sleep because I tend to wake up too early. It's just good to make you crash rapidly. So I don't know it improved the heart but it surely boost blood flow a lot and give a feeling of intense exercise. After years, as I aged, i had to augment the dose just to get similar effects. I take it whenever I feel lethargic in winter, but exercise is always better. I heard that bodybuilders use big doses of niacin for maximum pumps. We are all different, my advise is to take it slow, with exercise.

[@RenoMechant]

@@IchLiegFlach, best is to take it right after the meal. That reduces mostly the flush, or at least shortens it.

[@glenntimberlake2413]

@@IchLiegFlach Work your way into something new (to you) a little at a time. Increase it as you get used to it. Build up a little tolerance and an understanding of how it makes you feel. And remember different people may have different reactions. Some people’s bodies will tolerate things better than others. Also, if you don’t want to be turning super red and itching and hot when you are going to be some place … that may not be the good time to take your niacin and then get a big flush right when you don’t want it. Because it will be visible. Experience. I know.

[@HalfGodHalfBeast]

if it (niacin) prevents lipocytes from releasing fat would that prevent weight loss?

[@Sara-wb2bs]

Also, take Boron and Selenium for the heart.

[@terrifictomm]

Wow! The mention in the Cochrane Study of the risk of increased glucose intolerance was just that. A Mention! Like one line. But SO IMPORTANT to me! I took 3g of niacin for over six months with my doctor's knowledge. To say, I had his approval might be stretching it. High brought it up as a supplement. He thought it might help lower my cholesterol. I can’t be certain that the niacin caused an increase in my fasting glucose. But I do know that several years ago my fasting glucose when I wasn’t eating any carbohydrates, or extremely low carbohydrates, was about 120. These days my fasting glucose, eating no carbohydrates, is between 160 and 190. Before when I wasn’t eating carbohydrates I was actually able to skip my insulin. Now I can’t. This certainly wasn't a Study and I’m certainly not an N=1. But it is possible that the niacin supplementation increased my glucose intolerance.

[@k8eekatt]

Thanks for sharing your experience

[@shawnshawn7477]

It's well known that Niacin can cause blood glucose issues. This is why it isn't recommended as a treatment if you have a history of diabetes. I am curious if you had your actual insulin level, not just glucose tested? The insulin level would be a better indicator of insulin resistance. Lowering LDL might not be a good thing....

[@terrifictomm]

@@shawnshawn7477 My fasting insulin has been measured twice in the past 18 months. It was 19 the first time and 16 the second.

[@terrifictomm]

@@shawnshawn7477 My triglycerides to HDL Ratio is 2.1. So almost good. I wasn't trying up lower my LDL, but raise my HDL.

[@kasiar1540]

Look into magnesium. Dr. Levy has a fantastic book about it and diabetes is mentioned

[@4Lights.5Liights]

Here's the odd observation: when taking niacin, my glucose spikes, but my A1C overall has been dropping (measured every 3 months). (FYI, daily 500-1000mg)

[@stanleyyu2079]

For anyone who is concerned about glucose spike, please look up this paper, "Effects of nicotinic acid on fatty acid kinetics, fuel selection, and pathways of glucose production in women" published in 2000, Wang et al. This paper showed the timing of the glucose spike which starts to rise 2 hours after taking nicotinic acid and then peaks in one hour (Fig. 4). Just start to exercise at the 2 hour mark to reduce the blood glucose. That should solve the problem. Glucose spike is only temporary.

[@erikjanse3994]

Did you came across, if there is a difference in the effectiveness between the regular Niacin and the flush free Niacin?

[@larsnystrom6698]

@erikjanse3994 It's the flushing kind of Niacin (Nicotinic Acid) which is used for lowering cholesterol. and LDL in very high doses. The nonflushing kinds aren't used for that. It's also interesting that Nicotinic Acid is used as a precursor of NAD+ in another pathway than the salwage pathway, which is utilized by the other forms of vitamin B3. But flushing might prevent you from using the doses one would like for that purpose. Anything above 50 mg give most people flushings. Some can increase the dose eventually.

[@ryankittle3431]

Thanks for being balanced and objective. Watched a Doctor the other day bring up the Niacin studies, and his conclusion was that niacin is never helpful to anyone, and could just be harmful. Can you do a video on the potential for Niacin to help increase NAD levels.

