Types of Enzyme Inhibition: Competitive vs Noncompetitive | Michaelis-Menten Kinetics

[@shadowarena]

I will never understand how a KZbin video can explain concepts easier and simpler than my textbooks. Thanks for this! It helped me understand enzyme kinematics

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@renuk8560]

Yeah, textbooks' explanation might be frustrating, but most of the time if you read carefully, processing every word, you can overcome that inconvenience and finally comprehend what it means. Though, videos like that are better, because they may sometimes underline important details, on which you wouldn't pay attention in usual circumstances.

[@chazruss7177]

Because the main goal of a textbook isn't to help you learn. The main goal of a textbook is to make money at all costs.

[@TheTosi98]

This is great. Our teaching systems don't understand how important is the repetition of concepts, and you really make it. Thanks very much sir! From Italy.

[@LikeDaniel]

Finally Km and Vmax make sense! Thank you so much for laying it out so simply!

[@MrPridizzle]

I felt, for a minute, that you were looking through the camera and into my soul... it was powerful :) great video, cheers from Arizona!!!

[@clip012]

www.nbcsandiego.com/news/local/ucsd-medical-student-aspiring-neurologist-not-letting-brain-tumor-stop-him/20297/

[@PremedHQ]

@@clip012 Dr. Dave Carlson is doing much better now! Thanks!

[@clip012]

@@PremedHQ Good to know. I wish him well. Hugs from Malaysia.

[@PremedHQ]

@@clip012 Thank you!

[@zuu4673]

@@PremedHQ i love your videos so much doctor.

[@angela.chance]

am having exam tomorrow. and you saved my life thanks..i love the teacher .he repeats to clear stuff, helps you grasp it.he doesn't get boring 😙

[@akosuafrimpong4465]

I have no idea about how I stumbled upon your channel, but I am so grateful. People like you motivate me to work harder everyday, thank you and God bless you!

[@user-po3ii1tl9z]

You should read up on his story. I believe he's in medical school now (or maybe about to graduate) but he was also going through some serious medical issues at the time which you can search up. He really is an inspirational individual.

[@carolyncrawford9992]

You have a gift for making seemingly complex topics feel simple and easy to understand. Thank you so much for these videos, they have helped me immensely in my studies for the MCAT.

[@rompiendoelcorojo]

This is the best explanation I’ve ever seen on this topic. Thank you so much.

[@harshsane8325]

Dayum I liked how this video helped me during my entrance and now during my 1st year medicine. They way you taught > the way my professors taught ❤️

[@A58i2]

You're a good Teacher Sir, I didn't like this course before, and because of your teaching, you've inspired a positive reaction in me

[@PremedHQ]

Wow, thanks!

[@Atrionix]

Hence, you could say that he was the enzyme that catalysed your positive reaction :D

[@DrPhysician]

I love the way you explain things! I'm frustrated that you did not explain these inhibitors with the Lineweaver-Burk Plots as well as the Michaelis-Menten plots.

[@bitseatgetaneh5873]

Such a great explanation!! Can’t thank you enough for clearly explaining something I’ve been wanting to understand for over 3 years!!

[@user-po3ii1tl9z]

The reason why I really like this video is because you don't even have to memorize anything anymore, the way you explain it ACTUALLY teaches people in a way where we can logically come to conclusions about what happens with Vmax and Km (like at 2:40, you can already guess that Vmax doesn't change but Km will increase, not because of the graph but because of the way you explained it so elegantly). Thank you :)

[@priyankaprajapati8217]

Thank you so much for such a simple explanation, glad I found this video while preparing for a technical interview!

[@mohammedahmedjalloh531]

Hello Sir! I cannot thank you enough, this is really a groundbreaking video for me!!!!!!!!!!!! THANK YOU

[@PremedHQ]

You're welcome! Glad you made a break through!

[@brittanywillut]

AMAZING!!! My biochem professor could never explain this.

[@koushikchatterjee7375]

I have seen many videoes from different sources but none explained it better like you did , love from India ❤❤

[@PremedHQ]

Thank you!

[@321123Nelly]

your voice is so smooth. thank you for these amazing explanations

[@Weifan]

how is Dr.Dave Carlson doing now? He is so helpful in teaching those concepts.

[@jakobroze7017]

Such a great video. Really breaks down this information into logical steps!

[@ssomu1993]

At last the concept of enzyme kinetics is now clear....thanks !

[@PremedHQ]

You're welcome!

[@pranavraheja]

Was trying to learn this from past 2 days... Thank got KZbin recommend me this 🙌 .... Love from india ♥️

[@sayliparab7851]

You are really good at teaching sir....I was always confused how km and vmax is affected in both the cases....thanks for the help

[@PremedHQ]

You're most welcome

[@sabrinasin123]

Ya. His video is really informative!

