Diuretics | Pharmacology

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Diuretics | Pharmacology | Dr Najeeb

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7 жыл бұрын

#drnajeeb #medicines #pharmacology #diuretics
Diuretics | Pharmacology | Dr Najeeb
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Diuretics-Pharmacology
00:00:00
Diuretic and Natriuretic.
00:02:02
Relationship between Cardiac Output (CO) and Renal Blood Flow (RBF), Percentage of RBF ending up as Filtrate; Concept of Glomerular Filtration Rate (GFR) as a function of CO and RBF. Understanding the role of processes such as Filtration, Reabsorption and Secretion.
00:16:19
Percentage ending up as Final Urine Volume, Clinical co-relate: Oliguria, Polyuria; Nephron as the "Master Processor".
00:28:59
Diuretic and Natriuretic drugs' action on nephrons.
00:30:26
Outline: Mechanisms and sites of Reabsorption (Na+ primarily), 1-Proximal Convoluted Tubule (PCT) 2-Thick part of Ascending Loop of Henle (TALOH) 3-Distal Convoluted Tubule (DCT) 4-Collecting Tubule (CT)
00:33:42
1-Proximal Convoluted Tubule (PCT); Anatomy of PCT & mechanisms of Reabsorption, Secretion, Exchange (Na+, H+, HCO3-), Role of Na+H+-counter transporter and Na+K+ ATPases.
00:50:00
Carbonic Anhydrase (CA) enzyme, H2CO3 (Carbonic Acid); [HCO3- and H+] and the drugs that act through blocking CA enzyme (CA inhibitors); Increased Na+, HCO3- and H2O in urine: Acetazolamide.
01:00:29
4-Collecting Tubule (CT) : Principal cells, Mechanisms of K+ wasting (Kaliuretic); K+ Wasters = All Diuretics acting proximal to CT.
01:13:00
Descending LOH: Freely permeable to H2O [along with PCT]; Ascending parts of LOH + initial DCT fully impermeable to H2O, Role of ADH in CT's water permeability and excretion of dilute and concentrated urine, Osmolarities in various parts of tubule & its rationale.
01:35:56
2-Thick part of Ascending Limb of Loop of Henle (TALOH); Na+ K+ 2Cl- Co-transporter, K+ leaky channels on luminal side; electro positivity in lumen and its effect on Ca+, Mg+ reabsorption; Drugs blocking NaKCl co-transporter; Loop Diuretics [Furosemide etc.]; Kaliuretic + Calcinuria + Magnesiumurea
02:04:15
3-Distal Convoluted Tubule (DCT): Na+Cl- co-transporter, Na+Ca+ counter transporter, role of Parathyroid hormone (PTH), Thiazide Diuretics as Ca+ retaining drugs; Renal stones.
02:19:15
Comparing Thiazide Diuretics, Furosemide and their effect on Ca+ absorption & its clinical implications; Osteoporosis, Hyperuricemia. Interaction with NSAIDS.
02:26:35
Drugs acting distally to DCT; Antikaliuretic drugs: Importance of Principal cells in K+ balance, Na+ channel blocking drugs, Role of Aldosterone;
02:48:50
Effects of Diuretics on Principal Cells; Amiloride, Triamterene; K+ Sparing drugs. Aldosterone Receptor Blockers (ARBs): Spironolactone
02:54:54
Osmotic Diuresis; PCT: Mannitol; Increased Extracellular Fluid Volume (ECFV)
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Пікірлер: 315

@VivekYadav-bd1bt 11 ай бұрын

Sir everytime u proove what u say always.......that is the crystal clear concepts....best teacher of medicine i have ever seen..

@DoctorNajeeb 11 ай бұрын

Thank you for all the love and support❤ Stay blessed ❤

@rajatpandurangi9209 Жыл бұрын

Legends be this clear and still ask 'Am I clear?'. Love from India Sir

@DoctorNajeeb Жыл бұрын

Thank you for your love and support ❤️

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@MuhairwaWycliff 2 ай бұрын

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@DoctorNajeeb 2 ай бұрын

Thank you for your love and support. You can sign up to get premium video library access. www.drnajeeblectures.com/

@bitsofskin2088 2 жыл бұрын

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@DoctorNajeeb 2 жыл бұрын

Thank you for your love and support. :) May you be blessed with knowledge, prosperity, love, and happiness, always. ❤️❤️❤️❤️

@rik8924 3 жыл бұрын

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@tanimadhar4280 3 жыл бұрын

The fact that you made me believe that even pharmacology can be understood and need not be crammed is itself praise worthy .. thank you so much sir ... Extremely grateful 🙏

@ismetkarabyk2040 2 жыл бұрын

@chiranjibidas1769 Жыл бұрын

I haven't seen any teacher teaching like this very clear fundamental not only in pharma but also in physiology also 🔥🔥

@DoctorNajeeb Жыл бұрын

Glad to hear that ❤ Keep supporting ❤

@suryaprasantnaram5141 Жыл бұрын

Yeah brother.

@ashifh4168 4 жыл бұрын

I missed a teacher like you during my graduation. Thanks for making the mechanism clear and simple. With prayers.

@anilkulria3871 2 жыл бұрын

After 5 years you are still liking every comment Great

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999

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Best teacher in the world

@aisharasool4598 4 жыл бұрын

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@papaibiswas7993 2 жыл бұрын

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@papaibiswas7993 2 жыл бұрын

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@co2_os 7 жыл бұрын

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@mannykamra8070 4 жыл бұрын

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