[@gatesroyale]

It's undoubtedly harmful. I initially started taking it due to all the hype surrounding it, while also engaging in daily six-hour walks. However, I soon encountered significant heart problems, with my heart refusing to slow down and instead maintaining a consistently high pace, fluctuating between 101 and 120 beats per minute. It's important to note that I was quite young when this happened; it occurred a year ago when I was just 24 years old. Although I did experience the pleasant sensation of flushing while on the medication, I have since discontinued its use.

[@ryankittle3431]

@@gatesroyale interesting experience. I’ve done intermittent doses of 500-750mg of flush niacin. I may have an elevated heart rate during the flush, but post flush, my HR is typical. Only potential issue I may of experienced dosing niacin so many days in a row was mild constipation.

[@fogfog8388]

I can see that people routinely take Niacin daily doses of 500mg +. This is crazy, even if common. No wonder some people get adverse effects. The daily recommended intake is 10-15 mg. Taking a megadose of 30x daily recommended is asking for trouble.

[@ryankittle3431]

@@fogfog8388 the RDA is the bare minimum of a vitamin or mineral one can take to not be in a disease state due to a major deficiency. There are benefits to many vitamins, taken well beyond the RDA.

[@fogfog8388]

@@ryankittle3431 Yes. Benefits and risks. Niacin mega-dosing helps with hypercholesteremia (whatever too much fat is called) but one is already sick by then. Many people might be netter off modifying diet.

[@ImaJunkyoBell]

Question on the mechanics section - "niacin binds to the fat cell at the GPCR which reduces the ability of the fat cell to release fat molecules" - assuming our body needs the energy don't we want to be using that fat as energy and is niacin preventing this?

[@Physionic]

Great point, and yes, you're right.

[@deJohnethan]

Great video! Would love to see a video about TMG / Betain. Whats your opinion on this supplement? According to Dr Brad Stanfield it seems quite promising and his statements are usually backed with good evidence. Im surprised you didnt pick up on the TMG topic yet?

[@Physionic]

It takes me 2-12 weeks for each investigation considering I read every study and take detailed notes on every study, and guess how many people ask me to cover things for them? ;-P I'm not fast, but I'm thorough.

[@Always-xl9db]

Yes, plz do 😊🙏 TMG is of high interest to many of us with MTHFR polymorphism (very common), because we can’t methylate B-vitamins that well. I’m taking 2g everyday,

[@chazwyman]

So if niacin inhibits the release of FAT. Does that not mean it is bad for a weight loss program, expecially a low carb one?

[@nassermj7671]

!!! This is better explained than those MD's who seem so busy to expound

[@marklawrence394]

If this increases blood sugar is it advisable for people with type 2 diabetes to avoid niacin?.

[@MichaelCzajka]

Niacin works: 500 mg/day of inositol nicotinate (& folate 5 mg with some B6) immediately reduced my cholesterol, Free Fatty Acids (FFA's), homocysteine, HBA1C and CRP in a week. Surprised my doctor how quick it turned around... even though it was his idea. Added a bit of Alpha Lipoic Acid later to normalise a fatty liver. :-) N.B. Inositol hexanicotinate is a slow release form of niacin that still works but doesn't give you the painful flush. The flush is still there... only reduced to a non-irritating level. I was already taking a B-complex.

[@TheJaYSolo]

did the ALA work for your fatty liver?

[@MichaelCzajka]

@@TheJaYSolo Yes

[@thatboyjodh]

@@MichaelCzajka Please help me how should i take niacin the flushing one 1grams(1000mg a day). Should I divide into two seperate doses 500mg morning and night? or just one time single dose. Which is better and are their studies? What about other vitamins and minerals like Natokinasse (4000CFU) magnesium(400mg), Vitamin D3(40,000IU), Trace minerals. Should I divide their doses as well morning and night? Or just take one time?? Please I have had this question stuck in my mind. Can't find the right answer. I have heart palpatations after covid vaccine. Please help me. What else should I take? Should I take both versions of B3? The flush and non flush are their any benefits?

[@MichaelCzajka]

@@thatboyjodh Inositol hexanicotinate works exactly the same as the flush version of niacin. Splitting a larger dose usually works better than taking it all at once... especially if you are taking the flush version of niacin. That's another advantage of the slow release version... you can usually take it once a day.

