Types of Enzyme Inhibition: Competitive vs Noncompetitive | Michaelis-Menten Kinetics

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Instructor: Dave Carlson
Enzymes Part 8 - Enzyme Inhibition

[@shadowarena]

I will never understand how a KZbin video can explain concepts easier and simpler than my textbooks. Thanks for this! It helped me understand enzyme kinematics

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@renuk8560]

Yeah, textbooks' explanation might be frustrating, but most of the time if you read carefully, processing every word, you can overcome that inconvenience and finally comprehend what it means. Though, videos like that are better, because they may sometimes underline important details, on which you wouldn't pay attention in usual circumstances.

[@MrPridizzle]

I felt, for a minute, that you were looking through the camera and into my soul... it was powerful :) great video, cheers from Arizona!!!

[@clip012]

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[@PremedHQ]

@@clip012 Dr. Dave Carlson is doing much better now! Thanks!

[@clip012]

@@PremedHQ Good to know. I wish him well. Hugs from Malaysia.

[@PremedHQ]

@@clip012 Thank you!

[@zuu4673]

@@PremedHQ i love your videos so much doctor.

[@LikeDaniel]

Finally Km and Vmax make sense! Thank you so much for laying it out so simply!

[@TheTosi98]

This is great. Our teaching systems don't understand how important is the repetition of concepts, and you really make it. Thanks very much sir! From Italy.

[@angelalourine1199]

am having exam tomorrow. and you saved my life thanks..i love the teacher .he repeats to clear stuff, helps you grasp it.he doesn't get boring 😙

[@akosuafrimpong4465]

I have no idea about how I stumbled upon your channel, but I am so grateful. People like you motivate me to work harder everyday, thank you and God bless you!

[@user-po3ii1tl9z]

You should read up on his story. I believe he's in medical school now (or maybe about to graduate) but he was also going through some serious medical issues at the time which you can search up. He really is an inspirational individual.

[@ne6761]

wow!!! are you God? because you explained it so well as if you were the one who discovered these things and made them come to reality!!! i've never understood a concept this good!!!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@carolyncrawford9992]

You have a gift for making seemingly complex topics feel simple and easy to understand. Thank you so much for these videos, they have helped me immensely in my studies for the MCAT.

[@DrPhysician]

I love the way you explain things! I'm frustrated that you did not explain these inhibitors with the Lineweaver-Burk Plots as well as the Michaelis-Menten plots.

[@rompiendoelcorojo]

This is the best explanation I’ve ever seen on this topic. Thank you so much.

[@Weifan]

how is Dr.Dave Carlson doing now? He is so helpful in teaching those concepts.

[@harshsane8325]

Dayum I liked how this video helped me during my entrance and now during my 1st year medicine. They way you taught > the way my professors taught ❤️

[@A58i2]

You're a good Teacher Sir, I didn't like this course before, and because of your teaching, you've inspired a positive reaction in me

[@PremedHQ]

Wow, thanks!

[@Atrionix]

Hence, you could say that he was the enzyme that catalysed your positive reaction :D

[@koushikchatterjee7375]

I have seen many videoes from different sources but none explained it better like you did , love from India ❤❤

[@PremedHQ]

Thank you!

[@motivational_Insights]

I think we should begin to advocate for a kind of Video textbook. Those textbooks are just bunch or words lumped together. This video explains what several pages of text cannot. It can't be clearer than this. At the end of the day, all you need is an understanding of the subject. Thank you so much professor.

[@pranavraheja]

Was trying to learn this from past 2 days... Thank got KZbin recommend me this 🙌 .... Love from india ♥️

[@bitseatgetaneh5873]

Such a great explanation!! Can’t thank you enough for clearly explaining something I’ve been wanting to understand for over 3 years!!

[@mohammedahmedjalloh531]

Hello Sir! I cannot thank you enough, this is really a groundbreaking video for me!!!!!!!!!!!! THANK YOU

[@PremedHQ]

You're welcome! Glad you made a break through!

[@Chelsea-gs7qj]

I love your videos, but there are 4 types of inhibition tested. Why didnt you mention uncompetitive or mixed?

[@priyankaprajapati8217]

Thank you so much for such a simple explanation, glad I found this video while preparing for a technical interview!

[@user-po3ii1tl9z]

The reason why I really like this video is because you don't even have to memorize anything anymore, the way you explain it ACTUALLY teaches people in a way where we can logically come to conclusions about what happens with Vmax and Km (like at 2:40, you can already guess that Vmax doesn't change but Km will increase, not because of the graph but because of the way you explained it so elegantly). Thank you :)

[@jakobroze7017]

Such a great video. Really breaks down this information into logical steps!

