Stephen Harrison (Harvard) Part 1: Virus structures: General principles

www.ibiology.o...
Harrison begins his talk by asking why most non-enveloped viruses and some enveloped viruses are symmetrical in shape. He proceeds to show us lovely images of the structures obtained by x-ray crystallography of numerous viral coat proteins. Deciphering these structures allowed scientists to understand that viral coat proteins form multimers, such as dimers and pentamers, which in turn interact with a scaffold that ensures that the coat proteins are correctly placed. This arrangement results in symmetrically shaped viruses.
In Part 1, Harrison also explains that enveloped viruses infect cells by inducing the fusion of the viral and host cell membranes. He delves deeper into the molecular mechanism of membrane fusion driven by the hemagglutinin or HA protein of the influenza virus in Part 2 of his talk.
Non-enveloped viruses, on the other hand, must enter cells by a mechanism other than membrane fusion. This is the focus of Part 3. Using rotavirus as a model, Harrison and his colleagues have used a combination of Xray crystallography and electron cryomicroscopy to decipher how the spike protein on the viral surface changes its conformation and perforates the cell membrane allowing the virus to enter the cell.

[@jjcool7967]

wow, this is outstanding, as a respiratory therapist for 32 years and pre-med I love anything Harvard school of medical school give out for free. Stephen Harrison is outstanding. I would love to go to Harvard but I not going to rule out Morehouse and Meharry Medical college

[@jaymuzquiz2942]

I never graduated high school but I love watching these presentations! This is so F@cking interesting I can't get enough!

[@kx4532]

Get back on it! Consider it an adventure.

[@M3ta1]

It's funny, most of the reason why disinterest happen is because of how it's taught. If only teachers realized this.

[@vittorio4866]

Don t worry...love is love, go deep with the subject

[@abhijeetsinghbarath4248]

Such a beautiful presentation; directly hammering the why, how and what about viruses into the head. Thank u dr. Stephen:)

[@gregory4279]

These mini presentations are gold! Icosahedral structure...loving this

[@lupe2562]

Hi Dr Harrison. Nice to see you, on this wonderful presentation. I worked at Harrison-Wiley lab at children hosp. Long time ago.

[@tomasmieger6826]

Thank you Stephen Harrison for this amazing Videolecture. Now I am going to check part 2 and 3.

[@SafeAndEffectiveTheySaid]

We have a few rules in physics, but emergence rules everywhere, we go through simplicity to extreme complexity in just a few steps, complexity grows exponentially the closer we look the more it increases.

[@JamesVestal-dz5qm]

Understanding that viruses are extracellular organelles is the history of how people used to learn that other people weren't whole people. Viruses and molecules have symmetry, but cells and organism's are asymmetrical. All life starts asymmetrical, yet all life seeks to create symmetry in its local environment. This ties back to Chris Cramer's statements that the entropy of the universe is always increasing, but we can locally decrease the entropy in places.

[@antn8387]

Thank you, fantastic presentation, Doctor.

[@let4be]

Thank you for your time and for sharing your knowledge!!!

[@manalokos]

This is amazing! Thank you!

[@rakeshmanathana]

Excellent lecture. Very clear and precise. Thanks!

[@riazshafik4430]

Now i'm watching this because of corona virus march 5 2020. If you still around can make a video specific for corona virus

[@tardarsauce3355]

I've been reading peer-reviewed literature on the coronavirus. If you still have questions, ask away

[@tracylynn1461]

Haha I dont see that happening... the world would u understand and that wont serve the purpose of this Corona virus to start with

[@jameslopes365]

this is nice thanks this is going to help my homework

[@tahsinhadidi598]

well done prof Hatem

[@herauthon]

are these viri symbionts with plants in the long term - t.i.- that plants are pushed into change due to viri like this ?

[@akmazam2713]

Excillent .Thanks sir

[@rayman28079]

Thanks Dr Stephen :)

[@mortkebab2849]

How do those shapes evolve? Evolution is usually a series of small changes, each of which is advantageous in its own right. So how does one go from a helix to an icosahedron, for example?

[@patldennis]

Helix is the shape of DNA polymers. Icosohedron is the shape of the virus itself. Two separate entities

[@mortkebab2849]

@@patldennis I'm talking about the symmetry of the virus. Some have a helical symmetry as he describes here: kzbin.info/www/bejne/gaCtiKiNr7uap7M

[@animalparty8206]

👍👍👍👍👍Amazing❤❤❤❤❤

[@Theodorus5]

This has become popular all of a sudden lol :)

[@ronaldderooij1774]

Right. This was my first introduction to biology in general and viruses in particular. I am a political scientist and I do not understand this. Back to basics first.

[@bobomaigret5430]

MIT CourseWare provides an intro Bio course. No charge. I believe it's accessible on KZbin.

[@dimibolhas]

Actually, that's some post graduate content, you will need to watch some lectures on protein structure and cellular biology first.

[@axel714]

where in nature virus are created ?

[@CobraQuotes1]

Bravo!

[@MasudRana-ps5hk]

Nice!

[@flyorraofficial]

Awesomeness

[@nancyhope2205]

You need to get engineers in here. I bet they could learn and explain it more clearly. This is great but I am struggling to understand. I am not sure that I am getting the right ideas ...

[@patldennis]

Not really Engineers have a tendency to insert their teleology, which is why so many of them spout intelligent design

[@joanieelmore4512]

@@patldennis kzbin.info/www/bejne/r5ytenSclranmNU

[@joanieelmore4512]

www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/pdf/SNI-13-167.pdf

[@tonymiller225]

Pretty much illuminates the difference in intellectual horsepower required between an arts and a science degree

[@marcuschiu8615]

19:13 tomato bushy stunt virus what? lol

[@henrybo5060]

Fabunan anti viral injection is the solution

[@goedelite]

I am impressed, as a physical scientist, by the amount of stuff doctors must commit to memory. How boring! I am happy I did not study medicine as my mother wished.

[@Kalumbatsch]

You're an actual physical scientist? Not an ethereal one?

[@coenraadloubser5768]

Just showing a microscope plate, then same under an electron microscope, then the same in a simulation, will do more to squash life taking bad information, than any appeal to reason. Drown the internet in more good info, like this, please!

[@mudchair16]

If they've never isolated and purified a virus by now, they never will. All they can do is their tissue culture pseudoscience which is easily refuted with controls.

[@willybumbum5351]

Carona

[@Darkwell0071]

But a hole in a box would not kill the CEO

[@ozusozudogruinsan]

I am not sure about the assumed knowledge or education level of your audience to understand this lecture. Unfortunately, It is not explained clearly...

[@ozusozudogruinsan]

When you talk about shapes, objects, symmetry, geometry, axis, subunits, folds etc. you lose the audience without explaining what it is or showing illustrations, diagrams etc. what, why, when, how are missing or difficult to visualize to understand what you are talking about...

[@zuhair1952]

uncomprehensive lecture

[@p_j_keenan]

Maybe you should watch parts 2 and three then?

[@grrobson1]

Negativity is a virus of the mind

[@PETERGIMLE]

zuhair jumaah 'Incomprehensible' (impossible to understand)or as you state 'uncomprehensive' (lacking in content)? And in the former case: did you add the comment for your own use? Merely curious.