Respiratory | External Respiration: Ventilation Perfusion Coupling

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[@BlaackAnchor]

At time 27:30, you said that ventilation decreases from apex to base, but actually it increases from apex to base of the lung. Perfusion also increases from apex to base, but much more significantly that we have a lower V/Q at the base.

[@caidenlu]

but shouldnt air goes against the direction of the gravity?

[@BlaackAnchor]

@@caidenlu we are talking about ventilation here, not just air. Thanks for your input....

[@caidenlu]

@@BlaackAnchorbut isn't ventilation the movement of air? but i get youre right, just still got confused here about why

[@caidenlu]

@@BlaackAnchor is it because at the end of expiration, the FRC at the apex area is more than the bottom, so the ventilation at the apex is considered lower?

[@omarnakhleh6600]

@@caidenlu The ventilation is low because the cross sectional area (surface area) is low in the apex of the lungs

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Zach, i'm in respiratory school and I got to tell you man you've saved my butt so many times with your videos. Thank you for your hard work!

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[@samoei3780]

Wow! this is exremely wonderful. Thanks alot, you made this things very easy. Point of correction- The lower zones of the lung ventilate better than the upper zones and the middle zones have intermediate ventilation.

[@samoei3780]

In addition ventilation perfusion ratio increases three times in the apex than in the base

[@SunShine-vq9sz]

But in that won't the v/q ratio be disturbed?Could u explain why u think ur point is right?

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[@athraaimad6859]

Hello u said that ventilation is better in the top(apex ) of the lung ,but actually it should be decreased bec all books said that lower zones of the lung ventilated better thant upper ,i wish u explain!! + ur the best in explaining physiology

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Yesni read the same

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You broke that down to the ground! Amazing Job!

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Extremely perfect! I really enjoyed it bro. Congratulations

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This was so perfect and helpful in every way! one of my favorite videos on KZbin.

[@danielmaroa3344]

Thanks you so much for the presentation on V/Q ratio . It was amazing . Great.

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Thought yall were capping but this a game changer fr

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Thank you so much for the video on V/Q. This is awesome.

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best teaching ever

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[@TGNJared]

Hey Zach, great video but wouldn't V AND Q be greater at the base compared to the apex (~28:00)? Pa > Pv > PA in Zone 3 so arteriolar perfusion pressure leads to good blood flow. For Ventilation, alveoli at the base have higher compliance and we would see an increase in ventilation for Zone 3 as well. Overall the the increase in Q > V so V/Q is decreased even though both are increased

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[@abhishekgholap1300]

28:00 . Isn’t Ventilation more at the base of the lung? Ref: Ganong’s

[@akshitverma3328]

The ventilation being talked abt is in the alveoli and not outside the alveoli..the ventilation will be more at the base but that phenomenon is applicable to the outside of the alveoli

[@rachellugtu2776]

Ventilation and perfusion is higher at the base and lower at the apex of the lungs. However, V/Q ratio is higher at the apex and lower at the base.

[@karthikeswaras2159]

Yes due to gravity

[@shayandin9709]

this doesnt make sense to me either

[@shayandin9709]

@@rachellugtu2776 if the perfusion is lowest at the apex then whould the apex of the lung not try and match the ventilation therefore at the top of the lung would have a high ventilation?

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[@neet-py9sz]

Ventilation increases from apex to the base. Please correct it ! Other than that ! A big fan ! Great job zack !

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Thanks ❤

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Wow great video Zach

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[@miladdulloo1997]

There is an error: ventilation is higher at the base than at the apex because of increasing compliance. The V/Q ratio is biggest at the apex because at the apex: Q higher is relatively to V. V/Q ratio is lowest at the base because V is higher comparatively to Q.

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[@THE______TRUTH]

I feel like you should have emphasized that the smooth muscle in the arterioles contracts and relaxes because capillaries dont have smooth muscle and so the illustration can be misleading.

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Elaborate

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[@flynn8936]

27:15 !Ventilation is higher at the base of the lungs (in an upright position) due to gravity pulling on lung tissue which increases pleural pressure!

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[@reezis1619]

Correction: Type 1 Alveolar cells make up 40% of the alveolar cells in number and Type 2 make up 60% of the cells in number, however the type 1 alveolar cells take up approx. 95% of the space and type 2 approx 5% of the space Correction 2: Nitric Oxide causes smooth muscle relaxation by activating guanylyl cyclase, increasing cGMP concentrations in the smooth muscle cell, activating cGMP dependent protein kinase which in the end phosphorylates and activates Myosin Light Chain phosphatase which leads to smooth muscle relaxation. It is not dependent on K+ efflux.

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