Preparation of effervescent granules

[@vaishnavi_mk_10]

Very nice and are really helpful😊

[@ProfessorTushar]

Glad to hear that

[@vidhimakwana7031]

Very informative video

[@ProfessorTushar]

So nice of you

[@Meme_king_00]

Sir kitne tablets ke liye banya hai

[@ProfessorTushar]

50 g granules.

[@laterleto]

did you add any excipients?

[@ProfessorTushar]

Yes

[@KENNAPILONES]

What kind of alcohol did you use?

[@ProfessorTushar]

95 %

[@mattzxo]

@@ProfessorTushar I thought you use 60%

[@FawzisFamily-rp9yp]

Sir, what kind of alcohol can we use? Is there a substitute for ethanol?

[@ProfessorTushar]

For the granulation of effervescent tablets, isopropyl alcohol or ethanol is commonly used as a granulating solvent. The strength of the alcohol typically used is around 95%. This high concentration helps in binding the components without dissolving the effervescent agents, which would prematurely react with water. The choice of alcohol and its strength are crucial to ensure proper granulation and maintain the stability of the effervescent tablets. While using organic solvents as a granulating agent, you must ensure that the OVI (organic volatile impurities) must be within limits.

[@karabolebotsa3952]

Can you still do it without the alcohol?

[@ProfessorTushar]

Yes, by fusion method.

[@surabhishinde948]

Can i replace alcohol with starch

[@ProfessorTushar]

Yes, you can use.

[@CraigoM04]

Roughly what is the maximum dosage of a certain supplement per effervescent tablet? (say, creatine for example)

[@ProfessorTushar]

Vitamin C effervescent tablet is available with a dose of 4000 mg per tablet.

[@vnis3836]

Hi, I wanted to ask that instead of using alcohol, is there any other option for the granulation process, and can I use water?

[@ProfessorTushar]

Yes, water can be used for preparing paracetamol tablet. Water can not be used if drug is sensitive to hydrolytic degradation or moisture sensitive.

[@abdellahgogop5653]

Could i discard tartaric acid??? Is there any other substance i could use it instead of tartrate???

[@ProfessorTushar]

You can use citric acid, fumaric acid, adipic acid and malic acid.

[@KENNAPILONES]

After the reaction of sodium bicarbonate and citric acid in a water, can we drink it?

[@ProfessorTushar]

Yes, these are commonly added in the formulation of effervescent granules and tablets.

[@MuhammadanasMuawia-ib1ir]

Nice

[@teenup]

can we connect, need help in development of effervescent tablet

[@ProfessorTushar]

You can send your queries on "[e-mail]".

[@aditikaushal3351]

Sir alcohol ke jgh kuch or bhi use kr skte hai kya

[@ProfessorTushar]

Yes, you can use fusion method. Mix all the ingredient in a porcelain dish. Put porcelain dish on water bath. Triturate it. This process will form granules without using alcohol.

[@surabhishinde948]

Sir may I know the reference for this procedure.

[@ProfessorTushar]

The Theory and Practice of Industrial Pharmacy; Book by Herbert A. Lieberman and Leon Lachman

[@surabhishinde948]

What is the title in the book?

[@ProfessorTushar]

The theory and practice of industrial pharmacy

[@AngelFaithLavinDineros]

@@ProfessorTushar may i please ask for the link f the book? or the specific chapter or page, thank you so much

[@muhammadnorfarizkhanjelani8263]

wokey, ai woulded seeh all de effervescentd only (wiggling my heads)