SL: Dr. Fung on Fasting & Autophagy

[@Physionic]

Don't hate the hater, hate the game... or something like that. :) (Subscribe, & Share, please)

[@Honeypepper.]

😄 "Don't hate the player, hate the game! Who's the player here, you or Dr. Fung? Just kidding

[@Pollito27918]

Thank you for the video!

[@Zothiqueness]

I know this is an old video but I need to ask you a question. I recently started an extended fast, recently diagnosed with diabetes, a1c was 7.3. I have been doing keto for a few months, not really enjoying it so I decided to do a long fast, I have in the past with no problems (before diabetes). I am not on medications as of right now. My blood sugar had been in the high 70s for the majority of the day, but as I approached the 96th hour, I started feeling extremely light and dizzy, tired, despite having had plenty of salt. I checked my blood sugar and it had dropped to 65 and I ended the fast. From what everyone is saying this should not have happened. Why did this happen to me? Does this mean my metabolism is just too broken? I really would like some answers. Thanks.

[@oolala53]

@@ZothiquenessI did TMAD for 3-week stints- not nearly the fasting of NINETY-SIX hours, but my bg got into the 60's multiple times. I am not surprised it dropped to 65 after 96 hours. It's possible it would not have continued to drop. Were you wearing a cgm? In any case, although tons of people are doing it, going more than 72 hours water fasting without supervision I have read is considered risky. Good luck, though with lower A1c. I guess the keto is new too? I couldn't pull it off. See Dr. Roy Taylor for an alternative, though no party. If I got an official diagnosis- I am still in normal range, but it had been rising, so I've been browsing- I'd do his protocol before trying keto.

[@DrYawningMoon]

​@@Zothiqueness Hi. A doctor here. Mainstay for reversing insulin resistance is weight loss, be it through fasting, keto, plant based or portion control, the goal is achieving calorie restriction, and should be done in a way most comfortable to you and to which you can stick to for a longer term. Prolonged fasting may be a quick approach but may not be the best approach given it cannot be sustained. Switching to intermittent fasting may be a viable tool for you given it is just a less severe form of fasting. Sugar less than 70 is classified as Stage 1 hypoglycemia with only weakness and other mild symptoms. But since you had dizziness at 65, it is a little worrisome. I would advise against a longer fast. It's best if you stick to less severe forms of calorie restriction. No need to worry about a broken metabolism or anything.

[@bing4126]

I dont think he actually means cutting calories wont make you lose weight. I think he means as a weight loss strategy trying to simply eat less calories is inefficient.

[@Physionic]

Do you know what he'd recommend, then?

[@PT121551]

When you eat less calories, your body will trigger also lower metabolism rate. So if later and you eat the same amount before you start cutting calories, you will gain the weight back. When you fast, you will allow the body to burn fat. When you eat, you are to eat good (whole) food, food that allows you to be satiated and not empty calories like a brownie.

[@_BhagavadGita]

@@Physionic It seems you are attempting to shift the goal post.

[@cw9007]

@@Physionic Obviously he recommends IF and eating very few carbs. I have personally found that by eating 20g of carbs a day and only eating in a six hour window I have lost nearly 30lbs and kept it off for over a year, despite eating about 600-700 calories more than I did on my previous diet that was high carb, low fat. The only way I ever lost weight before IF and keto was by restricting calories to below 1000 a day and it was unsustainable because I was constantly hungry.

[@whoah567]

Yes, I have seen other videos where Dr. Fung mentions that yes cutting calories does work to a certain extent, but he's skeptical that cutting calories alone will work long term for most people because of the change in metabolism it produces and the effort involved. He generally promotes intermittent fasting and low carb diet but not calorie counting. But indirectly he does encourage people to cut calories sometimes because he encourages people who experience weight loss plateaus to lengthen their fast over time, which at some point is going to cut calories, especially once you get into 24 hr or longer fasts. Not to mention the foods that people usually overeat contain carbs. If you're truly sticking to a low carb diet you will likely eat less calories without even thinking about it.

[@YCYMXXTT]

I m Dr Fung Fan, my wife follows his advice and success in reversing her type 2 diabetes. But I also like your way of explaining based on the scientific results, good work!

[@Physionic]

I'm really glad your wife is doing better, ChengYC. His advice is overall solid. Thanks!

[@LTPottenger]

He doesn't say you won't lose weight from CICO he says you will gain all the weight back 99.5% of the time when you are obese and cites studies to show it's true, while with fasting the success rate is much higher.

[@ianfraser2009]

That is correct. He does not say you won't lose weight with CICO. The body adapts and you have to cut more calories. I would Recommend Dr Jason Fung to anyone and recommend his book to people. The Obesity Code

[@LTPottenger]

@@ianfraser2009 Same applies to exercise. That is why I only do cardio on fasting days. Otherwise it's just another form of calorie cutting.

[@ianfraser2009]

@@LTPottenger I do weight training when I'm fasting. Get your body to drop insulin levels and you start to tap into your fat for energy. I would Recommend his book. Thanks for your reply.

[@ianfraser2009]

@@LTPottenger I would Recommend you check out Benjamin Bikman PhD. Here is a link m.kzbin.info/www/bejne/bWPOoZWAhrScftk&feature=share

[@luckyhanger1326]

Every diet has a high failure rate, some folks have done fine with calorie restriction, many don't. Not many can succeed at fasting. Me, I eat a low fat high carb diet and have a BMI of 23. I eat allot of food. 😁

[@aliceinwonderland1120]

Thanks for the careful analysis. Your rebuttals seem a bit nit picky; they don’t undercut Dr Fungs key points or his practical advice on fasting and low carb eating. I have a brother who had been diabetic for years and had a toe amputated. He read Dr Fungs research, went keto and OMAD, lost 45 pounds and no longer takes insulin. He is officially no longer diabetic. He is pretty mad at conventional medicine who never told him there was a natural way to beat diabetes. He thinks Big Pharma and mainstream medicine have a vested financial interest in not letting the IF/keto natural remedy be known. Despicable.

[@LaurieR2255]

Dr. Fung's program works. Period. I have read all of his books. They make a lot of sense.

[@markdalton3834]

5:13 counting calories alone doesn't address the timing of hormonal response and the continued release of insulin throughout the day. Dr. Fung is saying that fasting and being fat adapted allows you to control hunger better than to just count calories a thus is not as sustainable to fasting.

[@sumosumo888]

I think dr Fung talks about autophagy as a general tool during general fast to prevent cancer. He has acknowledged many times that diseases and cancer when too advanced can no longer be cured. Prevention is what he is advocating

[@Physionic]

Understandable, but autophagy doesn't always prevent cancer, either.

[@sumosumo888]

@@Physionic certainly. But he is saying it helps. There are many reasons why cancer can occur. Dr Fung I feel is a pretty level headed doctor

[@GodofGamesss]

@@Physionic Sure, but you could also say that our immune system does not always prevent cancer. Even though our immune system is actually one of the biggest factors in preventing cancer. Just because autophagy wont always prevent cancer does not mean it's 'useless' or what ever point you seem to try to get across.

