Programmable Bacteria: Nature's Most Powerful Tool

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Patreon: / realscience
Twitter: / stephaniesamma
Instagram: / stephaniesammann
Credits:
Narrator: Stephanie Sammann
Writer: Ashleen Knutsen
Editor: Dylan Hennessy (www.behance.net/dylanhennessy1)
Illustrator/Animator: Kirtan Patel (kpatart.com/illustrations)
Animator: Mike Ridolfi (www.moboxgraphics.com/)
Sound: Graham Haerther (haerther.net)
Thumbnail: Simon Buckmaster ( / forgottentowel )
Producer: Brian McManus ( / realengineering )
Imagery courtesy of Getty Images
Music:
wonder---no-strings by tristan-barton
nano by evgeny-bardyuzha
the-undertake by borrtex
null by veshza
fall-equinox---alternative-version by the-bows
References:
[1] www.ncbi.nlm.nih.gov/pmc/arti...
[2] www.nature.com/articles/natur...
[3] news.bbc.co.uk/2/hi/science/na...
[4] www.pnas.org/content/pnas/ear...
[5] faculty.ccbcmd.edu/courses/bio...
[6] news.mit.edu/2019/determine-b...
[7] www.britannica.com/science/ba...
[8] www.edvotek.com/site/pdf/956.pdf
[9] science.sciencemag.org/conten...
[10] science.sciencemag.org/conten...
[11] www.researchgate.net/profile/...
[12] www.nature.com/articles/s4159...

[@fireaza]

Humans: *won't clean up their pollution* Bacteria: "Jeez, do I have to do EVERYTHING on this planet?"

[@alveolate]

humans: won't digest stuff in gut bacteria: guess i gotta do all the shit in here

[@fayas234]

Some one liked your comment 👍

[@ruslankazimov622]

@@alveolate human: poops* Bacteria: I guess I' ve to do all shitty work in here.

[@elongatedmusk3132]

@@ruslankazimov622 sad but true & SCARY

[@charlessarver1637]

Yes

[@redstonemaddness]

I cant wait for the day that a doctor can say “its just cancer”

[@ankitsharma1072]

that's a really huge and nice statement ...wow!!

[@justaguy6216]

"Yeah just pop on over to the chemist and grab the lung cancer pro biotics and come see me inna week" oh how I'd love to see that happen.

[@Ok-fj4mv]

@@SimonWoodburyForget you got em in the testys

[@user-pz6kq2tv9m]

YES PLEASE

[@Vikas-mi4pi]

😂😂😂

[@helenaeycken5335]

Mighty KZbin algorithm, I'm counting on you to recommend me more of these videos.

[@IlmarKiisk]

Subscribing and pressing the bell button might help with that..

[@supahotfire9426]

@@IlmarKiisk 😂😂

[@avirbd]

I love how you said "BP Deep Horizon" just to make sure we do not forget who was responsible.

[@alastairleith8612]

"Aiding the cleanup effort"… as per the narration … the clean up effort (so-called) did very little to mitigate the damage to the coastal dunes, estuaries, shores, shallow waters and deep waters of the Gulf of Mexico. Fishing communities on the Gulf are still being paid not to fish, because the ecological damage up and down the food chain was catastrophic. BP and all the companies that BP outsourced to and forced into cost-cutting shortcuts, basically got away with it. President Obama even obliging with a swim at a local beach while beaches up and down the coast around that particular beach were covered in oil droplets and regular local swimmers were prevented from swimming b/c it caused rashes and breathing issues.

[@GideAnn]

This is amazing! I have a very basic understanding of biology, enough to understand what is being explained. I am so grateful for videos like these that you people make. Thank you!

[@charlessarver1637]

They are wonderful 😊

[@zappedguy1327]

Bacteria eating cancer and plastic sounds amazing

[@ryanthompson3737]

All fun and games until the new terrorism is releasing bacteria that eat humans.

[@orppranator5230]

All fun and games until that bacteria figures out that it doesn’t just have to eat cancerous cells.

[@ivodepivo21]

All fun and games till One Party that has nucleair atomic weapons discovered how to modifi nucleair eating bacteria. Now this Party can use Their atomic Weapons to kill Their Enemy and Cure themselfs with these bacteria. War won, but at wich cost?

[@Padeir0]

There's a mismatch between the images and the narrative that may lead to misinformation. Most of the time the images focus on single-cell organisms that are not bacteria, even though there are bacteria in the background, they're not the focus of the images. When talking about human cells too, there's a bunch of single celled organisms in the screen but no human cell.

[@MeepMu]

With Covid, I had almost forgotten that cancer is also a thing

[@aljon5947]

Good thing we dont spread cancer to each other 2021: WRITE THAT DOWN, WRITE THAT DOWN!!!