[@MichaelCzajka]

@@thatboyjodh Nattokinase research says ~10,000 FU works but lower amounts don't show a noticeable benefit. Nattokinase is very gentle so you can take more of it without problems. Nattokinase has a fairly short peak action so splitting a dose over the day would probably help. Take it before food... rather than after food.

[@talisdgaf]

Is it good to take niacin if you have psoriasis? Does it improve it or worsen it?

[@jimdandy8996]

So would niacin inhibit or promote weight loss? Or have no effect?

[@Always-xl9db]

I would thing promote - improved metabolic health, increase in NAD+….but probably not a big effect

[@gif24gt60]

If the flush niacin may be good for blood pressure, how do u prevent the strain on the liver? Can it dissolve arterial plaque?

[@Victrola777]

I and a friend both ended up in the ER from taking 500 mg capsules of niacin ! 500 mg caps were the smallest caps they had on the shelf. We both suffered from super high blood pressure measured in the ER on different visits without knowing the other had gone ! DO NOT take the 500 mg caps ! Look for smaller dose caps. Smaller caps are not available in my area anywhere.

[@Emivioricomex]

Wow THANKS for SHARING.. Did u have more complications after that??

[@Victrola777]

@@Emivioricomex no, but it cost me a $2,000 ER bill !

[@kevshan6518]

Love your videos. Have you done one on vitamin K2 ? Thanks 😁👍

[@Physionic]

Not yet - thank you, though

[@kevshan6518]

@@Physionic thanks for reply 😁👍

[@Mellon-Musk]

​@@Physionic Thanks for the non biased info.. could you pls let us know if 1) Niacin with flush or without is best 2) Niacin or NMN with dosage Thanks

[@nikkmann149]

Keep up the great work man. Could definitely see you blowing up and becoming as popular as more plates more dates in the health and fitness realm. I'd argue your technical explanations and breakdowns for the lay person are even better than his.

[@sulla1537]

So what about the new study linking niacin to liver failure?

[@bastigchelaar6037]

Very interesting, any insight on why Niacin contributes in Gout attacks? Same for Creatine btw... Could it have anything to do related to non-alkalinity of the body due to the mentioned HDL-LDL?

[@sophiophile]

Can you please explain how this whole alkalinity thing isn't woo? Your body regulates pH extremely tightly. Extremely small deviations are acutely fatal, and basically no amount of diet shifts it.

[@SurferBobbyLew]

Ask yourself why the body regulates it so tightly because even tiny almost immeasurable differences have huge effect. So yes pH is extremely important!!

[@bastigchelaar6037]

@@sophiophile It is just my experience. It really helps to turn an attack and feel not like shit or walk like an old man... It sucks. Im not an expert but for me it is a thing... Having this for the last 10 years I can confirm diet can help against Gout.

[@yonidellarocha9714]

@@bastigchelaar6037 sure, diet helps, but it's less about ph and more about the components that you make available to your body. It's not like you eat a citric fruit and your blood becomes acidic, but instead you make citrates available to be used.

[@bastigchelaar6037]

@@yonidellarocha9714 Sure that makes sense, but why does Niacin then contribute in Gout Attacks?

[@ntbergeron3525]

The analysis of your chosen topics seems spot on. Your knowledge of how to read studies is excellent. I'm new to your channel so you may do this on other videos but I would appreciate an acknowledgement of who funded the studies you're quoting. For example in this video, did the pharmaceutical industry fund the research? That plays an important role in the end result, in my humble, non statistical nerd opinion. Keep up the good work. For the record, I used high dose niacin to help me lose 60 lbs. If memory serves, the effect on my blood work wasn't off the charts and I did have a MI about eight years after ceasing niacin usage so my results are mixed.

[@Physionic]

Thanks, N - means a lot to me. I’ve started writing the funding sources for each study I review in the description.

[@HD46409]

I'm a little confused. If I understand the explanation correctly, Niacin inhibits lipolysis. OK, but lipolysis is a necessary metabolic pathway particularly for active individuals (not to mention athletes). This may not be inconsistent with the larger study you referenced. Effectively, if I'm interpreting this video correctly, Niacin may be useful for "locking" down or sequestering lipids in fat cells for metabolically unhealthy people where sequestration of lipids may be the least worst outcome. For metabolically healthy people, this sequestration is really a bad idea. Do I have it about right?

