Serotonin's Role: Impulsivity, Aggression, Anxiety, and Cognition

[@stahpitt8531]

This is amazing, it's impossible to find quality pharmacology content like this on youtube.

[@booksgaming1426]

I'm really loving the journal references at the bottom, as well.

[@vegetossgss1114]

What about microglia?

[@iamthefiremanjj]

With 5htp people take way too high of a dosage! It's nice to start out low like 10-20mg and taking it around 12-1pm is best because the serotonin boost is actually stimulating, have it with green tea for the ECGC. Later on, the serotonin will be able to be converted to melatonin and you will have better sleep as well! This is a good time because 5htp can raise cortisol levels, and we start to trickle down cortisol in the afternoon!

[@Emadagban777]

Excellent explanation. I couldn't find such a clear and thorough yet concise information on this topic elsewhere.

[@kovacsmihai7022]

I found the video to be quite helpful. Thank you and keep up the good work. You've earned a new subscriber

[@melmars6760]

Such a helpful explanation. I had to go check out David Nutt and his research, as well as the Institute. So helpful for outlining the difference for 5ht1a and 5ht2a for me

[@Ace-od8en]

This was so good I subscribed. Quality content 👌 amazing British voice. Intelligent, authoritative and mature. I was looking for a very deep, scientific explanation and I found it. I will be exploring more of your channel and content. Thanks.

[@augustishotinaugust2897]

I wish they had much more information on what exactly dxm does to the brain and body

[@thebachu786]

a very well done video, great information content. crisp delivery!

[@ParallaxView111]

I would like to suggest this lecture demonstrates why a person's diet should be examined before going the pharmaceutical rout. For example how much tryptophan is in a vegan diet vs a diet that includes animal products: milk, beef, fish, chicken. These are the highest foods in tryptophan. Look at the actual milligrams per gram, not just weather or not a food contains tryptophan.

[@arsh925]

I am so glad I found this channel ❤️

[@ConnoisseurOfExistence]

Super informative, thanks!

[@aishaakhterakhter5384]

Thank you so much.

[@5-ht2a]

amazing

[@yogi9631]

GREAT INFO

[@vegetossgss1114]

What about microglia?

[@natecooper9457]

You had me at mdma

[@mariyajacob4107]

Thanku

[@Azur_Vita]

Are thete natural ways to increase 5-HT e.g. MDMA ?

[@philipm3173]

Meditation. MDMA will actually leave your 5-ht levels lower (well technically it will downregulate the receptors) afterwards if used to excess.

[@ivannovoselac3518]

I was thinking that anxiety is learned behavior not chemical imbalance?

[@msgirl01]

Like most mental health issues it's usually both.

[@-Datboijj-]

@@msgirl01 no its all chemical imbalance

[@msgirl01]

@@-Datboijj- what about people who get ptad related anxiety, or other situational anxiety. There are also hard wired changes that take place over time (like OP said learned behavior) to increase a propensity for anxiety. And hard wired genetic issues. There's also chemical imbalances resulting from chronic trauma. And sometimes it is purely an organic chemical imbalance. But that's certainly not the only cause.

[@r.l.mcdermid6034]

@@-Datboijj- didn't know that you were a psychologist lel. Anywho, if it were all chemical unbalances then no amount of cognitive behavioral therapy would work. Guess what? It does! If it can be unlearned than it can be learned. :)

[@user-jm3ob3hl2t]

It's a learned behavior because no one is born with chronic anxiety. Anxiety causes chemical changes in the brain when it happens. The amygdala releases nenorephorine and addernaline and if it happens constantly those pathways in the brain are more easily activated which is an inappropriate response. Basically a chemical imbalance due to the way some people's brain developed and is caused by stress and trauma previously.

[@mms7146]

loved the video. What Uni year is this supposed to target?

[@Cathy-ux9xd]

I have a high 5-hiaa urine result. I’m trying to understand why.

[@zakirzak1494]

@2:16 5HT1A -is it presynaptic or postsynaptic??? .... I thought it is presynaptic as it is a reuptake auto inhibitor via the feedback

[@leahwhite1712]

It is my understanding, and I may be wrong so someone correct me If I am: basically, it is both. It is a presynaptic receptor on serotonergic neurons, so neurons whose primary role is to release serotonin. In this way, it is inhibitory and autoregulates (so if 5ht bound to the presynaptic 5ht1a autoreceptor, it inhibits further release of 5ht..negative feedback loop, self-regulating). There are also 5ht1a receptors, primarily in limbic system, that are postsynaptic receptors on neurons whose primary role is to release modulators that are NOT serotonin. This postsynaptic 5HT1A heteroreceptor is also inhibitory, in that it can dampen the limbic system response by ceasing / lessening firing rates, regulating stress/anxiety in that way. So basically, it is found in the brain as both, both a presynaptic autoreceptor and postsynaptic heteroreceptor. Hope this helps!

[@bobbysmith36]

PERIOD

[@sorianasor9730]

why stimulation of serotonin receptor a2 lead to depression

[@mwaqask1]

Because it inhibits the release of dopamine and norepinephrine in the prefrontal cortex.

[@psych0pharm]

im waiting for the 1a's to be classified as a nootropic

[@thealgorithm4429]

5-HTP provides a great source of serotonin for the brain to munch on. It is extremely affordable as well.

[@SItgix]

please be careful when you spout out misinfirmation online, 5HTP is NOT a good source as it raises systemic serotonin and not only in the brain. 5HTP bypasses tryptophan hydroxylase (the amount of tryptophan metabolized is limited by the body with that process) and can therefore lead to too high serum serotonin levels in the body which have shown to be carcinogenic.

[@thealgorithm4429]

@@SItgix do you have a source for this information? Are you talking about short-term, or long-term use? People who use 5-HTP are already in the "low serum-level" category, they would need heavy long term exposure to face a dangerous level, if taken correctly, under the watch of a physician. I won't believe that high serum-serotonin levels are carcinogenic in humans either, until some reliable source is provided.

[@lebest8415]

Its actually bad for the heart because some of the 5htp is converted to sertonin in the blood which cause heart problems

[@BaconNCereal]

That shit hurt my kidneys

[@morganamarianana3088]

ok my serotonin is very low. wtf do I do

[@chickenmuffin]

Take some 5htp

[@lightshadow3101]

To complex I don’t understand it.):

[@philipm3173]

You can't jump in and expect to understand it if you don't have any background. First you need to read up on what receptors actually are and how they work on a basic level.

[@Sci-Co555]

so how can u enhance 5ht if it is depleted ?? how can you replenish it first ?? from my understanding it release it but if it depleted you get a headache

[@NSachs-tx8xb]

By taking SSRIs and 5htp.

[@taaj4403]

N. Sachs yes. It’s worked for me.

[@daveland2653]

I use L-Tryptophan as a supplement.

[@thealgorithm4429]

@@NSachs-tx8xb never take those at the same time. Both are effective, but potentially deadly in combination.

[@dinazzzzzzzzz]

Bapak susah

[@mariyajacob4107]

Thanku