Pharmacology - OPIOIDS (MADE EASY)

[@SpeedPharmacology]

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Is it free?

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Will it pay in Opiates?

[@StellaJaeR]

7:55 I do have a question. On the illustration part where excitatory pathway of opioids are displayed, isn't Cl- influx trigger hyperpolarization thereby decreasing action potential and no positive response? I'm kind of confused, can you further clarify this for me? Thank you so much, I love your videos btw.

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Nice timing, I have an exam on opioids in two days! Thanks!

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Does prolonged regular opioid use cause permanent changes in receptor function?

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[@lavishlavon]

*WOW* ... you sir have got to be (so far & that i can recall) the only person who has ever got this FULLY CORRECT. I like how you noted that the effect opioids have on breathing really boils down to the sensor that detects how much co2 is present (& in doing so, essentially blocks-to an extent- the alert that warns a person when their co2 levels get too high..& so they would feel that urge to BREATHEEE, to avoid death)...one would be surprised just how few people actual are aware of this, they think opioids just make your lungs not want to move or something. Also like how you mentioned the action Methadone has as an SNRI (tho i wouldve also liked to see you do the same for Bupe for it also has an interesting profile of agonism/antagonism). One last thing i was quite pleasantly surprised to hear you mention was the reason as to why Naloxone acts on the receptor as it does.. this is due to its HIGHER AFFINITY in contrast to other opioids!...again, this is unknown to most & it boggles their mind when you try explaining that to them especially when theyre not actually even aware that Naloxone (& naltrexone) are ALSO themselves OPIOIDS. Their mind is usually blown at that point & you then realize they just simply don't have the full in depth understanding as you may have. Idk, sometimes i feel like i'm the one going crazy in such a seemingly ignorant-uneducated world, but alas i am humbled once i remind myself just how truly ignorant we all are myself included. Lol, so its all good! Thank you much for this, refreshing!!

[@SpeedPharmacology]

Thank you for your thoughtful comment

[@SolidSiren]

I thought he said methadone acts as an SSRI? Meaning it can cause serotonin syndrome.

[@SolidSiren]

Low dose bupe is being investigated for treatment resistant depression

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Now I understand how opioids drugs work. Thank you very much 🙏

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Title:Opioids(MADE EASY) Me at 7:22 : *nervous laughter*

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I have severe constipation after opioids were used in arterial surgery. Any comment or direction I can research on what to do here?

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