[@jasongodwin1319]

This all sounds bad. I want fat to be released into my blood and I want fat to be packaged into ldl so I can use it for fuel. the only time ldl is bad is when the apo-b biomarker is removed which makes it oxidized then it clogs your arteries but l-1 and l-2 ldl are good and not oxidized. Am I missing something?

[@Burnrate]

When I learn about mechanisms it is always interesting to look at the evolutionary context of why the mechanism exists. What circumstances would make a human more likely to survive with that specific series of chemical events occurring? From a simple glance at foods high in B3 it seems like they are also foods that are high in fat; this makes me think it's a built in defense against high cholesterol. When you consume the fat you get the altered chemical pathway to reduce the impact of the fat in your blood. When you don't have these high fat foods you also don't have the B3 and your body is using more of the limited fat you are taking in. This is all ruined by the modern hyper processed foods and weird stuff we eat but looking at meat and whole foods it makes sense.

[@thomassaddul]

The only bad fats ate PUFAs

[@DanteLikesRock]

this video is about D3 not B3.

[@thomassaddul]

@@DanteLikesRock B3 not D3

[@DanteLikesRock]

@@thomassaddul true. my bad

[@connor6309]

I’m confused by your comment, as lean meats and whole grains do contain high levels of niacin but have low fat content

[@justsaying7065]

What about the fact that niacin can lower lp(a)? Should one take it for that purpose?

[@surajitgoswami1871]

Good one. Consider also that the "primary" cause behind heart attack being insulin resistance (which according to a UK diabetes doctor Roy Taylor comes from fat covering kidney beta cells). So if Niacin improves the lipid profile and blood glucose control is also improving (see the stages in Taylor's Life without Diabetes or just watch one of his interviews) you could be better off. This is much too nuanced for the Statin motivated researchers who don't want Niacin (an inexpensive supplement) to win. By the way, Dr. Taylor's protocol starts with a weight loss from lower calories just as you had indicated. But it goes beyond and provides guidelines now being rolled out in the UK NHS. But I got the cellular understanding from you that Dr. Taylor doesn't provide. My story is also rather nuanced. After being successful with a "keto" (low carb, higher fat and adequate protein) where my A1C had dropped to 5.9 without insulin (or other diabetes medications), I was staring at higher LdL and total non-Hdl Cholesterol. The keto community says LdL doesn't matter but I wasn't that brave and allowed the A1C to go back up to 6.5 with acceptable LdL (below 100). However recently, I was inching back up to a BMI to 24 (high for South Asians in my opinion and according Dr. Taylor as well with a lot of them as his patients given their numbers in the UK). I had also found out based on a doctor fleeing the Nazis from Austria to Duke University that high carbohydrate with very low fat works as well to improve blood glucose problems! Given my Indian background, I like that over keto. So as I see it you have two options to improve metabolic health: eat high fat but very low carb or high carb and very low fat, always making sure that your gut doesn't become leaky (a whole big area of diet management). This made sense from the mitochondrial level processes shown in this channel. Thank you.

[@amreshprasad5336]

How did your numbers change with the switch to high carb, low fat diet?

[@surajitgoswami1871]

@@amreshprasad5336 As I'm barely into my first week of the new approach, I'll have my A1C numbers checked on November 30, giving the new diet ample time to fail! However, I'm getting very surprised (pleasantly) with the morning blood glucose numbers around 110 . A long way to go as per Dr. Taylor with the first stage for me lasting till end of Nov, 2023 and then the second stage for another six months all the way to May, 2024. In Nov, 23 I will have the lipids checked as well. Most importantly, I'm hoping the new approach restores mitochondrial health (in terms of energy/ATP production) as well. With keto I slowly lost my ability to climb hills without stopping but it could be my age (i'm nearing 70 and had an heart attack in 2013 when I also had started on insulin). I think the fat was "wrapping" the mitochondrial outer layer that reduced its ability to carry out its function normally. Still without any insulin after two years, I know my brain function had improved with keto.