[@himum3429]

@@aljon5947 😂😂😂😭😭😭

[@charliecrome207]

You're not alone, unfortunately a lot of the cancer research has been massively slowed because of funding cuts during covid.

[@ernsthaeckel1205]

@@aljon5947 We can't spread cancer, but unfortunatly we can spread oncogenic viruses like EBV, HPV... that cause cancer.

[@MatanuskaHIGH]

All cancer deaths are covid now

[@kholozondi9904]

My absolute largest concern is how bacteria used to treat people can become pathogenic over time through mutations. But I'm also super excited to read scientific papers about the safety tests!!! And also, I suppose it's a lot easier to cure pathogenic bacteria as opposed to cancer.

[@randimcmillan3148]

Or weaponized

[@baronvonbon9669]

Completely logical and i havent thought of that ngl

[@baronvonbon9669]

@@randimcmillan3148 meh nukes are better and faster

[@ivodepivo21]

I would be indeed better to understand how cells, like bacteria or Higher complex cells, like Animals, Plants etc. behave or alter in different situations. Everything in our ecosystem is depended on each other to thrive and life. Altering the DNA of bacteria and function by Human modification Sounds like a bad ass cool idea to Cure, for Example Cancer. But I agree with you that complex of nature and better understanding how nature Works/ Cure disease is not be found in Human modification and altering DNA of organisms. Cure Cancer? Why not use Science to understand why and how Cancer cells emerge. Would it be Great I've Science could prevent Cancer or diseases?

[@charlessarver1637]

That's something we will always have to keep up on. Evolution is always moving. It's never static

[@nathanstrain2883]

Thank you @realengineering for sending me here!

[@BerCanUSA]

Love how this started simple then simply explained the complex! I look forward to sharing this with my students.

[@alexanderksiazek8790]

You need more views, good stuff

[@whythawk448]

Just when i was thinking that it has been a while since you last uploaded here

[@mrCetus]

I love this video so much. Thank you for making it and I really love the animation and the production as well as the narrator. World-class work is all I see here!

[@marcussmart3275]

This has profound implications for the future. Thanks bacteria, you can be so cool.

[@solaroid4442]

Just wait till this tech is abused by some insane government.

[@nareshchandrasarkar648]

Wow......thanks for giving such scientific videoes with good production

[@user-vz5bu6js4p]

thank you for the video! very interesting! great job, as always)

[@alexlandherr]

For bioengineers that know Python 3: import bacteria bac = bacteria.Bacterium() bac.read(“/home/realscience/bio_code/strain_1.dna“) while True: bac.eat() bac.make_proteins() bac.replicate()

[@Savant_Ananya]

Love the quality of these videos 😍

[@user-bp8yg3ko1r]

This channel has more educational value than my entire school life...

[@oliverm1255]

School is useless

[@andrewemerson1613]

@@oliverm1255 for information you use in daily life, mostly yeah. really what it (can and should) be good for is thinking and problem solving skills

[@rachitagarwal610]

Because it is REAL SCIENCE

[@MrLoobu]

Not with that attitude, you're just being programmed by a screen.

[@MrLoobu]

@@oliverm1255 I learned all this in grade school, yours just blows lol.

[@w0ttheh3ll]

The stock footage at 5:21 shows ciliates, which are eukaryotes.

[@anheyang7545]

Yeah

[@simonmasters3295]

Yes. Important to draw that distinction

[@thanapornnitsmer1567]

You mean protist?

[@longboardfella5306]

Outstanding as usual. And your segue to the sponsorship was seamless - and appropriate. Well done!

[@Davethreshold]

Bacteria, when magnified, creeps me out! Thank you for making me feel better about it. This piece redefines Spock's favorite word, "FASCINATING!" This narrator has an ADORAvoice. 🧡

[@lnarenkumar2327]

Omg same

[@chandamitagoswami7745]

I enjoy your videos so much!

[@Achalacha]

Thank you so much for the quality and the knowledge !

[@WASWERTYU]

I've been seeing your videos for a while now but only today clicked on one and I regret not doing it sooner. Engaging videos and actual references, you certainly live up to your channel name!

[@mrgaming2024..7]

I've watched this 6 times and it still gives me chill ☣️

[@tantzer6113]

Super high quality videos. Thank you!

[@mariamiry6459]

can they create "Prions" ( proteins) when re-heated ( if stored frozen at -70 °C ) and re-activatef inside the "new host" , and . . . ?!

[@jeffkiprop2151]

I have to say that thanks for the information I haven't learned that much about bacteria as in this video. Great work!

[@mohammedal-hammadi5085]

FANTASTIC! Your channel is fantastic really and I hope that you will make new videos about (Genetics, Genetic Engineering, Microorganisms, Virology, Biotechnology, Epigenetics and others) Thank you so much really.

