Qualitative and Quantitative Bio-analysis of Antibody Drug Conjugates (ADCs) using Mass Spectrometry

This webinar, presented by Hetal Sarvaiya, Associate Director, Mass Spectrometry, Protein Science, at AbbVie SSF, Oncology Discovery, will present mass spectrometry based platform methods for the development of antibody drug conjugates. Reliable interpretation and understanding of the drug exposure and in vivo biotransformation is critical to advancing programs through R&D. Accurate quantification of the dynamic changes of the ADCs in plasma such as deconjugation and determination of different drug to antibody ratios (DAR) half-life have safety and efficacy implications that must be considered. In the last decade, advances in LCMS techniques have enabled both qualitative and quantitative bioanalyses of these complex entities. This webinar will cover examples from both qualitative as well as quantitative analysis of ADCs using ultra high-resolution Bruker maxis II QTOF MS.