Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors

[@JC-xk8vh]

There should be a KZbin university and all the best KZbin Professors should teach there. You Sir would be one of them.

[@carlineyaimette]

Agreed

[@abdourahmanjallow9308]

agreed

[@alexdeschipper]

disagreed, he didn't mention one protein/one gene

[@alexdeschipper]

I'm sorry he did give example of genes but it hardly scratched the surface of different regulation of gene expression, where are all the lncRNA, miRNA, siRNA, different histone deacetylases and (de)methylases, cytosine methylases. No mentioning of tissue specific promotors, I don't know it just felt like a lot was missing

[@ProfessorDaveExplains]

@@alexdeschipper it's an introduction to the topic.

[@yasmine9046]

This is truly amazing how complex notions can become so easy to understand when clearly explained. I’m grateful for your channel. Lots of love from France.

[@Psiredem]

Je suis aussi français et je suis totalement d'accord ! (I'm French as well and I wholeheartedly agree!)

[@franceberat6928]

Parfaitement d’accord!!! C’est dommage que l’on est pas des aussi bonnes vidéos en français , il faudrait se mettre à la page

[@jebo2810]

Pareil mdrr

[@ProfessorDaveExplains]

Hey everyone, at 9:34 I drew a methyl group under the word acetylation and an acetyl group under the word methylation, sorry for this ridiculous error! Please correct in your minds. Oh also, I've been informed that at around 1:50, even though the labels have disappeared by that point, I previously marked the mRNA as 5' on the left and 3' on the right, and ribosomes read mRNA molecules 5' to 3', so technically the ribosome should have translated the mRNA left to right. Sorry for that small error as well!

[@younanoah8229]

thanks for the correction

[@strattieshots]

no forgiveness 😤

[@dheerendrapandey4494]

you are too good.......I understood that mistake by see that. but you are too responsible.....I have no words to thank you!! GOd bless you!!!

[@alwaysfreezing]

ok daddy

[@munmunchakraborty5262]

I am too much pleased after hearing your lecture.Thanks sir.

[@fajitaboys]

I'm literally coming here from Khan Academy--thats how high calibre you are of an educator. To be fair, the KA video I didn't like was a one-off, as generally they are pretty good. If anyone is wondering--watch this video by Prof D instead of "Regulation of transcriptions" in the KA MCAT>Biomolecules>Gene Control.

[@pablosamuelestradaochoa4127]

You seriously CAN'T IMAGINE HOW MUCH I LOVE YOUR YT CHANEL. OMFG, SUCH A GOOD, "FRIENDLY" (easy to understand) AND YET ACADEMICLY SUFFICIENT CONTENT, WOW! Im an instant new sub, keep up the excelent work!

[@lauragordon6414]

Wow! I was not looking forward to even this 13 minute clip. But, WAS I WRONG. Your presentation is by far one of the best. Again, most of us are visual learners and the animation along with your teaching was spot on and kept me interested and rarely was I lost or confused. Thank you so very much!

[@LostInThaStereo]

You just helped me survive my O. Chem final.... now I'm discovering you cover my Genetics final too. Just... wow.

[@poonamshah2480]

Thanks alot Professor Dave. Your teaching videos are not just clearing the concepts but arousing the curiosity to learn more about the topics.

[@flyingbunniess]

Professor Dave! I have been watching your videos for at least a year now. You got me an A- in Gen Chem 2, are currently helping me ace Organic Chem 1, and microbiology! THANK YOU. YOU ARE THE BEST

[@yoyoyakkamon4343434]

Professor Dave out here saving my A Level Biology grade amen

[@colloredbrothers]

I was interested in diet and people used to talk a lot about insulin metabolism at first, now I'm learning about genetics and gene expression because of research I did into the keto diet and its histone deacetylase inhibiting qualities, thank God for the internet and people like you Professor! I never really liked school but I do love learning with a passion.

[@polixaw1337]

Learning with passion is all you need!

[@RedHeadSH0T]

This is one of THE BEST biology videos on KZbin!

[@ailujotkins619]

You explain so easily that even if i don't know english very well i can understand you AND the topic. Incredible thank you

[@antwoinemorris7946]

This was very short and precise. I understand clearly all that he said more than how my professor taught it. Thank you professor 🙏🏽 🤗

[@feralscooter]

Awesome video. Very clear and to the point. Ive been watching a lot of videos trying to wrap my head around this stuff -- this video made it stick.

