Staphylococcus Aureus vs Immune System

00:21 Tissue Damage Activates Fibroblast to release Inteluekin-25 & Interleukin-33
00:30 Inteluekin-25 Activates Type 2 Innate lymphoid cell to Release Inteluekin-13 & AREG
1:05 Complement Pathway Activation.
1:50 Inteluekin-13 Attracts Mast Cells and are activated by Interleukin-33 and Component 5a to release Histamine
2:00 Inflammation
2:25 Staphylococcus Aureus evades the Complement System
3:00 S Aureus Cell Wall Anchored Proteins (Protein A, SasG, Isd, Collagen Adhesin)
3:17 Collagen Adhesin Mechanism
3:51 Phagocytes (Neutrophil & Monocyte)
4:03 Phagocyte Chemotaxis Pathway
4:45 Phagocytosis and Respiratory burst on Phagosomes.
5:40 Neutrophil Extracellular Tramps (NET's)
5:55 Macrophage
6:12 Toll-Like Receptors Activates Macrophages to release Interleukin-6, Interleukin-12 & Interleukin-23.
6:34 Interleukin-23 Activates Type 3 Innate lymphoid cell to release Neutrophil attracting chemokines, Interleukin-17 & Interleukin-22.
6:50 Interleukin-17 Activates Fibroblast to release anti-microbial peptides
7:02 S Aureus Biofilm
7:40 polysaccharide adhesin Synthesis
9:00 Quorum Sensing
10:06 S Aureus Virulent Factors (CHIPS, Hemolysin, Leukocidins)
REFERENCES:
📗 Biochemistry 4th
👨‍🔬 Donald Voet, Judith G. Voet
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📗 Molecular Biology of the Cell 6th
👨‍🔬 Alberts, Johnson, Lewis, Morgan, Raff, Roberts, Walters
-------------------------
📗 BROCK Biology of Microorganisms 13th
👨‍🔬 Madigan, Martinko, Stahl, Clark
-------------------------
📗 Netter's Essential Histology 2nd
-------------------------
📗 Introduction to Human Physiology 8th
👨‍🔬 Lauralee Sherwood
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📗 Janeway’s Immunobiology 9th
👨‍🔬 Kenneth Murphy, Casey Weaver
-------------------------
📗 Robbins Basic Pathology 9th
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📰 Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
📰 Bacterial Two-component and Hetero-heptameric Pore-forming Cytolytic Toxins: Structures, Poreforming Mechanism, and Organization of the Genes.
📰 Commensal StaphylococciInfluence Staphylococcus aureus Skin Colonization and Disease
📰 Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections
I use Painter Corel to do the drawings and After Effects to Animate the scenes.

[@anomalyp8584]

This is the single most amazing set of animations I have seen to this day!

[@patronsaintofpoison]

I am an IV drug user and when I was stupid and used just water to wash the injection site, instead of rubbing alcohol, I got an abscess. That's what this animation demonstrates, and was really amazed to find this! Fortunately, I treated myself with Neosporin, and my abscess went away- even though it went through a very gross, painful stage where it was leaking and spurting pus. I tell you truly, I NEVER get abscesses when I first clean the injection site with rubbing alcohol. Thank you for this information!

[@crypt0z]

Very informative! I am eager to hear what happens next. Thanks for publishing this.

[@Bubblegumluke16]

Hey, great video! Even though you have it correct in the descripition, in the title of the video staphylococcus is spelt wrong :)

[@zyadhadji1114]

Why they don't teach us this way in collège? 😩 Please the second part of this Amazing work .

[@cyanuranus6456]

0:15 Darn. That's a Bunch of Unique Germs on a Few Splinters

[@CantChooseUsernames]

I love the fact this happens every day!

[@bernexf4694]

Awesome, what happens next?

[@shadhoover9820]

Cool❤!

[@RyanNoodle2909]

🔥🔥🔥

[@MolecularAnimationsoftheCell]

If you liked the video give it a thumbs up and comment something so that the algorithm treats me well. ✌ if you want to support the channel? here is how www.patreon.com/MBoC

[@cyanuranus6456]

What is it Called That "Staphylococcus Aureus" Uses "Fibrin Strands" for a Weapon?

[@user-kl8ep1wj6s]

it's not slowly weakening them, it's killing them into pieces!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

[@desmond3828]

What about the adaptive immune system? That was only the innate in that video

[@hanalias1117]

Germs aaaaah!!!!!!!!!!!!!!!!!!!!!!

[@TommyBecker2023]

Goody

[@RyanNoodle2909]

100'000'000'000'subs

[@user-yp4dh2vc8r]

ينأ هاذا يهدار للفكر والوقت

[@theman-wq5on]

i'm glad you think the one thing keeping you alive and well is fake

[@RyanNoodle2909]

Leave me alone

[@busti4552]

Please stop using TTS and use a real voice actor instead.

[@MolecularAnimationsoftheCell]

I am working on it.

[@nickmcdonald3083]

I think the depersonalized voice is nice. It seems more scientific.

[@___bydiana]

😮😮😮

[@crypt0z]

@@nickmcdonald3083 Yea, I don't mind it at all. Honestly didn't even notice.

[@vicentealvarado5608]

@@crypt0z Wowww this blew my mind. Thought it was a real human voice.