Psilocybin and 5HT2A receptors - Are They Necessary for the Therapeutic Effects?

[@hippos_rock3855]

That “Psilocybin binds to TrkB receptors” paper you predicted just came out, lol

[@Neuropharmacist]

Haha

[@AsherBrandt]

Well done I liked your skepticism regarding the overall outcome the authors were trying to convey in this paper. As always we need more studies.

[@Neuropharmacist]

Thank you! I think this study just leaves too many open questions that should have been addressed.

[@slowfudgeballs9517]

You just want to trip more, don't you... ? More seriously: shamans or trained therapists need to be present directly after and you need to be really tripping balls.

[@julianmaster]

Awesome. Keep up the great work with your unique and valuable coverage!

[@Neuropharmacist]

Thank you! I'll try my best.

[@hhyy3173]

YES!!! This comment!

[@nicklamela2294]

Do you have an opinion on the activation of the 5HT2B receptor of psilocybin and heart valves and risks of HVD? Curious to get your opinion

[@Neuropharmacist]

Oh yeah! I'll try to do a video on that :)

[@nicklamela2294]

@@Neuropharmacist fantastic looking forward to it

[@lost4468yt]

I think anyone would struggle to take psilocybin enough to get any real impacts. Long term microdosing might be an issue. It should be noted that psychedelic farmers usually come from 5HT-2B (cardiac arrest, extreme vasoconstriction, etc) or 5HT-7 (massive thermal regulation failure). There are some other weird outliers with unknown causes of death, or just such bizarre pharmacology like alpha-MT (the amphetamine version of tryptamine, very simple molecular that is a psychedelic, a stimulant, an entactogen, an MAOI, and both a triple releaser as well as triple uptake inhibitor (yeah these two combined with an MAOI make an OD seem easy, but while it has killed the doses were way higher than expected), and it was even used by the USSR as an antidepressant at 10mg doses (microdosing essentially) until they found people were using it to trip and removed it).

[@yvanpearson7024]

What is your opinion on psilocybin and heart valve damage?

[@Neuropharmacist]

Remains a possibility, but is unlikely with non-chronic use. Might do a video on that at some point.

[@yvanpearson7024]

@@Neuropharmacist how about microdosing?

[@alexanderkenniethbam]

Hi, I would like to know your opinion on Nootropic Depots' Cognance which also includes 5HT2A.

[@rylandavis2976]

What do you mean it includes 5ht2a, 5ht2a is a receptor in your body. It's not a supplement or a drug. Some supplements have 5-htp in them, which is basically a precursor to serotonin. Other than that I have no idea what you are talking about

[@underdogg8240]

Yes, rodents dont have a prefrontal cortex either - msg - monosodium glutamate got approved for human consumption in spite of the brain tumor development in rats. I´m not saying this was smart - however rats are not the same as humans - humans don´t get this effect. But caution must be exercised anyhow

[@HansImWald]

I don't know if he is from the netherlands or from scandinavia.

[@Neuropharmacist]

You're on the right track.

[@HansImWald]

@@Neuropharmacist Thanks for your great work! I am a german doctor and I really like your content. I also have Asperger and will soon take therapeutic dose of psylocibin. I am really excited.

[@point8192]

Sounds Finnish :)

[@markc3197]

Fun to listen to science scramble like a terrible tee shot to explain that which has been explained by non scientific minds for decades

[@gratefulkm]

Let me throw my non science info in here, 1 As a long time very regular LSD and Mush taker, The most important part is the setting of the experience, And that to put someone in a room in a hospital, give them the drug, then surround them with doctors which control the environment, Would go down as possibly the most ineffective way to take the drug, this would massively affect the ability to relax and let go ! 2 LSD has been used on hundreds of thousands of patients from its discovery to its being banned, (at the request of the military) , To keep ignoring this fact, and to comment on LSD as a medicine without incorporating the past is foolish in the extreme 3 You have to understand what happened in San Francisco, When Owsley knocked up 5 million doses of LSD over a few years and distributed it freely, And I mean really really understand. Because this right here is why the authorities freaked ! The Owsley family were not uneducated , they were all top universities kids , they TESTED what Owsley made in thousands of ways to see what enhanced and allowed the drug to reach its fullest effects, they learnt the fastest way's to dissolve your mind and this knowledge was spreading, hence the ban ! 4 They have to explain why you can take mushrooms a thousand times and have an experience that you are very familiar with, yet you take mush one time in the right environment with the right music and you change forever and have an experience far far more out there, 5 Which means the drug is only half the story ! Because the effects of the drug can be changed vastly by the setting (music, lights, people, physical movement(do you know you cant get dizzy on mush or LSD ?) and words and language) (To hit this home 8 beers affect A, spin around affect B, 8 beers and then spin around affect C) 6 If you are really here trying to help people, then before you can comment on anything, you need to explain this " Dark star crashes Reason tatters The forces tear loose from the axis searchlight casting for faults In the clouds of delusion Shall we go You and I While we can through the transitive nightfall of diamonds Mirror shatters In formless reflections of matter Glass hand dissolving To Ice petals Revolving Lady in Velvet recedes In night of goodbye Shall we go You and i While we can Through The transitive nightfall of diamonds

[@gratefulkm]

@@OttomanSultana it's only theological ignorance that can think! Psychedilcs can be bad. Do they destroy the one consciousness delusion. Yes of course they do. It's funny to watch modern doctors try to use them to fix one consciousness. Life is multi consciousness. It's only the abrahamic roman slaves states that think man is the only consciousness

[@psilocybe8135]

@@gratefulkm Is that legit , about being immune to dizziness on mush?

[@gratefulkm]

@@psilocybe8135 watch videos of the famoud deadheads spinning. Harder to find as time goes by. All on lsd

[@gregteske3136]

True comment ! and great poetry 🤟 Ty Kevin 👋🪃🪃🇦🇺

[@bartkoot4983]

Yes. You are correct. Fun fact about lsd. Without lsd apple sould not be apple. With lsd you can repackage your information more convenient like a .ZIP in silicon valley they still use it. Even wonder why everyone thing that apple made is that convenient. It close to natural behavior and work excellent. I think it is also a form of evidence that it it not the optinion of anti Apple fans. There it works kind opposite.