[@Noamm92]

hands down this is the best video on youtube of this subject man

[@sdbeauty98]

Ugh so I took Gene expression this past fall and had to drop because I refuse to get a C in the course so I’m retaking it this spring. I so wish I found this video before because I honestly had no clue what was going on in the class, but this has helped me organize the concepts so much better! Thank you so much.

[@shreyasimhadri3863]

YOU, prof Dave, are an AMAZING teacher. Thank you so much for your videos that I will be binging as a novice neuroscience major!!!!

[@alannacronk9419]

bless this man and his plaid

[@subhamdatta3521]

yes

[@CaferOzdemir]

Great work as always Dave ! A small mistake: at 1:50 translation is happening in the wrong direction, it should start at 5’

[@hakersupatytsupra9556]

?

[@michellebadura8349]

Yes, this is driving me nuts also. Translation starts from the 5' end with the methyl-G cap, then the mRNA feeds through the ribosome and finally the 3'-poly-A tail end comes out.

[@junedaniel2981]

But shouldn't it go in the opposite direction. Because on the "parent" strand its 3-5 but building the opposite so thats 5-3

[@nonosaramago]

RNA is single stranded 🤨

[@mikeE997]

Thanks for the video. Much more direct and concise than KA. Exactly what I needed for quick review on operons for the MCAT.

[@daryljonesfoster4102]

What is MCAT ?

[@ashkanzhyar7665]

honestly iam not even exaggurating ur explanations are genuiny just the best

[@tomisakin]

This guy and AK lectures have saved my from my profs reading slides and calling it teaching

[@jorisvandevelden7317]

thanks professor Dave ! u made my nightly study session a lot more endurable

[@خليفةالحنطوبي-و3د]

professor Dave you are a best teacher for chemistry and biology thanks for your efforts

[@tkdlover19]

This is super helpful, but it would be even more helpful if you put in the corner which organisms these concepts apply to, since some of these only happen in bacteria and others in eukaryotes, and still others in both. This is something that confuses me all the time, so if you make more videos along these lines in the future, that would be very informative!

[@prabh69ps]

Thanks and Plz give this professor a nobel prize for making this vedio ❤️

[@aryaa7334]

I've graduated HS and passed the need to study these (taking econ in college) but i still remain loyal to watching dave

[@leonwennerholm3832]

You are my secret weapon when it comes to study. :-D

[@SCM_MINISTRIES_tv]

You're a great professor, your delivering techniques with clear expressional pictures makes it easier to understand things. But also suppose you're teaching someone who's being introduced to a topic the first time, you know, not to super summarize scientific concepts.

[@DudeWhoSaysDeez]

there is a minor error in this video: at 9:37, you color coded the three groups, but they are not properly matched below. The methyl group should be green, and the acetyl group should be red

[@ProfessorDaveExplains]

ah man what a dumb error! thanks for catching that.

[@DudeWhoSaysDeez]

Yeah it may be alot of work to re animate the video, but you could put an annotation with the correction

[@Standforthetruth18]

Damn, this is a piece of art. You teaching so much fun and. Simplified. Thanks a lot sir.

[@najdah1991]

thank you so much professor dave, you made it in a very simple explanation!

[@phanindraprasadpoudel4801]

Wow! wonderful teaching Prof. Dave! More than in a University.

[@artistworking7755]

Very nice video. A little correction, if am not mistaken in 9:35, the acetyl group and the methyl groups are switched. It should be acetyl -CH3CO and methyl is -CH3

[@ProfessorDaveExplains]

yes that was a dumb error on my part

[@happyeunjee1]

thank you so much~~~ This video had a lot of the details I needed to review :)

[@SahanTheMighty]

This is the first video I’ve watched in your channel and the opening credit had me in stitches 🤣😂🤣😂

[@anshulbhatt6392]

and why do boring class lectures where teachers just dictate notes still exist ? well majiority of learning happens in youtube anyways. Thanks to people like prof. Dave 🌻

[@emilemil1871]

I’m literally an idiot and I understood this just fine omg dont forget your hat king 👑 😌😌