[@mitzitakes522]

Also, it’s not just autophagy that can bring on healing. There are so many factors that can prevent healing, such as emotional trauma, stress, diet, environmental stressors, emotions, etc.

[@tomgorham5599]

If you disagree why not have a video where you debate with him on some of these topics.

[@Physionic]

That's be fun. I have my doubts he'd be interested, but I'd be open to having a discussion with him.

[@firmbeliever3847]

@@Physionic ask him

[@joecampbell2784]

That seems to be the fair way. One on one. Give him a chance to react to your criticism. It's not scientific but everyone I've known that tried calorie restriction failed. I remember someone saying that is why the TV show Biggest Losers never have a reunion show.

[@fareshajjar1208]

Because he is theorist who reads books and Dr. Fung is a clinician who treats thousands of patients. Would be a waste of time for all.

[@DanhNguyenCong2024]

@@fareshajjar1208 Dr. Fung is CURRENTLY practicing the principle. Real patients, real result! I can't agree with you more!!! Tks.

[@terrywhelan6651]

9 out of 10 people who cut calories generally head back to their old ways because you have treated the symptom not the cause. The cause is we eat too much too often. A low carbohydrate lifestyle like keto with intermittent fasting has saved my life and I will never be 320 lbs again. Today 195 lbs with 18% fat, 62 year old Canadian Male achieved in 3 years.

[@Physionic]

That’s a good way to put it, Terry. I agree we eat too much and too often. Keto is a great way to go.

[@terrywhelan6651]

@@Physionic Dr. Fung talks about his patients failures in general terms. Cutting calories does work but if you never get truly fat adapted you never solve the problem. Fasting is the best tool to cross this barrier, I tried beer for years but unfortunately it never worked. The problem with fasting is the pharmaceutical, fast and processed food industries don't make anything off it. Giving a type 2 diabetic insulin is like giving an alcoholic a bottle of whiskey. You just take the sugar and stuff it into your eyes and small blood vessels killing everything slowly while making the patient more obese. They never mention 93% of all people hospitalized with coronavirus are obese while nearly everyone who has symptoms has high insulin resistance and or a fatty liver. Insulin somehow negatively effects the lymphatic and immune systems. It's also strange how people like Republicans who live a great distance from the oceans seem to have mineral deficiencies from iodine, potassium, magnesium, chromium and zine not to mention omega 3's and many B vitamins if not most of them. We can talk about this another day. Don't take Dr. Fung literally when he's talking in general terms, he's a good man who is doing what doctors are supposed to do, he's saving lives including mine. Take care

[@joseromero81]

I'm a fan of Dr. Fung. But it's good to have objective analysis. This is what science is.

[@Physionic]

Thanks, Jose. I appreciate the balanced approach you have.

[@mathfaster]

I've listed to a lot of Dr. Fung's videos and have a couple of his books. Usually when he talks about calories in calories out not working it's in the context of long term weight loss which IIRC has about a 95.1% failure rate. Not sure why he didn't add that to his explanation.

[@Physionic]

Thats certainly a fair critique, but the concept of calories leading to weight loss is correct. Like I mentioned, that ultimately leads to physiological changes that make the process of weight loss more difficult, but the calorie is immune to physiological implications.

[@atty.karissatolentino-maxi7197]

Correct. When i listened to his videos, he said the calories in and out is not working for long term. Maybe he said it prior to that statement and he didn't restate it anymore.

[@andrewj4426]

What Dr Fung means is real world examples. Intermittent Fasting or low carb is easy for most people. Counting calories and food deprivation is very hard to stick to long term in the real world. that is what he meant but did not explain correctly.

[@natb9919]

@@Physionic Right but your body doesn't know how to count calories, humans made the concept up for our own understanding. Someone could consume only 1200 calories of brownies everyday and not lose any weight because their insulin would always be high.

[@grahamedwards6824]

@@Physionic when I am fasting I'm consuming zero calories. What's the problem?

[@mikeward9870]

The most useful correction is about MTOR and AMPK functionality (because it explains why there will likely be no better way to activate generalized autophagy than actually fasting).

[@barbarashirland9078]

That was the most clear simplified explanation of MTOR and AMPK I have ever heard. I plan to search your channel for more info on autophagy. Thank you.

[@wilmerwalton5089]

It's appears the regulating mechanism allows greater autophagy during fasting, than under Dr. Fung's explanation. I feel motivated to move-up the date of my next long fast.

[@ramblinrozz2242]

I tried to lose 80 pounds, I tracked i worked out . I lost the first 30 fairly fast, then struggled for 2 years trying to lose the rest. I often would drop calories to 800 a day for several weeks with no results. After 2 years I gave up only 40 pounds down. I did find I had a thyroid problem near the end of the 2 year period. I do wonder if the calorie restriction caused it. I a. Now on low carb and IF and my thyroid problem is gone. Dr. Had told me I would always need meds.

[@shannonmarko6809]

There have been scientific studies since the 1800s proving that calorie restriction doesn’t work long-term. 98% of people who lose weight can not maintain it. The last three times I calorie restricted I lost over 100 pounds each time and gained over 100 pounds back each time. Calorie restriction turned me into a binge eater as my grehlin went psycho. Calorie restriction turned me into a participant in the Minnesota starvation project, suffering multiple health concerns. I’m fasting and doing carnivore right now, and for the first time in my life my hunger is not an issue. I eat until stuffed! I’ve never done that in my life calorie counting and was always left wanting/deprived. I didn’t finish the video yet, but I had to write this. 👍🏻

[@Physionic]

I've heard that a few times, but the real culprit is dieting without having long term behavior changes. I wouldn't deny that most people regain the weight they took off from dieting, but I'd maintain that it's because they don't have a sustainable way of going about their weight loss. Ultimately, all nutrition styles that cause weight loss necessitate some form of calorie restriction, if its measured or not. I also wouldn't deny that fasting and/or carnivore can be highly effective - sometimes more effective at long term weight loss, but I'd still argue it's because of calorie restriction and having a simpler plan for maintaining that weight loss after the weight loss is achieved. Not to pit n=1 against n=1, but I've had an easy time changing my weight by counting calories, and I've helped others do the same (along with other nutrition strategies), and am part of several groups with literally tens of thousands of people who have lost weight by counting calories (and maintained it for years). It's not the best for everyone, I acknowledge that, but I do think calorie restriction is often confused with dieting, when there are subtle differences that make one 100% successful and the other, as you mentioned, a far cry from successful. Glad you're having success - thanks for chiming in, Shannon.

