Regulation of Pyruvate Dehydrogenase

[@natalygonzalez5770]

OMG! this is soooooo helpful for understanding the allosteric regulation of the PDH, thanks a lot =)

[@bellamuhko]

This is a bit misleading, Pyruvate dehydrogenase is 1 enzyme in the pyruvate dehydrogenase complex, which is a 3-enzyme complex, using 5 co-factors not the 2 mentioned in the video.

[@matthewalmario4171]

nerd

[@LeticiaRColon]

I think most would say that saying pyruvate dehydrogenase assumes you’re talking about the complex unless you specify that it’s the E1 pyruvate dehydrogenase. NAD+ and CoA are two of the five cofactors you are talking about and are the important ones in the general overview of the process.

[@matthewalmario4171]

Rina Colon yeah get it!

[@rimshajawed6369]

Leticia R. Colon b

[@areh0670]

Amazing Explanation ⭐⭐⭐

[@martinm6851]

Great video with excellent clarity.

[@lasilisal]

This makes a lot of sense, thank you!

[@applelover7801]

Well explained. 2 enzymes other than pyruvate dehydrogenase are required for the reaction .. dihydrolipoyl transacetylase and D. Dehydrogenase. deficiency or missing those enzymes, it causes metabolism disease

[@shaniathalia1065]

Pyruvate dehydrogenase is a complex made up of those three enzymes.

[@noel5544]

ooh my good , such a great explaination

[@anwrqayd9123]

Love her 🥺

[@HasnaELMOUTAWAKIL]

wooooooow just amaizng vedio but i have a question it does insulin inhibe or stimilut PHD activity

[@sciencenerd7639]

super helpful review! thanks!

[@senchooooopanza]

I was wondering, does anybody know why Protein Kinase A is an alosteric inhibitor of PDH?

[@lucilaalvarez5034]

I have observed a tendency for ppl to copy & write the same idea someone else has commented on..for example about her voice which seems to be a very clear/understandable one in contrary to what all these negative comments r saying. I wonder how limited your own individual opinion spectrum has to be for that to happen...

[@reemalmutawa]

khan academy is the best!

[@minhtu5059]

Thank you so much!!

[@slwankaedbey775]

it's just about Allosteric Regulation. there are other important types concerning phos and dephos

[@SalmaHadhood-v1b]

Thanks

[@jianingliang6439]

super clear!

[@johannesschluter1769]

very very helpfull thanks

[@keishlajim9196]

Where is go the Co2 that was remove of pyruvate?

[@feliscatus4921]

it's a waste product and it will be removed into the blood stream and out through our lungs

[@nadadew473]

Thanks 😄

[@RNcooley]

Correction fatty acids can contribute to glucose. The glycerol from triaglycerol can be used to synthesize glucose via gluconeogenesis. Glycerol --> Glycerol phosphate --> DHAP----> glyceraldehyde 3 Phosphate.

[@villeozzy13]

marcus cooley Your first statement is incorrect. Fatty acids do not contain the glycerol molecule. It's the backbone of the triacylglycerol. As such, the glycerol molecule of the triacylglycerol is indeed gluconeogenic, not the fatty acid.

[@teresaz2269]

Ville Skåtar you are right...

[@opaciisaac1799]

Fattty acid is not glycerol Marcus, glycerol can, but not fatty acid. Thanx

[@abdula5849]

ayo khan where did u go

[@blackmarlin3166]

My chemistry teacher aint got nothing on this

[@lazarkulasevic]

Who let Bernadette talk on KhanAcademy?

[@booloob]

you are also not describing allosteric regulation

[@AbhishekPatel-hw5un]

Bruh this voice is driving me crazy

[@nepramjoe]

Misleading video

[@hazka58]

I love those cute voices :3 jk jk.. good explanation! I might succeed in just 3 days of studying xD

[@NnnHyyu]

Why the hell did you take all this time explaining minor useless details while you can just say the answer in 6:32 This is really a bad explanation and a waste of time

[@gobindasethi5188]

Work on the the voice

[@demi-marie]

this girl talks so fast its fustrating

[@adfadf9785]

I hate this girl's voice. Bring back the man.