Reconsidering Aging, Muscle Growth, Niacin Supplementation, Your Questions, and More

[@Physionic]

You probably weren't expecting to sit on a couch with me and discuss science for 4 hours, but here we are... #nerdsunite. I turned off ads during the podcast, so hopefully your sleep won't be disturbed. ;-P Oh, and for those asking, this is the link to my dad's mug: joeveo.com/

[@seekfactsnotfiction9056]

Hey Nic, great content, love it. I wanna know if Protein (Dymatize Elite powder), Collagen powder (from beef bone broth) and Vitamin C (from natural organic dried Acerola and Camu Camu powder) In a fruitful smoothie are risk factors for the kidney function or if these supplements are not necessarily beneficial for building facial fat loss?! What is the relation of vitamin-C, protein and collagen with human organs (specially kidney) if someone has no any significant issues after test results, with the exception of low WBC and low range Cystatin-C which is still in normal range but lower end! Thanks for your scientific feedback

[@Starship_X]

Would love to see you do a deep dive on Bryan Johnson's Blueprint protocol... broken down on the diet/nutrition, exercise, sleep and supplements. It's an anti-aging/reverse-aging endeavor and allegedly follows the current scientific literature.

[@somla72]

I specifically paused the video right after you mentioning this mug just to not forget to check it out. Sounds like the mug of my dreams. Thanks for posting the link.

[@dantes4729]

I feel like david sinclair is a scammer and a fruad. Aubrey hasnt come out with anything and has been promising reversing aging for around 10 years or more now. In general I feel like this whole field is not going to come out with anything and if it does everyone watching this video will be long dead. Do you feel the same or do you think I'm drastically wrong for some reason?

[@videoartsproductions1]

You mention the potential risk of T2D when supplementing with Niacin which I've been aware of, since the underlying issue is fatty liver disease for T2B I wonder what's happening to the liver when the body metabolizes certain foods. Is the liver and pancreas accumulating visceral fat when people are supplementing with Niacin? It would be nice to now. I realize the therapeutic dosing is a pretty large amount, there must be a specific dosage that can be taken that is considered low enough to reduce risk of this happening even if they can't fully explain why this is. If Niacin supplementation is contributing to type 2 diabetes in a healthy person Dr. Taylor's hypothesis and research should be questioned. He's proven that each person has a body weight set point where the pancreas and liver no longer accumulate visceral fat on these organs. And as long as they maintain that body weight set point the T2D will stay in regression. I realize a lot of these people who have T2D don't produce cholesterol normally either so they're lipid panel don't reflect elevated LDL in their blood work because of Liver dysfunction. There are people with T2D who have very low or normal LDL levels without any drug intervention but yet they have extremely high A1C levels. So, the Lipid panel metric for predicting cardiovascular risk factors is flawed when it comes to these individuals. Perhaps there are people who have a predisposition to High LDL but don't necessarily get T2D. The Niacin supplementation cause for TB2 may have something to do with how the body metabolizes excessive Niacin in the liver while it also restricts cholesterol production but this contradicts Dr. Taylor's work to some degree when you think about it. There doesn't seem to be any clear understanding of either one of these metabolic phenomenon. If a Non-alcoholic fatty ( NAFLD) liver disease is the cause for T2D, then Niacin could be a contributing factor in large doses assuming the person was predisposed to begin with. Just how a fatty liver under produces LDL with some people with T2D. Since Niacin may cause fat to be deposited into the liver perhaps a complementary supplement that would work synergically to prevent this from happening would be required.

[@astrol4b]

Imagine a 8h podcast where you can go to sleep listening to Nick explaining molecules and waking up the next morning and he is still quietly talking about mithocondria. The perfect night.

[@nancykowalczyk2070]

Perfect…happens many a night…good for my brain, I’m sure😉

[@chadcollins6068]

Joe Pera would be put out of business permanently

[@withbeck255]

😂😂😂

[@pinkplayspkmn5011]

Yup I love it hear

[@RubyRedDances]

That’s pretty much what I look for in a podcast.

[@larshansen3081]

There is a component of your health span description that I like to call 'ME.' It stands for mindful enthusiasm. Consuming regular positive thoughtfulness feeds the biocorpus in a beneficial way. At the age of 60 I returned to university studies and achieved Deans list honors. Now, I am 70 preparing myself for another 10 years of exciting growth. Diet excites me, exercise excites me even more, but my exploration of creativity keeps me feeling healthy.