[@shannonmarko6809]

Cancer. Was it Dr. Fung who said, just one 7 day fast a year can help prevent cancer? And what about Jean-Jacques Trochon? He eliminated his cancer via fasting. I agree that not all cancers can or will respond to fasting, but surely some must? It’s not just autophagy occurring, right, there’s apoptosis.

[@andrewberg6961]

@@Physionic Thanks for all your careful work for us. (I'm a member---I hope that helps get a reply). I don't exactly disagree with your disagreements, except that I think you are perhaps a bit narrow in some of your arguments that he is "wrong." I think Dr. Fung's underlying point, which he skipped over here, is that in general neither calories out nor calories in are independent of each other or of the level of calorie restriction more specifically So while of course if you create a net energy imbalance weight will indeed go up or down, this is not as useful a thought as it might seem at first. The slowdown in BMR in response to a calorie deficit is one example. But so is changes in NEAT. Another example is the (short- and longer-term) response of Ghrelin and other hunger/satiety hormones to calorie restriction. In light of the latter factor, it's true of course that this speaks to long-term behavior, but it also suggests that "will power" is not in itself the answer, at least for most people. Does that make sense to you? Thanks, Andy

[@preteengal6962]

Good conclusion. On the overall, we give credit where it's due. Dr Fung is Godsent to improve our health that had gone down the drain over a very long period of time esp. diabetics T2 more than anyone else has ever done. God bless you Dr. Malice won't work. Just work together for better results.

[@1122redbird]

I cannot make any coherent sense of your remark.

[@Honeypepper.]

That's right! I love how you are unafraid to go after the big guys! Ain't nobody perfect😎

[@Physionic]

Thanks, WH! I'll admit, these type of videos also gain more traction, so its enticing, but I try to be fair in my critiques.

[@stratogustav]

@@Physionic Uninformed though, and taking things out of context is not fair critique. Epic fail on your critiques. As a losing strategy it has been proven over and over again that decreasing calories just isn't effective for the big majority of people. The reason is that people forget that insulin goes down while they sleep because they are not eating, so if they reduce calories they can lose weight then, or lose water weight during the day because of exercise. The body won't allow to use the storage unless your insulin is reduced. If your foods are low glycemic you can lose some weight during the day too because your insulin will be relatively lower, also if you are not eating all the time if course, but nothing will be as potent and efficient as straight up fasting because your body will use the storage. So thermodynamics never gets contradicted here, as you claim, you will still breath out the fat, but whether is what you just ate, or your storage, depends of your insulin. About autophagy, if bone broth gives you protein it gives you energy so it will reduce autophagy, so Dr. Fun us correct there too, plus it has been proven that amino acids directly trigger mTOR, so Dr. Fung is correct again. And about the body being smart searching for useless protein it has been empirically proven with visual evidence over and over again of people losing weight while triggering gluconeogenesis that they end up without loose skin, as opposed of people doing dirty fasting or reducing calories without triggering gluconeogenesis that end up with significant more loose skin. I lost a skin tag I had on my underarm all my life the first time I did a prolonged fast, so if that isn't the body being specific, then I don't know what is, scar tissue, stretch marks, disappearing on people fasting, the evidence is overwhelming. You need to make a video apologizing for how out of context you took everything on this video, and the things you were misleading people on.

[@lassunsnachSueden]

As a fellow researcher (but from a very different field) I really appreciate your videos.

[@Physionic]

Thank you!

[@Lethmyr_]

I think a strong point for Dr. Fung is that he is actually using fasting in his clinical practise and does improve the health of his patients. Concerning kcal Dr. Fung elaborates on that in his talks. He does not deny that it will lead to short term weight loss. But most of the time it does not work long term (over 2 years) for most of the people because a caloric deficite alone will long term just reduce the BMR. The most important factor for long term weight loss seems to be exercise because you increase your BMR longterm. The whole "thermodynamic" argument does not make sense. Your body is not a fixed system. You burn different calories differently and your body adapts its energy output based on your activity and based on what you eat. Eating 1500kcal of mainly fat and proteins compared to 1500kcal of sugar will definitely have different long term results on your weight loss and performance/health. Insulin resistance and leptin receptors are a huge factor in weight loss.

[@jimstormcrow]

We should remember that Dr. Fung is not the editor of this video.

[@Physionic]

He is the speaker of his words.

[@jimstormcrow]

@@Physionic but are all of his words being presented? Does he explain what he means more fully in a segment cut from the whole? I'm not a follower of his but I wonder how much of the conversation is trimmed to fit the required running time.

[@caroldiano6626]

What Dr fung meant to calories in calories out failed is for during insulin is high...but Dr Fung also recommend to less your calories amount if you want to loss weight but you have to keep your insulin low so that your metabolism will not suffer

[@richevans3643]

I am a. Dr. Fung fan.. big-time! I appreciate the science!! Great job!!

[@Physionic]

Thank you, Rich.

[@RaviPatel-wi7xk]

I just discovered you and have been binging your videos for the last 3 hours! LOL I'm learning so much. Appreciate the effort.

[@Physionic]

Thank you, Ravi.

[@tasst2674]

Thank you for your video, but the title is deceiving. Perhaps you should speak to Dr. Fung in person so he can respond to your understanding of his comments rather than picking apart his comments in excerpts of an interview he did. No one is right 100% all of the time, but each of us should be able to defend ourselves.

[@jimbort_de_breces]

At this point in time my go to sources for health, nutrition and longevity related science are: Jason Fung, Rhonda Patrick, Peter Attia, Gil Carvalho, Valter Longo, Michael Greger and Nicolas (from the macro to the micro) Verhoeven

[@hamiltoneast]

Overall, this seems like an "accurate" critique of Dr Fung's words. Much of it, however, takes Fung's words literally when Fung was taking short cuts to simplify his points. A face to face debate would prevent Nicolas from appearing to be taking cheap shots. Sure glad that I don't get my words parsed so strictly cuz I'd have to shut up, permanently.

[@josephyoung5204]

Does anyone know where I can watch the full interview?

[@Foto22417]

Thank you for this video. I appreciate the humor, but not your assumption that Dr Fung's followers can't be sensible and willing to hear counter arguments and learn more. It also makes you sound arrogant. I have followed Dr Fung's advice. Others have clarified that when he talks about calorie counting not working, he's talking about long-term behavior. That is, most people won't stick to it long term because it's a lot of work. In addition, he has mentioned that resting metabolic rate lowers as calorie consumption lowers, so that means that low-calorie diets become impossible to keep up at some point because the weight loss stalls despite the restrictive diet, and that discourages people from continuing. Anyway, thanks again! I'm really interested in the cancer-related info too.

[@Physionic]

My pleasure, Foto. I've had my fair share of Dr. Fung fans that have blindly attacked me; the same is true for fans of other people I've fairly critiqued, so although its not necessary, I do poke fun - if I come off as arrogant, that's unfortunate. I can see how calorie counting, itself, may not be feasible for everyone, but ultimately, caloric restriction is an immutable law to weight loss. Right, there are reductions in metabolic rate, but there are techniques for rejuvenating it and continuing down a weight loss period. No doubt a slowing of weight loss can be discouraging, however. Sure thing, I have more on fasting and cancer, if you're interested. Thanks for chiming in!

