Risk Factors for Disease Progression in Patients with Polycythemia Vera

Michael Grunwald, MD, of the Levine Cancer Institute of Atrium Health in North Carolina, discussed the REVEAL study at the 65th American Society of Hematology Annual Meeting & Exposition.
The REVEAL study, a prospective, multicenter trial, observed disease progression to myelofibrosis (MF) in 2,510 patients with polycythemia vera (PV) over the course of three years.
Dr. Grunwald and colleagues identified five risk factors for progression to MF, including elevated white blood cell count (leukocytosis), duration of time with PV, a history of thromboembolism, elevated variant allele frequency, and hematocrit ≤45.
“Now that we know these risk factors, we can observe patients who display these risk factors more closely and see if they're developing to myelofibrosis,” Dr. Grunwald said. “Maybe these patients should have more frequent blood counts. Maybe they should be seen more frequently.”

[@747rld]

My wife has PV and is only 30 yrs old. Her condition is worsening. We are in northern CA with limited medical resources. The doctors at UC Davis prescribed her blood thinners but that’s it. They won’t take her on, they say her case is too severe. She now has an enormous spleen that has induced a large hernia. And she’s on extreme amounts of pain every day… they won’t fix the hernia because of the other issues related to the PV. Can someone from the east coast please help my wife before it’s too late

[@rlove3222]

David is a pv patient in North Carolina

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David Wallace is the website owner and a pv patient

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Pv. Reporter. Com.

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Pv

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