[@tom_olofsson]

Will it work if I am mindlessly enthusiastic?

[@M3W3]

The moment I saw the 3hr 58mins… I pause the video to make a pot of tea and got my snacks out… ok now let’s get started

[@s.leeyork3848]

I cannot sleep while listening to you. You're very interesting and amusing. I usually need to take notes for my later deep dives. Thank you for these videos!

[@bogeycrow1968]

“Cut to the chase” is from old western movies. There was almost always a scene when the good guys (“black hats”), usually a posse, took off after the bad guys (black hats). The chase was a high point, often climactic, somewhat like the major point of an argument.

[@ryangray5562]

Perfect timing, needed to fall asleep again. Can't stop waking up at 3am

[@mystrength5640]

Check you Vitamin D3 Blood levels . Add Vit K2 M7 if needed.. to the D3 Cortisol? / Dopamine Levels .. Thyroid.,zinc, Magnesium.. Selenium etc.

[@APHaberman]

The argument for niacin compared to statins, as I understand it, is that statins interfere with the production of coq10. Which interferes with the production of energy for the heart and muscles and leads to muscle wasting. Niacin doesn't have this problem, from what I have read. Love your posts. Learn a lot from them.

[@claytonoxendine4756]

I will share with you my six month results so far with niacin to give you some insights into what it can do. My labs on 23 April 2023 before I started on niacin. Cholesterol 346; Triglycerides 261; HDL 36; LDL 258. One month later, I started taking 1000 mgs of niacin twice a day for a total of 2000 mgs daily. On 13 October 2023, I had my labs done again. They were as follows: Cholesterol 229; Triglycerides 102; HDL 45; and LDL 164. So you can see my lipid panels improvement in just six months time. I had tried Crestor and got no where near the results. It dropped my HDL.

[@farhat5325]

If I may jump in, Is taking niacin all you did ? Or did you do/take other things, like exercise or statins?

[@claytonoxendine4756]

No exercise. I am 65years old. I have Charcot Marie Tooth disease. This is why I can't exercise. I also eat a very high fat diet. The only other thing I do is a 16/8 hour fast. But I want to emphasize, my high fat diet is not affecting this. It is also high in saturated fats, no seed oils.

[@videoartsproductions1]

That is very impressive results congratulations. Can you share your current A1C readings. Also the 1 gram a day your taking is it a single dose or are you splitting it up? The Mayo Clinic has stated on their web page that for Adults-500 to 2000 milligrams (mg) one to three times a day as therapeutic dose to lower lower triglycerides and raise HDL.

[@farhat5325]

@@claytonoxendine4756 thanks for the reply, the results are impressive 👊

[@claytonoxendine4756]

My current A1C is 6.2 which is down from 6.5 six months ago. I am taking Berberine for that. I take the niacin in two divided doses.

[@TheTommyOhh]

I totally understand your questioning of yourself doing these as I am also in a field that relies on my analysis of data and my explanation of why I made the decision I did. However your analysis and thought process really comes through and makes you more respected and trusted than others in the space.

[@Physionic]

Thanks, Tommy. It isn’t easy, as you likely well know.

[@TheTommyOhh]

It isn't. BTW, new patreon member. I love the analysis and wish you success.

[@Physionic]

Thank you - I deeply appreciate it.

[@JPage-fj7mb]

To hopefully put you at ease, I feel it's safe to say your audience is generally very intelligent. We're watching/listening to your content to get a much more informed opinion than we might be able to generate ourselves, not seeking an infallible interpretation. NO ONE should be confusing this with medical advice/the final word on any topic. Your effort, attention to accuracy, and consideration of new studies are very much appreciated.

[@celiauzarski2064]

@JPage-fj7mb I second that thought about getting information. My gratitude to Nick for putting the studies understandable to the lay person. I love that he fleshes out research details so there is a more complete picture of how this stuff does (or does not) work.

[@naoumhalamoutis1960]

My Cardiologist continually stresses I go back to statins...lol. I have no brain fog and am improving daily for a 68 yr old. He said I am living dangerously. I can't believe this doctor I have. Top down medicine!