[@rema9147]

@@Physionic I see very few comments attacking you. Most were explaining their understanding of calories in and calories out. My understanding is that focusing on calories for weight loss hasn’t worked for many. Restricting calories should work but in practise it hasn’t. It would have been good if you challenged Dr. Fung over issues that ytouy believed to be not true. That would hgave made your interview more credible. Lastly, the statistics over calories diserves explanatioin on the data that were collected.

[@larshader9265]

I am a new subscriber so I am going through some of your old videos. You said calorie restriction below your BMR will result in weight loss, which it does. But if you reduce calories below bmr for too long your BMR set point will reduce. ie Biggest losers contestants that greatly reduced calories but eventually but put weight back on when they started eating "normally". Have you addressed this previously or could you address it in a future video?

[@karlkelman4485]

Plenty of animals respond to caloric restriction by simply reducing expenditure to bring themselves back into balance and avoid significant weight loss. Yes, cold-blooded animals can be better at this than mammals. Obviously, a big enough caloric restriction can't be overcome. But, I've read about studies showing minor caloric restriction in humans may just lower metabolism enough to restore balance, preventing weight loss. It's complex.

[@winstonvillamin8863]

It seems Dr. Fung is stating his hypothesis or theory on how authophagy works. Who knows, he maybe correct after all.

[@ChefBeauRD]

Dr. Fung states there is no "Muscle burning" during a fast, yet he then states that during the window of gluconeogenesis, that amino acids are used from protein until the primary fuel source switches from carbs to lipids/ketones. If so, though perhaps not significant enough to be labeled "Muscle burning," lean tissue loss would not be considered zero?

[@shaunnasworkshop]

Great job as always! So, are the following take aways of mine accurate? 1. For extended fasters (>3d), autophagy will be in high gear. If a person has, say a tablespoon of cream in coffee, it will have minimal effect on autophagy, because even if it causes a dip for a short time, the AMPK will otherwise be responding to the extreme deficit in energy (e.g. 100 calories a day after 3 days of zero calories is still going to trigger AMPK)? 2. Is there a known threshold where AMPK registers the energy as "low, initiate autophagy"? (Like, >10% basal metabolic need, etc?) 3. Do you know where the fasting community gets this idea that 4mg of protein is all it takes to stop autophagy?

[@Physionic]

Hey CI, I'll try and get to your questions tomorrow. I assume for #3, you mean 4 *grams* of protein?

[@shaunnasworkshop]

@@Physionic yes, though the community culture has come to add carbohydrate as a reason, too.

[@Physionic]

1. Right. 2. Not in an absolute number sense - it is potently stimulated by accumulating AMP, which would mean a pretty drastic decrease in cellular energy. 3. No, and I can say its BS, because of the absolute nature of the number.

[@shaunnasworkshop]

@@Physionic Thanks for the reply! I think I'm getting this. :)

[@zoopi451]

Valter Longo has studies showing that fasting mice before chemotherapy improves outcomes. One explanation I've heard is that cancer cell create a very hypoxic environment in center of the tumor and they release ROS so authophagy is a protective mechanism keeping them alive. And authophagy can be increased only so much so when you fast cancer cells don't have much room to increase it but normal cells do. So in effect you are making normal cells more resilent without the cancer cells getting much more resilient. Some evidence towards that idea is a study that turned off authophagy in cancer cells and the cells in the middle of the tumor died off. (don't really have links to the studies coz I heard them in a podcast) I know it's not your field but it'd would be interesting if you can make a video talking about Thomas Seyfriends ideas about cancer. He goes against the mainstream ideas that cancer is a genetic disease and argues that it's caused by the mitochondria. As a layperson idk if he is right but his experiments transferring the nucleus of a cancer cell and it producing normal cells and the reverse when he trasfers the mitochondria of a cancer cell into a normal cell and it produces cancer cells seem like really strong evidence for his beliefs. So I'm curious if you have any counter argument or explanation of why he may be wrong?

[@zoopi451]

I think this is his study with the experiments www.ncbi.nlm.nih.gov/pmc/articles/PMC4493566/

[@Physionic]

Hey zoopi, I've covered some of Dr. Longo's work on the channel, but I haven't gotten around to the ones on fasting and chemo - I've been meaning to get to them at some point - thanks for the reminder. As for Thomas Seyfriend, I'm not familiar with him. Fortunately, my degree spans over all the disciplines of medicine, and what you've introduced is extremely interesting to me. My current research is looking at mitochondrial autophagy. I'm absolutely curious to learn more on that idea, so I'll read into the review you supplied - I really appreciate it!

[@arielmalanga9303]

@@Physionic Longo is top-quality and credibility. He's actually a serious scientist.

[@tommymonroe8706]

Dr. Jason Fung is an incredible man!

[@DoggieFosters]

**raises hand** re: non-disbetics not becoming hypoglycemic: I was diagnosed 25 yrs ago with what the endocrinologist called "Fasting autoimmune hypoglycemia" (35 caught on random blood test,

[@flyoneagleswings]

Doctor Fung fan, But, I subscribed to your channel Because science is all about Challenging information. Thanks

[@Physionic]

I like people like you. Thank you.

[@SusanaXpeace2u]

You are missing the nuance, he deals with patients who cannot cut their calories, they have tried, and it can be a revelation to these people that it's easier to eat nothing than to eat in a restricted way. Abstinence is psychologically easier than perfect moderation. What dr jason fung needs is patients who lose weight. Dealing with people is different from submitting papers.

[@steveglobaltraveler3480]

When you discuss calorie reduction you maybe don’t consider the metabolism slowdown that occurs? Thanks and take care.

[@Physionic]

Sure, I don't deny that metabolism slows, but that doesn't change the energy of the calorie, so its still independent of the physiological changes (like metabolism slowing).

[@dialectixemcee2428]

according to what you're saying then I'll use his logic. 100 calories of coke vs 100 calories of beef do not burn the same way, even beyond "physics universality" the hormonal effect is much different, does protein not require more energy to burn than sugar? If I need 2k calories a day all other things equal, will my weight stay exactly the same if it all comes from chips, coke and twinkies vs veggies and meat?

[@headybrew]

"...that's not because tracking calories isn't effective. It's because people stop tracking..." Yes. That's exactly the point. It's dang near impossible for **most** people to do that forever. Dr. Fung knows damn well that CICO is true in the purely physical sense. But he also knows that you can't just tell people that and think your job is done. It doesn't work. Telling people to cut calories doesn't work. He's absolutely right when he says it. And you are straw-manning him by interpreting it as if he is speaking in a literal thermodynamic sense.