[@chrisp7336]

I think it is very important education providers like yourself be very honest, accurate and portray scientific findings exactly how they are presented in journals and not exaggerate or distort them in any way such as what has been mentioned here at 3:28 This is not what the literature is saying, there is on going debate in this area of research, how are you able to make a concluding statement like this with such confidence? when there is division between those currently researching in this area? You need to word this video more accurately to reflect the literature more honestly

[@Sai-pi4wq]

1:14 The more apt statement would be that the DNA segment will code for a hnRNA (heterogenous nuclear) which will undergo post transcriptional changes: Capping, tailing and splicing to produce mRNA. In prokaryotes this wouldn't be necessary as the genes are not split.

[@DoFliesCallUsWalks]

13 minutes beat 3 hours on the official AP course.

[@gamingsaiyanyt6492]

Sir u are brilliant and fabulous explainer of concepts .Thanks a lot May God bless you and keep making such videos. 😚😚

[@kaitlynwitkowski1108]

Why you explain it so much better than my textbook..

[@chasecolin22]

At 1:40, the ribosome is moving the wrong direction for translation. Please correct me if I am wrong.

[@tranghuyen4227]

I love biology and chemistry

[@MrRamaeri]

God bless you professor, thank you for your presentation.

[@TheOnlyDoctorMek]

this is an absolutely wonderful video specifically, thank you so much. you have no idea

[@karimnaraki7376]

this explanation was so great thank u professor

[@thebirdboy1766]

This is why younger professors are better, you can sense the enthusiasm

[@Lawrrenz]

Hey Prof, you mismatched acetylation (CH3CO) with methylation (CH3) @ 9:39. Otherwise, awesome summary lecture!

[@ProfessorDaveExplains]

i know what a dumb error :-/

[@ThomasJadallah]

To all the other premeds out there: let's all remember to thank professor Dave when we get into med school.

[@vickyimery47]

You’re an amazing teacher, thank You so much. 👌🏻🙏🏻🙌🏻

[@itsthatleo3970]

*I love it that this video is exactly whats in Campbell*

[@lehuang1924]

Your video is so great! Thank you so much!

[@adinkhan156]

You know you are cooked when you can't understand a topic even from a KZbin video 🥲

[@user-np2ne9qf2w]

9:39 has an error. Acetylation and methylation are flipped. Great vid tho!

[@ProfessorDaveExplains]

grr yeah i caught that one too late! luckily it's minor

[@yusinurahmah8551]

i pay my college to teach me but i always ended up on youtube because of some or so many reasons

[@pastimepursuit7212]

I am pretty sure I learned recently that methylation silences genes, esp with the formation of methyl bound domains and CpG islands from a khan academy video. So I don't know what that is about 9:40

[@biobrotherslectures793]

A big fan of you sir !! Your video tutorials helped me a loot ❤

[@o.n.c5853]

i enjoy your lessons alot as they have been so so helpful..keep it up

[@witty_me]

Another wonderful session, thanks a ton

[@sandhya9646]

thanks professor dave easy to learn 😃😃😃😃😃

[@michelletarbox8220]

Hi Professor Dave, one tiny thing I noticed in this video. When you say that methylation can make the DNA more accessible. It is the opposite, methylation makes the chromatin to coil tighter making the DNA less accessible. Thank you

[@nonosaramago]

Acctually he was talking about histone modification. Although DNA methylation normally silences genes by blocking access to the promotor (although it could also induce them by blocking access of a repressor to the operator) methylation and acetylation of histones (that is, post translational modification of the histone proteins) is much more complex. Nucleosomes, made of histones, have many tails, and depending of which of them are modified, this can either activate the gene by promoting opening of chromating or silence it.

[@debashishray8721]

Excellent❤❤video sir thank you

[@zerothehero123]

Just found your channel and I absolutely love it! Very in depth videos for real science geeks! Subbed and liked!

[@AngryTango]

Professor Dave knows his stuff

[@lewis3954]

Hi Professor Dave, it's a bit late but at 9:38 your acetyl and methyl group are labelled the wrong way round :) Edit: Just seen a comment further down addressing this.

[@louisdefilippi8982]

This is an excellent review!