[@motivational_Insights]

I think we should begin to advocate for a kind of Video textbook. Those textbooks are just bunch or words lumped together. This video explains what several pages of text cannot. It can't be clearer than this. At the end of the day, all you need is an understanding of the subject. Thank you so much professor.

[@williamallotey270]

I liked before the lecture, this i know you are the best

[@zuluflexxboswellow133]

I wish i had the power to give you a billion views,coz this is far from just a job well done...simple english everything is just understandable

[@princesspat5239]

i'm in biomed and i really want to get into medical, i wish i had found these resources. Love your videos, they're great for my bio course!

[@Chelsea-gs7qj]

I love your videos, but there are 4 types of inhibition tested. Why didnt you mention uncompetitive or mixed?

[@faisha1917]

Finally, I got a clear vision and explanation about enzymes fully, after all this years ^.^, thank you! I have subscribed by the way, hopefully will make me easier to study more

[@maarinahope]

You are the best tutor

[@nethinduwarapitiya5497]

crystal clear teaching! great video

[@nicholasachuz8329]

calm and straight to the point

[@sagarsatapathy4600]

I watched 10 videos to understand this concept but I was not feeling confident and then after watching this, I didn't need any other video to understand enzyme inhibition more

[@PremedHQ]

Thank you! Please share this channel with your peers!

[@VeronicaJosef-ls2dx]

So wonderful, well explained and understandable...👍👍👍🌹

[@PS-qc9gc]

It was so very helpful.thank you so much...you are a very good teacher.i liked the way you explain things.😊

[@ne6761]

wow!!! are you God? because you explained it so well as if you were the one who discovered these things and made them come to reality!!! i've never understood a concept this good!!!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@aamnakhan7856]

no concern with enzyme but I randomly click this video, why he is so smoothly teaching😍🤩

[@mounikab8735]

Excellent sir, and , thank you so much sir. Now I am clear with this concept.

[@LeoVu-l2y]

I need to start paying my tuition to you rather than my professor who can barely explain a concept.

[@lowkeycam9151]

thank you! this is truly a lifesaver

[@Ltrina_02]

So much better now!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@noorel-tawil8775]

this was the most helpful video ! Thank you !

[@lakhdeepsingh9132]

Also apparently noncompetitive inhibitors can bind to either the allosteric site of enzyme itself or of the enzyme-substrate complex... something I did not know.

[@starrani5264]

Thanks , all these lectures are very useful.

[@leishembilyting5086]

Just blessed to have seen this 🌸!

[@siakapmerah5018]

thank you so much for the explanation! so grateful to see this video!!!

[@stirfry3018]

wow how are these free?! thank you so much

[@lancevercitti3904]

I just happened to find this today, thank you so much! My book is not too good at explaining this concept.😀😀

[@DrSunilKumarJaswal]

Nice for the students of different courses like MLT and Biochemistry subjects people

[@LilyGraceySa]

I nearly cried because a lot of people explained it to me and it didn’t make sense! You are such a treasure, you actually explain what it means! Would’ve loved if you taught me the whole biochemistry course, then the stiff material would’ve actually became imaginable. Thank you!! ❤❤

[@tikizone2535]

Thank you so much Sir. Greetings from India

[@darondasavage4140]

Thorough explanation. Thank you

[@PremedHQ]

Glad it was helpful!

[@shivamgarg2711]

Thank uh sir ❤️ you made it crystal clear... am from india preparing for neet ug....your teaching style 💕❤️

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@dianagreen4450]

this is brilliant!!! so well explained, thank you

[@zpii9317]

so helpful video. love from Georgia

[@فاطمهعظیمی-غ4ز]

you are my lovely professor😊😊😊😊

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maybe it's all the caffein but I am loving this guy.

[@ranahaddad5446]

Wow! Well explained! Thank you!

[@audioderyne]

thanks so much. you are an excellect teacher.

[@ankushdubey8985]

Love from India ❤️❤️❤️

[@User-s868]

That was definitely helpful, thanks 😊

[@charlesukonna3502]

You're really really good 💯💯

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@myagagasy]

Thank you so much 😊 you're a life saver 🙏🏽

[@sabrinasin123]

Thanks for your sharing, sir. By the way, I have a question that wish you could clarify for me. Is it the Michaelis Menten Plot actually is a standard plot that can comparing with the certain enzyme that we want to study? And is it we could identify our inhibitor whether is competitive or non-competitive after plotting the graph? Thanks.