[@sayliparab7851]

You are really good at teaching sir....I was always confused how km and vmax is affected in both the cases....thanks for the help

[@PremedHQ]

You're most welcome

[@sabrinasin123]

Ya. His video is really informative!

[@321123Nelly]

your voice is so smooth. thank you for these amazing explanations

[@ssomu1993]

At last the concept of enzyme kinetics is now clear....thanks !

[@PremedHQ]

You're welcome!

[@zuluflexxboswellow133]

I wish i had the power to give you a billion views,coz this is far from just a job well done...simple english everything is just understandable

[@sagarsatapathy4600]

I watched 10 videos to understand this concept but I was not feeling confident and then after watching this, I didn't need any other video to understand enzyme inhibition more

[@PremedHQ]

Thank you! Please share this channel with your peers!

[@LilyGraceySa]

I nearly cried because a lot of people explained it to me and it didn’t make sense! You are such a treasure, you actually explain what it means! Would’ve loved if you taught me the whole biochemistry course, then the stiff material would’ve actually became imaginable. Thank you!! ❤❤

[@williamallotey270]

I liked before the lecture, this i know you are the best

[@aamnakhan7856]

no concern with enzyme but I randomly click this video, why he is so smoothly teaching😍🤩

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You are the best tutor

[@princesspat5239]

i'm in biomed and i really want to get into medical, i wish i had found these resources. Love your videos, they're great for my bio course!

[@VeronicaJosef-ls2dx]

So wonderful, well explained and understandable...👍👍👍🌹

[@drsunilkumarsknowledgehub5288]

Nice for the students of different courses like MLT and Biochemistry subjects people

[@lakhdeepsingh9132]

Also apparently noncompetitive inhibitors can bind to either the allosteric site of enzyme itself or of the enzyme-substrate complex... something I did not know.

[@nicholasachuz8329]

calm and straight to the point

[@nicolevillalon9737]

Brilliant explanation. Thank you!

[@shivamgarg2711]

Thank uh sir ❤️ you made it crystal clear... am from india preparing for neet ug....your teaching style 💕❤️

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@Ltrina_02]

So much better now!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@lancevercitti3904]

I just happened to find this today, thank you so much! My book is not too good at explaining this concept.😀😀

[@faisha1917]

Finally, I got a clear vision and explanation about enzymes fully, after all this years ^.^, thank you! I have subscribed by the way, hopefully will make me easier to study more

[@nethinduwarapitiya5497]

crystal clear teaching! great video

[@stirfry3018]

wow how are these free?! thank you so much

[@tikizone2535]

Thank you so much Sir. Greetings from India

[@lowkeycam9151]

thank you! this is truly a lifesaver

[@charlesukonna3502]

You're really really good 💯💯

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@mounikab8735]

Excellent sir, and , thank you so much sir. Now I am clear with this concept.

[@user-so2vd9wc8r]

you are my lovely professor😊😊😊😊

[@PS-qc9gc]

It was so very helpful.thank you so much...you are a very good teacher.i liked the way you explain things.😊

[@noorel-tawil8775]

this was the most helpful video ! Thank you !

[@leishembilyting5086]

Just blessed to have seen this 🌸!

[@starrani5264]

Thanks , all these lectures are very useful.

[@mohamedismail777]

Nice video it explains the competitive and noncompetitive inhibition very well. It will be great if you can also make a video of uncompetitive inhibition as well please :)

[@darondasavage4140]

Thorough explanation. Thank you

[@PremedHQ]

Glad it was helpful!

[@rolandmalone5431]

Awesome explanation

[@audioderyne]

thanks so much. you are an excellect teacher.

[@sabrinasin123]

Thanks for your sharing, sir. By the way, I have a question that wish you could clarify for me. Is it the Michaelis Menten Plot actually is a standard plot that can comparing with the certain enzyme that we want to study? And is it we could identify our inhibitor whether is competitive or non-competitive after plotting the graph? Thanks.

[@ankushdubey8985]

Love from India ❤️❤️❤️

[@myagagasy]

Thank you so much 😊 you're a life saver 🙏🏽

[@zpii9317]

so helpful video. love from Georgia

[@siakapmerah5018]

thank you so much for the explanation! so grateful to see this video!!!

[@astaghfirullah10000]

Great video.