[@saveyourselves5923]

The "counting calories doesn't lead to sustainable weight loss" has always confused me. I've tried several methods and, surprisingly, the only thing that worked was the counting of calories. Sure, it's difficult. I'm a rather petite individual with a diminutive caloric need... but with an appetite that outstrips that of my six foot boyfriend by more than double. I usually walk ten thousand steps a day JUST so I can burn more calories and eat more without gaining weight. I also have candidiasis, which apparently is why I have INSANE cravings for carbs and sugar. Such is life.

[@larryk.watson2778]

We need all of you guys.. thanks for the content.

[@Physionic]

Thanks very much, Larry. I appreciate the kind words.

[@greghelton4668]

I watched a number of Dr. Fung’s videos. Outside the interview you used, I’ve never seen him claim excess calories doesn’t lead to weight gain. He’s pretty clear on that. I’ve also never heard him say all cancers are cured by fasting either. In fact he has a comprehensive video about how there are many different types of cancers cells in any given cancer patient and hence any one drug or treatment generally doesn’t work well in curing patients. It also seems he’s learning as time goes on. I also learned a few things from your video.

[@Physionic]

Thanks for chiming in, Greg. I’m glad to hear he’s become more nuanced. I appreciate that in a professional.

[@mpoharper]

He never said that cancer would be cured by fasting. In Cancer Code he is quite clear. His book was a fascinating read by the way.

[@Gregski3]

So is fasting the best way to get the autophagy? How many hours do you need to fast to start it?

[@steemitdoc4702]

Very informative video. As a big fan of various fasting methods, it's good to get a bit of a scientific "reality check" after watching so many pro-fasting videos.

[@Physionic]

Thank you, Steemit. I've enjoyed using fasting, myself. It's a great tool.

[@IonTrone]

You have much to learn Young Jedi! Reading research papers (assuming the researchers, conflicts of interest, and their funding network is fully vetted, and the mice in the labs were not conspiring to alter the results) and nitpicking on videos can be a fun exercise or mayhaps an attempt to get some science cred. We all like what we like to do :) But there's a huge difference between reading research papers versus having decades of real-world experience with thousands of real-world patients with real-world results, like Dr. Westman or Dr. Fung. The above are orders of magnitude more trustworthy (from the perspective of people/patients trying to figure out what to do) than someone reading research papers :)

[@tomgoff7887]

Yes, that's the probnlem with science. It doesn't always give us the answers we want. No worries though, there are always silver-tongued quacks and others who will tell us what we want to hear.

[@petercandance2330]

You should have a word with Dr Thomas Seyfried. His claim is that cancer cells cannot live on fats/fatty acids alone, they need glucose and glutamine, and that studies showing Cancer cell survival on fats/fatty acids still do contain either glucose or glutamine in their environments.

[@holirumicsfriend]

Great video! A lot of great stuff in this video, a lot of great stuff from Dr. Fung. Good to have such a detailed discussion! Dr. Fung could improve by not sayin, “right” am many times… people who say “right” a lot are usually trying to persuade rather than inform!

[@yunuscom]

You said that in some types of cancer, autophagy may do more harm than good. For example, if autophagy is applied for lung cancer, what will be the result?

[@sambocap]

Great video and appreciate your take on these topics. My question is who's funding the studies you reference in your videos? I think you know where I'm getting at....

[@nicola4594]

Hi Nic, really interesting what you said about cancer cells. When fasting would the body target killing cancer cells through apoptosis?

[@renaudli5834]

According to many testimonies online on fasting and cure of cancer, looks like autophagy kills cancer cells too.

[@toutounr8120]

I love the soundtrack in the beginning, what's the track?😊

[@Physionic]

From the youtube audio library, not sure of the track name.

[@firmbeliever3847]

So is fasting good or not? I think it is. When we get into the needy greedy we'll always find something off. Still think fasting is a great healing process.

[@Physionic]

Fasting is perfectly fine and can provide benefits.

[@ramankahlon4400]

What do you think about removing wheat/grain from diet to loose weight. I see many doctors are suggesting this nowadays. Have you read dr. William Davis wheat belly what do you think about that.

[@caroldiano6626]

Sometimes scientific knowledge has no successful result..Dr Fung preach what he saw and happenings to his successful patients

[@mitzitakes522]

I first tried keto (Atkins) in the early 2000’s and had to lose 10 lbs. I was exercising and doing weights at 1000 calories with no fat (and high carbs (5% fat only per day) . Couldn’t lose any weight for 3 weeks and was very bloated until I switched to Atkins. I didn’t count calories and ate as much h as I wanted. I lost about Je weight and saw more muscle than I ever had in my life, plus had lots of energy. Today, I have the opposite problem. I eat lots f good healthy fat and protein . I’m having a hard time gaining weight , exercise moderately (no weights yet, just aerobics). I count and must b consuming 1800-2100 calories per day. I’m 5’7” and skinny but I feel I’m losing muscle mass. I’d like to build muscle at 58 years old. Any advice? I’m starting light weights next week.

[@RashidaBlake]

I’m losing weight at a caloric surplus.🤷🏾‍♀️

[@jayhoughton4174]

Great video, and much as I like Dr Fung, I agree that he is sometimes "lazy" in his terminology, possibly because he feels that the majority of his audience do not need to know the absolute facts, just those that he feels are enough to convey the message. I've been trying to find some articles on how you can initiate autophagy, and there seems to be a lack of published information. I mean yes, there is discussion on fasting can help trigger it, but fasting is also referred to as less than (say) 600 calories a day in some studies, so will intermittent fasting of (say) 16:8 initiate it, or reduced calories in (say less than 600 a day), or will both of these lead to ketosis and therefore the energy produced from ketones will stop autophagy? As you are a researcher in this field, can you help clarify this? :)

[@NovemberRain313]

Wow, i never heard the energy produced from ketones can prevent autophagy!

[@jonathanmagic5633]

I appreciate the fact check, Fung does ramble and goes round in circles and not right on everything however I appreciate Dr's who are looking to explore the boundaries as mainstream medicine all too often has no answers for people.

[@r.f.pennington746]

I"m wondering if you have factored in the body's tendency to lower the basic metabolic rate when calories are restricted, setting off one of the survival mechanisms we tend to have. It may be slight for some, pronounced in others, but it is a factor in the "restrict calories-move more" argument. Just seeing your take on it. Most items aren't two-sided but multi-faceted.

[@Physionic]

Agreed, RF. I do think it's a factor to consider that makes fat loss more difficult over time. Although, there is a limit to that reduction. I have content explaining some of those studies.

