Psychedelic Therapy With Psilocybin and MDMA: Basics + History (What Took So Long?)

Psychedelic therapy is about to be FDA approved: psilocybin for depression and MDMA for post-traumatic stress disorder (PTSD). Why did it take so long for FDA approval? This video covers the medical and legal history of psychedelic psychotherapy and research, from the CIA’s MKULTRA to modern clinical trials with MAPS, Compass Pathways, and the Usona Institute. It also explores current controversies, such as the potential for abuse (even in medical settings), and the future of psychedelic medicine.
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Right to Try Psilocybin demonstration at DEA HQ: vimeo.com/710866736

[@Alexrock2012]

This, ladies and gentlemen, is quality content

[@ihmcurious]

Thank you Mr. Croissant

[@cptcap7531]

MDMA has helped me greatly with my PTSD and depression.

[@surfthelastmile575]

I did two sessions of mdma alone with music in a dark room, i was suffering from ptsd from a bad break up. Anger has almost gone totally that is the greatest change i saw straight away

[@freddewfan]

This is supreme content. I literally got thousand times more interested in reading academic paper and scientific literature based of your take and your storytelling. Congratulations! Keep on going and I'm sure your future will be bright ✨

[@Axelvad]

I tried MDMA and 4 hits of DMT the same night. The day after i was quite clear in my mind. Fresh is one way to put it. I certainly believe psychedelics can be used as pharma.

[@Keizenholdt]

Your channel is criminally underappreciated. Thank you for all of the research. Would it be too much trouble to link your sources that you quote in the description so that we could learn more?

[@ihmcurious]

Thank you! They won't all fit in the description, but there should be enough info to search for them. Let me know if you have trouble finding any particular ones!

[@johndalton4559]

I can only dito this, insanely high quality I'm sending this to everyone I know.

[@emerjay348]

Great channel glad to be a subsriber, I love news from science, psychology, technology and other fields. You do it in great way, going into detail, bringing up sources, best of luck in growing your channel.

[@no0n]

couldn't agree more. anyone have any recomendations for similar channels/websites/twitter accounts?

[@Anaesify]

Continuing to love the content, but I also hope you keep making content about stuff other than trippy drugs (as a person who loves trippy drugs!) so that you don't get pigeonholed by the algorithm

[@tylerbradley8124]

I concur. I think the bioethics aspect of your videos is outstanding. Please keep this in mind!

[@bartoszglen590]

great topic - PLEASE MORE!

[@kiowa9454]

Now Ihm curious too

[@maxpowers802]

great video, love to see how much this channel is growing

[@RobertRichard-6385]

Psychedelics definitely have the potential to deal with mental health issues like anxiety and depression , they really helped me, I was able to get dmt,shrooms,lsd,mdma, edibles from this specialist who ship discreetly to any location

[@RobertRichard-6385]

Dude is on Instagram

[@thanaa]

good stuff man, keep it up

[@TheMATHEHOUSE]

Feel like i´m dying with all my trauma. I really need, but i live in Brazil, MDMA won´t be legal for a long time.

[@vitulus_]

I read an article recently where Australia has become one of the first countries to recognise psychedelics as medicine. Whilst the US has had some slow progress, fortunately many other countries are putting out good research and use.

[@TheBear710]

We have a slow system for a reason… gridlock isn’t bad all the time either

[@vitulus_]

@@TheBear710 Who is 'we'?

[@TheBear710]

@@vitulus_ we as in me and my fellow Americans have a slow process for a reason..

[@vitulus_]

​@@TheBear710 Ah right. Perhaps I shouldn't have said slow process, but more so the US was quite behind after the war on drugs in terms of stigma and regulations. They're definitely catching up though with the FDA granting quite a lot of research in such use of drugs.

[@sipper2136]

The language they've used on these clinical trials does sound very woo but I find psychedelics generally work far better when people have a positive mindset going in, and treat any difficulties in the trip as building resilience as opposed to being "bad trips" so though the idea of an inner healing voice may not be rigorous, it may be a useful framework to think of such a mental construct. It's immoral to prevent people from changing their mental state with the threat of imprisonment, and a crying shame research was stalled for decades on these drugs because, the therapeutic potential is majorly inhibited by the context these drugs pop up in having to go through black market channels, and many people are not surrounded by the right social supports or do not have the knowledge to help them to extract the most benefits and least risks possible from these drugs. They've helped me a lot but it wasn't an easy journey, with many difficult trips before I learned how to better deal with the overwhelming emotions the experiences would evoke. MDMA is considerably easier to handle than either LSD or psilocybin and it's hard to even see it being in the same psychedelic category, and it's more consistent ability to generate positive feelings towards others gives it a unique role. Hopefully the research starts to extend towards including non-serotonergic psychedelics like ibogaine and salvia as well, as their potential in addiction and analgesia may be even more profound. Thanks for the video! I first saw your videos on cerebral organoids and I've been watching since. If you want to go down a rarely studied rabbit hole perhaps the role of 5ht2a receptor agonists in immunomodulation and TNF production would be your cup of tea. There are a few odd case studies of patients with rheumatic diseases taking psychedelics and going into remission, as well as some in-vitro studies showing 5-Meo-DMT, LSD, etc drastically lowering production of inflammatory cytokines.

[@Freddus]

Danke!

[@m.i.c.h.o]

Thank you for this collection of information!