[@joegabrail7175]

Bless ur soul professor dave

[@demitriwelling1348]

Excellent explanation, thanks again.

[@pastimepursuit7212]

8:25 also, just know trp operon MAKES tryptophan, and lac operon DIGESTS lactose. Should be able to figure out the rest. ALSO, the most confusing stuff begins at 10:36.

[@pastimepursuit7212]

3:05 & 8:59 although this video isn't over that info, that diagram is way wrong. The right lung has 3 lobes. The left lung has 2. Still great content!!

[@Zetsuke4]

THis is explained soo good omg

[@abdullahinuhuyau5173]

Thanks Proff.

[@dancevideo2]

The textbook descriptions show all the intron RNA being synthesized, then spliced out and simply forgotten. Do we know for sure the discarded intron segments, some quite long,, have no further effects before being degraded?

[@nonosaramago]

This artticle has an amazing explanation of all function introns can have: www.ncbi.nlm.nih.gov/pmc/articles/PMC3325483/ So yes, they could have mRNA nested inside them or some kind of non-coding RNA like miRNA or snRNA which could have regulatory functions. I really recommend the read!

[@shinywarm6906]

Beautifully clear. Thanks

[@gamb]

acetylation, methylation, and phosphorylation are no longer considered the same for loosening supercoiling around histones. Histone becomes neutral/less positive if: acetylated or methyl groups are broken down by demethylase, causing the slightly negative sugar-phosphate backbone of the DNA to bind less tightly, unwinding the supercoiling. great vid just slightly out of date info

[@carlinasabella8732]

this video is extremely helpful, thank u very much

[@bioscienceswithshahtareenswati]

Amazing sir..💖❤

[@amalialatifa6248]

this is help me a lot. amazing

[@ManuelRavasqueira]

Hi, 1. Does every transcription envolve a regulatory mechanism (e.g methylation, TF or other)? In the sense that the expression of every gene is regulated through a gene regulatory network? Thank you and sorry if it is very basic question

[@Ranunculus744]

That face at 0:10 gets me every fucking time

[@Filthycoffin]

Do you have any information on what one would do if their DNA was turned off by medication such as Cipro or benzodiazepines? Would one go to normalize or regulate the body? I have thought about the methylation system and possibly fecal transplant to restore the gut microbiotic and the mitochondria. The genetic factor has mutated to mthfr homozygous c677t

[@marianasayuriudo5429]

Thank you very much for your brilliant explanation.

[@EKCPUNJAB]

Is transcription a controlling factor in enzyme production for translation or transcription itself??

[@angibeller.gildemontes4872]

Brilliant!! Thanks for this 🙏🏽🙏🏽🙏🏽

[@subhamdatta3521]

yeah

[@sunehrikiran5638]

you're the best professor !

[@subhamdatta3521]

yeah

[@MrKhya123]

Thank you professor. You got subscribed

[@kajomiinyosha1161]

Thank you so much prof. , colud you please explain gene expression in eukaryotic 🥺please

[@chrisp7336]

Hi professor Dave, how do you back up the statement at 3:28 about the evolution of the regulatory mechanisms very early on in life?? I want to press you on this because I think your making a huge statement here more than the scientific literature can prove or back up. Keen to hear your response

[@ProfessorDaveExplains]

I'm not aware of any controversy surrounding that statement. Also, it's not necessary to post the same thing twice.

[@nipunsharma7418]

A theoretical physicist in making

[@StephenGillie]

This video begs you to watch previous videos more than it explains anything.

[@ProfessorDaveExplains]

I reference my video on gene expression because it's impossible to understand the regulation of gene expression without first understanding gene expression. I have the common courtesy to direct my viewers to prerequisite knowledge if they need it.

[@ismaildin69]

Professor kindly you may help me how to identify TF of my gene sequences or TF of my genes motifs

[@angelocastro2697]

This is very helpful. Keep it up! You just got my sub :)

[@puneetsingh.R.]

Very nice video....easy to learn

[@thetop1076]

just loved it, such tough concepts explained cleanly ! bless professor Dave

[@nassimazer1608]

Thank you so much this video really helped!!

[@cheriedvm4509]

Very helpful video!

[@emptypotatoskin]

Wow this cleared so much up. Thank you!