[@andrewberg6961]

@@Physionic On this point about hormone reaction to calorie deficits, I have a question. Many note that these changes are quasi-permanent. For example, I've seen studies where even after one year after some discrete weight loss, the ghrelin and other hormonal response to food have not gone back to baseline. I've seen one study where even after four years, some of these hormonals levels (and BMR) are different for someone who arrived at a given weight after substantial. weight loss vs someone who was always at that weight. Do you know if there are any really long-term studies of this? If I lose 40 pounds say (as I did several years ago and mostly kept off), can I hope that over time, the process of normalization of my hormonal responses to food will continue and I will eventually look the same as someone who was always at my current weight , in this regard? Thanks

[@vaughanstarr3725]

I recognize you are responding to a single video and the arguments articulated therein, however when doing so it is only fair that what is known of an individual's position be used for context. Otherwise you run the risk of cherry picking a strawman for your own ends. Fung talks about long term cal restriction in the obese and how the overwhelming majority fail at this owing to metabolic slow down/adaptation. As as extreme illustrator of this he cites the Biggest Loser study which shows participants with substantially reduced RMR's. The failure rate of such is massive, obviously. Outside of this, using yourself, a young, lean, active male with a high degree of muscle mass as an example of how cal restriction can work, is not exactly an apples to apples comparison when we are talking about the obese to morbidly obese with little in the way of muscle or activity for decades. So why include such?

[@Physionic]

No doubt long term calorie restriction leads to initial weight loss and that can creep back up over time; however, it isn't much of a revelation to think that if you are on a diet and then stop that diet that you won't revert back to old eating habits. As for the changes in RMR, I'd look into my body set point podcast where I discuss the mechanisms for that. Finally, what's the solution then? Fasting? That always makes me chuckle, because its literally the same thing, just more extreme. You'll lose weight fasting, no doubt, and then what? And also, what does a fast do? It's the most aggressive form of calorie deficit. I think its a good way to go, but people make it out to be the second coming of Christ, haha.

[@vaughanstarr3725]

@@Physionic I appreciate the reply. I note that within such my opening observation that the snippet of video you respond to would not fairly be called representative of Fung's position is passed upon, as is my observation of your personal weight loss not being an apples to apples comparison when talking about the morbidly obese who have been largely inactive for decades. To respond to that which you did write: In the same way you don't need a weatherman to tell you when it's raining outside, anyone who goes upon a diet can tell you that things start out great, losing weight hand over fist, then slow, then stop. And that also, such an approach has a catastrophic rate of failure across decades of real world implementation. Not exactly the best hill to die on then. As to your statement that if people go back to their old ways upon diet failure the weight will go back up. Agreed. Especially if done so from a position of lowered overall metabolism. But if that is the argument, why stop there? Why not state that if they had not eaten that way in first place such a situation would never have developed? It's as accurate as your statement and also, just like yours, does absolutely nothing to solve the problem. Now, does fasting? I would not suggest such. Because to do so would be to embrace dogma. That some can point to RCT's in support of such dogma in no way altering real world outcomes when it comes to the implementation of such. After all, according to some, communism is a model of societal perfection...in theory. All diets result in caloric restriction and fasting is indeed the most aggressive of them. Will this deprivation be offset by windows of normal eating when it comes to the physical and psychological? Don't know. Can such an approach work for those for whom food clearly has a psychological dependence? Don't know. Does it offer huge benefits? In term of pronounced results, yep. Is it easy to implement? Arguably the easiest. Are there further health benefits to be had if consuming your cals in a very narrow eating window and fasting outside of such? One of your own vids talks of such. So, the second coming? No. But a viable alternative and under-talked about option when held against prescription which has totally failed in real world application? I would say so, yes. And perhaps that it s the best that can be hoped for when faced with a problem for which no approach has demonstrated long term majority success, or even anything remotely approaching such.

[@monicabostan1081]

@@vaughanstarr3725 I thoroughly enjoyed and agreed with your comments. The young gentleman in the video might have all the best intentions but let's face it, a better understanding of life, human body, everything around us really, stems not only from the amount of theoretical knowledge found in books, but from being alive long enough to understand how real life works. In other words, we get a better grip with age. If he had the audacity (for lack of a better term) to present himself (a young, lean, active person) as a compelling example for the "almighty" calories in-calories out equation in the face of all those morbidly obese people out there fighting for their life, he is clearly a long way from the said grip. Give him another 20 years or so. And some actual medical practice where he takes his nose off the books and looks at real human patients. Loved your communism analogy. As a concept, it looked great on paper but if one grew up in Romania during Ceausescu's regime like I did, one would have a better understanding of how theoretical concepts don't always apply successfully to real life. No malice intended on the young man here, wishing him the best of luck with growing and learning.

[@marianweigh6411]

No one I've heard, including Dr Fung, recommends fasting as the only thing you need to do. Different doctors have different emphasis points. But all the respectable ones also talk about cutting out refined sugars, processed foods, and 'vegetable' oils, and they recommend cutting carbs and/or eating whole foods (eat real food!). Fasting is a part of a total scheme for good health.

[@Allagi22]

Dr Fung claims cutting calories doesn't lead to weight loss? THE WHOLE REASON that fasting leads to weight loss is BECAUSE you are reducing your caloric intake. I can't take that guy seriously if he claims to be a MEDICAL DOCTOR and says that cutting calories doesn't lead to weight loss while also promoting fasting for weight loss. The mental gymnastics are staggering. Not to mention that this man is selling his books and promoting his channel. He has a financial reason for you to trust only HIS advice over proven weight loss advice, the most basic of which, is that a caloric deficit will ALWAYS lead to weight loss over the long term.

[@Physionic]

To be fair, I want people to subscribe to my channel, too. :) I agree with your overall first point, though, Allagi.

[@jamescalifornia2964]

Good information. I must do a fast for weight loss. It seems the most practical solution. KETO scared me with all that fat ... seems unhealthy.

[@Physionic]

Fasting for weight loss works well.

[@NoLefTurnUnStoned.]

Fasting is a good supplemental weight loss but rapid weight loss can be very easily regained, and some... You don’t need to go full Keto and high fat. 5 months ago I was diagnosed as pre-diabetic. I stopped eating: Wheat, gluten, all white carbs, beer, soft drinks, chips/crisps, any processed foods and all processed sugar. I eat tons of fish, green veg, lentils, beans, avocados, salads, nuts, seeds... Some apples, a little banana, papaya, berries... Some butter, goats cheese, Greek yoghurt... Small amount of “brown” non-wheat carbs like brown rice noodles, brown rice, buckwheat, potatoes, yam, sweet potatoes... I have an eating window roughly between 16:00 and 20:00 where I make easy to prepare delicious fresh food! I’ve dropped 11kgs in 5 months and still going...I’m not even doing enough exercise. Hunger is a thing of the past...I feel younger and my blood tests are improving monthly. You don’t need loads of fat, but if you avoid poisonous high sugar carbs, things like olive oil, avocados, olives, butter, yoghurt, goats cheese can be eaten as you like. It’s the unhealthy fats that should be avoided!