[@deenial]

I watched a lot of Discovery Channel in the 90s as a kid, so I am innoculated against being excited with miraculous claims of stuff that work on mice, because it seems most treatments available to regular people are pretty much the same as they were back then. Hope I’m wrong

[@erilgaz]

Thankfully, you are wrong about that about cancer. There actually are lots of new treatments available today that weren't there 30 years ago. And thank god for that, my grandma is alive thanks to those new treatments.

[@Tendzere]

There are some new treatments like biological therapy or antibody drug conjugates

[@alastairleith8612]

@@erilgaz there's also lots of literature showing how all the western world disease epidemics are associated with poor nutrition and other lifestyle factors, but it's mostly nutrition. Meat eating a dairy is strongly associated with HD, several cancers, diabetes and obesity related diseases macular degeneration etc etc. We find compelling evidence in both population studies and clinical trials. many well known US MDs run dietary intervention programs to get people of waiting lists for heart surgery or off diabetes medications under doctor's supervision. But people all want to be able to get cancer and then take a table to cure their disease, that's a condition of a society that preferences individual prosperity over population health and environmental//ecological outcomes.

[@lagelanden-5791]

great video as always!

[@JustCallMeLiberty]

This Gives new meaning to the old saying "what's gotten into you?"

[@ankitsharma1072]

i am an engineer watching video at 2:47 AM , yeah just 3 AM thoughts. :)lol

[@awesomenitin]

I am watching at 4:10 AM.

[@MatanuskaHIGH]

You want a cookie? 🤷‍♂️.

[@Raj-gr6dy]

@@MatanuskaHIGH I do. Can you give me one? Chocolate chips included, please.

[@samuelaguiar1433]

I'm often warching your videos to learn english. Thank tou for the content, it's very important for me.

[@tim40gabby25]

*watching *you - but I can't speak Portuguese :)

[@Think_Inc]

That “Real Water” thing was kinda funny.

[@charliecrome207]

Yeah, I prefer it to that artificial "imitation water"

[@dunkleosteusterrelli]

normal store water is purified tap water I'm guessing real water is rainwater because oceanwater tastes like ass

[@ytmechanic876]

Great clip, so much potential!

[@Maryjane022]

Thank you for sharing this!☺️

[@00HoODBoy]

thank you. great channel

[@paulsun4539]

Great video; thanks! 😃

[@MongoosePreservationSociety]

These videos are great

[@ejoshcoron]

So cool!! What an awesome channel

[@Phantom_Deluxe7]

You guys are worth 1 million subscribers

[@kimbratton9620]

This is an amazing channel!

[@aubreytraverse.]

Love the work that you do on this channel keep up the great work thank you!

[@user-tc4yr5rk2t]

amazing!!

[@SyIe12]

THANK YOU!!

[@suruchimishra1532]

Such a informative video....👍👍

[@varungk3388]

Don't forget there are numerous Eukaryotic Unicellular organisms too.

[@KFC431]

I hope clinical trials for these kind of bacteria come soon. They can help us solve plastic and air polution.

[@grantzimmerman7704]

Great video! One comment though, around 4:00 you started talking about bacteria evolving to eat chitin, i just wanted to clarify that evolution really doesn’t happen until a selection factor causes natural selection, we evolve all the time, in little tiny ways that might be beneficial, harmful or neither!

[@mecsympalebeaugosse8444]

Wow, just WOW!

[@ArshnoorSingh13]

Its amazing to think that how these small things are a big part of our lives. Good job micro-buddies :)

[@ivodepivo21]

Big part of our Lives is a understatement. 😁 All live as we know it, is evolved from single bacteria's. Without bacteria there would be no Animals, Plants, Trees, insects, Sea life, Birds, fungus etc. Everything in nature would die or excist without bacteria's

[@-cheshire-cat]

12:35 Grocery shopping, driving to work, exercise, cooking food.. yes, how in the world do you find the time to do anything else in life?

[@tedjinielalmi2649]

One of my favourite channels

[@patrickstar686]

Holy shit this is awesome

[@36.shanthoshkumar87]

thank you yur the best youtuber

[@williamsutter2152]

When I was 10, I gave one of my cats the middle name Yersinia, after Yersinia pestis, as I loved learning about pathogens like Yersinia pestis.

[@bengoodchild883]

Thanks!

[@FreqZY]

Thanks bacteria! I didn't know they did so much to help us :)

[@luispires6935]

KZbin, u better start recommending useful information like this!

[@zachyrish2682]

How did youtube's algorithm took so long to recommend me this diamond star channel ?

[@jupiter7795]

Good background music.

[@dandavatsdasa8345]

Great Narrations! Some of the simpler things are more tried and true. A for instance might be producing biofuels with algae and converting plastics into biodiesel. Even knowledge itself can be a two edged sword. Be on the lookout, be alert, be wary! Thank you for sharing great educational videos!

