Premenstrual dysphoric disorder (PMDD) and Hormonal Treatments by Professor Jayashri Kulkarni

[@veronicachristopher9321]

Many relationships have been damaged by my severe PMDD along with depression, anxiety, PTSD and OCD. It's too heavy for people. So, like most heavy souls, I'm a writer. My childhood is too much for others to bear and they always leave without a thought how heavy it must be for me. So I release myself onto paper ❤

[@robins6177]

Use progesterone (Progestelle) from this site clearwoman.com and eliminate using products with xenoestrogens. Use personaldevelopmentschool.com for therapy . I healed all of it using these.

[@janehernandez4520]

me too no one likes or understands me struggling with all the same thing....

[@sahil1205]

Yes me too, from India

[@mydizzymelody]

I hear you. 💔

[@rdwrer1331]

It's as if you took the words out of my mouth...exactly what I've gone through.

[@RebeccaEWebber]

Thank you. I am doing research to understand the connection between my CPTSD and PMDD. I have been disabled for over 5 years with so many "ideas" of what was going on from so many people. I finally feel like I am on to the right answers.

[@Chlosar96]

I’m not diagnosed that but am certain I have CPTSD and PMDD. I’ve always felt like something is wrong with me but finally with the right resources I think I can start to get the right kind of help. Wishing you luck on your journey x

[@RebeccaEWebber]

@@Chlosar96 I am glad you are finding good resources! I would like to know what is working for you.

[@barbieblue3336]

Yes Get your hormone levels tested before your period. Bio identical progesterone helped me.

[@lizfraser4543]

I just made the PMDD connection within the last 2 months. Every month. Same issue. Its a horrible time every month. I have been hospitalized twice because of it. My life seems out of control and I feel like there is no hope.

[@PsychiatrySimplified]

Sorry to hear. While we can’t give medical advice here is a review we published recently highlighting the algorithm for treatment. Hope this is of benefit. psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@priyanshiagarwal8157]

I feel exactly the same, and it's so exhausting to hide it from the world

[@rdwrer1331]

Right there with you! It sucks! But it's NOT the real you, it's evil chemicals imbalanced

[@carasun2499]

Thank you So Much for this video. I suffer from depression, ptsd and anxiety and got all these diagnosises some years after I quit the birth control pill. I was so much into this 'birth control pill is worst' that I lost my focus. My symptoms get worse the last 2 weeks in the cycle and the menstrual pain is not to handle without medication . Natural progresterone made me wanna die. Ssri's alone didn't help. I needed to quit my job because of my mental health . Now I started Nextstellis and already feel more stable but if it will make me depressed or more aggressive , I will try zoely. This hole topic is so important and interesting for psychiatry. I am glad I found this video. The professor is really mind blowing in her way to see all these connections. Thanks a lot. :)

[@sunflowerguy5314]

This condition is destroying my marriage. I have been married to two different people for 14 years. She refuses to get any help and I am sick of the violence and the erratic behaviour

[@annieyoung6851]

She is amazing and has helped me so much with my diagnosis

[@barbieblue3336]

Get your hormone levels tested before your period. Bio identical progesterone helped me. Yes

[@klima1237]

Hey guys. 25 year old woman struggling with PMDD. It effects 25 of my life. I want to know what works for you? How do you maintain a healthy relation to yourself during menstruations? How do you decrease stress and anxiety? It just overwhelms my body, it’s not even overthinking for me, it just ruins my body with pressure in solar plexus, insomnia, anxiety and paranoia. What do you guys do?

[@PsychiatrySimplified]

Sorry to hear. Please have a read here - covered PMDD and treatments in detail including nutraceutical's and hormones. psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@aasha9499]

I m 47 yrs having same issues for many years. Is it safe to take pill at this age? I m premenopausal with severe symptoms of PMDD. Not able to do my job even feeling helpless at home. What to do. I took many sessions of psychologist. But nothing works. Doing yoga, trying meditation sometimes but in this phase of cycle nothing works. Even i took SSRIs but it has also side effects always feel like drowsy.

[@PsychiatrySimplified]

You might want to look at the video on menopausal treatments HRT vs Antidepressants in Perimenopausal Depression by Prof Jayashri Kulkarni kzbin.info/www/bejne/mZ_LgJhsotWcbac. Individuals morphing from PMDD to perimenopause may benefit from Menopausal hormonal Rx. This has shown benefit for mood and other physical symptoms most beneficial during perimenopause. This will need a discussion with the doctor. There are several options that the doctor will decide based on individual media history. Estrogen only hormonal Rx vs combined Rx - newer agents such as tibolone, TESC are also available. Ps not medical advice

[@iphisrising2016]

Great video, thank you! I'm curious if you know of any research about treatment of PMDD in the trans and non-binary population? Anecdotally trans men and AFAB non-binary people seem to benefit from testosterone treatment, but I've been unable to find any studies on the subject.