[@jimking6484]

Fat is burned in the mitochondria. Weight loss or fat loss? If you want to lose fat, eat clean, low glucose (Your body is required to store fat when insulin is present and it will release fat to burn for energy when insulin is not present.) Also, increase your exercise to (4) 60 nonstop minute zone 2 sessions a week at an intensity that you could hold on a conversation but it would be uncomfortable. Want to lose weight, fast but be aware that it’s not a exponential weight loss.

[@bobcocampo]

What is the best test to know if you are in Autophagy?

[@caroldanson5476]

I think he is referring to people who reduce calories but don't stick to the diet and gain it all back on. Also if you reduce calories and don't exercise your body will reset metabolic densnd

[@Physionic]

Understandable, Carol. That isn't an indictment of the calorie deficit, then, but rather a person's ability to stick to it. Metabolism does shift in any calorie deficit. Actually, I'll be releasing content on that next week. Thanks for chiming in.

[@BruceWedding]

I've become a huge fan of yours. Thanks for what you do. I'm not clear on one thing. Dr. Fung mentioned bone broth potentially halting or lowering autophagy. I've personally done a 23 day fast where I consumed a cup or so (10-12oz) of bone broth each day for the final 10 days. What impact does that have on autophagy? Empirically, I can say it had no measurable effect on my weight loss as I tracked it daily for the entire fast.

[@Physionic]

Thanks, Bruce. Bone broth might reduce autophagy slightly, but I'm sure you had it going at 90% or more throughout your fast, so I wouldn't worry about it.

[@danielswinger2986]

So do you think fasting is a good way to drop weight fast and keep the weight off?

[@Physionic]

Sure, if its implemented correctly, I absolutely do.

[@milanekrkane]

I think he means that ONLY cutting calories wont help with weight loss. Some people have no issue with that, but some people that ruined their metabolism cant simply cut 200 calories and eat 6 times per day... I think he argues that. Because if you watch his videos he mentions that kind of scenario a lot of times

[@callmeqi]

True or not the calories calculating works, it’s just not sustainable for human nature. Of course there’s small successful examples but these ppl must be very discipline and ensure the calories they take in is good calories. Calories counting is just boring!

[@jeffbuchholz954]

at ~ the 6 min mark or so you call him out for saying that cutting calories won't cause weight loss. You are correct, but I think he was being imprecise in an off the cuff discussion. You do mention that you realize physiological reasons for difficulty in keeping weight off, but I think you don't emphasize it as much as is true in the grand scheme of things. Study after study has shown the difficulty people have in keeping weight loss over time. Gary Taubes mentions some in his book, "Why We Get Fat and What to Do About It", a simplified version of his book, "Good Calories, Bad Calories". In those books, he makes the case that just cutting calories is very problematic for very many overweight people. He mentions one study where they put people on a very low calorie diet & they lost a lot of weight initially, but their metabolisms slowed down a lot and for as far into the future as they were studied, and they were dreaming of food and wanting food every waking hour. One big problem may well be continuing on poor, high carb, high sugar diets. In your own case, I assume that you were eating a pretty healthy diet when you cut calories. Those who continue "grazing", eating snacks & so on whenever they feel the urge and eat a HC diet with highly processed foods have great difficulty in continuing to follow a diet of just eating less of that same bad diet to cut calories. Dr. Fung gives the example of "America's Biggest Losers" who lose massive amounts of weight on a TV show by following a strict caloric restriction while drastically ramping up their exercise levels. He asks why don't they have followups on these people, like an online reunion a year or 2 or 3 down the road? He answers, because almost all of them gained all of that weight back and then some, many much more than they weighed before this entertainment/reality show tried to prove that cutting calorie intake and increasing calorie burn would make one lose weight. That is indeed a physiological "Law" one might say, but that is a construct that plays out very differently in "real life" than in a mathematical equation. Fasting &/or HFLC diets will tend to make things easier for most people to lose weight and keep it off in the long run without the agony of feeling like they are going hungry all of the time.

[@remusvisan]

Good to know although the fact that cutting calories make you loose weight or not it's not really that important as long as Dr. Fung's method is good anyway. Autophagy or not, fasting is definitely good for health.

[@angelicambience28]

I wish I could keep listening but the music unfortunately is too distracting. Hopefully you can minimize the Music volume on your future videos. Thanks

[@Physionic]

Thank you for the feedback.

[@alistairnicholson2046]

The Biggest Loser Study was in J Clin Endocrinol Metab. 2012 Jul;97(7):2489-96 . It showed massive fat loss over 30 weeks. It also showed a big drop in basal metabolic rate. In one case 1700 cal per day. The effects persisted for some time (2 years later?). Perhaps a reason for intermittent fasting recommendations - limiting duration of calorie deficit, or your video on part reversion of diabetes using cyclic calorie reduction as more effective long term strategies. Hence his deduction that eat less, exercise more, alone doesn't achieve the long term results expected. The body responds.

[@bobmciver6437]

Appreciate the content. Relationship(s) of cancer/fasting/autophagy tend to receive superficial discussion and descriptions of mTOR/AMPK can lack nuance in the attempt to get a point across.

[@Physionic]

Completely agree, Bob. Thanks.

[@marcjames3487]

Dr Fung certainly has a talent for explanation. I just don't understand his throwaway comment that restricting calories doesn't affect weight and wonder if he had another meaning in his head. It would be great if you could give him an opportunity to say exactly what he meant.

[@crzyces1693]

I gotta get ready for my walk after almost 2 hours at the gym. Ugh. Skipped a day and tried to make up for it. Heh, ran out of energy after doing chest, lower back, quads, upper back (this is where I ran out of gas), delts, traps, then back to finish off my chest with cables...and back to lower back with reverse crunches. I'll just give this a thumbs up now since I already know something will be debunked and thoroughly explained. Maybe I should put my walk off for a few hours. I had half of a protein shake when I came home so we all know that means there is no way for me to burn energy stored in fat cells now making my 3-7 mile walk a complete waste of time. Darn magic insulin shields that defy the laws of not only thermodynamics, but space and time themselves!

[@wiblin701]

In Dr. Fungs defense I think his comments regarding caloric reduction and weight loss come from a clinicans perspective. As a family practioner for many years I can tell you that sending someone to the dietician who puts them on a caloric restricted diet scientifically calculated to have them lose lets say a pound a week essentially never works. I can think of 1 or 2 patients out of hundreds or thousands over the years that this approach worked for. Yes it can work for patients who are obsessive about their calorie intake but for the general population it doesn't work long term. Yes they stick with it for a month or 2 and lose some weight but inevitably it fails. Even fasting is difficult for many people to stick to long term but because of its simplicity and better physiologic impact i.e not reducing the metabolic rate that caloric restriction produces (according to Dr. Fung- is he correct?) it has been something that I have seen people be able to stick to and lose weight long term. Not a lot of people but at least some which is better then essentialy none with caloric restriction.

