Spravato (Esketamine Nasal Spray) now FDA approved for Treatment Resistant Depression!

[@DavidLindermanMusic]

I heard from a nose specialist(Medical doctor) that the second most common reason for nasal septal perforations is the use of topics nasal sprays, however it’s still extremely rare even with chronic long term use. I was told that yes nasal sprays after long term use can cause septal perforations and that even short term use of nasal sprays can cause septal perforations, however both instances are rare, even with chronic use. So septal perforations from long term or short term chronic use of nasal sprays is rare. Lastly I was told, intranasal medications can cause septal perforations however this is exceedingly rare, meaning extremely rare. So I don’t know what to think about the safety of nasal sprays with the nasal passage ways. If septal perforation is extremely rare with intranasal medications then I guess I wouldn’t worry about it.

[@a.evansrn107]

This was an extremely informative video. Even though you don’t have a ton of views on this video it is the most educationally and detailed, informative video that I’ve viewed on the drug. Thank you. To me the long term affects of this medication are questionable. Some studies say it could potentially lead to a degenerative brain disease. I think I will wait for further long-term studies to be conducted and evaluated

[@DanGreer]

Thank you for the compliment! I think that is a very valid point. The package insert for the medication discusses how long term cognitive and memory impairment has been seen in people who have abused ketamine, so I would guess that esketamine could cause those same things to happen.

[@grootStudioCity]

Dan, am I on the right channel? I found you over trying to get my life back from depression. With the thoughts taking the drug as needed.

[@DanGreer]

It is a good question and not determined if it can be used as needed. Maybe it could just be used as a boost when depression gets bad, but currently it was approved as a scheduled medication.

[@warriorstyles3139]

It actually changes the way the brain fires alot like DPDR in people with mental illnesses the mind shuts down to reboot same thing happens here just stronger imo

[@DanGreer]

That is well thought out and makes sense. I agree it would change the way the brain fires if there is proliferation of synapses in certain parts of the brain.

[@DanGreer]

@@DevonCrowell Ketamine and Esketamine is thought to work for depression by allowing brain cells to grow more connections. This strengthening of connections may help the brain to fire correctly and correct depression processes.

[@QueenH.]

I can’t feel my emotions nor hear my thoughts for 4 years u think this can help me ????

[@displayfireworks]

It sounds like the 2 hour post observation period continues for every dosing no matter how many weeks the pt. is into therapy. Also is there a position the pt must be and or stay in when the dose is administered? Does the required healthcare setting change as the pt progresses into therapy? For example once pt is into weeks say 4 and beyond does the setting still have to have advanced life support etc. Can a home care health professional visit the home and spend the 2 hours with the pt in the home setting? Thanks for the information in the video and the website link

[@DanGreer]

Yes the 2 hour observation period is for every dose. The patient's head should be tilted back 45 degrees, at least while administering it to keep it in the nose. The last question is a good one, but I don't think that level of detail has been established yet, but it would be nice if it could be in the home setting!

[@patrickmcmullen1190]

Hi Dan. I'm in the process of trying Spravato. I've been on phone etc. But anyway, still waiting for a center near me that carries my insurance. I only see like 3 places with in a hundred miles and i'm in central Florida! It's been approved for two whole months. I read that you have to take the oral anti depressant simultaneously with it. I'm worried because I can't tolerate side effects of the oral ones. That's why i am resistant to them. I'm currently on Gabapentin, but that's not a anti depressant. So, am i out of luck?

[@DanGreer]

Hi Patrick, it is hard to say since it is still so new. It was only studied and approved to be used in conjunction with an antidepressant medication. You still may be able to get it if your doctor feels comfortable. It would be considered "off-label" and insurance companies may give push back on paying for it. You could look for ketamine clinics as another option.

[@irishgirl1753]

Hi Patrick can you update how your doing I have treatment resistant depression 🫶🤗

[@TURK_182]

At least 2? I lost count of all the ones I trird

[@ayedew9227]

Lil pump gave them the idea.

[@srgt.stones8627]

Lmao Lil pump is dumber than a Sack of potatoes he didnt do shit... And that's offensive to the potatoes Lmao

[@samp739]

I have severe comorbid anxiety depression . Currently just starting done 56 84 no effect

[@DanGreer]

I'm sorry to hear that, it may take some time to fully help, or maybe it isn't the right medication for you.

[@Snnjzhzzj]

Hi i wanted to ask you if the drug gets fda approved does it mean it immediatly will hit the market, and how long might it take to come to europe. I live in eastern europe and i suffer from treatment resistant depression. I wanted to know how much are the chances for the drug to come to my hands as soon as possible and at what price, if u have any idea. I cant-find any info online, if u replied it would mean a lot to me

[@DanGreer]

This drug is expected to come to market in the United States at the end of the month. I unfortunately do not know how long it will take to come to other countries or at what cost. This will probably depend on the laws and regulations of the country that you live in. The drug company (Janssen Pharmaceutical) may be able to answer your questions.

[@Snnjzhzzj]

Dan Friend one more question, has sprovato hit the US market already, for example if u go in a pharmacy can u buy one and at what cost? If its not in the market yet when can it be approximately

[@DanGreer]

@@Snnjzhzzj It is not a drug that can be taken out of a pharmacy. It must be given in a clinic by a healthcare provider and the patient has to be monitored for 2 hours after the dose. It is expected to be released at the end of the month. The expected cost is $590 and $885 per dose without insurance.

[@DanGreer]

@@DevonCrowell Yes per dose, that is the expected cash price

[@anti7035]

Esketiiiiiiiiit

[@djrafa1]

I hope is going to help million Peoples..

[@DanGreer]

I hope so as well

[@danutaraus4415]

They gonna charge 5000-6,000 per month.That's medication for the rich only- crazy

[@DanGreer]

@@danutaraus4415 I saw a WAC of $590 and $885 (depending on the dose) per dose, and insurance should cover some of it. Where did you see 5-6K?

[@warriorstyles3139]

Thats if big Pharma doesn't make it so expensive just so people will still buy the damn PILLS

[@TURK_182]

@@DanGreer thanks, I was looking for the pirce

[@warriorstyles3139]

Shit i sit in the dr room at least 2 hours every time i go anyways at least i would know why i have to wait two hours.

[@DanGreer]

I like the positive spin on the wait

[@akathehnic]

That's exactly what I thought when he said that 😂

[@rickberglund2134]

Dan, you are a beautiful man

[@DanGreer]

Thanks Rick

[@collinr811]

Is there anyway to get ahold of Spravato Online. I cant afford the clinical setting cost.

[@DanGreer]

Not legally in the US

[@collinr811]

@@DanGreer how about illegally?

[@DanGreer]

@@collinr811 no clue

[@colinschabel]

I want it really bad but, it sounds like a pain in the ass. Going to a ketamine clinic sounds much easier

[@Steen7777]

ESKEREEETITT

[@elpiton7356]

Just inhaled some esketitmine ESKETIT