[@PsychiatrySimplified]

Thank for your feedback. Great question. This requires specialist input. Hormone Rx can present with SX Of PMDD. This would require a full evaluation based on the Sx presentation. If a doctor has already been involved in care they would be in the best position to answer this.

[@pinkowbs]

Trans women are not real so having any research is a waste of time

[@roselereau6981]

If I kept a Skyla IUD in, can I just add the estradiol patch? Can I test out the Zoely with the IUD still in?

[@PsychiatrySimplified]

This a question for the doctor - sorry but it would be inappropriate for me to answer that as its so individualized.

[@Adam-ie8ed]

what about bio identical coc? or is that something big pharma is not interested in?

[@Alliepallie333]

I just wonder where are the tests of varying exercise such as weight lifting on pmdd, mine almost dissipated before this pandemic, that the minute I came into lockdowns. The anxiety and symptoms all flooded back on/off in severity but certainly noticeable sudden on off. Waking up the next day fine, day before hardly functioning. Biological I have worked on changing gene expression and neuroplasticity as first port of call. I know i've limited mine in past, by increasing cardiovascular to boost serotonin when I am most vulnerable. Certain exercise increase BDNF, and helps neural pathways. Upping magnesium, b6 and serotonin naturally have worked in past.

[@PsychiatrySimplified]

Good point about exercise. We covered the antidepressant effects of exercise here - psychscenehub.com/psychinsights/antidepressant-effects-of-physical-activity/

[@coolworx]

I wonder if the rising levels of estrogen-mimicking chemical pollution plays any part.

[@PsychiatrySimplified]

Noah Namey difficult to say. Here is some detailed reading about PMDD and PMS psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@barbieblue3336]

Yes Get your hormone levels tested before your period. Bio identical progesterone helped me.

[@lin_is_a_bird]

My doctor is trying anti-psychotics for my PMDD. Would you recommend this or could this be harmful?

[@PsychiatrySimplified]

PMDD is a constellation of symptoms. Low dose AP such as quetiapine is evidence based in the treatment of PMDD along with others. Your doctor will be able to advise on the rationale and the target symptoms. Wish you well.

[@blondellbesson5831]

You can try supplements like magnesium, kelp, vitamins D3, vitamins b complex and evening primrose oil

[@lin_is_a_bird]

@@blondellbesson5831 interesting. I haven’t heard of using kelp or primrose. I’ll look that up! Thank you ❤️

[@clairetaylor5608]

why does the progesterone only pill make PMDD worse?

[@PsychiatrySimplified]

Its likely that the effect of progesterone exacerbates the prexexisting vulnerability that is associated with PMDD - the pathogenesis of PMDD - is proposed to me more to do with the response to the hormone rather than the levels. Progesterone also has a different response ( e.g only increases DA ) when there is pre exposure to Estrogen. You can read more here psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@Al.531]

If you are on a pill for PMDD and skip your period, will you still get PMDD symptoms?

[@butterflybeginnings]

I have been exploring this for 22 years now in myself and was unaware earlier. I found this talk to be quite inaccurate from the number of years I have been talking with women. I feel that there are quite significantly consistent signs for PMDD and that it is not a variable as what this Dr made out. I think that if there is variability then it is more that there is something else happening like BPD, which anyone who is a high functioning Borderline will have the sudden fluctuations in coping and then not and coping again out side of the 7 to 10 days before the onset of menses with the settling into a clear mind and energy again by day two of bleeding. Any upset outside of that seems to either be inline with the average person stressing over something or if it is extreme, then it is usually more about an inability to manage stress and will have the aspect of BPD or PTSD. After the childhood trauma is dealt with, you will either notice there is not pattern in line with PMDD or that the pattern becomes really apparent in line with the pre onset to the 2 days after onset. And dIet and exercise does actually help when done right as it helps with brain function. As PMDD is more like an allergic reaction to the female hormones and not an imbalance, and poor diet is usually a part of the emotional eating or not eating, it is a contributing factor and I have observed it in myself and others. But hey, I am just a random person who loves to research and find out more about this and I am not a Dr looking at all the variables like complications with crossovers between things like ADHD, dyslexia, PTSD, BPD, etc... If not for the diagnosis from an amazing endocrinologist, psychiatrist who listened and psych nurse, I would not be the thriving person I am today. Even though a private Psych past year tried to diagnose something else within 1 session 15 years after the first diagnosis. It is challenging when mental health symptoms cross over, which is what I feel alot of the conclusions in this presentation showed. I look forward to the psych industry understanding the causes and finding solutions through the body without mucking around with hormones to do it. I am exploring nootropic stacking, which seems to be having some good results over the last few months. I am still exploring it though.