[@m.i.c.h.o]

@Victoriakarenka wow no way! Ship me 2 tons of dmt.

[@ihmcurious]

@Victoriakarenka stop trying to sell drugs on my channel. How dare you not offer me a cut?

[@m.i.c.h.o]

@@ihmcurious lol

[@unitedchainsofamerica]

I love it!!!

[@isthattrue1083]

Well, the trippy feelings and things like that are a side effect of the reordering of neural pathways in the brain to a healthy state.

[@ihmcurious]

Is that true?

[@benjamin2713]

great video

[@Ninja_Cheshie]

You'd have to find the right music for the right person.

[@FisherKot11235]

Psychedelics are the best thing that ever happened to me. Weed is the worst thing that ever happened to me. Just to be honest.

[@bigzachful]

Same here!

[@theforcefor]

The treatment of ADHD with psychodelics intersted me, is there any videos in Ihm about it?

[@ihmcurious]

No videos yet, but MindMed is doing a Phase 2a clinical trial using 20 microgram doses of LSD, on the high end of what could be considered a "microdose", twice a week for 6 weeks. I don't think any of their research has been published, but if anyone knows otherwise please reply here!

[@RobertRichard-6385]

I can refer you to this mate who guided me through my first ever dmt experience he got mushrooms,LSD, MDMA and other psychedelic he ships discreetly to any location

[@RobertRichard-6385]

Dude is on Instagram

[@RobertRichard-6385]

@mrwrghttrip

[@VegasPerformer]

Can you do a video on artificial intelligence... also The Fermi paradox

[@lucilanavarrete9287]

I hope so. I am looking about Portugal and Australia but there is still weird.

[@RobertRichard-6385]

I can refer you to this mate who guided me through my first ever dmt experience he got mushrooms,LSD, MDMA and other psychedelic he ships discreetly to any location

[@RobertRichard-6385]

Dude is on Instagram

[@RobertRichard-6385]

@mrwrghttrip

[@thebananababies4520]

this shiz b crazy cool but I'm kinda doubting the ppl that really need help will get it unfortunately. Keep it up with these grand works of educational media!

[@LucasHenry7551]

Mycologist's psychedelic wisdom saved me from the darkness of meth and heroin addiction.

[@Jeronimo-gs2so]

My experience on MDMA has been a great benefit while breaking through one ought to take the right dosage, below usually where l get mine

[@Jeronimo-gs2so]

He's on Instagram handle

[@Jeronimo-gs2so]

@novatripps

[@Superbbsuper]

Does this apply to canada?

[@ihmcurious]

Not directly. But they are taking some similar steps, e.g. their Special Access Program. And the US is a leader in international drug policy, so other countries might be more willing to relax restrictions after the US sets an example. There are some other efforts going on to de-schedule psychedelics internationally, from organizations who aren't so optimistic about US drug policy. Time will tell!

[@exosproudmamabear558]

So where actually fda in the trial? They aproved phase 1 in 2018 and phase 2 in 2022. Did they start phase 3? When will it go to the depression guidelines? In 2024?

[@ihmcurious]

You can check the status of specific drug trials here: psychedelicalpha.com/data/psychedelic-drug-development-tracker

[@exosproudmamabear558]

@@ihmcurious Thanks

[@mookfaru835]

The system is extremely slow, people knew this in 1970. That’s 50 years apart.

[@TVtheTV]

💙

[@PlanetCookie3]

Is it really gonna be approved in 1 month on May 2024, will mdma be approved on August 11, 2024, or will both psychedelics be approved in a few more years? I'm sick of all this waiting

[@LucasHenry7551]

Dude is on Instagram

[@LucasHenry7551]

@mrwrghttrip

[@BrendenODell-ns8bh]

What about MDA & MDE???

[@bigzachful]

Never heard of MDE?

[@RobertRichard-6385]

I can refer you to this mate who guided me through my first ever dmt experience he got mushrooms,LSD, MDMA and other psychedelic he ships discreetly to any location

[@RobertRichard-6385]

Dude is on Instagram

[@RobertRichard-6385]

@mrwrghttrip

[@andrew6657]

hard on of the shaman 🤣

[@mikegLXIVMM]

The DEA is addicted to their tax-funded budget and power. They will only legalize certain drugs if they are forced to.

[@grumpycat8528]

You are eggtastic

[@zahar1875]

what's the story about nazi?

[@ihmcurious]

While LSD was being discovered at Sandoz, a couple hundred miles away at the Dachau concentration camp Nazis were experimenting with mescaline for interrogation and mind control. This inspired similar experiments in the US. Some of this history is covered in Acid Dreams by Martin Lee & Bruce Shlain (quoted in the video) and Poisoner in Chief by Stephen Kinzer. I'll cover it in another video, after I cover some more brain news...

[@georgekatogiritis7355]

Perhaps I was fortunate to use an array of drugs in my youth

[@bestof2382]

You remind me of Adam Ragusea, but you are cool like bill nye and funny, well you are way cooler than bill nye, Bill nye more like bill bye, and hello ihm curious

[@UniDocs_Mahapushpa_Cyavana]

Humans need to stop being so prudish about their inner madness 🤪. Like, millennia ago.

[@8________________D-]

HARD ON OF THE SHAMBALAM!!! 🍄🍆 NO CONSENT!