Neutrophils: First Line of Defense

We've covered macrophages and dendritic cells, so let's move on to neutrophils. These are the most abundant white blood cells, and they act as the first line of defense in innate immunity. How do they form, and what do they do mechanistically? Let's find out!
Script by Niyati Vachharajani
Select images provided by BioRender.com
Watch the whole Immunology playlist: bit.ly/ProfDave...
General Chemistry Tutorials: bit.ly/ProfDave...
Organic Chemistry Tutorials: bit.ly/ProfDave...
Biochemistry Tutorials: bit.ly/ProfDave...
Biology/Genetics Tutorials: bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: bit.ly/ProfDave...
Biopsychology Tutorials: bit.ly/ProfDave...
Microbiology/Infectious Diseases Tutorials: bit.ly/ProfDave...
History of Drugs Videos: bit.ly/ProfDave...
EMAIL► [e-mail]
PATREON► / professordaveexplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: amzn.to/2HtNpVH
Bookshop: bit.ly/39cKADM
Barnes and Noble: bit.ly/3pUjmrn
Book Depository: bit.ly/3aOVDlT

[@jonathanpicket124]

Despite being a PhD. candidate studying the basic biology of phagocytosis and cell death/cell corpse clearance, I've never learned about human immunology before. I'm in a worm lab, so we don't ever really think about human systems. It's really cool to be able to watch short videos like this and broaden my understanding of how similar but very different humans and worms are. 😅

[@jonathanpicket124]

@ryan80166 I'm pretty sure Dave has a masters degree. Regardless, he has a much broader degree of biology knowledge than I do. This is exactly why he's so great as a science communicator. My biology expertise is more specific.

[@jonathanpicket124]

@ryan80166 You don't need a PhD. to be a professor. If you teach at the college level, you are a professor. There's a big difference between being a professor and being a PI. The fact that you don't understand this demonstrates a very limited understanding of how academia works. Also, I didn't say that I've never heard of neurtrophils. And, knowledge about immunology (nor A&P) is not necessary to be in a biology/biochemistry PhD. program. Have you ever heard of the Dunning Kruger effect? Your comments seem to exemplify it pretty well.

[@PinkBeard9127]

Lessss go more biology lessons.

[@tobiaszczarnota7879]

I am currently reading Kurzgesagt's 'Immune', at my college in Southern UK.

[@Sunlight252]

👍🏻

[@bulwinkle]

Wow! Thats a lot of alphabet soup to digest.

[@IKilledEarl]

My thoughts exactly. Kinda useless and annoying to keep listing off a bunch of acronyms without explaining what they are or what they do. I know this video would be several hours long if he did that, but he should either explain what the acronyms mean or not bother boring us with meaningless strings of letters. Way too much technical jargon and not enough practical information. Not his best video, imo.

[@AnarchoReptiloidUa]

👍👍👍

[@lunaluvsx]

Gonna help me in 9th grade bio I hope

[@uncleanunicorn4571]

Hope we get detailed discussion of NK cells. also, Fond memories of the moment in the dover trial, where behe claimed there was no knowledge of the evolution of the immune system, The defendants plopped down fifty textbooks which he had never read.

[@urielpolak9949]

Jippy

[@KoRntech]

4:11 I've seen that Phagocytosis before Ghostbusters 2 when the mood ooze in the bathtub reached for Dana. I know not relevant whatsoever.

[@Talia926]

Dude, FYI- there’s no neutrophils in that blood smear you show in your video. The blood smear includes blood cells and reactive lymphocytes with multiple nucleoli which is indicative of a leukemia. I would send that slide for path review. But there’s no segs ( short for segmented neutrophil).

[@sciencenerd7639]

hooray, immunology!

[@unikkmanx]

If the neutrophils are not in the tumor environment，can we still divide them into N1 and N2 subtypes?

[@nabadmusa8792]

Good Teacher. But neutrophils are NOT the first line of defence in innate immuty. The barrier system is.

[@desmond3828]

Does the phagocytosis mechanisms (zipper and trigger) occur in other phagocytes like DCs and macrophages and monocytes?

[@Claudioserafino-r2y]

Can you do a video analyzing or debunking the claims that most products and even tap water are containing hormone disrupting levels of estrogen? Jake tran made a video going into detail about this claim and i am very curious of what your take on this is. What makes it suspicious is that afterwards he advertises a solution to the problem. @ProfessorDaveExplains

[@angwelio]

I don't even study anything close to science But I like learning things I will never use

[@fakepng1]

These are so interesting, but I cant find a way to understand shortened terms for some names for these cells and their properties. Can anyone help in recommending a sort of common place for these?

[@-JA-]

🙂👍

[@InfinityNess]

Each day I thank professor critical.

[@kasumikatsana2453]

Does the phagocytosis actin mechanisms apply to other phagocytic cells?

[@bennettstegall2889]

I cant swim

[@GuidetteExpert]

I dont understand why it says monocyte being granulocyte.

[@nadapenny8592]

Multicellular organisms are something else, man

[@k2p104]

Myfavourite neutrophile is phy the neutrophil.

[@ebaystars]

will you do a clip on the effects of Carica Papaya on PLT levels, (Cold extract etc) in relief/prevention of DHF in Dengue affected patients. I'm in asia and it's used a lot in the Phillipines Pakistan India etc look up NIH, "cement lorry driver carica papaya" thanks (PS loved your Flat Earth Pizza Toaster) (The mosquito carrying this infection is now seen in Europe as the climate changes etc.)

[@medicinefuture]

excellent Dave,

[@JesterSatans]

Thank you Professor Dave.

[@waelfadlallah8939]

Donny!

[@donchristie420]

Wa elly

[@JohnSmith-us9fv]

Awesome work 👍❤

[@mechcamify]

I see Natural Killer T cells, the subject of my PhD dissertation, may have a video soon by professor Dave. 🎉

[@jamiegallier2106]

❤❤❤

[@wondimagegnpauloskumma1981]

Wow i learned a lot Thanks Dave❤❤❤❤

[@Naomi.Robertson]

I'll have to take your word for it

[@johnnyblaze9217]

Talk more about how T cells can “reprogram” neutrophils by using cytokine signaling. Things like activating NETS, and ordering it to live longer (up to 5-7 days) etc

[@ProfessorDaveExplains]

I talk about NETS, so I don't think you actually watched it.

[@johnnyblaze9217]

@@ProfessorDaveExplains no you did talk about it, I’m just using it as an example, there is far more than can be activated on a neutrophil via CD4 T cells than Nets, just would like a far more dense overview of the capabilities considering it’s focusing on JUST the neutrophil.

[@dan797]

Fascinating. Thanks Professor Dave.

[@darkness8488]

PLEASE MORE ON IMMUNITY I LOVE THESE

[@رامهالصاعدي-ص1غ]

I’ve just listened to one of your videos before 7 years from now and looked for one of your recent videos, I thought there would be changes and I felt sad a bit, but when I found out that you’re still using your same style of teaching.., I was relieved, please don’t change I like your content the way it is , thank you so much professor 🤍