Randy Schekman (HHMI & UCB) 2: Genes and proteins required for secretion

[@franciscahammerschlag4103]

I am not a scientist but a translator. I love your talks. I have learned so much. Thank you for making this public to the non-scientist community.

[@DrLOVaasjo]

"The pursuit of science of its own curiosity driven understanding, inevitably has practical applications" Quote as powerful as the pathway described. Thank you. Quote extracted from final minutes of Schekman seminar 2.

[@lastchance8142]

Yet another example of a complex and intricate biological system mediated by numerous proteins and enzymes, themselves complex machines , choreographed in what seems to be an irreducible pathway essential for the viability of the cell. The oft mentioned evolutionary conservation of this mechanism begs the question of what possible alternative could be imagined to function in any supposed intermediate state.

[@txukiki]

Bravo,Randy ! Thank you VERY MUCH for sharing. I learn a lot with you. Such an interesting work you do. We love you !

[@ardd.c.8113]

The photo editing of the protest picture is superb! Im sure it used to say 'mice' instead of 'yeast'...

[@numericalcode]

No wonder this man is considered one of the greatest biologists

[@FarnhamJ07]

Excellent talk. Budding and secretion involving regular, self-assembling scaffolding proteins sure makes me wonder lots about viral connections.

[@Bio-portal_dr_Lukasz_Sobkowiak]

Interesting talk concerning modern molecular biology!

[@thefenerbahcesk4156]

17:30 How did they put the signal peptide on the enzyme?

[@Thomaaasooo]

you replace the gene in the yeast's genome with a version that codes for the protein plus the signal seuqence.

[@vidyas1044]

Great lecture!

[@ishitvvats2044]

Yeast have feelings too.❤

[@so-oo6ti]

Japan is trying to discharge radioactively contaminated water into the sea, and I'm curious about this part.

[@thefenerbahcesk4156]

5:08 Is pretty funny, but I think that picture is photoshopped.

[@contr4dixion]

Hahahaah..... I hope so...

[@13satyakamsharma]

I think it’s as a joke lmao. He presented the same image in his Nobel prize presentation (at least the one found on nobelprize.org has that image too!).

[@stellarlas]

Living in Berkeley the past ten years I'd say it's real

[@priyankchaturvedi2851]

Randy rocks.

[@priyankchaturvedi2851]

His work is the base for mordern medicine.

[@rebeccakane8854]

love the lecture but so confused by this guys throat

[@This_is_Primo]

2024 damn