[@anettebianca6855]

fascinating

[@nibblrrr7124]

5:21 5:41 Aren't those paramecia (protozoans, i.e. single-celled eukaryotic "animals"), rather than bacteria? (Just nitpicking about stock footage, great video nonetheless!)

[@idris.k9818]

Best content on KZbin 🙌

[@kotor1357]

Can you make a video that goes in detail about genome editing?

[@TimothyMorigeau]

Amazing

[@nathanlevesque7812]

We're surrounded by biodegradable nanites, but we're too stuck in the past to realize it. Every time scientists talk about what nanotech could do I get a little frustrated that genetic engineering is held back so much. Why synthesize a microscopic robot from scratch when nanomachines already evolved billions of years ago? So we can create a new kind of waste?

[@Gumballa87]

Watching it for the great content - listening to it for the voice.

[@cavemann_]

That's great

[@fayas234]

Hello real science ❤️

[@theone8189]

In the future, we can "engineer" the bacteria from our gut microbiome to cure anything from aging, depression and etc.. by growing them in our own bioreacter, our gut. We can control the outcomes with nutrient/precursors.

[@tim40gabby25]

.. and then what?. I fear a dystopian future, an earth ruled by the proxies of bodies in a box, with senescent brains just about keeping things ticking over. A relatively early death, say x4 peak reproductive age, is required. Old uk duffer and curmudgeon here, counting the days :)

[@theone8189]

@@tim40gabby25 We are guided more by our biological urges. Most societies expect old people just to go to a corner and wait to die. At that point, we all see through the vanity of life. Some react by turning spiritual, some charitable, and sadly, some request, "Help me die" to all aged care workers. Life is so vain, and yet so precious. Be happy.

[@totalgej]

Do yeast next please! They are also very modifiable and can be very usefull

[@marcorozo9922]

Nice video 🙂

[@ryanvance1020]

hey, this is really good! congratulations!

[@tim40gabby25]

A plastic eating bug - what could go wrong?.. cautious old uk duffer here, checking my drinking cup for holes..

[@quitlife9279]

Honestly when bacteria eventually evolve to more efficiently decompose plastics and fossil fuels human civilization might just permanently revert a few thousand years.

[@livinginsyn4814]

Are we using CRISPR for the genetic programming or something else?

[@dj_laundry_list]

Just commenting to boost engagement

[@NirajKumar-iz3vh]

nice video helped me sleep!

[@strictlykev311]

I wonder what would happen if the bacteria further evolved after being modified for a different intention. Like if u gave someone bacteria to consume cancer and then it adapted to consume good cells as well once cancer cells were gone

[@ronnyfuentes709]

Mechanics use a special tank and pump with bacteria in it to clean grease or oil covered tools as the bacteria break it down

[@lukaszu8011]

Love your voice :)

[@capedbaldy6404]

I like how some people are germophobes when the moment you finish washing or sanitizing your hands, germs immediately go on your hands without you knowing

[@aniklal1095]

Narrator voice is so calm

[@geoffwalters3662]

I have something called a "Milwaukee Tumor." Its from too much beer (old people will know that most US beer used to be brewed in Milwaukee)

[@nikolaskhf]

Cancer cell, using mask: don't eat me Body, without question: alright, I won't

[@CaptivaLP]

As a pharmacist I love bacteria. We use them to produce soooo many different drugs

[@Zhippy]

Well, as long as we don't create a monster that ends up devastating us, or even wipe us out.

[@geoffrygifari3377]

another fascinating thing is that it appears life can concoct an enzyme to do anything it wants.... maybe eating plastic is just the beginning

[@steffenschuldenzucker1692]

But this is not a review of gene-modified bacteria. This is a review of what it's like to live with gene-modified bacteria.

[@swapnilmishra4123]

Discussion about bacteria? Lacto bacillus...enters the chat.

[@aljon5947]

Where are the subtitles pls?

[@Cat_Trainer]

I Love Bacteria, they were so underated, they help us without even us knowing it,

[@joshuabaughn3734]

Some other KZbinr who does this in a professional manner (Californians Shoot me now) Modified baker's yeast to produce Beta Carotene. He then mixed it in with the Unmodified baker's yeast. The result was a Vitamin rich bread.

[@Jared-vq4zy]

One of my favorite uses of bacteria is to convert fish poop into food for the plants in my aquarium which then produces oxygen inside the tanks which allows the fish to survive without the need for a aerator or filter.

[@rich763690]

""NOW THE TABLES ARE TURNING AS WE LEARN TO GENETICALLY PROGRAM THEM...................."" OOOOOH THE HUBRIS..............

[@231shivakumarvt2]

They r like unsung heroes in recombinant DNA technology, BT.