[@lauraw.7008]

😮after a couple of “old school” responses from my friend’s cardiologist, she said that’s it. I need a new cardiologist.

[@chucktierney]

I have been following the healthcare space for almost 30 years which is long enough to experience the "High Carb or Carb loading for muscle growth" era as the latest greatest science. What I have learned throughout the years is that the science is always evolving, it's not like the laws of physics which are hard and fast. I have learned to respond to conversations regarding Health Science is "My understanding of the current literature is...".

[@marknasia5293]

“cut to the chase” refers to 1920’s film, where they stop going over the main film and go to the “chase scene” I love your work. Thank you for going into depth, thank you for the long videos, seriously i need the details to understand what is going on. And, no I don’t use your videos as a sleep aid.

[@vladbalo7160]

Great content. Big fan. I’m a 52 years old vegan on whole foods nutrition so obviously low fat and lowish protein (like 50-70 g/kg body weight) and I run marathons and do bodywights. So essentially I brake your paradigm that high protein diet essentially for recovery. Surprisingly I don’t need much. So this is the way to break the contradiction between lower lifespan and health span with low protein nutrition.

[@jellybeanvinkler4878]

I wonder if this will change for you as you age, as Don Layman and others claim. At 52, you are still young.

[@RoseMary-gl4ee]

No falling asleep, stop-and-go once in a while. Carry on, your podcasts are great!

[@_negentropy_]

Thanks for all the work you put into your analyses, Nick! So helpful! Greatly appreciated!

[@beingandreafabulously]

Thank you for all of the amazing knowledge. I love that you are a deep thinker, like me. I won’t watch a video that’s under 45 min. I listen to you while I do light work. I need the details, the challenge. I need to feel like I’m learning or it’s not worth it. Your presentations are spot on 💯🎯

[@lauraw.7008]

I’m late to the party on this one; 2:00:43 your caution and humility makes me more comfortable listening and believing that you’ve truly done your research. Plus - your willingness to say “oh wow, I did have a blind spot,” if you find you did.

[@Physionic]

I never have the assumption I know everything. Thanks for following along, Laura!

[@RNancyP]

I hope you don’t get deterred by naysayers. I’m so grateful for your work and generosity. PLEASE continue doing what you do!

[@Physionic]

Nah Nancy - nothing will stop me. Thank you for your support. :)

[@RNancyP]

@@Physionic 👏

[@jimking6484]

“Mr Science”, your description of how energy and muscle hypertrophy are interconnected is absolutely fabulous. WOW! Great knowledge! #KickAss100YrOld

[@annettestevens2260]

Thanks

[@Physionic]

Thank you

[@Chaotic313]

I was literally sipping from MY joeveo as you reached for yours, lol. I can attest to how well it attains perfect temperature and keeps it there for hours (Thanks dad). ❤ And I am more than good with long podcasts. This is great information that takes time to share properly. Thanks for helping to clarify the whole more protein/less protein issue. That one's always made my head spin.

[@TheParadisecove]

Thank-you for posting about the "joeveo"..

[@jasonuren3479]

Always click as soon as I see a new Physionic video drops. 👍👏

[@PatrickCooperAdventure]

You do have quite a relaxing voice I must say, but the content is fascinating so...no falling asleep.

[@flyonthesink2990]

I agree with you. Short podcasts are not good. I really enjoy watching and listening to you. You are very thoughtful in explaining everything to your audience so that we understand it all. Keep up the good work. :)

[@abramjones9091]

I'm a 44teen year old with 2nd stage kidney disease. I eat healthy for the most part and exercise regularly. I definitely feel a difference when taking 300mg of NR every other day or so. Less pain, more energy, and better sleep. Never had a supplement with such an extreme impact.

[@Jessica-kk1cz]

I don’t mind long content. Just my two cents. I get lots of people have limited time, me too, the time stamps help.

[@farquat329]

Finally watched whole video after 2 weeks my god that was lots of information thanks for your work Nicolas

[@hrah000]

You are doing a novel job, your informations are quite valuable.it's our job to verify all the papers and information before using any medicine and make sure with the doctors whether it fits or not with a specific body with certain conditions and requirements. It's also true that all bodies don't respond to a medicine 100% in the same way with 100% the same results. Good luck!