[@bhawnasuryawanshi2350]

Wow, so clear explanation

[@aditichokshii]

This helped so much!! thank you!!

[@sunshine-qw5md]

omg thank you, this video explains it so well. and I also just realised I've learned this stuff before lmaoo

[@Ghasi83]

Thank you Professor!

[@rolandmalone5431]

Awesome explanation

[@rtdpoe620]

thank you for this clear explanation

[@nathanrumpf5660]

Fantastic explanation. Thank you!

[@jacklyngarcia8887]

I love the video but there is no explanation of uncompetitive inhibitors :(

[@nyikomhlarhimusic]

Thank you veeeery much🎉

[@rugvedkulkarni1593]

So Km is the concentration of substrate needed to get to 1/2 the maxiumun reaction rate?

[@seelamlakshmi1002]

Very well explained sir!!

[@tiringozerihun6110]

It really helpful Thank you.

[@erikruizmd]

In competitive inhibition, Km is indeed increased but.... affinity doesnt necesarily change. Competitive inhibitors interfere with substrate binding due to the inhibitor's own high affinity for the enzyme's active site. This causes the measured Km value to increase; however, the actual enzyme affinity for the substrate remains unchanged.

[@khalildaoud671]

The dicrease in the affinity is related to [s] as you increase it, so the affinity of the inhibitor doesn't play a role in this equation as it remains constant.

[@Heyjudeeeee12321]

can we have videos of questions regarding this so its easy for both qualitative and quntitative analysis

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@sandyzhao2706]

this video was soooo helpful. Thank you very much ^_^

[@stasiuschlaffke3444]

When will the competitive inhibitor molecule leave the active site?

[@astaghfirullah10000]

Great video.

[@luwambrhane4570]

It was really good explanation thanks

[@urukhai666]

Thanks a lot! That was really helpful))

[@carolinaamador8863]

I have a question: With non competitive inhibition, the Km is the same because those enzymes that are not affected by the inhibitor are still have the same affinity for the substrate. However, the Km is lower with competitive inhibition because some of the enzymes are being inhibited. Now the question is, in competitive inhibition, do those enzymes that are not inhibited and working on the substrate still have the same affinity for the substrate? Thank you for the excellent explanations.

[@faithmadi2991]

With competitive inhibition the Km is higher so the affinity is lower. And (just what I think) the general affinity of the enzymes are taken into consideration, but I think the enzymes that aren't inhibited still have the same affinity; however I think the overall affinity changes

[@thesmiler119]

It's all about competition. It's not that all active sites are occupied but each substrate has to compete with inhibitor there. So even if we end up getting our substrates attached with enzymes that substrate would have competed with the inhibitor. So affinity has decreased irrespective of if substrates attches or not.

[@thesmiler119]

And when substrates would have competed, then the affinity would definitely have decreased. Look! There's a substrate who doesn't have to compete and there's this that have to. It's for sure that the one who has to compete will lose its affinity

[@bambangkiranadi2576]

Excellent lecture.

[@mikaelaprim4273]

but why does km change? doesnt the active site change when non competitive inhibitor binds, hence decreasing affinity

[@SameeraKetavarapu]

Thank you so much.😀

[@zolani-kabane]

Well explained. Thank you

[@nunitchagucci3047]

What is his name? He is such a well explaned teacher!

[@makkenavijayakrishna1858]

What about allosteric activation

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@muireey1475]

You are awesome thank you very much

[@naciburakcakr2793]

You are really awesome

[@rehanabokhari4482]

Nice explanation

[@odysseysalehi3933]

Thanks god i found you

[@hajraafzal1570]

Well explained.

[@guruvunaik8818]

great explaination like from india

[@vidushibanerjee2418]

I have one doubt though... isn't in competitive inhibition the inhibitor would bind to enzyme irreversibly then there would be no free enzymes... so even if you flood it with substrate how would the reaction proceed as the enzymes conc or rather the free or effective enzyme conc has decreased. Please explain

[@nelakudrikova1212]

I am not sure but we have 2 types of inhibitions - reversible and irreversible . Reversible are COMPETITIVE , UNCOMPETITIVE and MIXED Irreversible is that the inhibitor binds covalently with or destroys the functional group on an enzyme that is crucial for enzymes functionality . - so In competitive , I don’t think the enzyme can bind irreversibly , it’s always reversible

[@RajuSharma-fz2tp]

I came for 5:22 thanks !!

[@mohamedismail777]

Nice video it explains the competitive and noncompetitive inhibition very well. It will be great if you can also make a video of uncompetitive inhibition as well please :)

[@Sara-pk8wv]

you are amazing 🔥