This is amazing, it's impossible to find quality pharmacology content like this on youtube.
@booksgaming14263 жыл бұрын
I'm really loving the journal references at the bottom, as well.
@vegetossgss1114 Жыл бұрын
What about microglia?
@iamthefiremanjj Жыл бұрын
With 5htp people take way too high of a dosage! It's nice to start out low like 10-20mg and taking it around 12-1pm is best because the serotonin boost is actually stimulating, have it with green tea for the ECGC. Later on, the serotonin will be able to be converted to melatonin and you will have better sleep as well! This is a good time because 5htp can raise cortisol levels, and we start to trickle down cortisol in the afternoon!
@Emadagban7772 жыл бұрын
Excellent explanation. I couldn't find such a clear and thorough yet concise information on this topic elsewhere.
@kovacsmihai70225 жыл бұрын
I found the video to be quite helpful. Thank you and keep up the good work. You've earned a new subscriber
@melmars67603 жыл бұрын
Such a helpful explanation. I had to go check out David Nutt and his research, as well as the Institute. So helpful for outlining the difference for 5ht1a and 5ht2a for me
@Ace-od8en4 жыл бұрын
This was so good I subscribed. Quality content 👌 amazing British voice. Intelligent, authoritative and mature. I was looking for a very deep, scientific explanation and I found it. I will be exploring more of your channel and content. Thanks.
@augustishotinaugust28974 жыл бұрын
I wish they had much more information on what exactly dxm does to the brain and body
@thebachu7863 жыл бұрын
a very well done video, great information content. crisp delivery!
@ParallaxView1112 жыл бұрын
I would like to suggest this lecture demonstrates why a person's diet should be examined before going the pharmaceutical rout. For example how much tryptophan is in a vegan diet vs a diet that includes animal products: milk, beef, fish, chicken. These are the highest foods in tryptophan. Look at the actual milligrams per gram, not just weather or not a food contains tryptophan.
@arsh9253 жыл бұрын
I am so glad I found this channel ❤️
@ConnoisseurOfExistence2 жыл бұрын
Super informative, thanks!
@aishaakhterakhter5384 Жыл бұрын
Thank you so much.
@5-ht2a4 жыл бұрын
amazing
@yogi9631 Жыл бұрын
GREAT INFO
@vegetossgss1114 Жыл бұрын
What about microglia?
@natecooper94574 жыл бұрын
You had me at mdma
@mariyajacob41074 жыл бұрын
Thanku
@Azur_Vita2 жыл бұрын
Are thete natural ways to increase 5-HT e.g. MDMA ?
@philipm3173 Жыл бұрын
Meditation. MDMA will actually leave your 5-ht levels lower (well technically it will downregulate the receptors) afterwards if used to excess.
@ivannovoselac35183 жыл бұрын
I was thinking that anxiety is learned behavior not chemical imbalance?
@msgirl013 жыл бұрын
Like most mental health issues it's usually both.
@-Datboijj-3 жыл бұрын
@@msgirl01 no its all chemical imbalance
@msgirl013 жыл бұрын
@@-Datboijj- what about people who get ptad related anxiety, or other situational anxiety. There are also hard wired changes that take place over time (like OP said learned behavior) to increase a propensity for anxiety. And hard wired genetic issues. There's also chemical imbalances resulting from chronic trauma. And sometimes it is purely an organic chemical imbalance. But that's certainly not the only cause.
@r.l.mcdermid60343 жыл бұрын
@@-Datboijj- didn't know that you were a psychologist lel. Anywho, if it were all chemical unbalances then no amount of cognitive behavioral therapy would work. Guess what? It does! If it can be unlearned than it can be learned. :)
@user-jm3ob3hl2t3 жыл бұрын
It's a learned behavior because no one is born with chronic anxiety. Anxiety causes chemical changes in the brain when it happens. The amygdala releases nenorephorine and addernaline and if it happens constantly those pathways in the brain are more easily activated which is an inappropriate response. Basically a chemical imbalance due to the way some people's brain developed and is caused by stress and trauma previously.
@mms71463 жыл бұрын
loved the video. What Uni year is this supposed to target?
@Cathy-ux9xd2 жыл бұрын
I have a high 5-hiaa urine result. I’m trying to understand why.
@zakirzak14943 жыл бұрын
@2:16 5HT1A -is it presynaptic or postsynaptic??? .... I thought it is presynaptic as it is a reuptake auto inhibitor via the feedback
@leahwhite17122 жыл бұрын
It is my understanding, and I may be wrong so someone correct me If I am: basically, it is both. It is a presynaptic receptor on serotonergic neurons, so neurons whose primary role is to release serotonin. In this way, it is inhibitory and autoregulates (so if 5ht bound to the presynaptic 5ht1a autoreceptor, it inhibits further release of 5ht..negative feedback loop, self-regulating). There are also 5ht1a receptors, primarily in limbic system, that are postsynaptic receptors on neurons whose primary role is to release modulators that are NOT serotonin. This postsynaptic 5HT1A heteroreceptor is also inhibitory, in that it can dampen the limbic system response by ceasing / lessening firing rates, regulating stress/anxiety in that way. So basically, it is found in the brain as both, both a presynaptic autoreceptor and postsynaptic heteroreceptor. Hope this helps!
@bobbysmith365 жыл бұрын
PERIOD
@sorianasor9730 Жыл бұрын
why stimulation of serotonin receptor a2 lead to depression
@mwaqask1Ай бұрын
Because it inhibits the release of dopamine and norepinephrine in the prefrontal cortex.
@psych0pharm3 жыл бұрын
im waiting for the 1a's to be classified as a nootropic
@thealgorithm44293 жыл бұрын
5-HTP provides a great source of serotonin for the brain to munch on. It is extremely affordable as well.
@SItgix3 жыл бұрын
please be careful when you spout out misinfirmation online, 5HTP is NOT a good source as it raises systemic serotonin and not only in the brain. 5HTP bypasses tryptophan hydroxylase (the amount of tryptophan metabolized is limited by the body with that process) and can therefore lead to too high serum serotonin levels in the body which have shown to be carcinogenic.
@thealgorithm44293 жыл бұрын
@@SItgix do you have a source for this information? Are you talking about short-term, or long-term use? People who use 5-HTP are already in the "low serum-level" category, they would need heavy long term exposure to face a dangerous level, if taken correctly, under the watch of a physician. I won't believe that high serum-serotonin levels are carcinogenic in humans either, until some reliable source is provided.
@lebest84153 жыл бұрын
Its actually bad for the heart because some of the 5htp is converted to sertonin in the blood which cause heart problems
@BaconNCereal2 жыл бұрын
That shit hurt my kidneys
@morganamarianana30882 жыл бұрын
ok my serotonin is very low. wtf do I do
@chickenmuffin2 жыл бұрын
Take some 5htp
@lightshadow31014 жыл бұрын
To complex I don’t understand it.):
@philipm3173 Жыл бұрын
You can't jump in and expect to understand it if you don't have any background. First you need to read up on what receptors actually are and how they work on a basic level.
@Sci-Co5554 жыл бұрын
so how can u enhance 5ht if it is depleted ?? how can you replenish it first ?? from my understanding it release it but if it depleted you get a headache
@NSachs-tx8xb4 жыл бұрын
By taking SSRIs and 5htp.
@taaj44034 жыл бұрын
N. Sachs yes. It’s worked for me.
@daveland26533 жыл бұрын
I use L-Tryptophan as a supplement.
@thealgorithm44293 жыл бұрын
@@NSachs-tx8xb never take those at the same time. Both are effective, but potentially deadly in combination.