[@JerseyCityGuy]

First off, thank you so much for your honesty and allowing us to not only share your journey but sharing your observations along the way. I did have one thought regarding the Soma tract. I am 71 years old. The thought recently struck me (duh) that sex is a message to ones own body. That is , if your body understands that you are sexually active it will interpret that activity as still worth keeping you around and worthy of a future. since you still procreate.

[@phillialevine]

Nick, you are completely right. Your podcasts are a great health benefit. I learn a lot but I can also sleep, I’m so grateful for your duality.

[@georgbrindlinger1008]

Thanks a lot! I really appreciate you content, and your strictly evidence based approach. You are one of my fav healthspan/longevity podcasters, all the way up there with sheeky..

[@jamescalifornia2964]

Good stuff here 👍

[@MichaeltheORIGINAL1]

I love listening to those long-format podcasts in the background while playing games like Ghost Recon Wildlands/Breakpoint, ETS2/ATS, and many many more... :D Just wanted to say thanks for all your science-based videos, they are immensely helpful and always interesting. :)

[@Physionic]

Good game choices :)

[@nancykowalczyk2070]

I don’t want shortened Podcasts!!! I want the details/ minutiae/ ect!!

[@lauraw.7008]

🎉❤ I want both. Sometimes I’m on for a long walk listening to Physionic. Other time I’m “wait, what was the bottom line from Physionic about…(Glycine, Creatine, etc).

[@KIYALongevity]

The distinction in longevity with protein consumption is more focused on animal protein versus consuming plant proteins over the long run.

[@tombombadyl4535]

I think Valter Longo would argue that so-called “Blue Zone” populations do not eat a lot of protein period. They eat little to no meat, some fish, mainly plant based protein but not that much of it. Protein in any form promotes IGF-1.

[@nivlakhera9]

You are awesome !!! Such a gift to my patients- I can’t sit with them for hours so I outsource them to your channel thanks from me and my other doctor frenz 🙂

[@cizagui]

Superb podcast. Muchisimas gracias. I listened early in the morning and I could not stop listening for almost the full session. I will re-listen some sections that I could not comprehend clearly (preparing breakfast) and do some pertinent research.

[@ARCHI-Crypto]

Thanks!

[@Physionic]

Thank you! I appreciate it!

[@keithianlocke]

I was regularly taking a daily Niacin B3 supplement. After a couple months I started noticing my blood pressure falling on the low side, the first sign was ache/pain in lower left arm and confirmed with blood pressure monitor. As soon as I stopped taking the daily tablet, the blood pressure went straight back to a normal healthy pressure. I now just take just 1 niacin tablet per week, and it hasn't made blood pressure drop like it did.

[@peterz53]

At 30min on Attia. Great content but he seems to have skewed more recently too much towards exercise vs diet. Overall, in many other podcasts I see too much talk about weight training, which evolutionarily doesn't seem to make much sense, in contrast to lower level activity and movements throughout the day. In any case, he has had great highly qualified guests on to discuss lipidology and other subjects in depth and I like his concept of trying to design a physical activity routine which will not only get us to out 90s in good shape but are things we can actually do in out 80s and 90s.

[@linda7279]

Nick, Ive been here through the entire podcast. Love the content and Im not considered a nerd, lol. Your real, humanness is so refreshing. I also dont think a few sponsors would hurt you at all woth your high level of integrity. God bless, hon...

[@Nivloc317]

Actually, I enjoyed watching you struggle to find your cognative footing, as you were talking about Statins and Niacin. It makes you all the more trustworthy.

[@candrad]

You’re so smart I wish I could have had you for a son,really,you have helped me understand things I never could have!

[@_Keith_]

As far as the quality of life versus longevity issue... I think the thing to do is to eat the right amount needed to fuel the specific activity level. That's the balance, whereas both overeating and undereating are undesirable extremes.

[@Aviation_Professional]

Being dismissive of B3 is a HUGE mistake!! Remnded me to take my creatine today too!! lol Good stuff

[@hvvijuka]

Please make video on thyroid Harmone role on cells

[@naoumhalamoutis1960]

Great conversation! Long video but well appreciated. Thanks!

[@Gul0gulo]

I’m with you on the l night of a podcast! The longer the better 😂

[@williamhenry3337]

Thank you for all your hard work.