[@schrodinger6429]

Good Sir I have a question on intermmitent fasting and muscle loss if you don't mind. If I'm in the state of running ketosis in my body and doing anerobic and aerobic activity at the same time say maybe cycling? Will I then lose muscle mass in that process ? Also something like age related muscle loss. Like Men over 30's; when one would workout during ketosis have any detrimental effect on that particular person?

[@oilsandmoreforhealth4829]

Sugars are one of the main feeders for many cancers; starve the cancer and what happens?

[@Physionic]

I have a video discussing this in depth that will release in a few weeks. It's simply not that simple, as much as many influencers explain it that simply.

[@dickensyuen6137]

I think what he means not all calories is the same and calories numbers don’t mean anything to the metabolism of body. Just imagine if you intake 1000 calorie of sugar vs 1000 calorie of protein, sugar will definitely make you fatter cos not only the calories, but hormones and how body metabolize different macro nutrients is more important.

[@JeffreyFate]

I enjoy your straightforward (obviously scientific based) approach to these critiques. Sorry if you already did one and I didn't see it, but can you go deeper into the interaction of IGF-1 as it relates to cell over growth (as far as I know, how cancer takes hold as a disease or condition) and fasting? I'm confused how fasting, which increases IGF-1 can have anti-cancer effects.

[@Physionic]

Thanks, Jeffrey, I appreciate it - that's the aim. IGF is a growth stimulus, but the stimulus is likely insufficient to generate growth in a catabolic environment. IGF could bind its receptor and send its signal into the cell, but protein synthesis could be terminated due to lack of energy or amino acid availability. Also, tumors create their own microenvironments that are different from the rest of the body (in certain respects), so that could easily play a factor, as well. For example, tumors can recruit immune cells to *specifically* release growth factors - its a devilish process, but it localizes growth signal within the tumor, leaving the rest of the body at low levels. Just a few different situations - I have some videos on most of it, if you're interested. I hope to cover more on the topic in the future!

[@health-seeking]

I take chicken stock for fasting. I hope will not stop atophagy.

[@harleensingh7983]

Can you please talk about the potential benefits of fasting and hsv??? Please!!!

[@Hakbak33]

I like Dr Jason Fung’s videos but another perspective is always good. What I’m missing is when you disagree about the effect off counting calories why don’t you speak about the fact that the human metabolic goes down when someone cuts calories which makes it harder to loose weight with this method. End I miss a conclusion saying general speaking it’s good to follow Dr Fung’s method or maybe other methods are just as good ?

[@marlenerobinson7684]

Dr Fung. You mentioned in one Video that Folic Acid +Beta-carlton gives more cancer if you're on a fast. I'm going through a water fast right now and was taking my multi vitamins that had both of them. Is there another supplement that will cause more cancer? Please could you let me know. THANK YOU DR FUNG

[@basselalmourani3051]

Hi, my uncle has atg 4 cancer in the bladder, unfortunately, so do you think keto with omad will help? I note here that his kidneys are weak that's why the doctors don't want to go in chemotherapy, so I am thinking about fasting actually 😐

[@sismarin]

So restricted calorie intake did not cause your metabolic rate to fall? How exactly did you manage that?

[@lukapopovic6668]

I think ,instead of cancer cells he thought of the cells that would become cancerous soon. @Physionic I thought that cancer cells that that rely on fat have not been discovered yet,can you make a video about it, thanks

[@ikottagemtem2649]

Not all persons are the same and foods have effect on individuals. There is no perfect results on everyone. It's a guide and if you lose weight go for it. Its ALL your take and results. That's a general idea.

[@mmuthuvel6829]

Science explains the human experiences. It can not predict human experiences. We need to experiment.Experiments on rat may not be true in case of human beings.I do consider both your and fungs arguments on calories. He does say "calorie reduction does not help" but he adds "harmones to be fixed". I expect your views on fixing harmones.

[@Wallow28]

Thoughts on prolonged fasting apparently being muscle sparing? Trying to decide between PSMF rapid fat loss style and prolonged fasts of like 72 hours? Presume PSMF is better but would be interested in your take

[@Physionic]

Fasting does spare muscle, but it’s not ideal (in some cases detrimental) for muscle growth.

[@Wallow28]

@@Physionic was thinking more for minicut purposes as willpower wise I'm better with shorter harsher periods than longer easier ones. So for example 3 day prolonged fast vs say a week of PSMF?

[@Physionic]

Wallow28 either one would be fine for muscle retention, unless you’re highly muscular, in which case anything over a few days may be detrimental.

[@CarbageMan]

You're just wrong about your "physical law of thermodynamics." The calories in and calories out aren't the only variables in the equation. I did if your way and was successful in my 20's. In my 50's, I had to use keto and fasting because it DIDN'T work. IMO, Fung correctly attributes this to hormone (insulin) balance, which I corrected. The worst advice I ever got was to eat several times a day-well, maybe next to sweetening with agave nectar! Fasting and keto changed my life, as I beat diabetes and have maintained proper blood sugar and moderate basal insulin for about four years. PS: If I have any concerns about the three books I read by Dr Jason Fung, it's that I under-estimated the need for protein during my eating periods and the need for resistance training during my extended fasts. The combination of not doing resistance training (though I had resistance training experience) and not optimizing protein while eating probably led to undesirable loss of lean mass. Since, I have altered my habits and re-gained significant lean mass--even beyond 55 years old. Now, I just have to crack the body builder's trick of building and cutting, but I figure fasting under better conditions will help with that. I've taken to working out fasted, then feasting (not late in the evening) and fasting a weekend day or two, while eating a high protein diet, which could no longer be considered keto, but is definitely very low carb. My ketones only spike when I fast more than a day, but they always show up in my blood and breath.

[@imyourtrance5537]

science is strong, thanks for the efforts

[@Physionic]

You bet

[@somaking77]

Hey there - thanks for the video! So if I did want to stimulate autophagy, what's the solution? Is it to consume nothing, to lower ATP? Currently the Bulletproof diet thinks that protein restriction is enough and they recommend eating fat and carb on a protein fasting day. And also Fung allows bone broth and cream while fasting... which would also inhibit authphagy?

[@Physionic]

My pleasure. The greatest driver of autophagy is complete water fasting. Consumption of any kind decreases autophagic flux relative to fasting.

[@nonacee5065]

@@Physionic Jason Fung said that in another video. He said if you want autophagy then only water fast but he's talking to a majority who are looking for weight loss so he addresses that more in the fasting methods.

[@lonesurvivor8306]

Love to geek out on your videos :)

[@Physionic]

Happy to hear it, Minotee.

[@williambuckley6128]

With all that said would certain raw green vegetables keep you in autophagy in a 5 day fast?

[@Physionic]

Hey William, no. Keep in mind that autophagy isn't a switch that's on or off, its a scale.

[@tomgoff7887]

I'm inclined to side with RationalWiki's asserssment of Fung.

[@xcomfan]

Great vid, keep them coming!

[@Physionic]

Thanks, excomfan!