[@cindysextonfl]

My BioChem "professor" at USF is a complete Sh** show of a wet hot train-wreck that lost his ADHD medicine. His TA's are even worse and can't string together a complete non-distracted thought. "Teaching" is a necessary evil USF professors must pretend to do and distracts from their real research projects making $. I've given up going to class and have resorted to sources of focus and sanity on KZbin. Thank you for putting these lectures together for all the students that can't afford Ivy League or obtain access to real professors.

[@mikaelaprim4273]

but why does km change? doesnt the active site change when non competitive inhibitor binds, hence decreasing affinity

[@ranahaddad5446]

Wow! Well explained! Thank you!

[@tiringozerihun6110]

It really helpful Thank you.

[@hajraafzal1570]

Well explained.

[@dianagreen4450]

this is brilliant!!! so well explained, thank you

[@User-s868]

That was definitely helpful, thanks 😊

[@Heyjudeeeee12321]

can we have videos of questions regarding this so its easy for both qualitative and quntitative analysis

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@rehanabokhari4482]

Nice explanation

[@rugvedkulkarni1593]

So Km is the concentration of substrate needed to get to 1/2 the maxiumun reaction rate?

[@sunshine-qw5md]

omg thank you, this video explains it so well. and I also just realised I've learned this stuff before lmaoo

[@rtdpoe620]

thank you for this clear explanation

[@jacklyngarcia8887]

I love the video but there is no explanation of uncompetitive inhibitors :(

[@SameeraKetavarapu]

Thank you so much.😀

[@aditichokshii]

This helped so much!! thank you!!

[@erikruizmd]

In competitive inhibition, Km is indeed increased but.... affinity doesnt necesarily change. Competitive inhibitors interfere with substrate binding due to the inhibitor's own high affinity for the enzyme's active site. This causes the measured Km value to increase; however, the actual enzyme affinity for the substrate remains unchanged.

[@khalildaoud671]

The dicrease in the affinity is related to [s] as you increase it, so the affinity of the inhibitor doesn't play a role in this equation as it remains constant.

[@bhawnasuryawanshi2350]

Wow, so clear explanation

[@muhammadnazir7188]

I think I am gonna compete in MCAT after 1.5 yrs Insha Allah.

[@bambangkiranadi2576]

Excellent lecture.

[@guruvunaik8818]

great explaination like from india

[@nyikomhlarhimusic]

Thank you veeeery much🎉

[@syedmoomin2816]

Thanks # from India

[@seelamlakshmi1002]

Very well explained sir!!

[@14Truthfulls]

Thank you very much

[@carolinaamador8863]

I have a question: With non competitive inhibition, the Km is the same because those enzymes that are not affected by the inhibitor are still have the same affinity for the substrate. However, the Km is lower with competitive inhibition because some of the enzymes are being inhibited. Now the question is, in competitive inhibition, do those enzymes that are not inhibited and working on the substrate still have the same affinity for the substrate? Thank you for the excellent explanations.

[@faithmadi2991]

With competitive inhibition the Km is higher so the affinity is lower. And (just what I think) the general affinity of the enzymes are taken into consideration, but I think the enzymes that aren't inhibited still have the same affinity; however I think the overall affinity changes

[@thesmiler119]

It's all about competition. It's not that all active sites are occupied but each substrate has to compete with inhibitor there. So even if we end up getting our substrates attached with enzymes that substrate would have competed with the inhibitor. So affinity has decreased irrespective of if substrates attches or not.

[@thesmiler119]

And when substrates would have competed, then the affinity would definitely have decreased. Look! There's a substrate who doesn't have to compete and there's this that have to. It's for sure that the one who has to compete will lose its affinity

[@muireey1475]

You are awesome thank you very much

[@zolani-kabane]

Well explained. Thank you

[@naciburakcakr2793]

You are really awesome

[@chicagostreetstyle822]

Thank you

[@bubbyxd2012]

thank you thank you thank you! 😄😄😄

[@amnashaikh-sl1qi]

thank you!

[@luwambrhane4570]

It was really good explanation thanks

[@keyannasafforld2341]

AMAZING THSNK YOU

[@nunitchagucci3047]

What is his name? He is such a well explaned teacher!

[@RizwanAli-ry3nm]

Ty so much sir 🙏❤

[@stasiuschlaffke3444]

When will the competitive inhibitor molecule leave the active site?

[@user-ku1fx5fc7x]

Thank u so so much

[@2004511]

for the noncompetitive inhibitor scenario - I have two questions. 1)what would happen if I added more substrate or increased the concentration of substrate 2) would adding more enzymes increase Vmax? thank you so much!