[@Physionic]

Thank you, William

[@alanG3806]

Re Exercise and aging. As a young guy you probably don't appreciate the terrible impact of arthritis on health at ages over 60. It becomes really difficult to exercise when your joints become painful to move. I suspect this plays into health at advanced age at least as much as dietary variation. It comes to affect huge numbers of older people but appear to be often ignored in studies.

[@gaiacielo5090]

Have you tried carnivore diet? And I hope you get better

[@susanb3989]

Sugar is demons seed and I’m convinced causes or contributes to arthritis. When I eat desserts the next day my finger joints hurt. Every time. Also BMI >=27. Stay slim and don’t eat sugar, for prevention.

[@beingandreafabulously]

I suffered with arthritis really badly. It wasn’t until I changed my diet and removed glutinous foods like bread, pasta potatoes rice. It was amazing how quickly my body changed. And I no longer have arthritis. And I’m 60.

[@jellybeanvinkler4878]

Check into oxalate toxicity.

[@Finalforce100]

Thx a lot for all this detailed information, it help me understand the complexity of this matter in a much deeper way

[@michaelphillips4452]

"Cut to the chase" refers to movies, cutting out the drama and going directly to what people came to see....the chase scenes.

[@Arte-Libertad]

good point on skipping empathy... actually takes away from the experience...greed is bad

[@spacejunkisforever6311]

Love your Niacin section and introspection. Recently I have started a niacin based supplement (also contains alpha lipoic acid, and some random things like parsley, black pepper, and green tea extracts- which I guess is for absorption?). It’s a formula called “Time” - and is by Nuchido labs in London. They seem to have come to the same conclusions about niacin that you have.

[@jonfreelove]

Great job mate love this style and the matters covered

[@keithdow8327]

Thanks!

[@Physionic]

Thank you!

[@keithbyrd7566]

I absolutely enjoy this nerdy ultra-long format with the deep dive into various subjects.

[@jacksoneglise1657]

I speed Nick's videos to 1.75x and he is still clear to me in what he is explaining.

[@phillialevine]

Just wanted to say that I appreciate you a lot Nick

[@brendasmith9076]

Nick, I am always happy to see a new post from you!!!! I love how transparent you are and so full of wisdom and information. I wish I could afford your other group. Retirement is great, but income is fixed, I am Turing 73 this fall, leaving for Hondura to scuba dive for 1 week. I want to live a long and healthy life. Die after turning 100+, a day full of activity and family and fall asleep and wake up in The Spirit World. To do so, I need to make sure I get enough Protein & exercise to keep my body strong. I know there is so much controversy about Protien amounts and sources!!! Thank you for all your research to help me and others make the best choices! I do have a question about C 60, what are your thoughts on this? Thank you!

[@naoumhalamoutis1960]

I listen to you daily. I believe in your integrity.

[@APHaberman]

On nmn, there are studies, that I'm aware of, going back to 2019 that show improved endothelial function in its presence. Harvard came out with one this year that shows the same and other cardiovascular benefits. The increased feeling of energy that many people report may be due not to increased bodywide cellular nad production but, to these improved cardiovascular results.

[@chamuuemura5314]

2:04:30 As I think I heard on the Moss Report, synthetic drugs can be seen as faster, stronger, or longer versions of natural (such as assumedly niacin) foods, with the drawback of potentially more serious side effects. Thus we could assume statins might have more impact than niacin, but also with more potential drawbacks. Finasteride and saw palmetto may have a similar relationship regarding prostate health or Xanax and ashwagandha for anxiety.

[@rosetyler4801]

Just want to say I love the information you provide. I wouldn't want you to cut things down or shorten the amount of depth you go into topics. I think it's more interesting and beneficial as long form content. People that need the tldr version of everything need to realize these are important topics. They relate directly to life and making it better. If someone can't spare time for that, then they might need to reevaluate their outlook on things. Tiktok format videos should not be where someone gets important information from.

[@Physionic]

I can appreciate that stand point, Rose. Tends to be mine, as well.

[@gilgamesh.....]

I agree. Anything that can make my life better and give me more of it is more than worth my time.

