Corticosteroids (Part 02) Pharmacological Action of Glucocorticoids | Glucocorticoids | Steroids

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Corticosteroids are a class of drugs based on hormones formed in the adrenal gland or derived synthetically. They are created from cholesterol and divided into two major groups: glucocorticoids and mineralocorticoids. Common glucocorticoids are cortisol (hydrocortisone), prednisolone, dexamethasone, and corticosterone. An important mineralocorticoid in humans is aldosterone. Corticosteroids influence a wide range of physiological processes, including stress response, immune response, regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behaviour. The secretion of these hormones increases during stress related to anxiety and severe injury. Corticosteroids are often prescribed for severe allergies, skin problems, asthma, and arthritis. They are also used to help prevent organ rejection in transplant recipients. Chronic overproduction of these substances is associated with various disorders, such as Cushing′s syndrome
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Sir,if they increase glycogen deposition then glucose should be low( as glucose convert in glycogen) then why hyperglycemia ??

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[@aditiagare9716]

My doubt is how can Glucocorticoid decrease availability of glucose in tissue if we are doing our activities constantly ? We need energy and the body will provide it so how it works??

[@yuezhenyongshen7313]

Hi, aditi. Glucocorticoid is a stress hormone, in stress our brain requires more amount of glucose. This hormone sort of cuts the glucose supply of the peripheral organs. Thus more glucose in blood, so more available to brain. Other organs shifts to lipid as energy source. Glucocorticoid also cause lipolysis...,

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Sir can we write same pharmacological actions for hydrocortisone and prednisolone ?

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Sir jab glucocarticoid calabolic Harmon hai to phir glucose glycogen me kaise convert krta hai jab nhi pta hai to bachho gumrah Mt kijiye

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