Steve Horvath at Undoing Aging 2018

[@DanDascalescu-dandv]

Summary: the DNA methylation epigenetic clocks are highly accurate in predicting healthspan and age ("If you give me a urine sample, there's enough DNA there to tell you how old you are"). The DNAm clock should be used in anti-aging trials to evaluate effectiveness. It works in vitro as well. Diet (fish, fruits&vegetables), exercise, low BMI, education and income correlate with a lower epigenetic clock. Leukemia and cancers advance the measurement. "Age acceleration" = discrepancy between the methylation age and the chronological age. It's remarkably constant throughout life. Sampling should be done from multiple sites (blood, urine, buccal, saliva). Work is underway to develop a universal clock for mammals.

[@user-qh9lv1to3k]

I'm curious what the standard of methylation age is. Is it based on average-healthy person? For example, if my DNAm age is 40 while the chronological one 30, does that mean my body is similar to the health of a 'normal' 40-year-old?

[@christopherellis2663]

Mulțimesc mult

[@farshm.7400]

More people should support this cause.

[@stephenschuster7703]

exciting stuff

[@dongrey8975]

They have many pieces to the aging puzzle, but can't put it all together yet ~!

[@TaxLien]

Now there are methylation sequencing service on Internet that you can obtain your methylation data by providing a drop of blood or saliva. What is the math algorithm (statistics method) to calculate the biological age from the methylation sequencing data? What is the software or App that we can use to calculate our biological age with our methylation data imported into it?

[@mgalich1]

Thank goodness you are capturing slides finally

[@dongrey8975]

Wow, blood matching etc wow.

[@viviannemerr5084]

Showing the screen would have been more useful than the speaker’s face.

[@AndeyR]

Thanks

[@Martinit0]

20:48 I don't understand this statement

[@James-jc4xn]

Martinit0 what the yamanaka part or the transformation of a cell to a stem cell?

[@elcritico6105]

Do you know iPS cells?

[@eszterhorvath2599]

Probably Hungarian good mind!!!

[@jonnydazzels1565]

can that heal injuries? sign me up for tests. i want to be part of an experiement in anti-aging if it can heal injuries/disabilities. sign me up.

[@dongrey8975]

Poultry helps aging....

[@christopherellis2663]

Ne kérdezd, kiért szól a harang: érted szól. ⏰

[@marcelswoboda5427]

Study faster :D ^^

[@vickybiagini950]

Everything makes a rodent so much simpler. Humans have 206 bones, mouse don't. Humans have three layers of skin, Phalanges, Metatarsals, We are much bigger then mice also. I know you're not serious with this question? We are way more complex.

[@ChurchOfThought]

Extra bones arent extra organs. Structure...not size.

[@christophsteck531]

You should check your data a mous actually has more bones (225 ) than a human but I have to agree with church of thought Numbers of bones are not really relevant and the important structures and Systems that are at work during aging a pretty much universal process that you will find in almost every organism on earth are pretty much the same especially inbetween mammals

[@vickybiagini950]

The evidence in the lab for mice, not humans. Humans are way more complex then a simple rodent.

[@LarisaSheloukhovaCMT]

and what exactly makes a rodent so much simpler than a human?

[@k2ashley]

They have now tested on Humans and it works extremely well. It’s on my new reel today.

[@scottemptage2385]

@@LarisaSheloukhovaCMT ignore her. she is a troll that plauges all videos relating to life extension