[@brandongreen1177]

Thanks for the update!!! Love your content :-)

[@tom_olofsson]

The “chase scene” in a movie is where the good guys are running and the bad guys are chasing. If we cut away to a love scene and then back to the chase the director would say, “cut to ‘the chaze’” to illustrate that we cut back snd forth between the love scene and the chase scene. Since the chase scene is often more exciting than a slow love scene we say, “cut to the chase” as short hand for “get to the good stuff”.

[@kleanslate9906]

You can add 1 more to your MB interested group. Great explanation. Til now ive been writing to off to hype. You do outstanding work!

[@egyptiandeity1862]

First time here. I loved it❤

[@Physionic]

Welcome :)

[@911review]

I swear by niacin. When I was in my 20s I used it, a long with sauna, to detox, and I my vision improved, color was more vivid, smelled things I hadn't on years, and just felt better, and slept better,. Now, in my 60s, I am taking it again with great results, improved concentration, sleep, lowing anxiety and more

[@Galahad54]

I've been following statin research for decades. Statins have, like niacin, resulted in better lipid profile. However, for several years/decade+, statin use had 10% higher total mortality. Then, starting 2010-2013, statin users had 10% lower total mortality. It was never clear exactly what changed to make the statins have better numbers. Glad to hear that statins have been compared to niacin, with nearly neutral results. I've learned from listening to you that any study, or even several studies, have limits that aren't clearly made in the study itself. Of course, the popular literature is often/usually a big mess.

[@ratsters7]

My understanding (which could be wrong!) is that statins lower total cholesterol (LDL but also HDL) whereas niacin lowers LDL but not HDL. If that's correct (IF) then niacin is, in theory at least, better than statins? Cholesterol is roughly 80% HDL and 20% LDL, and it's the LDL that needs to be lowered and HDL to be left alone or increased (depending on what your bloods say). Which is what niacin does but not statins? I'm not at all clear about this, but it's the impression I've had recently. However, very much dose-dependent, and niacin isn't without its side effects.

[@garyhaughney2165]

thanks much. very interesting discussion.

[@RLeeErmy]

I know this is an old video but I would encourage you try methylene blue for yourself and report on any felt benefit. As a person with an auto-immune disease, I feel great for several hours after I take it. I do worry myself with any overdose or overuse concerns. Just too little info on what is too much. Thanks for a great video!

[@alreadythunkit]

Enjoyed the cast. I'm eating above maintenance to gain muscle but will fast when it starts getting out of control. Question: Do you recommend taking HMB during a fast to reduce muscle loss?

[@GrandmaMaeCorporation]

My Niacin experiment- I am unable to use statins because it shuts down my liver (bad reaction) my muscles turn to mush including my heart. I was excited to learn about Niacin therapy, so for three months I took high doses of Niacin (flushing type, th e non flushing won’t work). My cholesterol scores didn’t drop at all. The flushing only happened initially, once my body got use to it, it no longer happened). However I had some most pleasant side effect with my skin. My skin was no longer dry or had any dry patches on my knees elbows or ankles. My dark splotches (age spots) on my face disappeared the ones on my hands faded or disappeared. The few wrinkles on my face disappeared I just take it once a day now. I’m 65 years old. People think I’m with my father when I’m out with my husband. I’m thinking if it helps with my skin cell tissues it must be helpful with my blood vessels as well. I don’t experience any flushing anymore. I no longer take it multiple times a day. I will continue to take it.

[@jellybeanvinkler4878]

Wow! Interesting.

[@eggbenedict-gt7mw]

Skin health is useless, even niacin will not reduce cholesterol

[@glenallen320]

I take niacin most days, have done for a couple of years, still get the flush. The benefits you describe may well come from niacin’s ability to boost NAD production in the body. Studies have shown it to be more effective than other supplements that are far more expensive.

[@freedomsnotfree1221]

Niacin is wonderful

[@tendr247]

What strength is safe?

[@kirkfreis7903]

On par with Dr. Mobeen again. I've been using niacin for years. Love the heat rush. Just need to keep an eye on liver enzymes.

[@jamescalifornia2964]

I take Trimethylglycine (TMG ) supplement with niacin 👌

[@kirkfreis7903]

Good idea James. Thanks

[@rasn]

I freaking love your podcast dude! nyc woman watcher here, thank you for the information!