[@Always-xl9db]

High carb, low fat is a terrible idea from the metabolic view point…good luck

[@ldjt6184]

The guys at Mastering Diabetes don't seem to think so and are having great success with high carb, low fat in managing their diabetes, and have been for years.@@Always-xl9db

[@VagoniusThicket]

Why the political Nazi comment? Does that add validity to that Dr’s claim ? 🫤

[@chillyrodent]

I like niacin. Please start low and slow; some people rush the dose and end up with terrifying syncope (my roommate who decided last night that her first dose ever should be 500 mg.). If you go too fast, have liquid Benadryl on hand to cool the histamine reaction.

[@Frogman214]

Request a meta analysis of studies out there on Niacin boosting NAD and any longevity, repair or health span effects. Thanks for your consideration.

[@JerryWDaviscom]

Great information. I take 500mg of Niacin most days, and sometimes another 500mg at night because it helps me sleep. Niacin does seem to positively influence my mood/depression/whatever. I never get depressed when taking Niacin, although I take it primarily to enhance blood circulation. Your mention of hypoglycemia turned on a light for me. I think the Niacin must be what sometimes make me feel like I'm going into glycemic shock. I never would have imagined that Niacin might be the cause. Gonna take some now, on a full stomach and see what shakes out. I am 66 years old, in ideal health, in good physical condition, am 6 feet tall and weigh 185 lbs. I think considering Niacin for some kind of heart disease is wasted time and money. Look at organic cold-pressed coconut oil VS GMO corn oil for some heart disease revelation. I use that coconut oil and eat good butter and all meat fat on my plate (beef, only), and my cholesterol generally runs to the moon, but the LDL/HDL ratio is in perfect balance. Every time. And my blood tests are always 100 percent in every category. I am athletic and can perform on a very high level when I am motivated to train. I attribute my health first to the coconut oil, because when I learned how it performs in the human body about 19 years ago, I immediately swapped to it and never looked back. Liked, sub'd.

[@drali19741]

Do u use organic cold pressed coconut oil for cooking/deep frying /thanks

[@drali19741]

Do u use organic cold pressed coconut oil for cooking/deep frying /thanks

[@petervafeades4095]

very, very informative! I take 500mg daily and believe that I have benefited from it so I am biased (I do also take pitavastatin) and strive to maintain an APOB below 70. You did not go into niacin's remarkable, peculiar even, ability to lower Lp(a). Nevertheless I have continued to take it daily because it seems to raise NAD levels substantially (more than NMN which I have tried and discontinued) and I have been able to maintain a VO2max level in the top 1% for my age and gender over the past 6 years. This accomplishment cannot be due to just taking the appropriate supplements; I have a regular exercise routine, an excellent diet and worship my circadean rhythm. I am a retired 66yo white male engineering professor with a BMI of 23

[@tinayoga8844]

My previous doctor had me taking niacin (without statins). I had been taking it for years. And I actually enjoyed the flushing. After she closed her practice I saw reports that said niacin had no positive effect on hard outcomes. So I stopped taking niacin. A couple of years later, at age 59, my current doctor suggested I take a statin due to my high cholesterol. total cholesterol 232mg/dL 6.0mmol/L, LDL 167 4.33, HDL 52.6 1.36, TGs 60. 0.68 The oddity with this is the low triglycerides. It is the main reason I was reluctant to take a statin. With this video about niacin I wonder if maybe I should start taking it again. I will have to look carefully at the studies. Recently I have seen some weight to the ratio of triglycerides/HDL as an important factor.

[@Always-xl9db]

Low triglycerides are excellent news. Have you checked your lp(a) levels? Something to definitely look in! Another factor may be diet, rich in saturated fats.

[@mrofnocnon]

Statins are a poison!

[@tinayoga8844]

@@Always-xl9db As far as saturated fats, cream in my coffee (twice a week). Because of my low B12 level my doctor asked me if I was a vegetarian. No, I told him. I just don't eat much meat. Maybe once or twice a week. Typically more tuna and sardines. I never knew about lp(a) until recently. I will ask about it at my next physical.

[@bojax3434]

@@mrofnocnonanyone on this thread complaining about niacin being hard on the liver, but taking a statin, is nuts!

[@Mike.L.]

Niacin was sounding great until the 12:35 mark. I have type 2 diabetes. So much for Niacin.