[@jaaywalkaa]

very insightful comment - I wish the pharmaceutical prozac drugs were not the go to solution - I also am not a doctor but have isolated the blocked detox pathway beta-glucuronidase, an enzyme that deconjugates estrogens into their active forms- which when blocked makes estrogen be recycled and not eliminated and could be the cause of the crazy OOC (out of control) brain feeling hence I have told all the docs and psychs I feel like I am being poisoned by my hormones every month before one bright spark suggested I may have blocked detox pathways- so further on I researched and found calcium d-glucarate and DIM seem to lessen the severity - Im yet to try compounding chemist melatonin for the insomnia- all the SSRIs and Antipsyc meds made me a shell non person - would rather suffer the depression and I do. Also look into dr Lipovs Stellate Ganglion Block injection for PTSD - it resets the nerve fibres that have grown into the amygdala which is inflamed from the trauma and stuck on high alert - I dont know enough medical info on how neurotransmitters work and monthly hormone interactions but its a gut feeling its connected to PMDD. I am finding it hard to find a specialist to agree to administer as they are mainly pain specialists that deal in nerve pain - but its proven from Dr Lipovs studies that it resets the parasympathetic nervous system in most cases. And its long term relief after just one injection - will put the pharma out of alot of $$ if more doctors knew about this amazing intervention.

[@melicah2479]

Well you are onto something because your description sounds a lot like what I am experiencing.

[@jaaywalkaa]

@@melicah2479 yes dont give up finding resolution there are good doctors and psychiatrists out there that care and can guide you ! Try to find a doctor that works with a compounding chemist im finding much more progress since I did that.

[@priyadarshinibasu6551]

Today I came to know I suffer from PMDD. My life is getting worser and worser.😓😓

[@SacredWellnessByZuli]

Hang in there sister just for today

[@xDHalcyonn]

Supplements have helped me ten times more than birth control.

[@lifeofjules9504]

Hi can I ask what supplements you’re taking that you’ve found helpful. Thanks

[@xDHalcyonn]

@@lifeofjules9504 It's called Moody Bird by HUM brand.

[@barbieblue3336]

Yes Get your hormone levels tested before your period. Bio identical progesterone helped me.

[@fevvral]

Me too. I take l theanine, 5htp, l tyrosine, green tea extract, and magnesium.

[@dahliajames6966]

@@lifeofjules9504 Vitex is a great supplement too!

[@anatino]

Taking Zoley for three months only, continuously? What about after three months.

[@PsychiatrySimplified]

It really depends cyclical or continuous. here is a detailed article - pls have a discussion with your doctor. psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@anatino]

@@PsychiatrySimplified Thank you for answering back. I’m 47 perimenopausal with hectic periods, and going hysterical from anxiety. I’m in Canada and they don’t have Zoley here. They do have it in Romania where I’m from. I wonder if there is any similar ones they have in Canada. Any specifications? Thanks!

[@PsychiatrySimplified]

@@anatino it doesn’t have to be zoely. Transdermal oestradiol patch on its own or with cyclic progesterone is the principle. In the article there are few options mentioned. A family doctor should be able to discuss HRT.

[@anatino]

@@PsychiatrySimplified in Canada, the family doctors are not educated in HRT. I have a practitioner that charges 280 Canadian to speak about the issues and she can prescribe the estradiol. Unfortunately I tried Bioidentical prgesterone cream two months ago, and I went down hill. I cannot tolerate even my own progesterone after the ovulation. I probably have to try the estradiol patch. I have the gel at home but I’m scared to try it. I don’t know how many pumps and also because I take 0.5 lorazepam I’m thinking that will affect the GABA which is down regulated from the benzo. It’s pretty hard to start anything. Because the interactions.

[@PsychiatrySimplified]

Progesterone can lead to effects like that. Estradiol patch with cycling progesterone is something that is considered. Also tibolone is another one.

[@jayleenortiz4933]

Soy and saffron has help me feel as a treatment option, for my pmdd.

[@PsychiatrySimplified]

Jayleen ortiz interesting. Saffron has Veen mentioned in the natural therapies. A RCT has also been carried out. We recently published a synopsis on PMS and PMDD where natural therapies were covered psychscenehub.com/psychinsights/diagnosis-and-management-of-premenstrual-syndrome-premenstrual-dysphoric-disorder/

[@vrl4355]

How do you take this ?

[@barbieblue3336]

Get your hormone levels tested before your period. Bio identical progesterone helped me. Yes

[@angelamartin4797]

I don’t agree with this unfortunately. Lifestyle changes have been the ONLY thing that have helped with the RIGHT good quality supplements. I was diagnosed in 2010 and have tried everything. My pmdd is now manageable and I can function in my life again. The other point I disagree with is the speaker calling it a depression. Anyone with true PMDD will know that it’s not depression, it’s a feeling of being overwhelmed by everything then bouncing back to normal, like flicking a switch.

[@PsychiatrySimplified]

Thank you for your comments

[@kallikarlson5866]

I agree its not so simple to call it depression. Can you share some of the lifestyle changes you have made?

[@aslhanhanc8287]

Can you please share lifestyle change? I am non-functional almost 10 days almost each month. It starts suddenly in my body like someone clicks

[@Amanda-vl5ud]

Lifestyle and supplements didn't change anything for me unfortunately

[@hannibaleverfreshdimalanta5810]

drink k 5 moringga capsule everyday. works on my girlfriend.

[@siesies000]

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