[@janineclemons746]

After getting COVID 3x I started GlyNac, ALA, NMN sometimes Niacin. Restarted allulose to block carbs. I have to take prescription enzymes but don't assume diet can meet my needs, so I take numerous other supplements to rebuild. Good review. Thank you!

[@rg-cb2wd]

Any good glynac recommendations?

[@janineclemons746]

First I take a magnesium glycinate because it is well absorbed and you need the magnesium anyway. I'm not particular about the brand of NAC. I select products from well known online supplement websites with a lot of hope and faith that they do due diligence in quality assurance.

[@jonathonmills3563]

I never saw anyone that postulated that increasing NAD would lower cholesterol, s I find that criticism fair. I would like to see an NMN study that looked at epigenetic changes measured by DNA methylation.. that would be a relevant marker. BTW. I tried to watch this on the insider site but I couldn’t find it in the feed. So I’m watching and commenting here

[@JosvanderSpek11992]

Finally got all the  14 330 seconds down. Sorry it took 3 months. I’m actually glad I watched until the very end! You and I are not so dissimilar, I’m a bit more bullish on the longevity stuff then you, and also educated in astronomy and mathematics rather than biochemistry (which wás my second choice in high school, I’ll have you know ;).) About the same age. But imagine I were you had I taken the biochemistry route, and being a little more disciplined. But of course, the real question remains… _kom je nou gewoon uit Nederland?_ 😉 Da moe’k gewoon ff weten 😅 Thanks for yout efforts mate!

[@peacelilly75]

i love the podcast experience!

[@theshadow8008]

Just in time, have to download this cause tomorrow im going somewhere.

[@joey86bu1]

Best ASMR channel on youtube!

[@ldt6513]

This is really good stuff! Thank you!

[@Bepartofthepanacea]

❤😍😍😍 great work nikkkkk

[@jonathonmills3563]

This one will take a few days to watch! Which I will of course.

[@harmony8337]

It's a easy voice to fall asleep with. ☺️🤗

[@jonathonmills3563]

DHEA supplementation in older people to restore youthful levels is a common anti aging therapy, so it’s certainly a confounding variable in the TRIM study, as is Metformin

[@tombombadyl4535]

It’s David Sinclair vs Peter Attia. Peter Attia looks buff. David Sinclair looks young. At what age does Sinclairs functionality surpass Attia’s. Best podcast so far IMHO

[@Chaotic313]

"Cut to the chase" originated in the 1920's and alludes to the editing (cutting) of film to get to the exciting chase scene in the motion picture.

[@marknasia5293]

i didn’t check the comments before posting but great to see someone else actually listens in detail to the podcast, videos. This is my fav channel btw. cheers 😊

[@willsk3122]

You said that lowering cardiovascular risk by reducing inflammation isn't great because it increases your risk of infection, but what if you are at a higher risk of heart disease like having high Lp(a).

[@farquat329]

I dont know if i would watch all this video at once and i dont want to comment anything before watching whole material but i'm leaving comment now

[@donniedarko3259]

Can anyone give me the cliff notes? Thanks😃👍

[@AlexZaidi-e8w]

I'm fairly certain the literature points to methionine, tryptophan and another amino reduction for the protein effect... Lower those and keep the others normal and you get the health benifit minus the negative.

[@robertaprizner2691]

it would be interesting to find DR Tom Daysprings view on niacin his lipid talks are the best around. He is open to discussions see dr lipid

[@plantstho6599]

Does it matter if the niacin is flush or no flush?

[@joshhart8722]

Re: Niacin. I’ve been trying to square the notion that high HDL is protective from CVD, but that niacin is not protective despite the fact that it increases HDL. My operating hypothesis is that HDL is the “nascent” form of cholesterol, and that LDL is a downstream end product of HDL. Niacin supplementation increases the production of HDL, but in the absence of other interventions (lifestyle, statins, etc.), it is effectively just adding fuel to the production of more LDL. That is, increased HDL is converted to increased LDL.

[@mrofnocnon]

You must work for big Pharma with that kind of explanation. Niacin is a vitamin.

[@alphatonic1481]

I love long podcasts.

[@RandomStuff-ww1wv]

podcasts are usually conversations between 2 or more people thats why one single person going on for hours can be a bit harder to digest. When there is someone else you can get Qs from them of when you are being boring or funny or even just branching off